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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs)
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Citation:
Nucleic Acids Res. 2023 May 24:gkad415. doi: 10.1093/nar/gkad415. Online ahead of print Epub:
Yes Abstract:
Although targeting TfR1 to deliver oligonucleotides to skeletal muscle has been demonstrated in rodents, effectiveness and... Delivery Method:
antibody-linked Organism or Cell Type:
mice Citation Extract: Malecova B, Burke RS, Cochran M, Hood MD, Johns R, Kovach PR, Doppalapudi VR, Erdogan G, Arias JD, Darimont B, Miller CD, Huang H, Geall A, Younis HS, Levin AA. Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs). Nucleic Acids Res. 2023 May 24:gkad415. doi: 10.1093/nar/gkad415. Online ahead of print. |
The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit
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Citation:
Biomed Pharmacother. 2023 Jun 7;164:114952. doi: 10.1016/j.biopha.2023.114952. Online ahead of print Epub:
Not Epub Abstract:
KV7 channels exert a pivotal role regulating vascular tone in several vascular beds. In this context, KV7 channel agonists... Delivery Method:
Lipofectamine Organism or Cell Type:
cell culture: isolated pulmonary artery (PA) cells Citation Extract: Villegas-Esguevillas M, Cho S, Vera-Zambrano A, Kwon JW, Barreira B, Telli G, Navarro-Dorado J, Morales-Cano D, de Olaiz B, Moreno L, Greenwood I, Pérez-Vizcaíno F, Kim SJ, Climent B, Cogolludo A. The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit. Biomed Pharmacother. 2023 Jun 7;164:114952. doi: 10.1016/j.biopha.2023.114952. Online ahead of print. |
Plexina4 and cell survival in the developing zebrafish hindbrain
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Citation:
Dev Dyn. 2023 Jun 7. doi: 10.1002/dvdy.633. Online ahead of print Epub:
Not Epub Abstract:
Background: Growth factors are important in the developing and mature nervous system to support the survival of neurons.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Nurcombe ZW, Hehr CL, McFarlane S. Plexina4 and cell survival in the developing zebrafish hindbrain. Dev Dyn. 2023 Jun 7. doi: 10.1002/dvdy.633. Online ahead of print. |
Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl
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Citation:
Dev Biol. 2023 Jun 2;500:31-39. doi: 10.1016/j.ydbio.2023.06.001. Online ahead of print Epub:
Not Epub Abstract:
The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ... Delivery Method:
injection then electroporation Organism or Cell Type:
Ambystoma mexicanum (Axolotl) Citation Extract: Bay S, Öztürk G, Emekli N, Demircan T. Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl. Dev Biol. 2023 Jun 2;500:31-39. doi: 10.1016/j.ydbio.2023.06.001. Online ahead of print. |
Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia
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Citation:
Front Genet. 2023 May 15;14:1186882. doi: 10.3389/fgene.2023.1186882. eCollection 2023 Epub:
Not Epub Abstract:
Background: Biliary atresia (BA) is a destructive, obliterative cholangiopathy characterized by progressive fibro-inflammatory... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bai MR, Pei HY, Zhou Y, Song HL, Pan WH, Gong YM, Wu WJ, Yu WW, Cui MM, Gu BL, Chu X, Cai W. Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia. Front Genet. 2023 May 15;14:1186882. doi: 10.3389/fgene.2023.1186882. eCollection 2023. |
Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivity in vivo
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Citation:
Front Synaptic Neurosci. 2023 May 12;15:1176864. doi: 10.3389/fnsyn.2023.1176864. eCollection 2023 Epub:
Not Epub Abstract:
Cannabis exposure during gestation evokes significant molecular modifications to neurodevelopmental programs leading to... Delivery Method:
electroporation Organism or Cell Type:
Xenopus laevis tadpoles Citation Extract: Del Rio R Jr, Serrano RG, Gomez E, Martinez JC, Edward MA, Santos RA, Diaz KS, Cohen-Cory S. Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivity in vivo. Front Synaptic Neurosci. 2023 May 12;15:1176864. doi: 10.3389/fnsyn.2023.1176864. eCollection 2023. |
The U1 antisense morpholino oligonucleotide (AMO) disrupts U1 snRNP structure to promote intronic PCPA modification of pre-mRNAs
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Citation:
J Biol Chem. 2023 May 22:104854. doi: 10.1016/j.jbc.2023.104854. Online ahead of print Epub:
Yes Abstract:
Functional depletion of the U1 small nuclear ribonucleoprotein (snRNP) with a 25 nt U1 AMO (antisense morpholino... Delivery Method:
electroporation Organism or Cell Type:
cell culture: HeLa Citation Extract: Feng Q, Lin Z, Deng Y, Ran Y, Yu R, Xiang AP, Ye C, Yao C. The U1 antisense morpholino oligonucleotide (AMO) disrupts U1 snRNP structure to promote intronic PCPA modification of pre-mRNAs. J Biol Chem. 2023 May 22:104854. doi: 10.1016/j.jbc.2023.104854. Online ahead of print. |
Cartilage regeneration in zebrafish depends on Nrg1/ErbB signaling pathway
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Citation:
Front Cell Dev Biol. 2023 Apr 4;11:1123299. doi: 10.3389/fcell.2023.1123299. eCollection 2023 Epub:
Not Epub Abstract:
Objective: Cartilage, as the majority of adult mammalian tissues, has limited regeneration capacity. Cartilage degradation... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sapède D, Bahraoui S, Abou Nassif L, Barthelaix A, Mathieu M, Jorgensen C, Djouad F. Cartilage regeneration in zebrafish depends on Nrg1/ErbB signaling pathway. Front Cell Dev Biol. 2023 Apr 4;11:1123299. doi: 10.3389/fcell.2023.1123299. eCollection 2023. |
Genetic deletion of the inflammation-regulated microRNA miR-146a increases exon-skipping mediated dystrophin restoration in Duchenne muscular dystrophy
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Citation:
bioRxiv. 2023 May 9:2023.05.09.540042. doi: 10.1101/2023.05.09.540042. Preprint Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused by loss of function mutations in the Dystrophin gene... Delivery Method:
intramuscular (i.m.) or intravenous (i.v.) injection Organism or Cell Type:
mice Citation Extract: McCormack NM, Calabrese KA, Tully CB, Heier CR, Fiorillo AA. Genetic deletion of the inflammation-regulated microRNA miR-146a increases exon-skipping mediated dystrophin restoration in Duchenne muscular dystrophy. bioRxiv. 2023 May 9:2023.05.09.540042. doi: 10.1101/2023.05.09.540042. Preprint. |
A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish
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Citation:
Hum Genomics. 2023 May 19;17(1):44. doi: 10.1186/s40246-023-00491-7 Epub:
Not Epub Abstract:
Background: Ubiquitin-related rare diseases are generally characterized by developmental delays and mental retardation, but the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Shin U, Choi Y, Ko HS, Myung K, Lee S, Cheon CK, Lee Y. A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish. Hum Genomics. 2023 May 19;17(1):44. doi: 10.1186/s40246-023-00491-7. |