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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Neuronal migration prevents spatial competition in retinal morphogenesis

Authors:
Rocha-Martins M, Nerli E, Kretzschmar J, Weigert M, Icha J, Myers EW, Norden C
Citation:
Nature. 2023:[Epub ahead of print]. doi:10.1038/s41586-023-06392-y
Epub:
Yes
Abstract:
The concomitant occurrence of tissue growth and organization is a hallmark of organismal development. This often means that...
Link:
https://www.nature.com/articles/s41586-023-06392-y
Organism or Cell Type:
zebrafish
Citation Extract:
Rocha-Martins M, Nerli E, Kretzschmar J, Weigert M, Icha J, Myers EW, Norden C. Neuronal migration prevents spatial competition in retinal morphogenesis. Nature. 2023:[Epub ahead of print]. doi:10.1038/s41586-023-06392-y.

Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos

Authors:
Xu R, Zhu Q, Zhao Y, Chen M, Yang L, Shen S, Yang G, Shi Z, Zhang X, Shi Q, Kou X, Zhao Y, Wang H, Jiang C, Li C, Gao S, Liu X
Citation:
Nat Commun. 2023;14:4807. doi:10.1038/s41467-023-40496-3
Epub:
Not Epub
Abstract:
Somatic cell nuclear transfer (SCNT) can be used to reprogram differentiated somatic cells to a totipotent state but has poor...
Link:
https://www.nature.com/articles/s41467-023-40496-3
Delivery Method:
microinjection
Organism or Cell Type:
mouse zygote
Citation Extract:
Xu R, Zhu Q, Zhao Y, Chen M, Yang L, Shen S, Yang G, Shi Z, Zhang X, Shi Q, Kou X, Zhao Y, Wang H, Jiang C, Li C, Gao S, Liu X. Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos. Nat Commun. 2023;14:4807. doi:10.1038/s41467-023-40496-3.

An integeative GWAS followed by functional investigation reveals possible involvement of CNTNAP5 in glaucomatous neurodegeneration

Authors:
Chakraborty S, Roy SS, Sarma J, Das S, Saha S, Bhattacharjee S, Acharya M
Citation:
J Neurochem. Poster Sessions A. 2023;166: 30-88. Poster 3A. doi:10.1111/jnc.15896
Epub:
Not Epub
Abstract:
Primary angle closure glaucoma (PACG) is one of the major leading causes of blindness. In India, ~30% of people show a narrow...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.15896
Organism or Cell Type:
zebrafish
Citation Extract:
Chakraborty S, Roy SS, Sarma J, Das S, Saha S, Bhattacharjee S, Acharya M. An integeative GWAS followed by functional investigation reveals possible involvement of CNTNAP5 in glaucomatous neurodegeneration. J Neurochem. Poster Sessions A. 2023;166: 30-88. Poster 3A. doi:10.1111/jnc.15896.

Ribo-On and Ribo-Off tools using a self-cleaving ribozyme allow manipulation of endogenous gene expression in C. elegans

Authors:
Fang J, Wang J, Wang Y, Liu X, Chen B, Zou W
Citation:
Commun Biol. 2023;6:816. doi:10.1038/s42003-023-05184-4
Epub:
Not Epub
Abstract:
Investigating gene function relies on the efficient manipulation of endogenous gene expression. Currently, a limited number of...
Link:
https://www.nature.com/articles/s42003-023-05184-4
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Caenorhabditis elegans (roundworm)
Citation Extract:
Fang J, Wang J, Wang Y, Liu X, Chen B, Zou W. Ribo-On and Ribo-Off tools using a self-cleaving ribozyme allow manipulation of endogenous gene expression in C. elegans. Commun Biol. 2023;6:816. doi:10.1038/s42003-023-05184-4.

The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders

Authors:
Li X, Kheirabadi M, Dougherty PG, Kamer KJ, Shen X, Estrella NL, Peddigari S, Pathak A, Blake SL, Sizensky E, Genio CD, Gaur AB, Dhanabal M, Girgenrath M, Sethuraman N, Qian Z
Citation:
Mol Ther Nucleic Acids. 2023 Jun 29;33:273-285. doi: 10.1016/j.omtn.2023.06.022. eCollection 2023 Sep 12
Epub:
Not Epub
Abstract:
Biological therapeutic agents are highly targeted and potent but limited in their ability to reach intracellular targets. These...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00172-5
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Li X, Kheirabadi M, Dougherty PG, Kamer KJ, Shen X, Estrella NL, Peddigari S, Pathak A, Blake SL, Sizensky E, Genio CD, Gaur AB, Dhanabal M, Girgenrath M, Sethuraman N, Qian Z. The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders. Mol Ther Nucleic Acids. 2023 Jun 29;33:273-285. doi: 10.1016/j.omtn.2023.06.022. eCollection 2023 Sep 12.

Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach

Authors:
Tsurusaki T, Sato K, Imai H, Hirai K, Takahashi D, Wada T
Citation:
Sci Rep. 2023;13:12576. doi:10.1038/s41598-023-38698-2
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a promising type of antisense oligonucleotides, but their challenging...
Link:
https://www.nature.com/articles/s41598-023-38698-2
Citation Extract:
Tsurusaki T, Sato K, Imai H, Hirai K, Takahashi D, Wada T. Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach. Sci Rep. 2023;13:12576. doi:10.1038/s41598-023-38698-2.

Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans

Authors:
Dery KJ, Kojima H, Kageyama S, Kadono K, Hirao H, Cheng B, Zhai Y, Farmer DG, Kaldas FM, Yuan X, Eltzschig HK, Kupiec-Weglinski JW
Citation:
Sci Transl Med. 2023 Aug 2;15(707):eadf2059. doi: 10.1126/scitranslmed.adf2059. Epub 2023 Aug 2. PMID: 37531413
Epub:
Not Epub
Abstract:
Although alternative splicing (AS) drives transcriptional responses and cellular adaptation to environmental stresses, its...
Link:
https://www.science.org/doi/10.1126/scitranslmed.adf2059
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Dery KJ, Kojima H, Kageyama S, Kadono K, Hirao H, Cheng B, Zhai Y, Farmer DG, Kaldas FM, Yuan X, Eltzschig HK, Kupiec-Weglinski JW. Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans. Sci Transl Med. 2023 Aug 2;15(707):eadf2059. doi: 10.1126/scitranslmed.adf2059. Epub 2023 Aug 2. PMID: 37531413.

Aicardi Syndrome Is a Genetically Heterogeneous Disorder

Authors:
Ha TT, Burgess R, Newman M, Moey C, Mandelstam SA, Gardner AE, Ivancevic AM, Pham D, Kumar R, Smith N, Patel C, Malone S, Ryan MM, Calvert S, van Eyk CL, Lardelli M, Berkovic SF, Leventer RJ, Richards LJ, Scheffer IE, Gecz J, Corbett MA
Citation:
Genes. 2023;14(8):1565. doi:10.3390/genes14081565
Epub:
Not Epub
Abstract:
Aicardi Syndrome (AIC) is a rare neurodevelopmental disorder recognized by the classical triad of agenesis of the corpus...
Link:
https://www.mdpi.com/2073-4425/14/8/1565
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ha TT, Burgess R, Newman M, Moey C, Mandelstam SA, Gardner AE, Ivancevic AM, Pham D, Kumar R, Smith N, Patel C, Malone S, Ryan MM, Calvert S, van Eyk CL, Lardelli M, Berkovic SF, Leventer RJ, Richards LJ, Scheffer IE, Gecz J, Corbett MA. Aicardi Syndrome Is a Genetically Heterogeneous Disorder. Genes. 2023;14(8):1565. doi:10.3390/genes14081565.

Recognition of H2AK119ub plays an important role in RSF1-regulated early Xenopus development

Authors:
Parast SM, Yu D, Chen C, Dickinson AJ, Chang C, Wang H
Citation:
Front Cell Dev Biol. 2023 Jul 17;11:1168643. doi: 10.3389/fcell.2023.1168643. eCollection 2023
Epub:
Not Epub
Abstract:
Polycomb group (PcG) proteins are key regulators of gene expression and developmental programs via covalent modification of...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2023.1168643/full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Parast SM, Yu D, Chen C, Dickinson AJ, Chang C, Wang H. Recognition of H2AK119ub plays an important role in RSF1-regulated early Xenopus development. Front Cell Dev Biol. 2023 Jul 17;11:1168643. doi: 10.3389/fcell.2023.1168643. eCollection 2023.

Microenvironmental Snail1-induced immunosuppression promotes melanoma growth

Authors:
Arumi-Planas M, Rodriguez-Baena FJ, Cabello-Torres F, Gracia F, Lopez-Blau C, Nieto MA, Sanchez-Laorden B
Citation:
Oncogene. 2023 Jul 29. doi: 10.1038/s41388-023-02793-5. Online ahead of print
Epub:
Yes
Abstract:
Melanoma is an aggressive form of skin cancer due to its high metastatic abilities and resistance to therapies. Melanoma cells...
Link:
https://www.nature.com/articles/s41388-023-02793-5
Citation Extract:
Arumi-Planas M, Rodriguez-Baena FJ, Cabello-Torres F, Gracia F, Lopez-Blau C, Nieto MA, Sanchez-Laorden B. Microenvironmental Snail1-induced immunosuppression promotes melanoma growth. Oncogene. 2023 Jul 29. doi: 10.1038/s41388-023-02793-5. Online ahead of print.

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