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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Aicardi Syndrome Is a Genetically Heterogeneous Disorder

Authors:
Ha TT, Burgess R, Newman M, Moey C, Mandelstam SA, Gardner AE, Ivancevic AM, Pham D, Kumar R, Smith N, Patel C, Malone S, Ryan MM, Calvert S, van Eyk CL, Lardelli M, Berkovic SF, Leventer RJ, Richards LJ, Scheffer IE, Gecz J, Corbett MA
Citation:
Genes. 2023;14(8):1565. doi:10.3390/genes14081565
Epub:
Not Epub
Abstract:
Aicardi Syndrome (AIC) is a rare neurodevelopmental disorder recognized by the classical triad of agenesis of the corpus...
Link:
https://www.mdpi.com/2073-4425/14/8/1565
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ha TT, Burgess R, Newman M, Moey C, Mandelstam SA, Gardner AE, Ivancevic AM, Pham D, Kumar R, Smith N, Patel C, Malone S, Ryan MM, Calvert S, van Eyk CL, Lardelli M, Berkovic SF, Leventer RJ, Richards LJ, Scheffer IE, Gecz J, Corbett MA. Aicardi Syndrome Is a Genetically Heterogeneous Disorder. Genes. 2023;14(8):1565. doi:10.3390/genes14081565.

Recognition of H2AK119ub plays an important role in RSF1-regulated early Xenopus development

Authors:
Parast SM, Yu D, Chen C, Dickinson AJ, Chang C, Wang H
Citation:
Front Cell Dev Biol. 2023 Jul 17;11:1168643. doi: 10.3389/fcell.2023.1168643. eCollection 2023
Epub:
Not Epub
Abstract:
Polycomb group (PcG) proteins are key regulators of gene expression and developmental programs via covalent modification of...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2023.1168643/full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Parast SM, Yu D, Chen C, Dickinson AJ, Chang C, Wang H. Recognition of H2AK119ub plays an important role in RSF1-regulated early Xenopus development. Front Cell Dev Biol. 2023 Jul 17;11:1168643. doi: 10.3389/fcell.2023.1168643. eCollection 2023.

Microenvironmental Snail1-induced immunosuppression promotes melanoma growth

Authors:
Arumi-Planas M, Rodriguez-Baena FJ, Cabello-Torres F, Gracia F, Lopez-Blau C, Nieto MA, Sanchez-Laorden B
Citation:
Oncogene. 2023 Jul 29. doi: 10.1038/s41388-023-02793-5. Online ahead of print
Epub:
Yes
Abstract:
Melanoma is an aggressive form of skin cancer due to its high metastatic abilities and resistance to therapies. Melanoma cells...
Link:
https://www.nature.com/articles/s41388-023-02793-5
Citation Extract:
Arumi-Planas M, Rodriguez-Baena FJ, Cabello-Torres F, Gracia F, Lopez-Blau C, Nieto MA, Sanchez-Laorden B. Microenvironmental Snail1-induced immunosuppression promotes melanoma growth. Oncogene. 2023 Jul 29. doi: 10.1038/s41388-023-02793-5. Online ahead of print.

mRNA location and translation rate determine protein targeting to dual destinations

Authors:
Gasparski AN, Moissoglu K, Pallikkuth S, Meydan S, Guydosh NR, Mili S
Citation:
Mol Cell. 2023 Jul 20:S1097-2765(23)00514-2. doi: 10.1016/j.molcel.2023.06.036. Online ahead of print
Epub:
Yes
Abstract:
Numerous proteins are targeted to two or multiple subcellular destinations where they exert distinct functional consequences....
Link:
https://www.sciencedirect.com/science/article/pii/S1097276523005142
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: MDA-MB-231
Citation Extract:
Gasparski AN, Moissoglu K, Pallikkuth S, Meydan S, Guydosh NR, Mili S. mRNA location and translation rate determine protein targeting to dual destinations. Mol Cell. 2023 Jul 20:S1097-2765(23)00514-2. doi: 10.1016/j.molcel.2023.06.036. Online ahead of print.

Ensemble-Learning and Feature Selection Techniques for Enhanced Antisense Oligonucleotide Efficacy Prediction in Exon Skipping

Authors:
Zhu A, Chiba S, Shimizu Y, Kunitake K, Okuno Y, Aoki Y, Yokota T
Citation:
Pharmaceutics. 2023 Jun 24;15(7):1808. doi: 10.3390/pharmaceutics15071808
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (ASO)-mediated exon skipping has become a valuable tool for investigating gene function and...
Link:
https://www.mdpi.com/1999-4923/15/7/1808
Citation Extract:
Zhu A, Chiba S, Shimizu Y, Kunitake K, Okuno Y, Aoki Y, Yokota T. Ensemble-Learning and Feature Selection Techniques for Enhanced Antisense Oligonucleotide Efficacy Prediction in Exon Skipping. Pharmaceutics. 2023 Jun 24;15(7):1808. doi: 10.3390/pharmaceutics15071808.

