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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network
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Citation:
Elife. 2023 May 25;12:e85594. doi: 10.7554/eLife.85594 Epub:
Not Epub Abstract:
Genetic studies in human and mice have established a dual role for Vsx genes in retina development: an early function in... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Letelier J, Buono L, Almuedo-Castillo M, Zang J, Mounieres C, González-Díaz S, Polvillo R, Sanabria-Reinoso E, Corbacho J, Sousa-Ortega A, Diez Del Corral R, Neuhauss SCF, Martínez-Morales JR. Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. Elife. 2023 May 25;12:e85594. doi: 10.7554/eLife.85594. |
Identification of an α-l-iduronidase (IDUA) M1T mutation in a Chinese family with autosomal recessive mucopolysaccharidosis I
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Citation:
Ann N Y Acad Sci. 2023 Jun 22. doi: 10.1111/nyas.15016. Online ahead of print Epub:
Yes Abstract:
Mucopolysaccharidoses (MPS) are a group of rare congenital metabolic disorders caused by the deficiency or low activity of... Organism or Cell Type:
zebrafish Citation Extract: Liu D, Jiang Z, Deng L, Li H, Jiang H. Identification of an α-l-iduronidase (IDUA) M1T mutation in a Chinese family with autosomal recessive mucopolysaccharidosis I. Ann N Y Acad Sci. 2023 Jun 22. doi: 10.1111/nyas.15016. Online ahead of print. |
DNAJB6 isoform specific knockdown: Therapeutic potential for limb girdle muscular dystrophy D1
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Citation:
Mol Ther Nucleic Acids. 2023 May 16;32:937-948. doi: 10.1016/j.omtn.2023.05.017. eCollection 2023 Jun 13 Epub:
Not Epub Abstract:
Dominant missense mutations in DNAJB6, a co-chaperone of HSP70, cause limb girdle muscular dystrophy (LGMD) D1. No treatments... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
Cell culture: murine primary myotubes, human primary LGMDD1 myoblasts; mice Citation Extract: Findlay AR, Paing MM, Daw JA, Haller M, Bengoechea R, Pittman SK, Li S, Wang F, Miller TM, True HL, Chou TF, Weihl CC. DNAJB6 isoform specific knockdown: Therapeutic potential for limb girdle muscular dystrophy D1. Mol Ther Nucleic Acids. 2023 May 16;32:937-948. doi: 10.1016/j.omtn.2023.05.017. eCollection 2023 Jun 13. |
Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation
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Citation:
Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2301725120. doi: 10.1073/pnas.2301725120. Epub 2023 May 22 Epub:
Not Epub Abstract:
Understanding of the evolution of metazoans from their unicellular ancestors is a fundamental question in biology. In contrast... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yong X, Jia G, Liu Z, Zhou C, Yi J, Tang Y, Chen L, Chen L, Wang Y, Sun Q, Billadeau DD, Su Z, Jia D. Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2301725120. doi: 10.1073/pnas.2301725120. Epub 2023 May 22. |
Actin filaments accumulated in the nucleus remain in the vicinity of condensing chromosomes in the zebrafish early embryo
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Citation:
Biol Open. 2023 May 15;12(5):bio059783. doi: 10.1242/bio.059783. Epub 2023 May 17 Epub:
Not Epub Abstract:
In the cytoplasm, filamentous actin (F-actin) plays a critical role in cell regulation, including cell migration, stress fiber... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Oda H, Sato Y, Kawashima SA, Fujiwara Y, Pálfy M, Wu E, Vastenhouw NL, Kanai M, Kimura H. Actin filaments accumulated in the nucleus remain in the vicinity of condensing chromosomes in the zebrafish early embryo. Biol Open. 2023 May 15;12(5):bio059783. doi: 10.1242/bio.059783. Epub 2023 May 17. |
Functional characterization of stap2b in zebrafish vascular development
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Citation:
FASEB J. 2023 Jul;37(7):e23053. doi: 10.1096/fj.202201314RRR Epub:
Not Epub Abstract:
The genetic control and signaling pathways of vascular development are not comprehensively understood. Transcription factors... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Wang YS, Chen YT, Wu CY. Functional characterization of stap2b in zebrafish vascular development. FASEB J. 2023 Jul;37(7):e23053. doi: 10.1096/fj.202201314RRR. |
A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription
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Citation:
Mol Cell. 2023 Jul 6;83(13):2222-2239.e5. doi: 10.1016/j.molcel.2023.05.029. Epub 2023 Jun 16. Epub:
Yes Abstract:
The transcriptional termination of unstable non-coding RNAs (ncRNAs) is poorly understood compared to coding transcripts. We... Delivery Method:
electroporation Organism or Cell Type:
cell culture Citation Extract: Estell C, Davidson L, Eaton JD, Kimura H, Gold VAM, West S. A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription. Mol Cell. 2023 Jul 6;83(13):2222-2239.e5. doi: 10.1016/j.molcel.2023.05.029. Epub 2023 Jun 16. . |
Recruitment of transcription factor ETS1 to activated accessible regions promotes the transcriptional program of cilia genes
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Citation:
Nucleic Acids Res. 2023 Jun 16:gkad506. doi: 10.1093/nar/gkad506. Online ahead of print Epub:
Not Epub Abstract:
Defects in cilia genes, which are critical for cilia formation and function, can cause complicated ciliopathy syndromes... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang D, Zhang C, Zhu Y, Xie H, Yue C, Li M, Wei W, Peng Y, Yin G, Guo Y, Guan Y. Recruitment of transcription factor ETS1 to activated accessible regions promotes the transcriptional program of cilia genes. Nucleic Acids Res. 2023 Jun 16:gkad506. doi: 10.1093/nar/gkad506. Online ahead of print. |
Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals
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Citation:
J Cell Commun Signal. 2023 Jun 20. doi: 10.1007/s12079-023-00775-6. Online ahead of print Epub:
Yes Abstract:
Liver fibrosis is an aberrant wound healing response to tissue injury characterized by excessive extracellular matrix... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhao Y, Wang H, He T, Ma B, Chen G, Tzeng C. Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals. J Cell Commun Signal. 2023 Jun 20. doi: 10.1007/s12079-023-00775-6. Online ahead of print. |
A Role for Microsomal Glutathione Transferase 1 in Melanin Biosynthesis and Melanoma Progression
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Citation:
J Biol Chem. 2023 Jun 13:104920. doi:10.1016/j.jbc.2023.104920. Online ahead of print Epub:
Not Epub Abstract:
Recent advancements in the treatment of melanoma are encouraging, but there remains a need to identify additional therapeutic... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang J, Ye ZW, Bräutigam L, Chakraborty P, Luo Z, Culpepper J, Aslam M, Zhang L, Johansson K, Haeggström JZ, Xu J, Olsson M, Townsend DM, Mehrotra S, Morgenstern R, Tew KD. A Role for Microsomal Glutathione Transferase 1 in Melanin Biosynthesis and Melanoma Progression. J Biol Chem. 2023 Jun 13:104920. doi:10.1016/j.jbc.2023.104920. Online ahead of print. |