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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

The Power of Human Protective Modifiers: PLS3 and CORO1C Unravel Impaired Endocytosis in Spinal Muscular Atrophy and Rescue SMA Phenotype

Authors:
Hosseinibarkooie S, Peters M, Torres-Benito L, Rastetter RH, Hupperich K, Hoffmann A, Mendoza-Ferreira N, Kaczmarek A, Janzen E, Milbradt J, Lamkemeyer T, Rigo F, Bennett CF, Guschlbauer C, Büschges A, Hammerschmidt M, Riessland M, Kye MJ, Clemen CS, Wirth B
Citation:
Am J Hum Genet. 2016 Aug 3. pii: S0002-9297(16)30288-9. doi: 10.1016/j.ajhg.2016.07.014. [Epub ahead of print]
Epub:
Yes
Abstract:
Homozygous loss of SMN1 causes spinal muscular atrophy (SMA), the most common and devastating childhood genetic motor-neuron...
Link:
http://www.sciencedirect.com/science/article/pii/S0002929716302889
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hosseinibarkooie S, Peters M, Torres-Benito L, Rastetter RH, Hupperich K, Hoffmann A, Mendoza-Ferreira N, Kaczmarek A, Janzen E, Milbradt J, Lamkemeyer T, Rigo F, Bennett CF, Guschlbauer C, Büschges A, Hammerschmidt M, Riessland M, Kye MJ, Clemen CS, Wirth B. The Power of Human Protective Modifiers: PLS3 and CORO1C Unravel Impaired Endocytosis in Spinal Muscular Atrophy and Rescue SMA Phenotype. Am J Hum Genet. 2016 Aug 3. pii: S0002-9297(16)30288-9. doi: 10.1016/j.ajhg.2016.07.014. [Epub ahead of print].

Nodal signalling in Xenopus: the role of Xnr5 in left/right asymmetry and heart development

Authors:
Tadjuidje E, Kofron M, Mir A, Wylie C, Heasman J, Cha SW
Citation:
Open Biol. 2016 Aug;6(8). pii: 150187. doi: 10.1098/rsob.150187
Epub:
Not Epub
Abstract:
Nodal class TGF-β signalling molecules play essential roles in establishing the vertebrate body plan. In all vertebrates, nodal...
Link:
http://rsob.royalsocietypublishing.org/content/6/8/150187
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Tadjuidje E, Kofron M, Mir A, Wylie C, Heasman J, Cha SW. Nodal signalling in Xenopus: the role of Xnr5 in left/right asymmetry and heart development. Open Biol. 2016 Aug;6(8). pii: 150187. doi: 10.1098/rsob.150187.

Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin

Authors:
Gillis WQ, Kirmizitas A, Iwasaki Y, Ki DH, Wyrick JM, Thomsen GH
Citation:
Cell Commun Signal. 2016 Aug 2;14(1):15. doi: 10.1186/s12964-016-0138-x
Epub:
Not Epub
Abstract:
BACKGROUND: Canonical Wnt signals, transduced by stabilized β-catenin, play similar roles across animals in maintaining stem...
Link:
https://biosignaling.biomedcentral.com/articles/10.1186/s12964-016-0138-x
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Gillis WQ, Kirmizitas A, Iwasaki Y, Ki DH, Wyrick JM, Thomsen GH. Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin. Cell Commun Signal. 2016 Aug 2;14(1):15. doi: 10.1186/s12964-016-0138-x.

Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells

Authors:
Monteiro R, Pinheiro P, Joseph N, Peterkin T, Koth J, Repapi E, Bonkhofer F, Kirmizitas A, Patient R
Citation:
Dev Cell. 2016 Aug 3. pii: S1534-5807(16)30427-0. doi: 10.1016/j.devcel.2016.06.024. [Epub ahead of print]
Epub:
Yes
Abstract:
Hematopoietic stem cells (HSCs) are self-renewing multipotent stem cells that generate mature blood lineages throughout life....
Link:
http://www.sciencedirect.com/science/article/pii/S1534580716304270
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Monteiro R, Pinheiro P, Joseph N, Peterkin T, Koth J, Repapi E, Bonkhofer F, Kirmizitas A, Patient R. Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Dev Cell. 2016 Aug 3. pii: S1534-5807(16)30427-0. doi: 10.1016/j.devcel.2016.06.024. [Epub ahead of print].

A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia

Authors:
Lichtenstein DA, Crispin AW, Sendamarai AK, Campagna DR, Schmitz-Abe K, Sousa CM, Kafina MD, Schmidt PJ, Niemeyer CM, Porter J, May A, Patnaik MM, Heeney MM, Kimmelman A, Bottomley SS, Paw BH, Markianos K, Fleming MD
Citation:
Blood. 2016 Aug 3. pii: blood-2016-05-719062. [Epub ahead of print]
Epub:
Yes
Abstract:
The congenital sideroblastic anemias (CSAs) are a heterogeneous group of inherited blood disorders characterized by...
Link:
http://www.bloodjournal.org/content/early/2016/08/03/blood-2016-05-719062.long
Citation Extract:
Lichtenstein DA, Crispin AW, Sendamarai AK, Campagna DR, Schmitz-Abe K, Sousa CM, Kafina MD, Schmidt PJ, Niemeyer CM, Porter J, May A, Patnaik MM, Heeney MM, Kimmelman A, Bottomley SS, Paw BH, Markianos K, Fleming MD. A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia. Blood. 2016 Aug 3. pii: blood-2016-05-719062. [Epub ahead of print].

