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Genetic compensation response contributes to Pleurodeles waltl limb regeneration

Authors: 
Yin B, Yu C, Liu Y, Cai H, Wu W, Ye T, Wang L, Xiao L, Zhu Y, Guo H, Zhang K, Wang H
Citation: 
NPJ Regen Med. 2025 May 31;10(1):25. doi: 10.1038/s41536-025-00417-y. PMID: 40450023; PMCID: PMC12126524
Abstract: 
Hippo-Yap/Taz pathway is essential for tissue regeneration in multiple species. However, we found that in the highly regenerative salamanders, Yap knockout does not compromise the limb regeneration due to genetic compensation response (GCR). Specifically, the mutated Yap locus derived non-sense mRNA, which was recognized by UPF3A to instruct compensatory Taz induction. Blocking Yap mRNA or protein indeed inhibits regeneration. GCR could be utilized to maintain the robustness of limb regeneration.
Epub: 
Not Epub
Link to Publication: 
https://www.nature.com/articles/s41536-025-00417-y
Organism or Cell Type: 
Pleurodeles waltl (Iberian ribbed newt)
Delivery Method: 
injection by glass microcapillaries and PV830 PicoPump followed by electroporation