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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Restoring Dystrophin Expression with Exon 44 and 53 Skipping in the DMD Gene in Immortalized Myotubes

Authors:
Echigoya Y, Yokota T
Citation:
Methods Mol Biol. 2023;2587:125-139. doi: 10.1007/978-1-0716-2772-3_7
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomer (PMO)-mediated exon skipping is a therapeutic approach that applies to many Duchenne...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_7
Organism or Cell Type:
cell culture: myotubes
Citation Extract:
Echigoya Y, Yokota T. Restoring Dystrophin Expression with Exon 44 and 53 Skipping in the DMD Gene in Immortalized Myotubes. Methods Mol Biol. 2023;2587:125-139. doi: 10.1007/978-1-0716-2772-3_7.

Restoring Dystrophin Expression by Skipping Exons 6 and 8 in Neonatal Dystrophic Dogs

Authors:
Shah MNA, Yokota T
Citation:
Methods Mol Biol. 2023;2587:107-124. doi: 10.1007/978-1-0716-2772-3_6
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is caused by the mutations in the DMD gene resulting in no dystrophin production. Skipping...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_6
Organism or Cell Type:
Canis familiaris (dog) CXMDj
Citation Extract:
Shah MNA, Yokota T. Restoring Dystrophin Expression by Skipping Exons 6 and 8 in Neonatal Dystrophic Dogs. Methods Mol Biol. 2023;2587:107-124. doi: 10.1007/978-1-0716-2772-3_6.

Viltolarsen: From Preclinical Studies to FDA Approval

Authors:
Roshmi RR, Yokota T
Citation:
Methods Mol Biol. 2023;2587:31-41. doi: 10.1007/978-1-0716-2772-3_2
Epub:
Not Epub
Abstract:
Viltolarsen is a phosphorodiamidate morpholino antisense oligonucleotide (PMO) designed to skip exon 53 of the DMD gene for the...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_2
Citation Extract:
Roshmi RR, Yokota T. Viltolarsen: From Preclinical Studies to FDA Approval. Methods Mol Biol. 2023;2587:31-41. doi: 10.1007/978-1-0716-2772-3_2.

DNAJB6 Isoform Specific Knockdown: Therapeutic Potential for LGMDD1

Authors:
Findlay AR, Paing MM, Daw JA, Bengoechea R, Pittman SK, Li S, Wang F, Miller TM, True HL, Weihl CC
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.11.17.516920
Epub:
Not Epub
Abstract:
Dominant missense mutations in DNAJB6, an HSP40 co-chaperone, cause limb girdle muscular dystrophy (LGMD) D1. No treatments are...
Link:
https://www.biorxiv.org/content/10.1101/2022.11.17.516920v1
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: mouse myotubes & human myotubes, mice
Citation Extract:
Findlay AR, Paing MM, Daw JA, Bengoechea R, Pittman SK, Li S, Wang F, Miller TM, True HL, Weihl CC. DNAJB6 Isoform Specific Knockdown: Therapeutic Potential for LGMDD1. bioRxiv. 2022;[preprint] doi:10.1101/2022.11.17.516920.

Functional identification of the zebrafish Interleukin-1 receptor in an embryonic model of Il-1β-induced systemic inflammation

Authors:
Sebo DJ, Fetsko AR, Phipps KK, Taylor MR
Citation:
Front Immunol. 2022 Oct 26;13:1039161. doi: 10.3389/fimmu.2022.1039161. eCollection 2022
Epub:
Not Epub
Abstract:
Interleukin-1β (IL-1β) is a potent proinflammatory cytokine that plays a vital role in the innate immune system. To observe the...
Link:
https://www.frontiersin.org/articles/10.3389/fimmu.2022.1039161/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sebo DJ, Fetsko AR, Phipps KK, Taylor MR. Functional identification of the zebrafish Interleukin-1 receptor in an embryonic model of Il-1β-induced systemic inflammation. Front Immunol. 2022 Oct 26;13:1039161. doi: 10.3389/fimmu.2022.1039161. eCollection 2022.

An ancestral Wnt-Brachyury feedback loop in axial patterning and recruitment of mesoderm-determining target genes

Authors:
Schwaiger M, Andrikou C, Dnyansagar R, Murguia PF, Paganos P, Voronov D, Zimmermann B, Lebedeva T, Schmidt HA, Genikhovich G, Benvenuto G, Arnone MI, Technau U
Citation:
Nat Ecol Evol. 2022;[Epub] doi:10.1038/s41559-022-01905-w
Epub:
Yes
Abstract:
Transcription factors are crucial drivers of cellular differentiation during animal development and often share ancient...
Link:
https://www.nature.com/articles/s41559-022-01905-w
Citation Extract:
Schwaiger M, Andrikou C, Dnyansagar R, Murguia PF, Paganos P, Voronov D, Zimmermann B, Lebedeva T, Schmidt HA, Genikhovich G, Benvenuto G, Arnone MI, Technau U. An ancestral Wnt-Brachyury feedback loop in axial patterning and recruitment of mesoderm-determining target genes. Nat Ecol Evol. 2022;[Epub] doi:10.1038/s41559-022-01905-w.

Elf3 deficiency during zebrafish development alters extracellular matrix organization and disrupts tissue morphogenesis

Authors:
Sarmah S, Hawkins MR, Manikandan P, Farrell M, Marrs JA
Citation:
PLoS One. 2022 Nov 16;17(11):e0276255. doi: 10.1371/journal.pone.0276255. eCollection 2022
Epub:
Not Epub
Abstract:
E26 transformation specific (ETS) family transcription factors are expressed during embryogenesis and are involved in various...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0276255
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sarmah S, Hawkins MR, Manikandan P, Farrell M, Marrs JA. Elf3 deficiency during zebrafish development alters extracellular matrix organization and disrupts tissue morphogenesis. PLoS One. 2022 Nov 16;17(11):e0276255. doi: 10.1371/journal.pone.0276255. eCollection 2022.

NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae

Authors:
Konrad KD, Song JL
Citation:
microPubl Biol. 2022;[Epub] doi:10.17912/micropub.biology.000682
Epub:
Not Epub
Abstract:
NeuroD is a transcription factor (TF) that plays a dual role in vertebrate neurogenesis and glucose homeostasis in the pancreas...
Link:
https://www.micropublication.org/journals/biology/micropub-biology-000682
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Konrad KD, Song JL. NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae. microPubl Biol. 2022;[Epub] doi:10.17912/micropub.biology.000682.

Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation

Authors:
Zhang L, Wan M, Tohti R, Jin D, Zhong TP
Citation:
Int J Mol Sci. 2022;23:14182. doi:/10.3390/ijms232214182
Epub:
Not Epub
Abstract:
cAMP-PKA signaling plays a pivotal role in melanin synthesis and melanosome transport by responding to the binding of the α-...
Link:
https://www.mdpi.com/1422-0067/23/22/14182
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang L, Wan M, Tohti R, Jin D, Zhong TP. Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation. Int J Mol Sci. 2022;23:14182. doi:/10.3390/ijms232214182.

Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration

Authors:
Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, Hilgendorf KI, Frésard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM
Citation:
Cell Stem Cell. 2022;[Epub] doi:10.1016/j.stem.2022.10.009
Epub:
Yes
Abstract:
In aging, skeletal muscle strength and regenerative capacity decline, due in part to functional impairment of muscle stem cells...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1934590922004271
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: mouse muscle stem cells
Citation Extract:
Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, Hilgendorf KI, Frésard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM. Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration. Cell Stem Cell. 2022;[Epub] doi:10.1016/j.stem.2022.10.009.

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