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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Determining the importance of the stringent response for methicillin-resistant Staphylococcus aureus virulence using a zebrafish model of infection

Authors:
Choudhury NR, Urwin L, Salamaga B, Prince LR, Renshaw SA, Corrigan RM
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.07.12.548523
Epub:
Not Epub
Abstract:
Staphylococcus aureus is a bacterial pathogen that poses a major threat to human health. The ability of this bacterium to adapt...
Link:
https://www.biorxiv.org/content/10.1101/2023.07.12.548523v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Choudhury NR, Urwin L, Salamaga B, Prince LR, Renshaw SA, Corrigan RM. Determining the importance of the stringent response for methicillin-resistant Staphylococcus aureus virulence using a zebrafish model of infection. bioRxiv. 2023;[preprint] doi:10.1101/2023.07.12.548523 .

A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics

Authors:
Ghosh C, Popella L, Dhamodharan V, Jung J, Barquist L, Höbartner C, Vogel J
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.07.11.548539
Epub:
Not Epub
Abstract:
Antisense oligomer (ASO)-based antibiotics that target mRNAs of essential bacterial genes have great potential for...
Link:
https://www.biorxiv.org/content/10.1101/2023.07.11.548539v1
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Salmonella enterica serovar Typhimurium strain SL1344
Citation Extract:
Ghosh C, Popella L, Dhamodharan V, Jung J, Barquist L, Höbartner C, Vogel J. A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics. bioRxiv. 2023;[preprint] doi:10.1101/2023.07.11.548539.

Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo

Authors:
Cacialli P, Dogan S, Linnerz T, Pasche C, Bertrand JY
Citation:
Stem Cell Reports. 2023 Jul 11;18(7):1534-1546. doi: 10.1016/j.stemcr.2023.05.022
Epub:
Not Epub
Abstract:
Hematopoietic stem cells (HSCs) guarantee the continuous supply of all blood lineages during life. In response to stress, HSCs...
Link:
https://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(23)00201-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cacialli P, Dogan S, Linnerz T, Pasche C, Bertrand JY. Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo. Stem Cell Reports. 2023 Jul 11;18(7):1534-1546. doi: 10.1016/j.stemcr.2023.05.022.

Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer

Authors:
He S, Song W, Cui S, Li J, Jiang Y, Chen X, Peng L
Citation:
Cell Oncol (Dordr). 2023 Jul 5. doi: 10.1007/s13402-023-00839-0. Online ahead of print
Epub:
Yes
Abstract:
Purpose: MicroRNA-146b (miR-146b) alleviates experimental colitis in mice by mediating macrophage polarization and the release...
Link:
https://link.springer.com/article/10.1007/s13402-023-00839-0
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: primary bone marrow-derived macrophages (BMDMs)
Citation Extract:
He S, Song W, Cui S, Li J, Jiang Y, Chen X, Peng L. Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer. Cell Oncol (Dordr). 2023 Jul 5. doi: 10.1007/s13402-023-00839-0. Online ahead of print.

RAS-independent ERK activation by constitutively active KSR3 in non-chordate metazoa

Authors:
Chessel A, De Crozé N, Molina MD, Taberner L, Dru P, Martin L, Lepage T
Citation:
Nat Commun. 2023 Jul 5;14(1):3970. doi: 10.1038/s41467-023-39606-y
Epub:
Not Epub
Abstract:
During early development of the sea urchin embryo, activation of ERK signalling in mesodermal precursors is not triggered by...
Link:
https://www.nature.com/articles/s41467-023-39606-y
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotus lividus (sea urchin)
Citation Extract:
Chessel A, De Crozé N, Molina MD, Taberner L, Dru P, Martin L, Lepage T. RAS-independent ERK activation by constitutively active KSR3 in non-chordate metazoa. Nat Commun. 2023 Jul 5;14(1):3970. doi: 10.1038/s41467-023-39606-y.

Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms

Authors:
Güiza J, Solís F, Valenzuela B, Arancibia D, Zamorano P, González J, Saavedra J, Neely A, Salgado M, Martínez AD, Sáez JC, Vega JL
Citation:
Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2307898120. doi: 10.1073/pnas.2307898120. Epub 2023 Jul 24
Epub:
Not Epub
Abstract:
Cells of vertebrate and invertebrate organisms express proteins specialized in membrane channel-based cell-cell communication...
Link:
https://www.pnas.org/doi/10.1073/pnas.2307898120
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Güiza J, Solís F, Valenzuela B, Arancibia D, Zamorano P, González J, Saavedra J, Neely A, Salgado M, Martínez AD, Sáez JC, Vega JL. Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2307898120. doi: 10.1073/pnas.2307898120. Epub 2023 Jul 24.

Prediction of human pharmacokinetics of phosphorodiamidate morpholino oligonucleotides in Duchenne muscular dystrophy patients using viltolarsen

Authors:
Imai S, Suda Y, Mori J, Sasaki Y, Yamada T, Kusano K
Citation:
Drug Metab Dispos. 2023 Jul 19:DMD-AR-2023-001425. doi: 10.1124/dmd.123.001425. Online ahead of print
Epub:
Yes
Abstract:
Several modified antisense oligonucleotides (ASOs) have recently been approved for clinical use. Some are phosphorodiamidate...
Link:
https://dmd.aspetjournals.org/content/early/2023/07/19/dmd.123.001425.long
Delivery Method:
intravenous (i.v.)
Organism or Cell Type:
mice, rats, cynomolgus monkeys, dogs, humans
Citation Extract:
Imai S, Suda Y, Mori J, Sasaki Y, Yamada T, Kusano K. Prediction of human pharmacokinetics of phosphorodiamidate morpholino oligonucleotides in Duchenne muscular dystrophy patients using viltolarsen. Drug Metab Dispos. 2023 Jul 19:DMD-AR-2023-001425. doi: 10.1124/dmd.123.001425. Online ahead of print.

Development of small fluorescent probes for the analysis of autophagy kinetics

Authors:
Sakurai HT, Iwashita H, Arakawa S, Yikelamu A, Kusaba M, Kofuji S, Nishina H, Ishiyama M, Ueno Y, Shimizu S
Citation:
iScience. 2023 Jun 28;26(7):107218. doi: 10.1016/j.isci.2023.107218. eCollection 2023 Jul 21
Epub:
Not Epub
Abstract:
Autophagy is a dynamic process that degrades subcellular constituents, and its activity is measured by autophagic flux. The...
Link:
https://www.cell.com/iscience/fulltext/S2589-0042(23)01295-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sakurai HT, Iwashita H, Arakawa S, Yikelamu A, Kusaba M, Kofuji S, Nishina H, Ishiyama M, Ueno Y, Shimizu S. Development of small fluorescent probes for the analysis of autophagy kinetics. iScience. 2023 Jun 28;26(7):107218. doi: 10.1016/j.isci.2023.107218. eCollection 2023 Jul 21.

lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway

Authors:
Sun L, Ping L, Gao R, Zhang B, Chen X
Citation:
Genes. 2023;14:1371. doi:10.3390/genes14071371
Epub:
Not Epub
Abstract:
Background: In vertebrates, the development of the inner ear is a delicate process, whereas its relating molecular pathways are...
Link:
https://www.mdpi.com/2073-4425/14/7/1371
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sun L, Ping L, Gao R, Zhang B, Chen X. lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway. Genes. 2023;14:1371. doi:10.3390/genes14071371.

Upf3a but not Upf1 mediates the genetic compensation response induced by leg1 deleterious mutations in an H3K4me3-independent manner

Authors:
Xie A, Ma Z, Wang J, Zhang Y, Chen Y, Yang C, Chen J, Peng J
Citation:
Cell Discov. 2023 Jun 27;9(1):63. doi: 10.1038/s41421-023-00550-2
Epub:
Not Epub
Abstract:
Genetic compensation responses (GCRs) can be induced by deleterious mutations in living organisms in order to maintain genetic...
Link:
https://www.nature.com/articles/s41421-023-00550-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xie A, Ma Z, Wang J, Zhang Y, Chen Y, Yang C, Chen J, Peng J. Upf3a but not Upf1 mediates the genetic compensation response induced by leg1 deleterious mutations in an H3K4me3-independent manner. Cell Discov. 2023 Jun 27;9(1):63. doi: 10.1038/s41421-023-00550-2.

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