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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer
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Citation:
Cell Oncol (Dordr). 2023 Jul 5. doi: 10.1007/s13402-023-00839-0. Online ahead of print Epub:
Yes Abstract:
Purpose: MicroRNA-146b (miR-146b) alleviates experimental colitis in mice by mediating macrophage polarization and the release... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: primary bone marrow-derived macrophages (BMDMs) Citation Extract: He S, Song W, Cui S, Li J, Jiang Y, Chen X, Peng L. Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer. Cell Oncol (Dordr). 2023 Jul 5. doi: 10.1007/s13402-023-00839-0. Online ahead of print. |
RAS-independent ERK activation by constitutively active KSR3 in non-chordate metazoa
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Citation:
Nat Commun. 2023 Jul 5;14(1):3970. doi: 10.1038/s41467-023-39606-y Epub:
Not Epub Abstract:
During early development of the sea urchin embryo, activation of ERK signalling in mesodermal precursors is not triggered by... Delivery Method:
microinjection Organism or Cell Type:
Paracentrotus lividus (sea urchin) Citation Extract: Chessel A, De Crozé N, Molina MD, Taberner L, Dru P, Martin L, Lepage T. RAS-independent ERK activation by constitutively active KSR3 in non-chordate metazoa. Nat Commun. 2023 Jul 5;14(1):3970. doi: 10.1038/s41467-023-39606-y. |
Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms
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Citation:
Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2307898120. doi: 10.1073/pnas.2307898120. Epub 2023 Jul 24 Epub:
Not Epub Abstract:
Cells of vertebrate and invertebrate organisms express proteins specialized in membrane channel-based cell-cell communication... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Güiza J, Solís F, Valenzuela B, Arancibia D, Zamorano P, González J, Saavedra J, Neely A, Salgado M, Martínez AD, Sáez JC, Vega JL. Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2307898120. doi: 10.1073/pnas.2307898120. Epub 2023 Jul 24. |
Prediction of human pharmacokinetics of phosphorodiamidate morpholino oligonucleotides in Duchenne muscular dystrophy patients using viltolarsen
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Citation:
Drug Metab Dispos. 2023 Jul 19:DMD-AR-2023-001425. doi: 10.1124/dmd.123.001425. Online ahead of print Epub:
Yes Abstract:
Several modified antisense oligonucleotides (ASOs) have recently been approved for clinical use. Some are phosphorodiamidate... Delivery Method:
intravenous (i.v.) Organism or Cell Type:
mice, rats, cynomolgus monkeys, dogs, humans Citation Extract: Imai S, Suda Y, Mori J, Sasaki Y, Yamada T, Kusano K. Prediction of human pharmacokinetics of phosphorodiamidate morpholino oligonucleotides in Duchenne muscular dystrophy patients using viltolarsen. Drug Metab Dispos. 2023 Jul 19:DMD-AR-2023-001425. doi: 10.1124/dmd.123.001425. Online ahead of print. |
Development of small fluorescent probes for the analysis of autophagy kinetics
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Citation:
iScience. 2023 Jun 28;26(7):107218. doi: 10.1016/j.isci.2023.107218. eCollection 2023 Jul 21 Epub:
Not Epub Abstract:
Autophagy is a dynamic process that degrades subcellular constituents, and its activity is measured by autophagic flux. The... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sakurai HT, Iwashita H, Arakawa S, Yikelamu A, Kusaba M, Kofuji S, Nishina H, Ishiyama M, Ueno Y, Shimizu S. Development of small fluorescent probes for the analysis of autophagy kinetics. iScience. 2023 Jun 28;26(7):107218. doi: 10.1016/j.isci.2023.107218. eCollection 2023 Jul 21. |
lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway
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Citation:
Genes. 2023;14:1371. doi:10.3390/genes14071371 Epub:
Not Epub Abstract:
Background: In vertebrates, the development of the inner ear is a delicate process, whereas its relating molecular pathways are... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sun L, Ping L, Gao R, Zhang B, Chen X. lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway. Genes. 2023;14:1371. doi:10.3390/genes14071371. |
Upf3a but not Upf1 mediates the genetic compensation response induced by leg1 deleterious mutations in an H3K4me3-independent manner
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Citation:
Cell Discov. 2023 Jun 27;9(1):63. doi: 10.1038/s41421-023-00550-2 Epub:
Not Epub Abstract:
Genetic compensation responses (GCRs) can be induced by deleterious mutations in living organisms in order to maintain genetic... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Xie A, Ma Z, Wang J, Zhang Y, Chen Y, Yang C, Chen J, Peng J. Upf3a but not Upf1 mediates the genetic compensation response induced by leg1 deleterious mutations in an H3K4me3-independent manner. Cell Discov. 2023 Jun 27;9(1):63. doi: 10.1038/s41421-023-00550-2. |
Deep intronic founder mutations identified in the ERCC4/XPF gene are potential therapeutic targets for a high-frequency form of xeroderma pigmentosum
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Citation:
Proc Natl Acad Sci U S A. 2023 Jul 4;120(27):e2217423120. doi: 10.1073/pnas.2217423120. Epub 2023 Jun 26 Epub:
Not Epub Abstract:
Xeroderma pigmentosum (XP) is a genodermatosis defined by cutaneous photosensitivity with an increased risk of skin tumors... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: XP43NG, XP3YO Citation Extract: Senju C, Nakazawa Y, Oso T, Shimada M, Kato K, Matsuse M, Tsujimoto M, Masaki T, Miyazaki Y, Fukushima S, Tateishi S, Utani A, Murota H, Tanaka K, Mitsutake N, Moriwaki S, Nishigori C, Ogi T. Deep intronic founder mutations identified in the ERCC4/XPF gene are potential therapeutic targets for a high-frequency form of xeroderma pigmentosum. Proc Natl Acad Sci U S A. 2023 Jul 4;120(27):e2217423120. doi: 10.1073/pnas.2217423120. Epub 2023 Jun 26. |
Synthesis and Biophysical Studies of High Affinity Morpholino Oligomers Containing G-clamp Analogs
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Citation:
ChemRxiv. 2023:[preprint] doi:10.26434/chemrxiv-2023-fhfbr Epub:
Not Epub Abstract:
Synthesis of chlorophosphoramidate morpholino monomers containing tricyclic cytosine analogs phenoxazine, G-clamp, and G8AE-... Citation Extract: Sinha S, Das A, Ghosh A, Kundu J, Egli M, Manoharan M. Synthesis and Biophysical Studies of High Affinity Morpholino Oligomers Containing G-clamp Analogs. ChemRxiv. 2023:[preprint] doi:10.26434/chemrxiv-2023-fhfbr. |
Identification of protein phosphatase 4 catalytic subunit as a Wnt promoting factor in pan-cancer and Xenopus early embryogenesis
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Citation:
Sci Rep. 2023 Jun 23;13(1):10240. doi: 10.1038/s41598-023-35719-y Epub:
Not Epub Abstract:
Protein Phosphatase 4 Catalytic Subunit (PPP4C) is an evolutionarily conserved protein involved in multiple biological and... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Wang Y, Han W, Yun S, Han J. Identification of protein phosphatase 4 catalytic subunit as a Wnt promoting factor in pan-cancer and Xenopus early embryogenesis. Sci Rep. 2023 Jun 23;13(1):10240. doi: 10.1038/s41598-023-35719-y. |