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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12351 scientific papers returned from the database with the search filters currently being used below.

The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction

Authors:
Chiang DY, Verkerk AO, Victorio R, Shneyer BI, van der Vaart B, Jouni M, Narendran N, Kc A, Sampognaro JR, Vetrano-Olsen F, Oh JS, Buys E, de Jonge B, Shah DA, Kiviniemi T, Burridge PW, Bezzina CR, Akhmanova A, MacRae CA
Citation:
Circ Res. 2023 Dec 14. doi: 10.1161/CIRCRESAHA.123.323231. Online ahead of print
Epub:
Yes
Abstract:
Background: The Brugada syndrome is associated with loss-of-function SCN5A variants, yet these account for only ≈20% of cases....
Link:
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.123.323231
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chiang DY, Verkerk AO, Victorio R, Shneyer BI, van der Vaart B, Jouni M, Narendran N, Kc A, Sampognaro JR, Vetrano-Olsen F, Oh JS, Buys E, de Jonge B, Shah DA, Kiviniemi T, Burridge PW, Bezzina CR, Akhmanova A, MacRae CA. The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction. Circ Res. 2023 Dec 14. doi: 10.1161/CIRCRESAHA.123.323231. Online ahead of print.

Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation

Authors:
Ermis E, Nargis T, Webster K, Tersey SA, Anderson RM, Mirmira RG
Citation:
J Biol Chem. 2023;[Epub ahead of print] doi:10.1016/j.jbc.2023.105561
Epub:
Yes
Abstract:
Chronic inflammation is the underlying cause of many diseases, including type 1 diabetes, obesity, and non-alcoholic fatty...
Link:
https://www.sciencedirect.com/science/article/pii/S0021925823025899
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ermis E, Nargis T, Webster K, Tersey SA, Anderson RM, Mirmira RG. Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation. J Biol Chem. 2023;[Epub ahead of print] doi:10.1016/j.jbc.2023.105561.

CKAP5 enables formation of persistent actin bundles templated by dynamically instable microtubules

Authors:
Sabo J, Zdimalova MD, Slater PG, Lowery LA, Braun M, Lansky Z
Citation:
Curr Biol. 2023;[Epub] doi:10.1016/j.cub.2023.11.031
Epub:
Yes
Abstract:
Cytoskeletal rearrangements and crosstalk between microtubules and actin filaments are vital for living organisms. Recently, an...
Link:
https://www.cell.com/current-biology/pdf/S0960-9822(23)01581-6.pdf
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Sabo J, Zdimalova MD, Slater PG, Lowery LA, Braun M, Lansky Z. CKAP5 enables formation of persistent actin bundles templated by dynamically instable microtubules. Curr Biol. 2023;[Epub] doi:10.1016/j.cub.2023.11.031.

Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis

Authors:
Cheng S, Xia IF, Wanner R, Abello J, Stratman AN, Nicoli S
Citation:
eLife 13:RP94094
Epub:
Not Epub
Abstract:
Vascular smooth muscle cells (VSMCs) envelop vertebrate brain arteries and play a crucial role in regulating cerebral blood...
Link:
https://elifesciences.org/articles/94094
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cheng S, Xia IF, Wanner R, Abello J, Stratman AN, Nicoli S. Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis. eLife 13:RP94094.

Ruvbl1 is Essential for Ciliary Beating during Xenopus laevis Embryogenesis

Authors:
Kim CY, Lee HK, Lee H, Lee HS
Citation:
Dev Reprod. 2023 Sep;27(3):159-165. doi: 10.12717/DR.2023.27.3.159. Epub 2023 Sep 30
Epub:
Not Epub
Abstract:
The Ruvb-like AAA ATPase1 (Ruvbl1; also known as Pontin) is an evolutionary conserved protein belonging to the adenosine...
Link:
https://www.ksdb.org/archive/view_article?pid=dr-27-3-159
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim CY, Lee HK, Lee H, Lee HS. Ruvbl1 is Essential for Ciliary Beating during Xenopus laevis Embryogenesis. Dev Reprod. 2023 Sep;27(3):159-165. doi: 10.12717/DR.2023.27.3.159. Epub 2023 Sep 30.

Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation

Authors:
Yang Y, Zhao C, Chen B, Yu X, Zhou Y, Ni D, Zhang X, Zhang J, Ling X, Zhang Z, Huo R
Citation:
BMC Biol. 2023 Dec 8;21(1):285. doi: 10.1186/s12915-023-01760-6
Epub:
Not Epub
Abstract:
Background: Immature cumulus-oocyte complexes are retrieved to obtain mature oocytes by in vitro maturation (IVM), a laboratory...
Link:
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-023-01760-6
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Yang Y, Zhao C, Chen B, Yu X, Zhou Y, Ni D, Zhang X, Zhang J, Ling X, Zhang Z, Huo R. Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation. BMC Biol. 2023 Dec 8;21(1):285. doi: 10.1186/s12915-023-01760-6.

