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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12156 scientific papers returned from the database with the search filters currently being used below.

Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments

Authors:
Tanwar J, Ahuja K, Sharma A, Sehgal P, Ranjan G, Sultan F, Agrawal A, D'Angelo D, Priya A, Yenamandra VK, Singh A, Raffaello A, Madesh M, Rizzuto R, Sivasubbu S, Motiani RK
Citation:
PLoS Biol. 2024 Nov 11;22(11):e3002895. doi: 10.1371/journal.pbio.3002895. Epub ahead of print. PMID: 39527653
Epub:
Not Epub
Abstract:
Mitochondria regulate several physiological functions through mitochondrial Ca2+ dynamics. However, role of mitochondrial Ca2+...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002895
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tanwar J, Ahuja K, Sharma A, Sehgal P, Ranjan G, Sultan F, Agrawal A, D'Angelo D, Priya A, Yenamandra VK, Singh A, Raffaello A, Madesh M, Rizzuto R, Sivasubbu S, Motiani RK. Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments. PLoS Biol. 2024 Nov 11;22(11):e3002895. doi: 10.1371/journal.pbio.3002895. Epub ahead of print. PMID: 39527653.

Manic Fringe promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development

Authors:
Yang J, Wang Z, Zhou Y, Jiang S, Qin X, Xu Z, Wang Y, Zuo M, Meng Z, Chen S, Wang Q, Wang J, Sun K
Citation:
J Mol Med (Berl). 2024 Nov 11. doi: 10.1007/s00109-024-02492-y. Epub ahead of print. PMID: 39528804
Epub:
Not Epub
Abstract:
A fundamental event in the formation of heart valves involves the transformation of endocardial cells within the outflow...
Link:
https://link.springer.com/article/10.1007/s00109-024-02492-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang J, Wang Z, Zhou Y, Jiang S, Qin X, Xu Z, Wang Y, Zuo M, Meng Z, Chen S, Wang Q, Wang J, Sun K. Manic Fringe promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development. J Mol Med (Berl). 2024 Nov 11. doi: 10.1007/s00109-024-02492-y. Epub ahead of print. PMID: 39528804.

Characterization of Nonclinical Drug Metabolism and Pharmacokinetic Properties of Phosphorodiamidate Morpholino Oligonucleotides, A Novel Drug Class for Duchenne Muscular Dystrophy

Authors:
Goey A, Mukashyaka MC, Patel Y, Rodino-Klapac LR, East L
Citation:
Drug Metab Dispos. 2024 Nov 8:DMD-AR-2024-001819. doi: 10.1124/dmd.124.001819. Epub ahead of print. PMID: 39516029
Epub:
Not Epub
Abstract:
Eteplirsen, golodirsen, and casimersen are phosphorodiamidate morpholino oligomers (PMOs) that are approved in the United...
Link:
https://dmd.aspetjournals.org/article/S0090-9556(24)15943-0/abstract
Delivery Method:
intravenous (i.v.) bolus
Organism or Cell Type:
in vivo: CByB6F1 & mdx mice, Sprague Dawley rats & cynomolgus monkeys; in vitro: hepatic microsomes from CD-1 mice, Sprague Dawley rats, cynomolgus monkeys and humans; cell culture: Caco-2, CHO & HEK293
Citation Extract:
Goey A, Mukashyaka MC, Patel Y, Rodino-Klapac LR, East L. Characterization of Nonclinical Drug Metabolism and Pharmacokinetic Properties of Phosphorodiamidate Morpholino Oligonucleotides, A Novel Drug Class for Duchenne Muscular Dystrophy. Drug Metab Dispos. 2024 Nov 8:DMD-AR-2024-001819. doi: 10.1124/dmd.124.001819. Epub ahead of print. PMID: 39516029.

F86. Molecular mechanism of the TNIK gene affecting the action of antipsychotic drugs through the glutamate pathway

Authors:
Xu Q, Qin S, He L, Yu S
Citation:
European Neuropsychopharmacology, Volume 87, Supplement 1, 2024, Pages 251-252, ISSN 0924-977X, https://doi.org/10.1016/j.euroneuro.2024.08.497
Epub:
Not Epub
Abstract:
Background Schizophrenia (SCZ) is a complex psychiatric disorder primarily treated with antipsychotic drugs (APDs), yet the...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0924977X24006965
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xu Q, Qin S, He L, Yu S. F86. Molecular mechanism of the TNIK gene affecting the action of antipsychotic drugs through the glutamate pathway. European Neuropsychopharmacology, Volume 87, Supplement 1, 2024, Pages 251-252, ISSN 0924-977X, https://doi.org/10.1016/j.euroneuro.2024.08.497.

