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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl
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Citation:
Dev Biol. 2023 Jun 2;500:31-39. doi: 10.1016/j.ydbio.2023.06.001. Online ahead of print Epub:
Not Epub Abstract:
The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ... Delivery Method:
injection then electroporation Organism or Cell Type:
Ambystoma mexicanum (Axolotl) Citation Extract: Bay S, Öztürk G, Emekli N, Demircan T. Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl. Dev Biol. 2023 Jun 2;500:31-39. doi: 10.1016/j.ydbio.2023.06.001. Online ahead of print. |
Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia
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Citation:
Front Genet. 2023 May 15;14:1186882. doi: 10.3389/fgene.2023.1186882. eCollection 2023 Epub:
Not Epub Abstract:
Background: Biliary atresia (BA) is a destructive, obliterative cholangiopathy characterized by progressive fibro-inflammatory... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bai MR, Pei HY, Zhou Y, Song HL, Pan WH, Gong YM, Wu WJ, Yu WW, Cui MM, Gu BL, Chu X, Cai W. Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia. Front Genet. 2023 May 15;14:1186882. doi: 10.3389/fgene.2023.1186882. eCollection 2023. |
Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivity in vivo
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Citation:
Front Synaptic Neurosci. 2023 May 12;15:1176864. doi: 10.3389/fnsyn.2023.1176864. eCollection 2023 Epub:
Not Epub Abstract:
Cannabis exposure during gestation evokes significant molecular modifications to neurodevelopmental programs leading to... Delivery Method:
electroporation Organism or Cell Type:
Xenopus laevis tadpoles Citation Extract: Del Rio R Jr, Serrano RG, Gomez E, Martinez JC, Edward MA, Santos RA, Diaz KS, Cohen-Cory S. Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivity in vivo. Front Synaptic Neurosci. 2023 May 12;15:1176864. doi: 10.3389/fnsyn.2023.1176864. eCollection 2023. |
The U1 antisense morpholino oligonucleotide (AMO) disrupts U1 snRNP structure to promote intronic PCPA modification of pre-mRNAs
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Citation:
J Biol Chem. 2023 May 22:104854. doi: 10.1016/j.jbc.2023.104854. Online ahead of print Epub:
Yes Abstract:
Functional depletion of the U1 small nuclear ribonucleoprotein (snRNP) with a 25 nt U1 AMO (antisense morpholino... Delivery Method:
electroporation Organism or Cell Type:
cell culture: HeLa Citation Extract: Feng Q, Lin Z, Deng Y, Ran Y, Yu R, Xiang AP, Ye C, Yao C. The U1 antisense morpholino oligonucleotide (AMO) disrupts U1 snRNP structure to promote intronic PCPA modification of pre-mRNAs. J Biol Chem. 2023 May 22:104854. doi: 10.1016/j.jbc.2023.104854. Online ahead of print. |
Cartilage regeneration in zebrafish depends on Nrg1/ErbB signaling pathway
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Citation:
Front Cell Dev Biol. 2023 Apr 4;11:1123299. doi: 10.3389/fcell.2023.1123299. eCollection 2023 Epub:
Not Epub Abstract:
Objective: Cartilage, as the majority of adult mammalian tissues, has limited regeneration capacity. Cartilage degradation... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sapède D, Bahraoui S, Abou Nassif L, Barthelaix A, Mathieu M, Jorgensen C, Djouad F. Cartilage regeneration in zebrafish depends on Nrg1/ErbB signaling pathway. Front Cell Dev Biol. 2023 Apr 4;11:1123299. doi: 10.3389/fcell.2023.1123299. eCollection 2023. |
Genetic deletion of the inflammation-regulated microRNA miR-146a increases exon-skipping mediated dystrophin restoration in Duchenne muscular dystrophy
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Citation:
bioRxiv. 2023 May 9:2023.05.09.540042. doi: 10.1101/2023.05.09.540042. Preprint Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused by loss of function mutations in the Dystrophin gene... Delivery Method:
intramuscular (i.m.) or intravenous (i.v.) injection Organism or Cell Type:
mice Citation Extract: McCormack NM, Calabrese KA, Tully CB, Heier CR, Fiorillo AA. Genetic deletion of the inflammation-regulated microRNA miR-146a increases exon-skipping mediated dystrophin restoration in Duchenne muscular dystrophy. bioRxiv. 2023 May 9:2023.05.09.540042. doi: 10.1101/2023.05.09.540042. Preprint. |
A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish
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Citation:
Hum Genomics. 2023 May 19;17(1):44. doi: 10.1186/s40246-023-00491-7 Epub:
Not Epub Abstract:
Background: Ubiquitin-related rare diseases are generally characterized by developmental delays and mental retardation, but the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Shin U, Choi Y, Ko HS, Myung K, Lee S, Cheon CK, Lee Y. A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish. Hum Genomics. 2023 May 19;17(1):44. doi: 10.1186/s40246-023-00491-7. |
Embryonic Ethanol but Not Cannabinoid Exposure Affects Zebrafish Cardiac Development via Agrin and Sonic Hedgehog Interaction
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Citation:
Cells. 2023 May 6;12(9):1327. doi: 10.3390/cells12091327 Epub:
Not Epub Abstract:
Recent studies demonstrate the adverse effects of cannabinoids on development, including via pathways shared with ethanol... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang C, Ezem N, Mackinnon S, Cole GJ. Embryonic Ethanol but Not Cannabinoid Exposure Affects Zebrafish Cardiac Development via Agrin and Sonic Hedgehog Interaction. Cells. 2023 May 6;12(9):1327. doi: 10.3390/cells12091327. |
The challenge of dissecting gene function in model organisms: Tools to characterize genetic mutants and assess transcriptional adaptation in zebrafish
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Citation:
Methods Cell Biol. 2023;176:1-25. doi: 10.1016/bs.mcb.2022.12.019. Epub 2023 Jan 27 Epub:
Not Epub Abstract:
Genome editing technologies including the CRISPR/Cas9 system have greatly improved our knowledge of gene function and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Cardenas-Rodriguez M, Drummond IA. The challenge of dissecting gene function in model organisms: Tools to characterize genetic mutants and assess transcriptional adaptation in zebrafish. Methods Cell Biol. 2023;176:1-25. doi: 10.1016/bs.mcb.2022.12.019. Epub 2023 Jan 27. |
Role of MicroRNAs and their Downstream Target Transcription Factors in Zebrafish Thrombopoiesis
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Citation:
Res Sq. 2023 Apr 24:rs.3.rs-2807790. doi: 10.21203/rs.3.rs-2807790/v1. Preprint Epub:
Not Epub Abstract:
Previous studies have shown that human platelets and megakaryocytes carry microRNAs suggesting their role in platelet function... Delivery Method:
Vivo-Morpholino piggyback Organism or Cell Type:
zebrafish Citation Extract: Qaryoute AA, Fallatah W, Dhinoja S, Raman R, Jagadeeswaran P. Role of MicroRNAs and their Downstream Target Transcription Factors in Zebrafish Thrombopoiesis. Res Sq. 2023 Apr 24:rs.3.rs-2807790. doi: 10.21203/rs.3.rs-2807790/v1. Preprint. |