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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence

Authors:
Konantz M, Alghisi E, Müller JS, Lenard A, Esain V, Carroll KJ, Kanz L, North TE, Lengerke C
Citation:
EMBO J. 2016 Sep 16. pii: e201593454. [Epub ahead of print]
Epub:
Yes
Abstract:
During development, hematopoietic stem cells (HSCs) emerge from aortic endothelial cells (ECs) through an intermediate stage...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Konantz M, Alghisi E, Müller JS, Lenard A, Esain V, Carroll KJ, Kanz L, North TE, Lengerke C. Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence. EMBO J. 2016 Sep 16. pii: e201593454. [Epub ahead of print].

Mechanistic evaluation of benzo[a]pyrene's developmental toxicities mediated by reduced Cyp19a1b activity

Authors:
Alharthy KM, Albaqami FF, Thornton C, Corrales J, Willett KL
Citation:
Toxicol Sci. 2016 Sep 14. pii: kfw182. [Epub ahead of print]
Epub:
Yes
Abstract:
Benzo[a]pyrene (BaP) is a ubiquitous environmental contaminant that is both an endocrine disruptor and a carcinogen. Aromatase...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Alharthy KM, Albaqami FF, Thornton C, Corrales J, Willett KL. Mechanistic evaluation of benzo[a]pyrene's developmental toxicities mediated by reduced Cyp19a1b activity. Toxicol Sci. 2016 Sep 14. pii: kfw182. [Epub ahead of print].

Internal Oligoguanidinium-based Cellular Transporter Enhances Antisense Efficacy of Morpholinos in in vitro and Zebrafish model

Authors:
Bhadra J, Pattanayak S, Khan PP, Kundu J, Sinha S
Citation:
Bioconjug Chem. 2016 Sep 14. [Epub ahead of print]
Epub:
Yes
Abstract:
Efficient cellular transporter is highly desirable for the therapeutic applications of antisense phosphorodiamidate morpholino...
Organism or Cell Type:
zebrafish
Citation Extract:
Bhadra J, Pattanayak S, Khan PP, Kundu J, Sinha S. Internal Oligoguanidinium-based Cellular Transporter Enhances Antisense Efficacy of Morpholinos in in vitro and Zebrafish model. Bioconjug Chem. 2016 Sep 14. [Epub ahead of print].

Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish

Authors:
Martella A, Sepe RM, Silvestri C, Zang J, Fasano G, Carnevali O, De Girolamo P, Neuhauss SC, Sordino P, Di Marzo V
Citation:
FASEB J. 2016 Sep 13. pii: fj.201600602R. [Epub ahead of print]
Epub:
Yes
Abstract:
The developmental role of the endocannabinoid system still remains to be fully understood. Here, we report the presence of a...
Organism or Cell Type:
zebrafish
Citation Extract:
Martella A, Sepe RM, Silvestri C, Zang J, Fasano G, Carnevali O, De Girolamo P, Neuhauss SC, Sordino P, Di Marzo V. Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish. FASEB J. 2016 Sep 13. pii: fj.201600602R. [Epub ahead of print].

Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy

Authors:
Hammond SM, Hazell G, Shabanpoor F, Saleh AF, Bowerman M, Sleigh JN, Meijboom KE, Zhou H, Muntoni F, Talbot K, Gait MJ, Wood MJ
Citation:
Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10962-7. doi: 10.1073/pnas.1605731113. Epub 2016 Sep 12
Epub:
Yes
Abstract:
The development of antisense oligonucleotide therapy is an important advance in the identification of corrective therapy for...
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hammond SM, Hazell G, Shabanpoor F, Saleh AF, Bowerman M, Sleigh JN, Meijboom KE, Zhou H, Muntoni F, Talbot K, Gait MJ, Wood MJ. Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10962-7. doi: 10.1073/pnas.1605731113. Epub 2016 Sep 12.

β-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes

Authors:
Lutgen V, Narasipura SD, Sharma A, Min S, Al-Harthi L
Citation:
J Neuroinflammation. 2016 Sep 10;13(1):242
Epub:
Not Epub
Abstract:
BACKGROUND: Neurological disorders have been linked to abnormal excitatory neurotransmission. Perturbations in glutamate...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Lutgen V, Narasipura SD, Sharma A, Min S, Al-Harthi L. β-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes. J Neuroinflammation. 2016 Sep 10;13(1):242.

