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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

mRNA Location and Translation Rate Determine Protein Targeting to Dual Destinations

Authors:
Gasparski AN, Moissoglu K, Pallikkuth S, Meydan S, Guydosh NR, Mili S
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.04.24.538105
Epub:
Not Epub
Abstract:
Numerous proteins are targeted to two or multiple subcellular destinations where they exert distinct functional consequences....
Link:
https://www.biorxiv.org/content/10.1101/2023.04.24.538105v1
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: MDA-MB-231
Citation Extract:
Gasparski AN, Moissoglu K, Pallikkuth S, Meydan S, Guydosh NR, Mili S. mRNA Location and Translation Rate Determine Protein Targeting to Dual Destinations. bioRxiv. 2023;[preprint] doi:10.1101/2023.04.24.538105.

Epigenetic landscape reveals MECOM as an endothelial lineage regulator

Authors:
Lv J, Meng S, Gu Q, Zheng R, Gao X, Kim J-d, Chen M, Xia B, Zuo Y, Zhu S, Zhao D, Li Y, Wang G, Wang X, Meng Q, Cao Q, Cooke JP, Fang L, Chen K, Zhang L
Citation:
Nat Commun. 2023;14:2390. doi:/10.1038/s41467-023-38002-w
Epub:
Not Epub
Abstract:
A comprehensive understanding of endothelial cell lineage specification will advance cardiovascular regenerative medicine....
Link:
https://www.nature.com/articles/s41467-023-38002-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lv J, Meng S, Gu Q, Zheng R, Gao X, Kim J-d, Chen M, Xia B, Zuo Y, Zhu S, Zhao D, Li Y, Wang G, Wang X, Meng Q, Cao Q, Cooke JP, Fang L, Chen K, Zhang L. Epigenetic landscape reveals MECOM as an endothelial lineage regulator. Nat Commun. 2023;14:2390. doi:/10.1038/s41467-023-38002-w.

PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma

Authors:
Haas M, Caron G, Chatonnet F, Manenti S, Alaterre E, Devin J, Delaloy C, Bertolin G, Viel R, Pignarre A, Llamas-Gutierrez F, Marchalot A, Decaux O, Tarte K, Delpy L, Moreaux J, Fest T
Citation:
Blood. 2022;139(15):2316-37. doi:10.1182/blood.2021014011
Epub:
Not Epub
Abstract:
The differentiation of B cells into plasmablasts (PBs) and then plasma cells (PCs) is associated with extensive cell...
Link:
https://www.sciencedirect.com/science/article/pii/S0006497122001471
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: Plasmoblasts (PBs) and CD23+ post-activated B cells
Citation Extract:
Haas M, Caron G, Chatonnet F, Manenti S, Alaterre E, Devin J, Delaloy C, Bertolin G, Viel R, Pignarre A, Llamas-Gutierrez F, Marchalot A, Decaux O, Tarte K, Delpy L, Moreaux J, Fest T. PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma. Blood. 2022;139(15):2316-37. doi:10.1182/blood.2021014011.

Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model

Authors:
Ulhaq ZS, Ogino Y, Tse WKF
Citation:
Biochem Biophys Res Commun. 2023;664:100-7. doi:10.1016/j.bbrc.2023.04.096
Epub:
Not Epub
Abstract:
Abstract: Fatty acid oxidation disorders (FAODs) are a group of rare genetic metabolic disorders caused by mutations in genes...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0006291X23005272
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ulhaq ZS, Ogino Y, Tse WKF. Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochem Biophys Res Commun. 2023;664:100-7. doi:10.1016/j.bbrc.2023.04.096.

Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish

Authors:
Patterson V, Ullah F, Bryant L, Griffin JN, Sidhu A, Saliganan S, Blaile M, Saenz MS, Smith R, Ellingwood S, Grange DK, Hu X, Mireguli M, Luo Y, Shen Y, Mulhern M, Zackai E, Ritter A, Izumi K, Hoefele J, Wagner M, Riedhammer KM, Seitz B, Robin NH, Goodloe D, Mignot C, Keren B, Cox H, Jarvis J, Hempel M, Gibson CF, Tran Mau-Them F, Vitobello A, Bruel AL, Sorlin A, Mehta S, Raymond FL, Gilmore K, Powell BC, Weck K, Li C, Vulto-van Silfhout AT, Giacomini T, Mancardi MM, Accogli A, Salpietro V, Zara F, Vora NL, Davis EE, Burdine R, Bhoj E
Citation:
Sci Adv. 2023 Apr 28;9(17):eade0631. doi: 10.1126/sciadv.ade0631. Epub 2023 Apr 26
Epub:
Not Epub
Abstract:
We report 21 families displaying neurodevelopmental differences and multiple congenital anomalies while bearing a series of...
Link:
https://www.science.org/doi/10.1126/sciadv.ade0631
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Patterson V, Ullah F, Bryant L, Griffin JN, Sidhu A, Saliganan S, Blaile M, Saenz MS, Smith R, Ellingwood S, Grange DK, Hu X, Mireguli M, Luo Y, Shen Y, Mulhern M, Zackai E, Ritter A, Izumi K, Hoefele J, Wagner M, Riedhammer KM, Seitz B, Robin NH, Goodloe D, Mignot C, Keren B, Cox H, Jarvis J, Hempel M, Gibson CF, Tran Mau-Them F, Vitobello A, Bruel AL, Sorlin A, Mehta S, Raymond FL, Gilmore K, Powell BC, Weck K, Li C, Vulto-van Silfhout AT, Giacomini T, Mancardi MM, Accogli A, Salpietro V, Zara F, Vora NL, Davis EE, Burdine R, Bhoj E. Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish. Sci Adv. 2023 Apr 28;9(17):eade0631. doi: 10.1126/sciadv.ade0631. Epub 2023 Apr 26.