Automated, high-throughput quantification of EGFP-expressing neutrophils in zebrafish by machine learning and a highly-parallelized microscope

Authors:
Efromson J, Ferrero G, Bègue A, Doman TJJ, Dugo C, Barker A, Saliu V, Reamey P, Kim K, Harfouche M, Yoder JA
Citation:
PLoS ONE. 2023;18(12):e0295711. doi:10.1371/journal.pone.0295711
Epub:
Not Epub
Abstract:
Normal development of the immune system is essential for overall health and disease resistance. Bony fish, such as the...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0295711
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Efromson J, Ferrero G, Bègue A, Doman TJJ, Dugo C, Barker A, Saliu V, Reamey P, Kim K, Harfouche M, Yoder JA. Automated, high-throughput quantification of EGFP-expressing neutrophils in zebrafish by machine learning and a highly-parallelized microscope. PLoS ONE. 2023;18(12):e0295711. doi:10.1371/journal.pone.0295711.

The role of MAPRE2 and microtubules in Brugada syndrome pathogenesis

Authors:
Chiang D, Shneyer B, Verkerk A, Van Der Vaart B, Victorio R , Narendran N, Kc A, Buys E, Akhmanova A, Bezzina C, Macrae C
Citation:
Eur Heart J. 2023;44(Suppl 2):ehad655.3059 doi:10.1093/eurheartj/ehad655.3059
Epub:
Not Epub
Abstract:
Background: Brugada syndrome (BrS) is associated with loss-of-function variants in SCN5A (encoding NaV1.5), which are found in...
Link:
https://academic.oup.com/eurheartj/article/44/Supplement_2/ehad655.3059/7390948
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chiang D, Shneyer B, Verkerk A, Van Der Vaart B, Victorio R , Narendran N, Kc A, Buys E, Akhmanova A, Bezzina C, Macrae C. The role of MAPRE2 and microtubules in Brugada syndrome pathogenesis. Eur Heart J. 2023;44(Suppl 2):ehad655.3059 doi:10.1093/eurheartj/ehad655.3059.

Networking to Optimize Dmd exon 53 Skipping in the Brain of mdx52 Mouse Model

Authors:
Doisy M, Vacca O, Fergus C, Gileadi T, Verhaeg M, Saoudi A, Tensorer T, Garcia L, Kelly VP, Montanaro F, Morgan JE, van Putten M , Aartsma-Rus A, Vaillend C, Muntoni F, Goyenvalle A
Citation:
Biomedicines. 2023;11(12):3243. doi:10.3390/biomedicines11123243
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene that disrupt the open reading frame and thus prevent...
Link:
https://www.mdpi.com/2227-9059/11/12/3243
Delivery Method:
Endo-Porter, injection
Organism or Cell Type:
cell culture: H2K-mdx52 myotube, primary-mdx52 myotubes, mice
Citation Extract:
Doisy M, Vacca O, Fergus C, Gileadi T, Verhaeg M, Saoudi A, Tensorer T, Garcia L, Kelly VP, Montanaro F, Morgan JE, van Putten M , Aartsma-Rus A, Vaillend C, Muntoni F, Goyenvalle A. Networking to Optimize Dmd exon 53 Skipping in the Brain of mdx52 Mouse Model. Biomedicines. 2023;11(12):3243. doi:10.3390/biomedicines11123243.

Inactivating negative regulators of cortical branched actin enhances persistence of single cell migration

Authors:
Fokin AI, Boutillon A, James J, Courtois L, Vacher S, Simanov G, Wang Y, Polesskaya A, Bièche I, David NB, Gautreau AM
Citation:
J Cell Sci. 2023 Dec 7:jcs.261332. doi: 10.1242/jcs.261332. Online ahead of print
Epub:
Yes
Abstract:
The Rac1-WAVE-Arp2/3 pathway pushes the plasma membrane by polymerizing branched actin, thereby powering membrane protrusions...
Link:
https://journals.biologists.com/jcs/article-abstract/doi/10.1242/jcs.261332/336525/Inactivating-negative-regulators-of-cortical
Citation Extract:
Fokin AI, Boutillon A, James J, Courtois L, Vacher S, Simanov G, Wang Y, Polesskaya A, Bièche I, David NB, Gautreau AM. Inactivating negative regulators of cortical branched actin enhances persistence of single cell migration. J Cell Sci. 2023 Dec 7:jcs.261332. doi: 10.1242/jcs.261332. Online ahead of print.

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