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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

A median fin derived from the lateral plate mesoderm and the origin of paired fins

Authors:
Tzung KW, Lalonde RL, Prummel KD, Mahabaleshwar H, Moran HR, Stundl J, Cass AN, Le Y, Lea R, Dorey K, Tomecka MJ, Zhang C, Brombacher EC, White WT, Roehl HH, Tulenko FJ, Winkler C, Currie PD, Amaya E, Davis MC, Bronner ME, Mosimann C, Carney TJ
Citation:
Nature. 2023 Jun;618(7965):543-549. doi:10.1038/s41586-023-06100-w. Epub 2023 May 24
Epub:
Not Epub
Abstract:
The development of paired appendages was a key innovation during evolution and facilitated the aquatic to terrestrial...
Link:
https://www.nature.com/articles/s41586-023-06100-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tzung KW, Lalonde RL, Prummel KD, Mahabaleshwar H, Moran HR, Stundl J, Cass AN, Le Y, Lea R, Dorey K, Tomecka MJ, Zhang C, Brombacher EC, White WT, Roehl HH, Tulenko FJ, Winkler C, Currie PD, Amaya E, Davis MC, Bronner ME, Mosimann C, Carney TJ. A median fin derived from the lateral plate mesoderm and the origin of paired fins . Nature. 2023 Jun;618(7965):543-549. doi:10.1038/s41586-023-06100-w. Epub 2023 May 24.

Cerebellar granular neuron progenitors exit their germinative niche via Barhl1 mediated silencing of T-Cell Factor transcriptional activity

Authors:
Bou-Rouphael J, Doulazmi M, Eschstruth A, Abdou A, Durand BC
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.05.25.542248
Epub:
Not Epub
Abstract:
T-Cell Factors (TCFs) are the main transcriptional effectors of Wnt/β-catenin signaling. TCF responsiveness is a hallmark of...
Link:
https://www.biorxiv.org/content/10.1101/2023.05.25.542248v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis
Citation Extract:
Bou-Rouphael J, Doulazmi M, Eschstruth A, Abdou A, Durand BC. Cerebellar granular neuron progenitors exit their germinative niche via Barhl1 mediated silencing of T-Cell Factor transcriptional activity. bioRxiv. 2023;[preprint] doi:10.1101/2023.05.25.542248.

Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction

Authors:
Alvizi L, Nani D, Brito LA, Kobayashi GS, Passos-Bueno MR, Mayor R
Citation:
Nat Commun. 2023 May 24;14(1):2868. doi: 10.1038/s41467-023-38526-1
Epub:
Not Epub
Abstract:
Gene-environment interactions are believed to play a role in multifactorial phenotypes, although poorly described...
Link:
https://www.nature.com/articles/s41467-023-38526-1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Alvizi L, Nani D, Brito LA, Kobayashi GS, Passos-Bueno MR, Mayor R. Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction. Nat Commun. 2023 May 24;14(1):2868. doi: 10.1038/s41467-023-38526-1.

Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network

Authors:
Letelier J, Buono L, Almuedo-Castillo M, Zang J, Mounieres C, González-Díaz S, Polvillo R, Sanabria-Reinoso E, Corbacho J, Sousa-Ortega A, Diez Del Corral R, Neuhauss SCF, Martínez-Morales JR
Citation:
Elife. 2023 May 25;12:e85594. doi: 10.7554/eLife.85594
Epub:
Not Epub
Abstract:
Genetic studies in human and mice have established a dual role for Vsx genes in retina development: an early function in...
Link:
https://elifesciences.org/articles/85594
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Letelier J, Buono L, Almuedo-Castillo M, Zang J, Mounieres C, González-Díaz S, Polvillo R, Sanabria-Reinoso E, Corbacho J, Sousa-Ortega A, Diez Del Corral R, Neuhauss SCF, Martínez-Morales JR. Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. Elife. 2023 May 25;12:e85594. doi: 10.7554/eLife.85594.

Identification of an α-l-iduronidase (IDUA) M1T mutation in a Chinese family with autosomal recessive mucopolysaccharidosis I

Authors:
Liu D, Jiang Z, Deng L, Li H, Jiang H
Citation:
Ann N Y Acad Sci. 2023 Jun 22. doi: 10.1111/nyas.15016. Online ahead of print
Epub:
Yes
Abstract:
Mucopolysaccharidoses (MPS) are a group of rare congenital metabolic disorders caused by the deficiency or low activity of...
Link:
https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/nyas.15016
Organism or Cell Type:
zebrafish
Citation Extract:
Liu D, Jiang Z, Deng L, Li H, Jiang H. Identification of an α-l-iduronidase (IDUA) M1T mutation in a Chinese family with autosomal recessive mucopolysaccharidosis I. Ann N Y Acad Sci. 2023 Jun 22. doi: 10.1111/nyas.15016. Online ahead of print.

