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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Channa argus)

Authors:
Sun D, Qi X, Wen H, Li C, Li J, Chen J, Tao Z, Zhu M, Zhang X, Li Y
Citation:
Open Biol. 2023 Feb;13(2):220235. doi: 10.1098/rsob.220235. Epub 2023 Feb 15
Epub:
Not Epub
Abstract:
Body colour is an important economic trait for commercial fishes. Recently, a new colour morph displaying market-favoured...
Link:
https://royalsocietypublishing.org/doi/10.1098/rsob.220235
Delivery Method:
microinjection
Organism or Cell Type:
Channa argus (northern snakehead fish)
Citation Extract:
Sun D, Qi X, Wen H, Li C, Li J, Chen J, Tao Z, Zhu M, Zhang X, Li Y. The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Channa argus). Open Biol. 2023 Feb;13(2):220235. doi: 10.1098/rsob.220235. Epub 2023 Feb 15.

Milk fat globule epidermal growth factor 8a regulates neurogenesis in telencephalon and affects larval behavior in zebrafish

Authors:
Luo Y, Lu D, Zhou J, Wu J, Wang W, Qian L
Citation:
Stem Cells Dev. 2023 Feb 14. doi: 10.1089/scd.2022.0247. Online ahead of print
Epub:
Yes
Abstract:
Mfge8, a secreted glycoprotein, is a key molecule that mediates the phagocytosis of apoptotic cells. Previous research reported...
Link:
https://www.liebertpub.com/doi/10.1089/scd.2022.0247
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Luo Y, Lu D, Zhou J, Wu J, Wang W, Qian L. Milk fat globule epidermal growth factor 8a regulates neurogenesis in telencephalon and affects larval behavior in zebrafish. Stem Cells Dev. 2023 Feb 14. doi: 10.1089/scd.2022.0247. Online ahead of print.

Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Müller glia proliferation in the light-damaged zebrafish retina

Authors:
Boyd P, Campbell LJ, Hyde DR
Citation:
Front Cell Dev Biol. 2023;11:1142586. doi:10.3389/fcell.2023.1142586
Epub:
Not Epub
Abstract:
Zebrafish possess the innate ability to fully regenerate any neurons lost following a retinal injury. This response is mediated...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2023.1142586/full
Delivery Method:
intravitreal (intraocular) injection then electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Boyd P, Campbell LJ, Hyde DR. Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Müller glia proliferation in the light-damaged zebrafish retina. Front Cell Dev Biol. 2023;11:1142586. doi:10.3389/fcell.2023.1142586.

Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes

Authors:
Linder MI, Mizoguchi Y, Hesse S, Csaba G, Tatematsu M, Łyszkiewicz M, Ziȩtara N, Jeske T, Hastreiter M, Rohlfs M, Liu Y, Grabowski P, Ahomaa K, Maier-Begandt D, Schwestka M, Pazhakh V, Isiaku AI, Miranda BB, Blombery P, Saito MK, Rusha E, Alizadeh Z, Pourpak Z, Kobayashi M, Rezaei N, Unal E, Hauck F, Drukker M, Walzog B, Rappsilber J, Zimmer R, Lieschke GJ, Klein C
Citation:
Blood. 2023;141(6):645-58. doi:10.1182/blood.2022016783
Epub:
Not Epub
Abstract:
The mechanisms of coordinated changes in proteome composition and their relevance for the differentiation of neutrophil...
Link:
https://ashpublications.org/blood/article/141/6/645/486790/Human-genetic-defects-in-SRP19-and-SRPRA-cause
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Linder MI, Mizoguchi Y, Hesse S, Csaba G, Tatematsu M, Łyszkiewicz M, Ziȩtara N, Jeske T, Hastreiter M, Rohlfs M, Liu Y, Grabowski P, Ahomaa K, Maier-Begandt D, Schwestka M, Pazhakh V, Isiaku AI, Miranda BB, Blombery P, Saito MK, Rusha E, Alizadeh Z, Pourpak Z, Kobayashi M, Rezaei N, Unal E, Hauck F, Drukker M, Walzog B, Rappsilber J, Zimmer R, Lieschke GJ, Klein C. Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes. Blood. 2023;141(6):645-58. doi:10.1182/blood.2022016783.

Converging Role for REEP1/SPG31 in Oxidative Stress

Authors:
Naef V, Meschini MC, Tessa A, Morani F, Corsinovi D, Ogi A, Marchese M, Ori M, Santorelli FM, Doccini S
Citation:
Int J Mol Sci. 2023;24(4):3527. doi:10.3390/ijms24043527
Epub:
Not Epub
Abstract:
Mutations in the receptor expression-enhancing protein 1 gene (REEP1) are associated with hereditary spastic paraplegia type 31...
Link:
https://www.mdpi.com/1422-0067/24/4/3527
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Naef V, Meschini MC, Tessa A, Morani F, Corsinovi D, Ogi A, Marchese M, Ori M, Santorelli FM, Doccini S. Converging Role for REEP1/SPG31 in Oxidative Stress. Int J Mol Sci. 2023;24(4):3527. doi:10.3390/ijms24043527.

Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: study protocol for a phase I/II clinical trial

Authors:
Ishizuka T, Komaki H, Asahina Y, Nakamura H, Motohashi N, Takeshita E, Motohashi Y, Ishiyama A, Yonee C, Maruyama S, Hida E, Aoki Y
Citation:
medRxiv. 2023;[preprint] doi:10.1101/2023.02.06.23285500
Epub:
Not Epub
Abstract:
Aim: The purpose of this study is to evaluate the safety and pharmacokinetics of the novel morpholino oligomer NS-089/NCNP-02...
Link:
https://www.medrxiv.org/content/10.1101/2023.02.06.23285500v1
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Ishizuka T, Komaki H, Asahina Y, Nakamura H, Motohashi N, Takeshita E, Motohashi Y, Ishiyama A, Yonee C, Maruyama S, Hida E, Aoki Y. Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: study protocol for a phase I/II clinical trial. medRxiv. 2023;[preprint] doi:10.1101/2023.02.06.23285500 .

Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration

Authors:
Sugitani K, Mokuya T, Homma S, Maeda M, Konno A, Ogai K
Citation:
Int J Mol Sci. 2023;24(4):3253. doi:10.3390/ijms24043253
Epub:
Not Epub
Abstract:
In contrast to the case in mammals, the fish optic nerve can spontaneously regenerate and visual function can be fully restored...
Link:
https://www.mdpi.com/1422-0067/24/4/3253
Delivery Method:
Vivo-Morpholino intraocular injection
Organism or Cell Type:
zebrafish
Citation Extract:
Sugitani K, Mokuya T, Homma S, Maeda M, Konno A, Ogai K. Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration. Int J Mol Sci. 2023;24(4):3253. doi:10.3390/ijms24043253.

Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis

Authors:
Heng J, Shi B, Zhou JY, Zhang Y, Ma D, Yang YG, Liu F
Citation:
Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2212212120. doi: 10.1073/pnas.2212212120. Epub 2023 Feb 6
Epub:
Not Epub
Abstract:
During vertebrate embryogenesis, hematopoietic stem and progenitor cell (HSPC) production through endothelial-to-hematopoietic...
Link:
https://www.pnas.org/doi/10.1073/pnas.2212212120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Heng J, Shi B, Zhou JY, Zhang Y, Ma D, Yang YG, Liu F. Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2212212120. doi: 10.1073/pnas.2212212120. Epub 2023 Feb 6.

Gaucher disease protects against tuberculosis

Authors:
Fan J, Hale VL, Lelieveld LT, Ramakrishna L
Citation:
Proc Natl Acad Sci USA. 2023;120(7):e2217673120 doi:10.1073/pnas.2217673120
Epub:
Not Epub
Abstract:
Biallelic mutations in the glucocerebrosidase (GBA1) gene cause Gaucher disease, characterized by lysosomal accumulation of...
Link:
https://www.pnas.org/doi/10.1073/pnas.2217673120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fan J, Hale VL, Lelieveld LT, Ramakrishna L. Gaucher disease protects against tuberculosis. Proc Natl Acad Sci USA. 2023;120(7):e2217673120 doi:10.1073/pnas.2217673120.

Ubiquitylation of BBSome is required for ciliary assembly and signaling

Authors:
Chiuso F, Delle Donne R, Giamundo G, Rinaldi L, Borzacchiello D, Moraca F, Intartaglia D, Iannucci R, Senatore E, Lignitto L, Garbi C, Conflitti P, Catalanotti B, Conte I, Feliciello A
Citation:
Ubiquitylation of BBSome is required for ciliary assembly and signaling. EMBO Rep. 2023 Feb 6:e55571. doi:10.15252/embr.202255571. Online ahead of print
Epub:
Yes
Abstract:
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal degeneration, obesity, renal abnormalities, postaxial...
Link:
https://www.embopress.org/doi/full/10.15252/embr.202255571
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka fish)
Citation Extract:
Chiuso F, Delle Donne R, Giamundo G, Rinaldi L, Borzacchiello D, Moraca F, Intartaglia D, Iannucci R, Senatore E, Lignitto L, Garbi C, Conflitti P, Catalanotti B, Conte I, Feliciello A. Ubiquitylation of BBSome is required for ciliary assembly and signaling. Ubiquitylation of BBSome is required for ciliary assembly and signaling. EMBO Rep. 2023 Feb 6:e55571. doi:10.15252/embr.202255571. Online ahead of print.

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