Multi-omics integration analysis identifies pathogenic candidate genes of congenital heart defects with vascular malformation

Authors:
Ding XW, Huang JX, Chen YH, Li ZY, Wu YZ, Qian ZL, Feng WQ, Li YR, Zhao LD, Zhao PJ, Lu YN, Yu Y
Citation:
European Heart Journal, Volume 45, Issue Supplement_1, October 2024, ehae666.2109, https://doi.org/10.1093/eurheartj/ehae666.2109
Epub:
Not Epub
Abstract:
Background Congenital heart defects (CHD) with vascular malformation harbors numerous genetic and epigenetic aberrations of...
Link:
https://academic.oup.com/eurheartj/article/45/Supplement_1/ehae666.2109/7836991
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ding XW, Huang JX, Chen YH, Li ZY, Wu YZ, Qian ZL, Feng WQ, Li YR, Zhao LD, Zhao PJ, Lu YN, Yu Y. Multi-omics integration analysis identifies pathogenic candidate genes of congenital heart defects with vascular malformation. European Heart Journal, Volume 45, Issue Supplement_1, October 2024, ehae666.2109, https://doi.org/10.1093/eurheartj/ehae666.2109.

Actin Depolymerizing Factor Destrin Regulates Cilia Development and Function during Vertebrate Embryogenesis

Authors:
Kim Y, Lee HK, Park KY, Ismail T, Lee H, Lee HS
Citation:
Dev Reprod. 2024 Sep;28(3):109-119. doi: 10.12717/DR.2024.28.3.109. Epub 2024 Sep 30. PMID: 39444639; PMCID: PMC11495882
Epub:
Not Epub
Abstract:
The actin cytoskeleton plays fundamental roles in ciliogenesis and the actin depolymerizing factor destrin regulates actin...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11495882/
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim Y, Lee HK, Park KY, Ismail T, Lee H, Lee HS. Actin Depolymerizing Factor Destrin Regulates Cilia Development and Function during Vertebrate Embryogenesis. Dev Reprod. 2024 Sep;28(3):109-119. doi: 10.12717/DR.2024.28.3.109. Epub 2024 Sep 30. PMID: 39444639; PMCID: PMC11495882.

Light-modulated neural control of sphincter regulation in the evolution of through-gut

Authors:
Yaguchi J, Sakai K, Horiuchi A, Yamamoto T, Yamashita T, Yaguchi S
Citation:
Nat Commun. 2024 Oct 18;15(1):8881. doi: 10.1038/s41467-024-53203-7. PMID: 39424783; PMCID: PMC11489725
Epub:
Not Epub
Abstract:
The development of a continuous digestive tract, or through-gut, represents a key milestone in bilaterian evolution. However,...
Link:
https://www.nature.com/articles/s41467-024-53203-7
Delivery Method:
microinjection
Organism or Cell Type:
Hemicentrotus pulcherrimus (sea urchin)
Citation Extract:
Yaguchi J, Sakai K, Horiuchi A, Yamamoto T, Yamashita T, Yaguchi S. Light-modulated neural control of sphincter regulation in the evolution of through-gut. Nat Commun. 2024 Oct 18;15(1):8881. doi: 10.1038/s41467-024-53203-7. PMID: 39424783; PMCID: PMC11489725.

Emx2 is an essential regulator of ciliated cell development across embryonic tissues

Authors:
Nguyen TK, Rodriguez J-M, Wesselman HM, Wingert RA
Citation:
ISCIENCE (2024), doi.org/10.1016/j.isci.2024.111271
Epub:
Not Epub
Abstract:
Cilia are hair-like organelles with vital physiological roles, and ciliogenesis defects underlie a range of severe congenital...
Link:
https://www.sciencedirect.com/science/article/pii/S2589004224024969
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nguyen TK, Rodriguez J-M, Wesselman HM, Wingert RA. Emx2 is an essential regulator of ciliated cell development across embryonic tissues. ISCIENCE (2024), doi.org/10.1016/j.isci.2024.111271.

An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis

Authors:
Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z, Yang M, Wang W, Xiao Q
Citation:
Eur J Cell Biol. 2024 Dec;103(4):151465. doi: 10.1016/j.ejcb.2024.151465. Epub 2024 Oct 24. PMID: 39471724.
Epub:
Not Epub
Abstract:
Mesoderm induction is a crucial step for vascular cell specification, vascular development and vasculogenesis. However, the...
Link:
https://www.sciencedirect.com/science/article/pii/S0171933524000827
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z, Yang M, Wang W, Xiao Q. An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis. Eur J Cell Biol. 2024 Dec;103(4):151465. doi: 10.1016/j.ejcb.2024.151465. Epub 2024 Oct 24. PMID: 39471724..

PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation

Authors:
Song K, Chen D, Li J, Zhang J, Tian Y, Xu X, Wang B, Huang Z, Lou S, Kang J, Zhang N, Yang X, Ma W
Citation:
Adv Biol (Weinh). 2024 Oct 22:e2400307. doi: 10.1002/adbi.202400307. Online ahead of print. PMID: 39435597
Epub:
Not Epub
Abstract:
Oocyte meiotic errors can cause infertility, miscarriage, and birth defects. Here the role and the underlying mechanism of p21...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/adbi.202400307
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocysts
Citation Extract:
Song K, Chen D, Li J, Zhang J, Tian Y, Xu X, Wang B, Huang Z, Lou S, Kang J, Zhang N, Yang X, Ma W. PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation. Adv Biol (Weinh). 2024 Oct 22:e2400307. doi: 10.1002/adbi.202400307. Online ahead of print. PMID: 39435597.

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