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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy

Authors:
Osman EY, Washington CW 3rd, Kaifer KA, Mazzasette C, Patitucci TN, Florea KM, Simon ME, Ko CP, Ebert AD, Lorson CL
Citation:
Mol Ther. 2016 Jul 12. doi: 10.1038/mt.2016.145. [Epub ahead of print]
Epub:
Yes
Abstract:
Loss of Survival Motor Neuron-1 (SMN1) causes Spinal Muscular Atrophy (SMA), a devastating neurodegenerative disease. SMN2 is a...
Delivery Method:
Endo-Porter (cultures), icv (mice)
Organism or Cell Type:
iPS-derived SMA motor neurons, mice
Citation Extract:
Osman EY, Washington CW 3rd, Kaifer KA, Mazzasette C, Patitucci TN, Florea KM, Simon ME, Ko CP, Ebert AD, Lorson CL. Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy. Mol Ther. 2016 Jul 12. doi: 10.1038/mt.2016.145. [Epub ahead of print].

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits

Authors:
Pankratz N, Schick UM, Zhou Y, Zhou W, Ahluwalia TS, Allende ML, Auer PL, Bork-Jensen J, Brody JA, Chen MH, Clavo V, Eicher JD, Grarup N, Hagedorn EJ, Hu B, Hunker K, Johnson AD, Leusink M, Lu Y, Lyytikäinen LP, Manichaikul A, Marioni RE, Nalls MA, Pazoki R, Smith AV, van Rooij FJ, Yang ML, Zhang X, Zhang Y, Asselbergs FW, Boerwinkle E, Borecki IB, Bottinger EP, Cushman M, de Bakker PI, Deary IJ, Dong L, Feitosa MF, Floyd JS, Franceschini N, Franco OH, Garcia ME, Grove ML, Gudnason V, Hansen T, Harris TB, Hofman A, Jackson RD, Jia J, Kähönen M, Launer LJ, Lehtimäki T, Liewald DC, Linneberg A, Liu Y, Loos RJ, <authors hidden: database constraint> Thuesen BH, Tracy RP, Uitterlinden AG, Wang J, Wang J, Dehghan A, Huo Y, Cupples LA, Wilson JG, Proia RL, Zon LI, O'Donnell CJ, Reiner AP, Ganesh SK
Citation:
Nat Genet. 2016 Jul 11. doi: 10.1038/ng.3607. [Epub ahead of print]
Epub:
Yes
Abstract:
Hematologic measures such as hematocrit and white blood cell (WBC) count are heritable and clinically relevant. We analyzed...
Organism or Cell Type:
zebrafish
Citation Extract:
Pankratz N, Schick UM, Zhou Y, Zhou W, Ahluwalia TS, Allende ML, Auer PL, Bork-Jensen J, Brody JA, Chen MH, Clavo V, Eicher JD, Grarup N, Hagedorn EJ, Hu B, Hunker K, Johnson AD, Leusink M, Lu Y, Lyytikäinen LP, Manichaikul A, Marioni RE, Nalls MA, Pazoki R, Smith AV, van Rooij FJ, Yang ML, Zhang X, Zhang Y, Asselbergs FW, Boerwinkle E, Borecki IB, Bottinger EP, Cushman M, de Bakker PI, Deary IJ, Dong L, Feitosa MF, Floyd JS, Franceschini N, Franco OH, Garcia ME, Grove ML, Gudnason V, Hansen T, Harris TB, Hofman A, Jackson RD, Jia J, Kähönen M, Launer LJ, Lehtimäki T, Liewald DC, Linneberg A, Liu Y, Loos RJ, <authors hidden: database constraint> Thuesen BH, Tracy RP, Uitterlinden AG, Wang J, Wang J, Dehghan A, Huo Y, Cupples LA, Wilson JG, Proia RL, Zon LI, O'Donnell CJ, Reiner AP, Ganesh SK. Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits. Nat Genet. 2016 Jul 11. doi: 10.1038/ng.3607. [Epub ahead of print].

