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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Synthesis of Chlorophosphoramidate Monomer Morpholinos and PMOs

Authors:
Kundu J, Ghosh U, Ghosh A, Pattanayak S, Das A, Sinha S
Citation:
Curr Protoc. 2023 Feb;3(2):e686. doi: 10.1002/cpz1.686
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a successful class of antisense reagents that efficiently modulate...
Link:
https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.686
Citation Extract:
Kundu J, Ghosh U, Ghosh A, Pattanayak S, Das A, Sinha S. Synthesis of Chlorophosphoramidate Monomer Morpholinos and PMOs. Curr Protoc. 2023 Feb;3(2):e686. doi: 10.1002/cpz1.686.

p16 INK4A drives non-alcoholic fatty liver disease phenotypes in high fat diet fed mice via biliary e2f1/foxo1/igf-1 signaling

Authors:
Kundu D, Kennedy L, Zhou T, Ekser B, Meadows V, Sybenga A, Kyritsi K, Chen L, Ceci L, Wu N, Wu C, Glaser S, Carpino G, Onori P, Gaudio E, Alpini G, Francis H
Citation:
Hepatology. 2023 Feb 20. doi: 10.1097/HEP.0000000000000307. Online ahead of print
Epub:
Yes
Abstract:
Backgroundand aim: Non-alcoholic fatty liver disease (NAFLD) is characterized by steatosis, hepatic inflammation, and fibrosis...
Link:
https://journals.lww.com/hep/Abstract/9900/p16_INK4A_drives_non_alcoholic_fatty_liver_disease.303.aspx
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Kundu D, Kennedy L, Zhou T, Ekser B, Meadows V, Sybenga A, Kyritsi K, Chen L, Ceci L, Wu N, Wu C, Glaser S, Carpino G, Onori P, Gaudio E, Alpini G, Francis H. p16 INK4A drives non-alcoholic fatty liver disease phenotypes in high fat diet fed mice via biliary e2f1/foxo1/igf-1 signaling. Hepatology. 2023 Feb 20. doi: 10.1097/HEP.0000000000000307. Online ahead of print.

Genetic analysis identifies the SLC4A3 anion exchanger as a major gene for short QT syndrome

Authors:
Christiansen MK, Kjær-Sørensen K, Clavsen NC, Dittmann S, Jensen MF, Guldbrandsen HØ, Pedersen LN, Sørensen RH, Lildballe DL, Müller K, Müller P, Vogel K, Rudic B, Borggrefe M, Oxvig C, Aalkjær C, Schulze-Bahr E, Matchkov V, Bundgaard H, Jensen Henrik K
Citation:
Heart Rhythm. 2023;[Epub] doi:10.1016/j.hrthm.2023.02.010
Epub:
Yes
Abstract:
Background: A variant in the SLC4A3 anion exchanger has been identified as a novel cause of short QT syndrome (SQTS), but the...
Link:
https://www.heartrhythmjournal.com/article/S1547-5271(23)00148-0/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Christiansen MK, Kjær-Sørensen K, Clavsen NC, Dittmann S, Jensen MF, Guldbrandsen HØ, Pedersen LN, Sørensen RH, Lildballe DL, Müller K, Müller P, Vogel K, Rudic B, Borggrefe M, Oxvig C, Aalkjær C, Schulze-Bahr E, Matchkov V, Bundgaard H, Jensen Henrik K. Genetic analysis identifies the SLC4A3 anion exchanger as a major gene for short QT syndrome. Heart Rhythm. 2023;[Epub] doi:10.1016/j.hrthm.2023.02.010.

Single-cell atavism reveals an ancient mechanism of cell type diversification in a sea anemone

Authors:
Babonis LS, Enjolras C, Reft AJ, Foster BM, Hugosson F, Ryan JF, Daly M, Martindale MQ
Citation:
Nat Commun. 2023;14:885. doi:10.1038/s41467-023-36615-9
Epub:
Not Epub
Abstract:
Cnidocytes are the explosive stinging cells unique to cnidarians (corals, jellyfish, etc). Specialized for prey capture and...
Link:
https://www.nature.com/articles/s41467-023-36615-9
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Babonis LS, Enjolras C, Reft AJ, Foster BM, Hugosson F, Ryan JF, Daly M, Martindale MQ. Single-cell atavism reveals an ancient mechanism of cell type diversification in a sea anemone. Nat Commun. 2023;14:885. doi:10.1038/s41467-023-36615-9.

CCN6 influences transcription and controls mitochondrial mass and muscle organization

Authors:
Ganguly A, Padhan DK, Sengupta A, Chakraborty P, Sen M
Citation:
FASEB J. 2023 Mar;37(3):e22815. doi: 10.1096/fj.202201533R
Epub:
Yes
Abstract:
Mutations in Cellular Communication Network Factor 6 (CCN6) are linked to the debilitating musculoskeletal disease Progressive...
Link:
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202201533R
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ganguly A, Padhan DK, Sengupta A, Chakraborty P, Sen M. CCN6 influences transcription and controls mitochondrial mass and muscle organization. FASEB J. 2023 Mar;37(3):e22815. doi: 10.1096/fj.202201533R.

EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy

Authors:
Canham L, Sendac S, Diagbouga MR, Wolodimeroff E, Pirri D, Tardajos Ayllon B, Feng S, Souilhol C, Chico TJA, Evans PC, Serbanovic-Canic J
Citation:
Arterioscler Thromb Vasc Biol. 2023 Feb 16. doi: 10.1161/ATVBAHA.122.318110. Online ahead of print
Epub:
Yes
Abstract:
Background: Hemodynamic wall shear stress (WSS) exerted on the endothelium by flowing blood determines the spatial distribution...
Link:
https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318110
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Canham L, Sendac S, Diagbouga MR, Wolodimeroff E, Pirri D, Tardajos Ayllon B, Feng S, Souilhol C, Chico TJA, Evans PC, Serbanovic-Canic J. EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy. Arterioscler Thromb Vasc Biol. 2023 Feb 16. doi: 10.1161/ATVBAHA.122.318110. Online ahead of print.

Therapeutic Phosphorodiamidate Morpholino Oligonucleotides, an RNA mimic: Physical Properties, Solution Structures, and Folding Thermodynamics

Authors:
Maksudov F, Kliuchnikov E, Pierson D, Ujwal ML, Marx KA, Chanda A, Barsegov V
Citation:
Mol Ther Nucleic Acids. 2023 Feb 14;31:631-647. doi:10.1016/j.omtn.2023.02.007
Epub:
Yes
Abstract:
Elucidating the structure-function relationships for therapeutic RNA mimicking phosphorodiamidate morpholino oligonucleotides (...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00027-6
Citation Extract:
Maksudov F, Kliuchnikov E, Pierson D, Ujwal ML, Marx KA, Chanda A, Barsegov V. Therapeutic Phosphorodiamidate Morpholino Oligonucleotides, an RNA mimic: Physical Properties, Solution Structures, and Folding Thermodynamics. Mol Ther Nucleic Acids. 2023 Feb 14;31:631-647. doi:10.1016/j.omtn.2023.02.007.

The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Channa argus)

Authors:
Sun D, Qi X, Wen H, Li C, Li J, Chen J, Tao Z, Zhu M, Zhang X, Li Y
Citation:
Open Biol. 2023 Feb;13(2):220235. doi: 10.1098/rsob.220235. Epub 2023 Feb 15
Epub:
Not Epub
Abstract:
Body colour is an important economic trait for commercial fishes. Recently, a new colour morph displaying market-favoured...
Link:
https://royalsocietypublishing.org/doi/10.1098/rsob.220235
Delivery Method:
microinjection
Organism or Cell Type:
Channa argus (northern snakehead fish)
Citation Extract:
Sun D, Qi X, Wen H, Li C, Li J, Chen J, Tao Z, Zhu M, Zhang X, Li Y. The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Channa argus). Open Biol. 2023 Feb;13(2):220235. doi: 10.1098/rsob.220235. Epub 2023 Feb 15.

Milk fat globule epidermal growth factor 8a regulates neurogenesis in telencephalon and affects larval behavior in zebrafish

Authors:
Luo Y, Lu D, Zhou J, Wu J, Wang W, Qian L
Citation:
Stem Cells Dev. 2023 Feb 14. doi: 10.1089/scd.2022.0247. Online ahead of print
Epub:
Yes
Abstract:
Mfge8, a secreted glycoprotein, is a key molecule that mediates the phagocytosis of apoptotic cells. Previous research reported...
Link:
https://www.liebertpub.com/doi/10.1089/scd.2022.0247
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Luo Y, Lu D, Zhou J, Wu J, Wang W, Qian L. Milk fat globule epidermal growth factor 8a regulates neurogenesis in telencephalon and affects larval behavior in zebrafish. Stem Cells Dev. 2023 Feb 14. doi: 10.1089/scd.2022.0247. Online ahead of print.

Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Müller glia proliferation in the light-damaged zebrafish retina

Authors:
Boyd P, Campbell LJ, Hyde DR
Citation:
Front Cell Dev Biol. 2023;11:1142586. doi:10.3389/fcell.2023.1142586
Epub:
Not Epub
Abstract:
Zebrafish possess the innate ability to fully regenerate any neurons lost following a retinal injury. This response is mediated...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2023.1142586/full
Delivery Method:
intravitreal (intraocular) injection then electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Boyd P, Campbell LJ, Hyde DR. Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Müller glia proliferation in the light-damaged zebrafish retina. Front Cell Dev Biol. 2023;11:1142586. doi:10.3389/fcell.2023.1142586.

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