Investigating Synthetic Oligonucleotide Targeting of Mir31 in Duchenne Muscular Dystrophy

Authors:
Hildyard JC, Wells DJ
Citation:
PLoS Curr. 2016 Jun 16;8. pii: ecurrents.md.99d88e72634387639707601b237467d7. doi: 10.1371/currents.md.99d88e72634387639707601b237467d7
Epub:
Not Epub
Abstract:
Exon-skipping via synthetic antisense oligonucleotides represents one of the most promising potential therapies for Duchenne...
Link:
http://currents.plos.org/md/article/investigating-synthetic-oligonucleotide-targeting-of-mir31-in-duchenne-muscular-dystrophy/
Delivery Method:
electroporation, cell bathing, Vivo-Morpholino
Organism or Cell Type:
cell culture: H2KSF1 (derived from an mdx-immortomouse cross), mdx mice
Citation Extract:
Hildyard JC, Wells DJ. Investigating Synthetic Oligonucleotide Targeting of Mir31 in Duchenne Muscular Dystrophy. PLoS Curr. 2016 Jun 16;8. pii: ecurrents.md.99d88e72634387639707601b237467d7. doi: 10.1371/currents.md.99d88e72634387639707601b237467d7.

HER2-positive breast cancer targeting and treatment by a peptide-conjugated mini nanodrug

Authors:
Ding H, Gangalum PR, Galstyan A, Fox I, Patil R, Hubbard P, Murali R, Ljubimova JY, Holler E
Citation:
Nanomedicine. 2016 Aug 9. pii: S1549-9634(16)30103-4. doi: 10.1016/j.nano.2016.07.013. [Epub ahead of print]
Epub:
Yes
Abstract:
HER2+ breast cancer is one of the most aggressive forms of breast cancer. The new polymalic acid-based mini nanodrug copolymers...
Link:
http://www.nanomedjournal.com/article/S1549-9634(16)30103-4/abstract
Delivery Method:
nanoparticle
Organism or Cell Type:
cell culture: BT474 human breast cancer, MDA-MB-468, mice
Citation Extract:
Ding H, Gangalum PR, Galstyan A, Fox I, Patil R, Hubbard P, Murali R, Ljubimova JY, Holler E. HER2-positive breast cancer targeting and treatment by a peptide-conjugated mini nanodrug. Nanomedicine. 2016 Aug 9. pii: S1549-9634(16)30103-4. doi: 10.1016/j.nano.2016.07.013. [Epub ahead of print].

Vitamin D receptor deficiency impairs inner ear development in zebrafish

Authors:
Kwon HJ
Citation:
Biochem Biophys Res Commun. 2016 Aug 12. pii: S0006-291X(16)31325-0. doi: 10.1016/j.bbrc.2016.08.070. [Epub ahead of print]
Epub:
Yes
Abstract:
The biological actions of vitamin D are largely mediated through binding to the vitamin D receptor (VDR), a member of the...
Link:
http://www.sciencedirect.com/science/article/pii/S0006291X16313250
Organism or Cell Type:
zebrafish
Citation Extract:
Kwon HJ. Vitamin D receptor deficiency impairs inner ear development in zebrafish. Biochem Biophys Res Commun. 2016 Aug 12. pii: S0006-291X(16)31325-0. doi: 10.1016/j.bbrc.2016.08.070. [Epub ahead of print].

Zebrafish P54 RNA helicases are cytoplasmic granules residents that are required for development and stress resilience

Authors:
Zampedri C, Tinoco-Cuellar M, Carrillo-Rosas S, Diaz-Tellez A, Ramos-Balderas JL, Pelegri F, Maldonado E
Citation:
Biol Open. 2016 Aug 3. pii: bio.015826. doi: 10.1242/bio.015826. [Epub ahead of print]
Epub:
Yes
Abstract:
Stress granules are cytoplasmic foci that directly respond to the protein synthesis status of the cell. Various environmental...
Link:
http://bio.biologists.org/content/early/2016/08/01/bio.015826.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zampedri C, Tinoco-Cuellar M, Carrillo-Rosas S, Diaz-Tellez A, Ramos-Balderas JL, Pelegri F, Maldonado E. Zebrafish P54 RNA helicases are cytoplasmic granules residents that are required for development and stress resilience. Biol Open. 2016 Aug 3. pii: bio.015826. doi: 10.1242/bio.015826. [Epub ahead of print].

Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish

Authors:
Powell R, Bubenshchikova E, Fukuyo Y, Hsu C, Lakiza O, Nomura H, Renfrew E, Garrity D, Obara T
Citation:
Mol Med Rep. 2016 Sep;14(3):2665-78. doi: 10.3892/mmr.2016.5550. Epub 2016 Jul 27
Epub:
Not Epub
Abstract:
Wilm's tumor 1 interacting protein (Wtip) was identified as an interacting partner of Wilm's tumor protein (WT1) in a...
Link:
https://www.spandidos-publications.com/mmr/14/3/2665
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Powell R, Bubenshchikova E, Fukuyo Y, Hsu C, Lakiza O, Nomura H, Renfrew E, Garrity D, Obara T. Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish. Mol Med Rep. 2016 Sep;14(3):2665-78. doi: 10.3892/mmr.2016.5550. Epub 2016 Jul 27.

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