BACE1 Inhibition Using 2'-OMePS Steric Blocking Antisense Oligonucleotides

Authors:
Chakravarthy M, Veedu RN
Citation:
Genes (Basel). 2019 Sep 12;10(9):705. doi: 10.3390/genes10090705
Epub:
Not Epub
Abstract:
Amyloid beta-peptide is produced by the cleavage of amyloid precursor protein by two secretases, a β-secretase, beta-site...
Link:
https://www.mdpi.com/2073-4425/10/9/705
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: HEK293
Citation Extract:
Chakravarthy M, Veedu RN. BACE1 Inhibition Using 2'-OMePS Steric Blocking Antisense Oligonucleotides. Genes (Basel). 2019 Sep 12;10(9):705. doi: 10.3390/genes10090705.

HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53

Authors:
Fu JL, Zheng SY, Wang Y, Hu XB, Xiao Y, Wang JM, Zhang L, Wang L, Nie Q, Hou M, Bai YY, Gan YW, Liang XM, Xie LL, Li DW
Citation:
Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2221522120. doi: 10.1073/pnas.2221522120. Epub 2023 Jul 24
Epub:
Yes
Abstract:
Cataract is a leading ocular disease causing global blindness. The mechanism of cataractogenesis has not been well defined....
Link:
https://www.pnas.org/doi/10.1073/pnas.2221522120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fu JL, Zheng SY, Wang Y, Hu XB, Xiao Y, Wang JM, Zhang L, Wang L, Nie Q, Hou M, Bai YY, Gan YW, Liang XM, Xie LL, Li DW. HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2221522120. doi: 10.1073/pnas.2221522120. Epub 2023 Jul 24.

Non-canonical function of folate/folate receptor 1 during neural tube formation

Authors:
Balashova OA, Panoutsopoulos AA, Visina O, Selhub J, Knoepfler PS, Borodinsky LN
Citation:
bioRxiv. 2023 Jul 21:[preprint]. doi:10.1101/2023.07.19.549718
Epub:
Not Epub
Abstract:
Folate supplementation reduces the occurrence of neural tube defects, one of the most common and serious birth defects,...
Link:
https://www.biorxiv.org/content/10.1101/2023.07.19.549718v1
Delivery Method:
Vivo-Morpholino, microinjection
Organism or Cell Type:
human neural organoids from iPSCs, Xenopus laevis
Citation Extract:
Balashova OA, Panoutsopoulos AA, Visina O, Selhub J, Knoepfler PS, Borodinsky LN. Non-canonical function of folate/folate receptor 1 during neural tube formation. bioRxiv. 2023 Jul 21:[preprint]. doi:10.1101/2023.07.19.549718.

Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1

Authors:
Westerich KJ, Tarbashevich K, Schick J, Gupta A, Zhu M, Hull K, Romo D, Zeuschner D, Goudarzi M, Gross-Thebing T, Raz E
Citation:
Dev Cell. 2023 Jul 11:S1534-5807(23)00307-6. doi: 10.1016/j.devcel.2023.06.009. Online ahead of print
Epub:
Not Epub
Abstract:
Germ granules, condensates of phase-separated RNA and protein, are organelles that are essential for germline development in...
Link:
https://www.cell.com/developmental-cell/pdfExtended/S1534-5807(23)00307-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Westerich KJ, Tarbashevich K, Schick J, Gupta A, Zhu M, Hull K, Romo D, Zeuschner D, Goudarzi M, Gross-Thebing T, Raz E. Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1. Dev Cell. 2023 Jul 11:S1534-5807(23)00307-6. doi: 10.1016/j.devcel.2023.06.009. Online ahead of print.

Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium

Authors:
Ghersi JJ, Baldissera G, Hintzen J, Luff SA, Cheng S, Xia IF, Sturgeon CM, Nicoli S
Citation:
Nat Cell Biol. 2023 Jul 17. doi: 10.1038/s41556-023-01187-9. Online ahead of print
Epub:
Yes
Abstract:
Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid and myeloid lineages. HSPCs are...
Link:
https://www.nature.com/articles/s41556-023-01187-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ghersi JJ, Baldissera G, Hintzen J, Luff SA, Cheng S, Xia IF, Sturgeon CM, Nicoli S. Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium. Nat Cell Biol. 2023 Jul 17. doi: 10.1038/s41556-023-01187-9. Online ahead of print.

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