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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation

Authors:
Gupta D, Orehek S, Turunen J, O’Donovan L, Gait MJ, El-Andaloussi S, Wood MJA
Citation:
Cells. 2023;12:2285. doi:10.3390/ cells12182285
Epub:
Not Epub
Abstract:
Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a crucial role in maintaining normal homeostatic processes under the...
Link:
https://www.mdpi.com/2073-4409/12/18/2285
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Gupta D, Orehek S, Turunen J, O’Donovan L, Gait MJ, El-Andaloussi S, Wood MJA. Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation. Cells. 2023;12:2285. doi:10.3390/ cells12182285.

Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain

Authors:
Thomas R, Connolly KJ, Brekk OR, Hinrich AJ, Hastings ML, Isacson O, Hallett PJ
Citation:
Sci Rep. 2023;13, 15164. doi:10.1038/s41598-023-41240-z
Epub:
Not Epub
Abstract:
Inflammatory processes and mechanisms are of central importance in neurodegenerative diseases. In the brain, α-...
Link:
https://www.nature.com/articles/s41598-023-41240-z
Delivery Method:
intracerebroventricular (i.c.v.) infusion, stereotaxic brain injection
Organism or Cell Type:
mice
Citation Extract:
Thomas R, Connolly KJ, Brekk OR, Hinrich AJ, Hastings ML, Isacson O, Hallett PJ. Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain. Sci Rep. 2023;13, 15164. doi:10.1038/s41598-023-41240-z.

Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence

Authors:
Sahai-Hernandez P, Pouget C, Eyal S, Svoboda O, Chacon J, Grimm L, Gjøen T, Traver D
Citation:
Elife. 2023 Sep 11;12:e58300. doi: 10.7554/eLife.58300
Epub:
Not Epub
Abstract:
Development of the dorsal aorta is a key step in the establishment of the adult blood-forming system, since hematopoietic stem...
Link:
https://elifesciences.org/articles/58300
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sahai-Hernandez P, Pouget C, Eyal S, Svoboda O, Chacon J, Grimm L, Gjøen T, Traver D. Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence. Elife. 2023 Sep 11;12:e58300. doi: 10.7554/eLife.58300.

β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the Developing Xenopus Thalamus

Authors:
Gao J, Lu Y, Luo Y, Duan X, Chen P, Zhang X, Wu X, Qiu M, Shen W
Citation:
Int J Mol Sci. 2023 Sep 2;24(17):13593. doi: 10.3390/ijms241713593
Epub:
Not Epub
Abstract:
In the vertebrate brain, sensory experience plays a crucial role in shaping thalamocortical connections for visual processing....
Link:
https://www.mdpi.com/1422-0067/24/17/13593
Delivery Method:
electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Gao J, Lu Y, Luo Y, Duan X, Chen P, Zhang X, Wu X, Qiu M, Shen W. β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the Developing Xenopus Thalamus. Int J Mol Sci. 2023 Sep 2;24(17):13593. doi: 10.3390/ijms241713593.

Toxic effects of exogenous retinoic acid on the neurodevelopment of zebrafish (Danio rerio) embryos

Authors:
Wang X, Ma T, Wei C, Liu J, Yu T, Zou Y, Liu S, Yang Z, Xi J
Citation:
Neurotoxicol Teratol. 2023 Sep 7:107291. doi: 10.1016/j.ntt.2023.107291. Online ahead of print
Epub:
Yes
Abstract:
Endogenous retinoic acid (RA) is essential for embryonic development and maintaining adult physiological processes. Human-...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0892036223001411
Organism or Cell Type:
zebrafish
Citation Extract:
Wang X, Ma T, Wei C, Liu J, Yu T, Zou Y, Liu S, Yang Z, Xi J. Toxic effects of exogenous retinoic acid on the neurodevelopment of zebrafish (Danio rerio) embryos. Neurotoxicol Teratol. 2023 Sep 7:107291. doi: 10.1016/j.ntt.2023.107291. Online ahead of print.