DNAJB6 isoform specific knockdown: Therapeutic potential for limb girdle muscular dystrophy D1

Authors:
Findlay AR, Paing MM, Daw JA, Haller M, Bengoechea R, Pittman SK, Li S, Wang F, Miller TM, True HL, Chou TF, Weihl CC
Citation:
Mol Ther Nucleic Acids. 2023 May 16;32:937-948. doi: 10.1016/j.omtn.2023.05.017. eCollection 2023 Jun 13
Epub:
Not Epub
Abstract:
Dominant missense mutations in DNAJB6, a co-chaperone of HSP70, cause limb girdle muscular dystrophy (LGMD) D1. No treatments...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00135-X
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Cell culture: murine primary myotubes, human primary LGMDD1 myoblasts; mice
Citation Extract:
Findlay AR, Paing MM, Daw JA, Haller M, Bengoechea R, Pittman SK, Li S, Wang F, Miller TM, True HL, Chou TF, Weihl CC. DNAJB6 isoform specific knockdown: Therapeutic potential for limb girdle muscular dystrophy D1. Mol Ther Nucleic Acids. 2023 May 16;32:937-948. doi: 10.1016/j.omtn.2023.05.017. eCollection 2023 Jun 13.

Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation

Authors:
Yong X, Jia G, Liu Z, Zhou C, Yi J, Tang Y, Chen L, Chen L, Wang Y, Sun Q, Billadeau DD, Su Z, Jia D
Citation:
Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2301725120. doi: 10.1073/pnas.2301725120. Epub 2023 May 22
Epub:
Not Epub
Abstract:
Understanding of the evolution of metazoans from their unicellular ancestors is a fundamental question in biology. In contrast...
Link:
https://www.pnas.org/doi/10.1073/pnas.2301725120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yong X, Jia G, Liu Z, Zhou C, Yi J, Tang Y, Chen L, Chen L, Wang Y, Sun Q, Billadeau DD, Su Z, Jia D. Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2301725120. doi: 10.1073/pnas.2301725120. Epub 2023 May 22.

Actin filaments accumulated in the nucleus remain in the vicinity of condensing chromosomes in the zebrafish early embryo

Authors:
Oda H, Sato Y, Kawashima SA, Fujiwara Y, Pálfy M, Wu E, Vastenhouw NL, Kanai M, Kimura H
Citation:
Biol Open. 2023 May 15;12(5):bio059783. doi: 10.1242/bio.059783. Epub 2023 May 17
Epub:
Not Epub
Abstract:
In the cytoplasm, filamentous actin (F-actin) plays a critical role in cell regulation, including cell migration, stress fiber...
Link:
https://journals.biologists.com/bio/article/12/5/bio059783/310414/Actin-filaments-accumulated-in-the-nucleus-remain
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oda H, Sato Y, Kawashima SA, Fujiwara Y, Pálfy M, Wu E, Vastenhouw NL, Kanai M, Kimura H. Actin filaments accumulated in the nucleus remain in the vicinity of condensing chromosomes in the zebrafish early embryo. Biol Open. 2023 May 15;12(5):bio059783. doi: 10.1242/bio.059783. Epub 2023 May 17.

Functional characterization of stap2b in zebrafish vascular development

Authors:
Wang YS, Chen YT, Wu CY
Citation:
FASEB J. 2023 Jul;37(7):e23053. doi: 10.1096/fj.202201314RRR
Epub:
Not Epub
Abstract:
The genetic control and signaling pathways of vascular development are not comprehensively understood. Transcription factors...
Link:
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202201314RRR
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang YS, Chen YT, Wu CY. Functional characterization of stap2b in zebrafish vascular development. FASEB J. 2023 Jul;37(7):e23053. doi: 10.1096/fj.202201314RRR.

A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription

Authors:
Estell C, Davidson L, Eaton JD, Kimura H, Gold VAM, West S
Citation:
Mol Cell. 2023 Jul 6;83(13):2222-2239.e5. doi: 10.1016/j.molcel.2023.05.029. Epub 2023 Jun 16.
Epub:
Yes
Abstract:
The transcriptional termination of unstable non-coding RNAs (ncRNAs) is poorly understood compared to coding transcripts. We...
Link:
https://www.sciencedirect.com/science/article/pii/S1097276523003854
Delivery Method:
electroporation
Organism or Cell Type:
cell culture
Citation Extract:
Estell C, Davidson L, Eaton JD, Kimura H, Gold VAM, West S. A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription. Mol Cell. 2023 Jul 6;83(13):2222-2239.e5. doi: 10.1016/j.molcel.2023.05.029. Epub 2023 Jun 16. .

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