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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Abstract 14239: Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve

Authors:
Lin Y, Yang Q, Lin X, Liu X, Kong X, Zhu L, Zhou B, Wang Y, Peng J, Zhu W, Wang J
Citation:
Circulation. 2023;148(Supp 1):A14239
Epub:
Not Epub
Abstract:
Background: Extracellular matrix (ECM) is involved in aortic valve development and aortic valve anomaly. ADAMTS gene mediated...
Link:
https://www.ahajournals.org/doi/10.1161/circ.148.suppl_1.14239
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin Y, Yang Q, Lin X, Liu X, Kong X, Zhu L, Zhou B, Wang Y, Peng J, Zhu W, Wang J. Abstract 14239: Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve. Circulation. 2023;148(Supp 1):A14239 .

Kif21a deficiency leads to impaired glomerular filtration barrier function

Authors:
Riedmann H, Kayser S, Helmstädter M, Epting D, Bergmann C
Citation:
Sci Rep. 2023 Nov 6;13(1):19161. doi: 10.1038/s41598-023-46270-1
Epub:
Not Epub
Abstract:
The renal glomerulus represents the major filtration body of the vertebrate nephron and is responsible for urine production and...
Link:
https://www.nature.com/articles/s41598-023-46270-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Riedmann H, Kayser S, Helmstädter M, Epting D, Bergmann C. Kif21a deficiency leads to impaired glomerular filtration barrier function. Sci Rep. 2023 Nov 6;13(1):19161. doi: 10.1038/s41598-023-46270-1.

Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina

Authors:
Veen K, Krylov A, Yu S, He J, Boyd P, Hyde DR, Mantamadiotis T, Cheng LY, Jusuf PR
Citation:
PLoS Genet. 2023 Nov 6;19(11):e1011010. doi: 10.1371/journal.pgen.1011010. Online ahead of print
Epub:
Not Epub
Abstract:
Damage to light-sensing photoreceptors (PRs) occurs in highly prevalent retinal diseases. As humans cannot regenerate new PRs,...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011010
Delivery Method:
injection then electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Veen K, Krylov A, Yu S, He J, Boyd P, Hyde DR, Mantamadiotis T, Cheng LY, Jusuf PR. Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina. PLoS Genet. 2023 Nov 6;19(11):e1011010. doi: 10.1371/journal.pgen.1011010. Online ahead of print.

The zebrafish paralog six2b is required for early proximal pronephros morphogenesis

Authors:
Belcher B, Vestal J, Lane S, Kell M, Smith L, Camarata T
Citation:
Sci Rep. 2023 Nov 11;13(1):19699. doi: 10.1038/s41598-023-47046-3
Epub:
Not Epub
Abstract:
The transcription factor Six2 plays a crucial role in maintaining self-renewing nephron progenitor cap mesenchyme (CM) during...
Link:
https://www.nature.com/articles/s41598-023-47046-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Belcher B, Vestal J, Lane S, Kell M, Smith L, Camarata T. The zebrafish paralog six2b is required for early proximal pronephros morphogenesis. Sci Rep. 2023 Nov 11;13(1):19699. doi: 10.1038/s41598-023-47046-3.

Loss of Nkd1 is dominant over loss of Axin2 in regulating Wnt signaling

Authors:
Bell I, Khan H, Stutt N, Horn M, Hydzik T, Lum W, Rea V, Clapham E, Hoeg L, Van Raay TJ
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.10.30.563773
Epub:
Not Epub
Abstract:
Wnt signaling is a crucial developmental pathway involved in early development as well as stem cell maintenance in adults and...
Link:
https://www.biorxiv.org/content/10.1101/2023.10.30.563773v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bell I, Khan H, Stutt N, Horn M, Hydzik T, Lum W, Rea V, Clapham E, Hoeg L, Van Raay TJ. Loss of Nkd1 is dominant over loss of Axin2 in regulating Wnt signaling. bioRxiv. 2023;[preprint] doi:10.1101/2023.10.30.563773.

Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia

Authors:
Zhang Q, Lee CL, Yang T, Li J, Zeng Q, Liu X, Liu Z, Ruan D, Li Z, Kan ASY, Cheung KW, Mak ASL, Ng VWY, Zhao H, Fan X, Duan YG, Zhong L, Chen M, Du M, Li RHW, Liu P, Ng EHY, Yeung WSB, Gao Y, Yao Y, Chiu PCN
Citation:
Sci Adv. 2023 Nov 3;9(44):eadi4777. doi: 10.1126/sciadv.adi4777. Epub 2023 Nov 3
Epub:
Not Epub
Abstract:
Early-onset preeclampsia (EOPE) is a severe pregnancy complication associated with defective trophoblast differentiation and...
Link:
https://www.science.org/doi/10.1126/sciadv.adi4777
Delivery Method:
nanoparticle intraperitoneal (i.p.)
Organism or Cell Type:
mice
Citation Extract:
Zhang Q, Lee CL, Yang T, Li J, Zeng Q, Liu X, Liu Z, Ruan D, Li Z, Kan ASY, Cheung KW, Mak ASL, Ng VWY, Zhao H, Fan X, Duan YG, Zhong L, Chen M, Du M, Li RHW, Liu P, Ng EHY, Yeung WSB, Gao Y, Yao Y, Chiu PCN. Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia. Sci Adv. 2023 Nov 3;9(44):eadi4777. doi: 10.1126/sciadv.adi4777. Epub 2023 Nov 3.

Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix

Authors:
Gupta M, Kurth T, Heinemann F, Schwille P, Keil S, Knopf F, Brand M
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.02.565243
Epub:
Not Epub
Abstract:
Embryonic development is orchestrated by the action of morphogens, which spread out from a local source and activate, in a...
Link:
https://www.biorxiv.org/content/10.1101/2023.11.02.565243v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gupta M, Kurth T, Heinemann F, Schwille P, Keil S, Knopf F, Brand M. Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.02.565243.

Candida albicans suppression of neutrophil reactive nitrogen species is rescued by host Hif-1α in vivo

Authors:
Burgess TB, Hammond FR, Szkuta PT, Lewis A, Christou S, Ayscough KR, Johnston SA, Condliffe AM, Elks PM
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.02.565128
Epub:
Not Epub
Abstract:
Candida spp. cause 750,000 cases per annum of invasive disease worldwide, with up to a 50% mortality rate. Poor efficacy of...
Link:
https://www.biorxiv.org/content/10.1101/2023.11.02.565128v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Burgess TB, Hammond FR, Szkuta PT, Lewis A, Christou S, Ayscough KR, Johnston SA, Condliffe AM, Elks PM. Candida albicans suppression of neutrophil reactive nitrogen species is rescued by host Hif-1α in vivo. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.02.565128.

Analysis of Vascular Morphogenesis in Zebrafish

Authors:
Hubert M, Herzog W
Citation:
Methods Mol Biol. 2023;2608:425-450. doi: 10.1007/978-1-0716-2887-4_24
Epub:
Not Epub
Abstract:
Analysis of cardiovascular development in zebrafish embryos has become a major driver of vascular research in recent years....
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2887-4_24
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hubert M, Herzog W. Analysis of Vascular Morphogenesis in Zebrafish. Methods Mol Biol. 2023;2608:425-450. doi: 10.1007/978-1-0716-2887-4_24.

Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with Morpholino Peptide Conjugates

Authors:
Hu J, Shen X, Kheirabadi M, Streeter MD, Qian Z, Mootha VV, Corey DR
Citation:
ACS Omega. 2023;[Epub] doi:10.1021/acsomega.3c05634
Epub:
Yes
Abstract:
Fuchs’ corneal endothelial dystrophy (FECD) is a major cause of vision loss. Corneal transplantation is the only effective...
Link:
https://pubs.acs.org/doi/10.1021/acsomega.3c05634
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: FECD patient-derived F35T corneal endothelial cells
Citation Extract:
Hu J, Shen X, Kheirabadi M, Streeter MD, Qian Z, Mootha VV, Corey DR. Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with Morpholino Peptide Conjugates. ACS Omega. 2023;[Epub] doi:10.1021/acsomega.3c05634.

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