Alternative splicing of its 5' UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

Authors:
Ang Z, Paruzzo L, Hayer KE, Schmidt C, Torres-Diz M, Xu F, Zankharia U, Zhang Y, Soldan SS, Zheng S, Falkenstein CD, Loftus JP, Yang SY, Asnani M, King Sainos P, Pillai V, Chong ER, Li M, Tasian SK, Barash Y, Lieberman PM, Ruella M, Schuster SJ, Thomas-Tikhonenko A
Citation:
Blood. 2023 Sep 8:blood.2023020400. doi: 10.1182/blood.2023020400. Online ahead of print
Epub:
Yes
Abstract:
Aberrant skipping of coding exons in CD19 and CD22 compromises responses to immunotherapy for B-cell malignancies. Here, we...
Link:
https://ashpublications.org/blood/article/doi/10.1182/blood.2023020400/497824/Alternative-splicing-of-its-5-UTR-limits-CD20-mRNA
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: OCI-Ly8, Raji, and MEC-1
Citation Extract:
Ang Z, Paruzzo L, Hayer KE, Schmidt C, Torres-Diz M, Xu F, Zankharia U, Zhang Y, Soldan SS, Zheng S, Falkenstein CD, Loftus JP, Yang SY, Asnani M, King Sainos P, Pillai V, Chong ER, Li M, Tasian SK, Barash Y, Lieberman PM, Ruella M, Schuster SJ, Thomas-Tikhonenko A. Alternative splicing of its 5' UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies. Blood. 2023 Sep 8:blood.2023020400. doi: 10.1182/blood.2023020400. Online ahead of print.

An ancient pan-cnidarian microRNA regulates stinging capsule biogenesis in Nematostella vectensis

Authors:
Fridrich A, Salinas-Saaverda M, Kozlolvski I, Surm JM, Chrysostomou E, Tripathi AM, Frank U, Moran Y
Citation:
Cell Rep. 2023 Sep 5;42(9):113072. doi: 10.1016/j.celrep.2023.113072. Online ahead of print
Epub:
Not Epub
Abstract:
An ancient evolutionary innovation of a novel cell type, the stinging cell (cnidocyte), appeared >600 million years ago in...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01083-5
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis
Citation Extract:
Fridrich A, Salinas-Saaverda M, Kozlolvski I, Surm JM, Chrysostomou E, Tripathi AM, Frank U, Moran Y. An ancient pan-cnidarian microRNA regulates stinging capsule biogenesis in Nematostella vectensis. Cell Rep. 2023 Sep 5;42(9):113072. doi: 10.1016/j.celrep.2023.113072. Online ahead of print.

Actomyosin remodeling regulates biomineral formation, growth and morphology during eukaryote skeletogenesis

Authors:
Hijaze E, Gildor T, Seidel R, Layous M, Winter M, Bertinetti L, Politi Y, de-Leon SB-T
Citation:
eLife. 2023;12:RP89080 doi:10.7554/eLife.89080.1
Epub:
Not Epub
Abstract:
Biomineralization had apparently evolved independently in different phyla, using distinct minerals, organic scaffolds and gene...
Link:
https://elifesciences.org/reviewed-preprints/89080
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotous lividus (sea urchin)
Citation Extract:
Hijaze E, Gildor T, Seidel R, Layous M, Winter M, Bertinetti L, Politi Y, de-Leon SB-T. Actomyosin remodeling regulates biomineral formation, growth and morphology during eukaryote skeletogenesis. eLife. 2023;12:RP89080 doi:10.7554/eLife.89080.1.

Inhibition of the serine protease HtrA1 by SerpinE2 suggests a role for an extracellular proteolytic pathway in the control of neural crest migration

Authors:
Pera EM, Nilsson-De Moura J, Pomeshchik Y, Roybon L, Milas I
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.09.05.556243
Epub:
Not Epub
Abstract:
Here we present an extracellular proteolytic mechanism involving the serine protease HtrA1 and its inhibitor SerpinE2 in the...
Link:
https://www.biorxiv.org/content/10.1101/2023.09.05.556243v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Pera EM, Nilsson-De Moura J, Pomeshchik Y, Roybon L, Milas I. Inhibition of the serine protease HtrA1 by SerpinE2 suggests a role for an extracellular proteolytic pathway in the control of neural crest migration. bioRxiv. 2023;[preprint] doi:10.1101/2023.09.05.556243 .

Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus

Authors:
Garfinkel AM, Mnatsakanyan N, Patel JH, Wills AE, Shteyman A, Smith PJS, Alavian KN, Jonas EA, Khokha MF
Citation:
Dev Cell. 2023;[Epub ahead of print] doi:10.1016/j.devcel.2023.08.015
Epub:
Not Epub
Abstract:
An instructive role for metabolism in embryonic patterning is emerging, although a role for mitochondria is poorly defined. We...
Link:
https://www.cell.com/developmental-cell/pdf/S1534-5807(23)00411-2.pdf
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Garfinkel AM, Mnatsakanyan N, Patel JH, Wills AE, Shteyman A, Smith PJS, Alavian KN, Jonas EA, Khokha MF. Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus. Dev Cell. 2023;[Epub ahead of print] doi:10.1016/j.devcel.2023.08.015.

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