Combining Zebrafish and Mouse Models to Test the Function of Deubiquitinating Enzyme (Dubs) Genes in Development: Role of USP45 in the Retina

Authors:
Toulis V, Garanto A, Marfany G
Citation:
Methods Mol Biol. 2016;1449:85-101. doi: 10.1007/978-1-4939-3756-1_3
Epub:
Not Epub
Abstract:
Ubiquitination is a dynamic and reversible posttranslational modification. Much effort has been devoted to characterize the...
Organism or Cell Type:
zebrafish
Citation Extract:
Toulis V, Garanto A, Marfany G. Combining Zebrafish and Mouse Models to Test the Function of Deubiquitinating Enzyme (Dubs) Genes in Development: Role of USP45 in the Retina. Methods Mol Biol. 2016;1449:85-101. doi: 10.1007/978-1-4939-3756-1_3.

HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation

Authors:
Rouhiainen A, Zhao X, Vanttola P, Qian K, Kulesskiy E, Kuja-Panula J, Gransalke K, Grönholm M, Unni E, Meistrich M, Tian L, Auvinen P, Rauvala H
Citation:
Sci Rep. 2016;6:32960. doi:10.1038/srep32960
Epub:
Not Epub
Abstract:
HMGB4 is a new member in the family of HMGB proteins that has been characterized in sperm cells, but little is known about its...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: E14 mouse cortical neurons and C2C12 myoblast cells
Citation Extract:
Rouhiainen A, Zhao X, Vanttola P, Qian K, Kulesskiy E, Kuja-Panula J, Gransalke K, Grönholm M, Unni E, Meistrich M, Tian L, Auvinen P, Rauvala H. HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation. Sci Rep. 2016;6:32960. doi:10.1038/srep32960.

Gold nanocluster formation using morpholino oligomer as template and assembly agent within hybrid bio-nanomaterials

Authors:
Chakraborty S, Rocha RC, Desireddy A, Artyushkova K, Sanchez T, Perry A III, Atanassov P, Martinez JS
Citation:
RSC Adv. 2016;[Epub ahead of print] doi:10.1039/C6RA16891D
Epub:
Yes
Abstract:
We report the use of a phosphorodiamidate morpholino oligomer as a DNA analogue to template the assembly of a gold nanocluster...
Citation Extract:
Chakraborty S, Rocha RC, Desireddy A, Artyushkova K, Sanchez T, Perry A III, Atanassov P, Martinez JS. Gold nanocluster formation using morpholino oligomer as template and assembly agent within hybrid bio-nanomaterials. RSC Adv. 2016;[Epub ahead of print] doi:10.1039/C6RA16891D .

SIRT2 deacetylates and inhibits the peroxidase activity of peroxiredoxin-1 to sensitize breast cancer cells to oxidant stress inducing agents

Authors:
Fiskus W, Coothankandaswamy V, Chen J, Ma H, Ha K, Saenz DT, Krieger SS, Mill CP, Sun B, Huang P, Mumm JS, Melnick A, Bhalla KN
Citation:
Cancer Res. 2016 Aug 8. pii: canres.0126.2016. [Epub ahead of print] doi:10.1158/0008-5472.CAN-16-0126
Epub:
Yes
Abstract:
SIRT2 is a protein deacetylase with tumor suppressor activity in breast and liver tumors where it is mutated, however, the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fiskus W, Coothankandaswamy V, Chen J, Ma H, Ha K, Saenz DT, Krieger SS, Mill CP, Sun B, Huang P, Mumm JS, Melnick A, Bhalla KN. SIRT2 deacetylates and inhibits the peroxidase activity of peroxiredoxin-1 to sensitize breast cancer cells to oxidant stress inducing agents. Cancer Res. 2016 Aug 8. pii: canres.0126.2016. [Epub ahead of print] doi:10.1158/0008-5472.CAN-16-0126.

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