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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function

Authors:
Cai W, Wang Y, Luo Y, Gao L, Zhang J, Jiang Z, Fan X, Li F, Xie Y, Wu X, Li Y, Yuan W.
Citation:
Int J Mol Sci. 2023;24(22):16364. doi:10.3390/ijms242216364
Epub:
Not Epub
Abstract:
Ankyrin repeat and suppression-of-cytokine-signaling box (Asb) proteins, a subset of ubiquitin ligase E3, include Asb5 with six...
Link:
https://www.mdpi.com/1422-0067/24/22/16364
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cai W, Wang Y, Luo Y, Gao L, Zhang J, Jiang Z, Fan X, Li F, Xie Y, Wu X, Li Y, Yuan W. . asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. Int J Mol Sci. 2023;24(22):16364. doi:10.3390/ijms242216364 .

Combined RhoA Morpholino and ChABC Treatment Protects Identified Lamprey Neurons from Retrograde Apoptosis after Spinal Cord Injury

Authors:
Hu J, Zhang KG, Rodemer W, Jin L-Q, Selzer ME
Citation:
Front Cell Neurosci. 2023;17:[Epub] doi:10.3389/fncel.2023.1292012
Epub:
Not Epub
Abstract:
Previously, we reported that RhoA knockdown by morpholino antisense oligonucleotides (MOs), and enzymatic digestion of...
Link:
https://www.frontiersin.org/articles/10.3389/fncel.2023.1292012/abstract
Delivery Method:
Gelfoam at lesion
Organism or Cell Type:
lamprey
Citation Extract:
Hu J, Zhang KG, Rodemer W, Jin L-Q, Selzer ME. Combined RhoA Morpholino and ChABC Treatment Protects Identified Lamprey Neurons from Retrograde Apoptosis after Spinal Cord Injury. Front Cell Neurosci. 2023;17:[Epub] doi:10.3389/fncel.2023.1292012.

Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer

Authors:
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X
Citation:
Drug Deliv Transl Res. 2024 May;14(5):1352-1369. doi: 10.1007/s13346-023-01469-7. Epub 2023 Nov 17. PMID: 37978163; PMCID: PMC10984892.
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (ASO) is a novel therapeutic platform for targeted cancer therapy. Previously, we have demonstrated...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10984892/
Delivery Method:
peptide-linked, exosome
Organism or Cell Type:
cell culture: SW620, xenograft mice
Citation Extract:
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X . Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer. Drug Deliv Transl Res. 2024 May;14(5):1352-1369. doi: 10.1007/s13346-023-01469-7. Epub 2023 Nov 17. PMID: 37978163; PMCID: PMC10984892..

Electrical impedance myography detects dystrophin-related muscle changes in mdx mice

Authors:
Hiyoshi T, Zhao F, Baba R, Hirakawa T, Kuboki R, Suzuki K, Tomimatsu Y, O'Donnell P, Han S, Zach N, Nakashima M
Citation:
Skelet Muscle. 2023 Nov 18;13(1):19. doi: 10.1186/s13395-023-00331-1
Epub:
Not Epub
Abstract:
Background: The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle...
Link:
https://skeletalmusclejournal.biomedcentral.com/articles/10.1186/s13395-023-00331-1
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hiyoshi T, Zhao F, Baba R, Hirakawa T, Kuboki R, Suzuki K, Tomimatsu Y, O'Donnell P, Han S, Zach N, Nakashima M. Electrical impedance myography detects dystrophin-related muscle changes in mdx mice. Skelet Muscle. 2023 Nov 18;13(1):19. doi: 10.1186/s13395-023-00331-1.

Vangl2 deficient zebrafish exhibit hallmarks of neural tube closure defects

Authors:
MacGowan J, Cardenas M, Williams MK
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.09.566412
Epub:
Not Epub
Abstract:
Neural tube defects (NTDs) are among the most devastating and common congenital anomalies worldwide, and the ability to model...
Link:
https://www.biorxiv.org/content/10.1101/2023.11.09.566412v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
MacGowan J, Cardenas M, Williams MK. Vangl2 deficient zebrafish exhibit hallmarks of neural tube closure defects. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.09.566412.