Voltage-gated sodium channel activity mediates sea urchin larval skeletal patterning through spatial regulation of Wnt5 expression

Authors:
Thomas CF, Hawkins DY, Skidanova V, Marrujo SR, Gibson J, Ye Z, Bradham CA
Citation:
Development. 2023 May 4:dev.201460. doi: 10.1242/dev.201460. Online ahead of print
Epub:
Not Epub
Abstract:
Defining pattern formation mechanisms during embryonic development is important for understanding the etiology of birth defects...
Link:
https://journals.biologists.com/dev/article-abstract/doi/10.1242/dev.201460/308861/Voltage-gated-sodium-channel-activity-mediates-sea
Delivery Method:
microinjection
Organism or Cell Type:
Lytechinus variegatus (sea urchin)
Citation Extract:
Thomas CF, Hawkins DY, Skidanova V, Marrujo SR, Gibson J, Ye Z, Bradham CA. Voltage-gated sodium channel activity mediates sea urchin larval skeletal patterning through spatial regulation of Wnt5 expression. Development. 2023 May 4:dev.201460. doi: 10.1242/dev.201460. Online ahead of print.

BMP signaling is required to form the anterior neural plate border in ascidian embryos

Authors:
Liu B, Ren X, Satou Y
Citation:
Dev Genes Evol. 2023;[Epub] doi:10.1007/s00427-023-00702-0
Epub:
Not Epub
Abstract:
Cranial neurogenic placodes have been considered vertebrate innovations. However, anterior neural plate border (ANB) cells of...
Link:
https://link.springer.com/article/10.1007/s00427-023-00702-0
Organism or Cell Type:
ascidian
Citation Extract:
Liu B, Ren X, Satou Y. BMP signaling is required to form the anterior neural plate border in ascidian embryos. Dev Genes Evol. 2023;[Epub] doi:10.1007/s00427-023-00702-0.

The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for multiciliated cell differentiation in Xenopus

Authors:
Angerilli A, Tait J, Berges J, Shcherbakova I, Pokrovsky D, Schauer T, Smialowski P, Hsam O, Mentele E, Nicetto D, Rupp RA
Citation:
Life Sci Alliance. 2023 Apr 28;6(7):e202302023. doi: 10.26508/lsa.202302023. Print 2023 Jul
Epub:
Not Epub
Abstract:
H4 lysine 20 dimethylation (H4K20me2) is the most abundant histone modification in vertebrate chromatin. It arises from...
Link:
https://www.life-science-alliance.org/content/6/7/e202302023
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis
Citation Extract:
Angerilli A, Tait J, Berges J, Shcherbakova I, Pokrovsky D, Schauer T, Smialowski P, Hsam O, Mentele E, Nicetto D, Rupp RA. The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for multiciliated cell differentiation in Xenopus. Life Sci Alliance. 2023 Apr 28;6(7):e202302023. doi: 10.26508/lsa.202302023. Print 2023 Jul.

Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction

Authors:
Fontana CM, Terrin F, Facchinello N, Meneghetti G, Dinarello A, Gambarotto L, Zuccarotto A, Caichiolo M, Brocca G, Verin R, Nazio F, Carnevali O, Cecconi F, Bonaldo P, Dalla Valle L
Citation:
Biol Res. 2023 Apr 28;56(1):19. doi: 10.1186/s40659-023-00430-9
Epub:
Not Epub
Abstract:
Background: AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein...
Link:
https://biolres.biomedcentral.com/articles/10.1186/s40659-023-00430-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fontana CM, Terrin F, Facchinello N, Meneghetti G, Dinarello A, Gambarotto L, Zuccarotto A, Caichiolo M, Brocca G, Verin R, Nazio F, Carnevali O, Cecconi F, Bonaldo P, Dalla Valle L. Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction. Biol Res. 2023 Apr 28;56(1):19. doi: 10.1186/s40659-023-00430-9.

Proprotein Convertase Furin Regulates Melanogenesis via the Notch Signaling Pathway

Authors:
Luo L, Jia W, Zhang Y, Guo Y, Zhu J, Li C
Citation:
Discov Med. 2023 Apr 1;35(175):144-156. doi: 10.24976/Discov.Med.202335175.15
Epub:
Not Epub
Abstract:
Background: Furin is a calcium-dependent serine protease found in almost all mammals. It plays an important role in...
Link:
https://www.discovmed.com/EN/10.24976/Discov.Med.202335175.15
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Luo L, Jia W, Zhang Y, Guo Y, Zhu J, Li C. Proprotein Convertase Furin Regulates Melanogenesis via the Notch Signaling Pathway. Discov Med. 2023 Apr 1;35(175):144-156. doi: 10.24976/Discov.Med.202335175.15.

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