Antisense-Based Progerin Downregulation in HGPS-Like Patients’ Cells

Authors:
Harhouri K, Navarro C, Baquerre C, Da Silva N, Bartoli C, Casey F, Mawuse GK, Doubaj Y, Lévy N, De Sandre-Giovannoli A
Citation:
Cells, 2016;5(3):31. doi:10.3390/cells5030031
Epub:
Not Epub
Abstract:
Progeroid laminopathies, including Hutchinson-Gilford Progeria Syndrome (HGPS, OMIM #176670), are premature and accelerated...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: primary human dermal fibroblasts
Citation Extract:
Harhouri K, Navarro C, Baquerre C, Da Silva N, Bartoli C, Casey F, Mawuse GK, Doubaj Y, Lévy N, De Sandre-Giovannoli A. Antisense-Based Progerin Downregulation in HGPS-Like Patients’ Cells. Cells, 2016;5(3):31. doi:10.3390/cells5030031.

The splicing factor SRSF1 modulates pattern formation by inhibiting transcription of tissue specific genes during embryogenesis

Authors:
Lee SH, Lee HK, Kim C, Kim YK, Ismail T, Jeong Y, Park K, Park JW, Kwon OS, Kang BS, Lee DS, Park MJ, Park DS, Lee HS
Citation:
Biochem Biophys Res Commun. 2016 Jul 7. pii: S0006-291X(16)31136-6. doi: 10.1016/j.bbrc.2016.07.021. [Epub ahead of print]
Epub:
Yes
Abstract:
Alternative splicing is a major mechanism regulating pattern of gene expression through the production of multiple mRNAs from a...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Lee SH, Lee HK, Kim C, Kim YK, Ismail T, Jeong Y, Park K, Park JW, Kwon OS, Kang BS, Lee DS, Park MJ, Park DS, Lee HS. The splicing factor SRSF1 modulates pattern formation by inhibiting transcription of tissue specific genes during embryogenesis. Biochem Biophys Res Commun. 2016 Jul 7. pii: S0006-291X(16)31136-6. doi: 10.1016/j.bbrc.2016.07.021. [Epub ahead of print].

Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis

Authors:
Kenyon EJ, Luijten MN, Gill H, Li N, Rawlings M, Bull JC, Hadzhiev Y, van Steensel MA, Maher E, Mueller F
Citation:
BMC Dev Biol. 2016 Jul 8;16(1):23
Epub:
Not Epub
Abstract:
BACKGROUND: Birt-Hogg-Dubé syndrome (BHD) is a dominantly inherited familial cancer syndrome characterised by the development...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kenyon EJ, Luijten MN, Gill H, Li N, Rawlings M, Bull JC, Hadzhiev Y, van Steensel MA, Maher E, Mueller F. Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis. BMC Dev Biol. 2016 Jul 8;16(1):23.

Early-life glucocorticoids programme behaviour and metabolism in adulthood in zebrafish

Authors:
Wilson KS, Tucker CS, Al-Dujaili EA, Holmes MC, Hadoke PW, Kenyon CJ, Denvir MA
Citation:
J Endocrinol. 2016 Jul;230(1):125-42. doi: 10.1530/JOE-15-0376
Epub:
Not Epub
Abstract:
Glucocorticoids (GCs) in utero influence embryonic development with consequent programmed effects on adult physiology and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wilson KS, Tucker CS, Al-Dujaili EA, Holmes MC, Hadoke PW, Kenyon CJ, Denvir MA. Early-life glucocorticoids programme behaviour and metabolism in adulthood in zebrafish. J Endocrinol. 2016 Jul;230(1):125-42. doi: 10.1530/JOE-15-0376.

Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia

Authors:
Bolar NA, Golzio C, Živná M, Hayot G, Van Hemelrijk C, Schepers D, Vandeweyer G, Hoischen A, Huyghe JR, Raes A, Matthys E, Sys E, Azou M, Gubler M-C, Praet M, Van Camp G, McFadden K, Pediaditakis I, Přistoupilová A, Hodaňová K, Vyleťal P, Hartmannová H, Stránecký V, Hůlková H, Barešová V, Jedličková I, Sovová J, Hnízda A, Kidd K, Bleyer AJ, Spong RS, Vande Walle J, Mortier G, Brunner H, Van Laer L, Kmoch S, Katsanis N, Loeys BL
Citation:
Am J Hum Genet. 2016;99(1):174-87 doi:10.1016/j.ajhg.2016.05.028
Epub:
Not Epub
Abstract:
Autosomal-dominant tubulo-interstitial kidney disease (ADTKD) encompasses a group of disorders characterized by renal tubular...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bolar NA, Golzio C, Živná M, Hayot G, Van Hemelrijk C, Schepers D, Vandeweyer G, Hoischen A, Huyghe JR, Raes A, Matthys E, Sys E, Azou M, Gubler M-C, Praet M, Van Camp G, McFadden K, Pediaditakis I, Přistoupilová A, Hodaňová K, Vyleťal P, Hartmannová H, Stránecký V, Hůlková H, Barešová V, Jedličková I, Sovová J, Hnízda A, Kidd K, Bleyer AJ, Spong RS, Vande Walle J, Mortier G, Brunner H, Van Laer L, Kmoch S, Katsanis N, Loeys BL. Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia. Am J Hum Genet. 2016;99(1):174-87 doi:10.1016/j.ajhg.2016.05.028.

Wars2 is a determinant of angiogenesis

Authors:
Wang M, Sips P, Khin E, Rotival M, Sun X, Ahmed R, Widjaja AA, Schafer S, Yusoff P, Choksi PK, Ko NSJ, Singh MK, Epstein D, Guan Y, Houštěk J, Mracek T, Nuskova H, Mikell B, Tan J, Pesce F, Kolar F, Bottolo L, Mancini M, Hubner N, Pravenec M, Petretto E, MacRae C, Cook SA
Citation:
Nat Comm. 2016;7:12061. doi:10.1038/ncomms12061
Epub:
Not Epub
Abstract:
Coronary flow (CF) measured ex vivo is largely determined by capillary density that reflects angiogenic vessel formation in the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang M, Sips P, Khin E, Rotival M, Sun X, Ahmed R, Widjaja AA, Schafer S, Yusoff P, Choksi PK, Ko NSJ, Singh MK, Epstein D, Guan Y, Houštěk J, Mracek T, Nuskova H, Mikell B, Tan J, Pesce F, Kolar F, Bottolo L, Mancini M, Hubner N, Pravenec M, Petretto E, MacRae C, Cook SA. Wars2 is a determinant of angiogenesis. Nat Comm. 2016;7:12061. doi:10.1038/ncomms12061.

Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation

Authors:
Sako K, Pradhan SJ, Barone V, Ingles-Prieto Á, Müller P, Ruprecht V, Čapek D, Galande S, Janovjak H, Heisenberg C-P
Citation:
Cell Rep. 2016;[Epub ahead of print] doi:10.1016/j.celrep.2016.06.036
Epub:
Yes
Abstract:
During metazoan development, the temporal pattern of morphogen signaling is critical for organizing cell fates in space and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sako K, Pradhan SJ, Barone V, Ingles-Prieto Á, Müller P, Ruprecht V, Čapek D, Galande S, Janovjak H, Heisenberg C-P. Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation. Cell Rep. 2016;[Epub ahead of print] doi:10.1016/j.celrep.2016.06.036.

Dpp/BMP2-4 Mediates Signaling from the D-Quadrant Organizer in a Spiralian Embryo

Authors:
Lambert JD, Johnson AB, Hudson CN, Chan A
Citation:
Curr Biol. 2016;[Epub ahead of print] doi:10.1016/j.cub.2016.05.059
Epub:
Not Epub
Abstract:
In some animal groups, the secondary embryonic axis is patterned by a small group of cells, often called an organizer, that...
Delivery Method:
microinjection
Organism or Cell Type:
Ilyanassa (marine snail)
Citation Extract:
Lambert JD, Johnson AB, Hudson CN, Chan A. Dpp/BMP2-4 Mediates Signaling from the D-Quadrant Organizer in a Spiralian Embryo. Curr Biol. 2016;[Epub ahead of print] doi:10.1016/j.cub.2016.05.059.

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