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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Efficient manipulation of gene expression using Natronobacterium gregoryi Argonaute in zebrafish

Authors:
Dong Z, Chen X, Zhuo R, Li Y, Zhou Z, Sun Y, Liu Y, Liu M
Citation:
BMC Biol. 2023 Apr 24;21(1):95. doi: 10.1186/s12915-023-01599-x
Epub:
Not Epub
Abstract:
Background: Natronobacterium gregoryi Argonaute (NgAgo) was found to reduce mRNA without generating detectable DNA double-...
Link:
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-023-01599-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dong Z, Chen X, Zhuo R, Li Y, Zhou Z, Sun Y, Liu Y, Liu M. Efficient manipulation of gene expression using Natronobacterium gregoryi Argonaute in zebrafish. BMC Biol. 2023 Apr 24;21(1):95. doi: 10.1186/s12915-023-01599-x.

Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS

Authors:
Parameswaran J, Zhang N, Braems E, Tilahun K, Pant DC, Yin K, Asress S, Heeren K, Banerjee A, Davis E, Schwartz SL, Conn GL, Bassell GJ, Van Den Bosch L, Jiang J
Citation:
Elife. 2023 Apr 19;12:e85902. doi: 10.7554/eLife.85902. Online ahead of print
Epub:
Not Epub
Abstract:
GGGGCC (G4C2) hexanucleotide repeat expansion in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (...
Link:
https://elifesciences.org/articles/85902
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Parameswaran J, Zhang N, Braems E, Tilahun K, Pant DC, Yin K, Asress S, Heeren K, Banerjee A, Davis E, Schwartz SL, Conn GL, Bassell GJ, Van Den Bosch L, Jiang J. Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS. Elife. 2023 Apr 19;12:e85902. doi: 10.7554/eLife.85902. Online ahead of print.

The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis

Authors:
He X, Ge C, Xia J, Xia Z, Zhao L, Huang S, Wang R, Pan J, Cheng T, Xu PF, Wang F, Min J
Citation:
Adv Sci (Weinh). 2023 Apr 17:e2205345. doi:10.1002/advs.202205345. Online ahead of print
Epub:
Yes
Abstract:
The role of zinc in hematopoiesis is currently unclear. Here, SLC39A10 (ZIP10) is identified as a key zinc transporter in...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/advs.202205345
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
He X, Ge C, Xia J, Xia Z, Zhao L, Huang S, Wang R, Pan J, Cheng T, Xu PF, Wang F, Min J. The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis. Adv Sci (Weinh). 2023 Apr 17:e2205345. doi:10.1002/advs.202205345. Online ahead of print.

Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation

Authors:
Li Z, Lui KN, Lau ST, Lai FP, Li P, Chung PH, Wong KK, Tam PK, Garica-Barcelo MM, Hui CC, Sham PC, Ngan ES
Citation:
Nat Commun. 2023 Apr 15;14(1):2157. doi: 10.1038/s41467-023-37928-5
Epub:
Not Epub
Abstract:
Hirschsprung disease is characterized by the absence of enteric neurons caused by the defects of enteric neural crest cells,...
Link:
https://www.nature.com/articles/s41467-023-37928-5
Delivery Method:
Endo-Porter PEG
Organism or Cell Type:
cell culture: Hirschsprung disease enteric neural crest cells (HSCR-ENCC) from iPSCs
Citation Extract:
Li Z, Lui KN, Lau ST, Lai FP, Li P, Chung PH, Wong KK, Tam PK, Garica-Barcelo MM, Hui CC, Sham PC, Ngan ES. Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation. Nat Commun. 2023 Apr 15;14(1):2157. doi: 10.1038/s41467-023-37928-5.

Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation

Authors:
Cervino AS, Collodel MG, Lopez IA, Hochbaum D, Hukriede NA, Cirio MC
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.04.15.537039
Epub:
Not Epub
Abstract:
The nephron, functional unit of the vertebrate kidney, is specialized in metabolic wastes excretion and body fluids...
Link:
https://www.biorxiv.org/content/10.1101/2023.04.15.537039v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Cervino AS, Collodel MG, Lopez IA, Hochbaum D, Hukriede NA, Cirio MC. Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation. bioRxiv. 2023;[preprint] doi:10.1101/2023.04.15.537039.

