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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via a subcutaneous administration
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Citation:
JCI Insight. 2023;8(5):e160516. doi: 10.1172/jci.insight.160516. Online ahead of print Epub:
Not Epub Abstract:
Antisense oligonucleotide (AO)-mediated therapy is a promising strategy to treat several neurological diseases including spinal... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Aslesh T, Erkut E, Ren J, Lim KRQ, Woo S, Hatlevig S, Moulton HM, Gosgnach S, Greer J, Maruyama R, Yokota T. DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via a subcutaneous administration. JCI Insight. 2023;8(5):e160516. doi: 10.1172/jci.insight.160516. Online ahead of print. |
RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation
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Citation:
Cell Rep. 2023;42(2):112407. doi:10.1016/j.celrep.2023.112047 Epub:
Not Epub Abstract:
Mammalian development is precisely controlled by cell differentiation. Identifying new regulators and investigating their... Delivery Method:
microinjection Organism or Cell Type:
mouse embryo Citation Extract: Wu D, Dean J. RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation. Cell Rep. 2023;42(2):112407. doi:10.1016/j.celrep.2023.112047. |
The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs
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Citation:
Nat Commun. 2023 Jan 28;14(1):472. doi: 10.1038/s41467-023-36114-x Epub:
Not Epub Abstract:
Specialized chromatin-binding proteins are required for DNA-based processes during development. We recently established PWWP2A... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Herchenröther A, Gossen S, Friedrich T, Reim A, Daus N, Diegmüller F, Leers J, Sani HM, Gerstner S, Schwarz L, Stellmacher I, Szymkowiak LV, Nist A, Stiewe T, Borggrefe T, Mann M, Mackay JP, Bartkuhn M, Borchers A, Lan J, Hake SB. The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs. Nat Commun. 2023 Jan 28;14(1):472. doi: 10.1038/s41467-023-36114-x. |
The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity
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Citation:
J Transl Med. 2023 Jan 28;21(1):52. doi: 10.1186/s12967-023-03895-0 Epub:
Not Epub Abstract:
Background/aims: Arsenic trioxide (ATO) is the first-line therapeutic drug for acute promyelocytic leukemia. However, the... Delivery Method:
X-tremeGENE siRNA Transfection Reagent Organism or Cell Type:
cell culture: neonatal mouse cardiomyocytes Citation Extract: Shen X, Zhi F, Shi C, Xu J, Chao Y, Xu J, Bai Y, Jiang Y, Yang B. The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity. J Transl Med. 2023 Jan 28;21(1):52. doi: 10.1186/s12967-023-03895-0. |
Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries
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Citation:
JHEP Rep. 2022 Dec 17;5(3):100652. doi:10.1016/j.jhepr.2022.100652. eCollection 2023 Mar Epub:
Not Epub Abstract:
Background & aims: Chronic hepatitis delta is the most severe form of chronic viral hepatitis and is associated with faster... Delivery Method:
jetPRIMER transfection reagent Organism or Cell Type:
cell culture: Huh7 human hepatoma Citation Extract: Tseligka ED, Conzelmann S, Cambet Y, Schaer T, Negro F, Clément S. Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries. JHEP Rep. 2022 Dec 17;5(3):100652. doi:10.1016/j.jhepr.2022.100652. eCollection 2023 Mar. |
Crb3 stabilizes activated Ezrin-Radixin-Moesin to organize the apical domain of multiciliated cells
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Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.01.24.525309 Epub:
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Cell shape changes mainly rely on the remodeling of the actin cytoskeleton. Multiciliated cells (MCCs) of the mucociliary... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Burckle C, Raitiere J, Kodjabachian L, Le-Bivic A. Crb3 stabilizes activated Ezrin-Radixin-Moesin to organize the apical domain of multiciliated cells. bioRxiv. 2023;[preprint] doi:10.1101/2023.01.24.525309. |
Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish
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Citation:
Dev Cell. 2023;[Epub ahead of print] doi:10.1016/j.devcel.2022.12.013 Epub:
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Endothelial cells (ECs) line blood vessels and serve as a niche for hematopoietic stem and progenitor cells (HSPCs). Recent... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Nakajima H, Ishikawa H, Yamamoto T, Chiba A, Fukui H, Sako K, Fukumoto M, Mattonet K, Kwon H-B, Hui SP, Dobreva GD, Kikuchi K, Helker CSM, Stainier DYR, Mochizuki N. Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Dev Cell. 2023;[Epub ahead of print] doi:10.1016/j.devcel.2022.12.013. |
Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling
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Citation:
Nat Commun. 2023 Jan 20;14(1):337. doi: 10.1038/s41467-023-35991-6 Epub:
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Apical constriction is a cell shape change critical to vertebrate neural tube closure, and the contractile force required for... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Yoon J, Sun J, Lee M, Hwang YS, Daar IO. Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling. Nat Commun. 2023 Jan 20;14(1):337. doi: 10.1038/s41467-023-35991-6. |
Integrative genetic analysis illuminates ALS heritability and identifies risk genes
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Citation:
Nat Commun. 2023 Jan 20;14(1):342. doi: 10.1038/s41467-022-35724-1 Epub:
Not Epub Abstract:
Amyotrophic lateral sclerosis (ALS) has substantial heritability, in part shared with fronto-temporal dementia (FTD). We show... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Megat S, Mora N, Sanogo J, Roman O, Catanese A, Alami NO, Freischmidt A, Mingaj X, De Calbiac H, Muratet F, Dirrig-Grosch S, Dieterle S, Van Bakel N, Müller K, Sieverding K, Weishaupt J, Andersen PM, Weber M, Neuwirth C, Margelisch M, Sommacal A, Van Eijk KR, Veldink JH; Project Mine Als Sequencing Consortium; Lautrette G, Couratier P, Camuzat A, Le Ber I, Grassano M, Chio A, Boeckers T, Ludolph AC, Roselli F, Yilmazer-Hanke D, Millecamps S, Kabashi E, Storkebaum E, Sellier C, Dupuis L. Integrative genetic analysis illuminates ALS heritability and identifies risk genes. Nat Commun. 2023 Jan 20;14(1):342. doi: 10.1038/s41467-022-35724-1. |
Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D
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Citation:
Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2208941120. doi:10.1073/pnas.2208941120. Epub 2023 Jan 19 Epub:
Yes Abstract:
p97 is an essential AAA+ ATPase that extracts and unfolds substrate proteins from membranes and protein complexes. Through its... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Petrović S, Roske Y, Rami B, Phan MHQ, Panáková D, Heinemann U. Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2208941120. doi:10.1073/pnas.2208941120. Epub 2023 Jan 19. |