Maternal H3.3-Mediated Paternal Genome Reprogramming Contributes to Minor Zygotic Genome Activation

Authors:
Zhang J, Li X, Cui H, Xiao S, Song E, Zong M, Ling S, Rosenwaks Z, Gao S, Liu X, Kong Q, Wen D
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.07.566007
Epub:
Not Epub
Abstract:
In mice, zygotic genome activation (ZGA) is initiated at the late-one-cell stage, accompanied by an extensive incorporation of...
Link:
https://www.biorxiv.org/content/10.1101/2023.11.07.566007v1
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Zhang J, Li X, Cui H, Xiao S, Song E, Zong M, Ling S, Rosenwaks Z, Gao S, Liu X, Kong Q, Wen D. Maternal H3.3-Mediated Paternal Genome Reprogramming Contributes to Minor Zygotic Genome Activation. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.07.566007.

IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A

Authors:
Gebert M, Bartoszewska S, Opalinski L, Collawn JF, Bartoszewski R
Citation:
Cell Commun Signal. 2023 Nov 9;21(1):322. doi: 10.1186/s12964-023-01349-0
Epub:
Not Epub
Abstract:
The unfolded protein response is a survival signaling pathway that is induced during various types of ER stress. Here, we...
Link:
https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01349-0
Organism or Cell Type:
cell culture: 16HBE140
Citation Extract:
Gebert M, Bartoszewska S, Opalinski L, Collawn JF, Bartoszewski R. IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A. Cell Commun Signal. 2023 Nov 9;21(1):322. doi: 10.1186/s12964-023-01349-0.

The conserved wobble uridine tRNA thiolase Ctu1 is required to sustain development and differentiation

Authors:
YZW Yu, CQ Wang, Y Wang, H Shi, ZL Zhou
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.08.566201
Epub:
Not Epub
Abstract:
Recent studies have revealed that tRNA modification is an important epigenetic mechanism involved in gene expression. Cytosolic...
Link:
https://www.biorxiv.org/content/10.1101/2023.11.08.566201v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
YZW Yu, CQ Wang, Y Wang, H Shi, ZL Zhou. The conserved wobble uridine tRNA thiolase Ctu1 is required to sustain development and differentiation. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.08.566201.

Optimization and Safety Results of E1v1.11: a morpholino antisense oligonucleotide therapeutic for Spinal Muscular Atrophy

Authors:
Oconnor S, Hansen H, Osman E, Kaifer KD, Morcos P, Kacher M, Beatty D, Lorson C
Citation:
MDA Conference Abstracts. 2024;Poster 85
Epub:
Not Epub
Abstract:
Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder that is the leading genetic cause of infantile death,...
Link:
https://www.mdaconference.org/abstract-library/optimization-and-safety-results-of-e1v1-11-a-morpholino-antisense-oligonucleotide-therapeutic-for-spinal-muscular-atrophy/
Citation Extract:
Oconnor S, Hansen H, Osman E, Kaifer KD, Morcos P, Kacher M, Beatty D, Lorson C. Optimization and Safety Results of E1v1.11: a morpholino antisense oligonucleotide therapeutic for Spinal Muscular Atrophy. MDA Conference Abstracts. 2024;Poster 85.

Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration

Authors:
Liu C, Liu X, He Z, Zhang J, Tan X, Yang W, Zhang Y, Yu T, Liao S, Dai L, Xu Z, Li F, Huang Y, Zhao J
Citation:
Nat Commun. 2023 Nov 7;14(1):7167. doi: 10.1038/s41467-023-42929-5
Epub:
Not Epub
Abstract:
Organ regeneration necessitates precise coordination of accelerators and brakes to restore organ function. However, the...
Link:
https://www.nature.com/articles/s41467-023-42929-5
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Liu C, Liu X, He Z, Zhang J, Tan X, Yang W, Zhang Y, Yu T, Liao S, Dai L, Xu Z, Li F, Huang Y, Zhao J. Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration. Nat Commun. 2023 Nov 7;14(1):7167. doi: 10.1038/s41467-023-42929-5.

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