Production of sterile Atlantic salmon by germ cell ablation with antisense oligonucleotides

Authors:
Tveiten H, Andersen Ø, Swain JK, Johnsen H, Mommens M, Slanchev K
Citation:
bioRxiv;[preprint] doi:10.1101/2023.04.14.536849
Epub:
Not Epub
Abstract:
Cultivation of sterile-only fish in aquaculture offers multiple benefits of environmental, economical, and social value. A...
Link:
https://www.biorxiv.org/content/10.1101/2023.04.14.536849v1
Delivery Method:
microinjection
Organism or Cell Type:
Salmo salar (Atlantic salmon)
Citation Extract:
Tveiten H, Andersen Ø, Swain JK, Johnsen H, Mommens M, Slanchev K. Production of sterile Atlantic salmon by germ cell ablation with antisense oligonucleotides. bioRxiv;[preprint] doi:10.1101/2023.04.14.536849.

Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/II clinical trial

Authors:
Ishizuka T, Komaki H, Asahina Y, Nakamura H, Motohashi N, Takeshita E, Motohashi Y, Ishiyama A, Yonee C, Maruyama S, Hida E, Aoki Y
Citation:
Neuropsychopharmacol Rep. 2023 Jun;43(2):277-286. doi: 10.1002/npr2.12335. Epub 2023 Apr 3.
Epub:
Not Epub
Abstract:
Aim: The purpose of this study is to evaluate the safety and pharmacokinetics of the novel morpholino oligomer NS-089/NCNP-02...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/npr2.12335
Delivery Method:
intravenous (i.v.)
Organism or Cell Type:
human
Citation Extract:
Ishizuka T, Komaki H, Asahina Y, Nakamura H, Motohashi N, Takeshita E, Motohashi Y, Ishiyama A, Yonee C, Maruyama S, Hida E, Aoki Y. Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/II clinical trial. Neuropsychopharmacol Rep. 2023 Jun;43(2):277-286. doi: 10.1002/npr2.12335. Epub 2023 Apr 3..

Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation

Authors:
Yabe T, Uriu K, Takada S
Citation:
Nat Commun. 2023 Apr 13;14(1):2115. doi: 10.1038/s41467-023-37745-w
Epub:
Not Epub
Abstract:
The metameric pattern of somites is created based on oscillatory expression of clock genes in presomitic mesoderm. However, the...
Link:
https://www.nature.com/articles/s41467-023-37745-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yabe T, Uriu K, Takada S. Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation. Nat Commun. 2023 Apr 13;14(1):2115. doi: 10.1038/s41467-023-37745-w.

TAR Syndrome-associated Rbm8a deficiency causes hematopoietic defects and attenuates Wnt/PCP signaling

Authors:
Kocere A, Chiavacci E, Méndez-Acevedo KM, Soneson C, Hiltabidle MS, MacGowan JS, Panáková D, Williams MLK, Robinson MD, Mosimann C, Burger A
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.04.12.536513
Epub:
Not Epub
Abstract:
Defects in blood development frequently occur among syndromic congenital anomalies. Thrombocytopenia-Absent Radius (TAR)...
Link:
https://www.biorxiv.org/content/10.1101/2023.04.12.536513v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kocere A, Chiavacci E, Méndez-Acevedo KM, Soneson C, Hiltabidle MS, MacGowan JS, Panáková D, Williams MLK, Robinson MD, Mosimann C, Burger A. TAR Syndrome-associated Rbm8a deficiency causes hematopoietic defects and attenuates Wnt/PCP signaling. bioRxiv. 2023;[preprint] doi:10.1101/2023.04.12.536513 .

Screening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA's role in regulating miR-999

Authors:
Sheng P, Li L, Li T, Wang Y, Hiers NM, Mejia JS, Sanchez JS, Zhou L, Xie M
Citation:
Nat Commun. 2023 Apr 13;14(1):2108. doi: 10.1038/s41467-023-37819-9
Epub:
Not Epub
Abstract:
MicroRNAs (miRNA) load onto AGO proteins to target mRNAs for translational repression or degradation. However, miRNA...
Link:
https://www.nature.com/articles/s41467-023-37819-9
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: Drosophila S2
Citation Extract:
Sheng P, Li L, Li T, Wang Y, Hiers NM, Mejia JS, Sanchez JS, Zhou L, Xie M. Screening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA's role in regulating miR-999. Nat Commun. 2023 Apr 13;14(1):2108. doi: 10.1038/s41467-023-37819-9.

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