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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor

Authors:
Devotta A, Juraver-Geslin H, Griffin C, Saint-Jeannet JP
Citation:
Elife. 2023 May 10;12:e84036. doi: 10.7554/eLife.84036. Online ahead of print
Epub:
Yes
Abstract:
Natriuretic peptide signaling has been implicated in a broad range of physiological processes, regulating blood volume and...
Link:
https://elifesciences.org/articles/84036
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Devotta A, Juraver-Geslin H, Griffin C, Saint-Jeannet JP. Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor. Elife. 2023 May 10;12:e84036. doi: 10.7554/eLife.84036. Online ahead of print.

Efficacy and Safety of Viltolarsen in Boys With Duchenne Muscular Dystrophy: Results From the Phase 2, Open-Label, 4-Year Extension Study

Authors:
Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, McDonald CM, Smith EC, Zaidman CM, Nakagawa T; CINRG DNHS Investigators; Hoffman EP
Citation:
J Neuromuscul Dis. 2023;10(3):439-447. doi: 10.3233/JND-221656
Epub:
Not Epub
Abstract:
Background: Duchenne muscular dystrophy (DMD) is caused by DMD gene mutations, resulting in absence of functional dystrophin...
Link:
https://content.iospress.com/articles/journal-of-neuromuscular-diseases/jnd221656
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, McDonald CM, Smith EC, Zaidman CM, Nakagawa T; CINRG DNHS Investigators; Hoffman EP. Efficacy and Safety of Viltolarsen in Boys With Duchenne Muscular Dystrophy: Results From the Phase 2, Open-Label, 4-Year Extension Study. J Neuromuscul Dis. 2023;10(3):439-447. doi: 10.3233/JND-221656.

Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ

Authors:
Chen C-l, Syahirah R, Ravala S, Yen Y-C, Klose T, Deng Q, Tesmer JJG
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.05.04.539492
Epub:
Not Epub
Abstract:
The conversion of PIP2 to PIP3 by phosphoinositide 3-kinase γ (PI3Kγ) is a critical step in neutrophil chemotaxis and is...
Link:
https://www.biorxiv.org/content/10.1101/2023.05.04.539492v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen C-l, Syahirah R, Ravala S, Yen Y-C, Klose T, Deng Q, Tesmer JJG. Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. bioRxiv. 2023;[preprint] doi:10.1101/2023.05.04.539492 .

The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation

Authors:
Ding T, Ji J, Zhang W, Liu Y, Liu B, Han Y, Chen C, Yu L
Citation:
Cell Res. 2023;[Epub] doi:10.1038/s41422-023-00811-5
Epub:
Yes
Abstract:
Migrasomes are recently discovered organelles, which are formed on the ends or branch points of retraction fibers at the...
Link:
https://www.nature.com/articles/s41422-023-00811-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ding T, Ji J, Zhang W, Liu Y, Liu B, Han Y, Chen C, Yu L. The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation. Cell Res. 2023;[Epub] doi:10.1038/s41422-023-00811-5.

In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity

Authors:
Silva N, Campinho MA
Citation:
Front Endocrinol. 2023;14:1157685. doi:10.3389/fendo.2023.1157685
Epub:
Not Epub
Abstract:
Background: Maternally derived thyroid hormone (T3) is a fundamental factor for vertebrate neurodevelopment. In humans,...
Link:
https://www.frontiersin.org/articles/10.3389/fendo.2023.1157685/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Silva N, Campinho MA. In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity. Front Endocrinol. 2023;14:1157685. doi:10.3389/fendo.2023.1157685.

Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy

Authors:
Seifinejad A, Ramosaj M, Shan L, Li S, Possovre ML, Pfister C, Fronczek R, Garrett-Sinha LA, Frieser D, Honda M, Arribat Y, Grepper D, Amati F, Picot M, Agnoletto A, Iseli C, Chartrel N, Liblau R, Lammers GJ, Vassalli A, Tafti M
Citation:
Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2220911120. doi: 10.1073/pnas.2220911120. Epub 2023 May 1
Epub:
Not Epub
Abstract:
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic neuropeptide hypocretin/orexin (HCRT),...
Link:
https://www.pnas.org/doi/10.1073/pnas.2220911120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Seifinejad A, Ramosaj M, Shan L, Li S, Possovre ML, Pfister C, Fronczek R, Garrett-Sinha LA, Frieser D, Honda M, Arribat Y, Grepper D, Amati F, Picot M, Agnoletto A, Iseli C, Chartrel N, Liblau R, Lammers GJ, Vassalli A, Tafti M. Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2220911120. doi: 10.1073/pnas.2220911120. Epub 2023 May 1.

Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells

Authors:
Li H, Luo Q, Cai S, Tie R, Meng Y, Shan W, Xu Y, Zeng X, Qian P, Huang H
Citation:
Stem Cell Res Ther. 2023 Apr 30;14(1):117. doi: 10.1186/s13287-023-03328-1
Epub:
Not Epub
Abstract:
Background: In vertebrates, hematopoietic stem and progenitor cells (HSPCs) emerge from hemogenic endothelium in the floor of...
Link:
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-023-03328-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li H, Luo Q, Cai S, Tie R, Meng Y, Shan W, Xu Y, Zeng X, Qian P, Huang H. Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells. Stem Cell Res Ther. 2023 Apr 30;14(1):117. doi: 10.1186/s13287-023-03328-1.

mRNA Location and Translation Rate Determine Protein Targeting to Dual Destinations

Authors:
Gasparski AN, Moissoglu K, Pallikkuth S, Meydan S, Guydosh NR, Mili S
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.04.24.538105
Epub:
Not Epub
Abstract:
Numerous proteins are targeted to two or multiple subcellular destinations where they exert distinct functional consequences....
Link:
https://www.biorxiv.org/content/10.1101/2023.04.24.538105v1
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: MDA-MB-231
Citation Extract:
Gasparski AN, Moissoglu K, Pallikkuth S, Meydan S, Guydosh NR, Mili S. mRNA Location and Translation Rate Determine Protein Targeting to Dual Destinations. bioRxiv. 2023;[preprint] doi:10.1101/2023.04.24.538105.

Epigenetic landscape reveals MECOM as an endothelial lineage regulator

Authors:
Lv J, Meng S, Gu Q, Zheng R, Gao X, Kim J-d, Chen M, Xia B, Zuo Y, Zhu S, Zhao D, Li Y, Wang G, Wang X, Meng Q, Cao Q, Cooke JP, Fang L, Chen K, Zhang L
Citation:
Nat Commun. 2023;14:2390. doi:/10.1038/s41467-023-38002-w
Epub:
Not Epub
Abstract:
A comprehensive understanding of endothelial cell lineage specification will advance cardiovascular regenerative medicine....
Link:
https://www.nature.com/articles/s41467-023-38002-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lv J, Meng S, Gu Q, Zheng R, Gao X, Kim J-d, Chen M, Xia B, Zuo Y, Zhu S, Zhao D, Li Y, Wang G, Wang X, Meng Q, Cao Q, Cooke JP, Fang L, Chen K, Zhang L. Epigenetic landscape reveals MECOM as an endothelial lineage regulator. Nat Commun. 2023;14:2390. doi:/10.1038/s41467-023-38002-w.

PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma

Authors:
Haas M, Caron G, Chatonnet F, Manenti S, Alaterre E, Devin J, Delaloy C, Bertolin G, Viel R, Pignarre A, Llamas-Gutierrez F, Marchalot A, Decaux O, Tarte K, Delpy L, Moreaux J, Fest T
Citation:
Blood. 2022;139(15):2316-37. doi:10.1182/blood.2021014011
Epub:
Not Epub
Abstract:
The differentiation of B cells into plasmablasts (PBs) and then plasma cells (PCs) is associated with extensive cell...
Link:
https://www.sciencedirect.com/science/article/pii/S0006497122001471
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: Plasmoblasts (PBs) and CD23+ post-activated B cells
Citation Extract:
Haas M, Caron G, Chatonnet F, Manenti S, Alaterre E, Devin J, Delaloy C, Bertolin G, Viel R, Pignarre A, Llamas-Gutierrez F, Marchalot A, Decaux O, Tarte K, Delpy L, Moreaux J, Fest T. PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma. Blood. 2022;139(15):2316-37. doi:10.1182/blood.2021014011.

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