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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury

Authors:
Wan Y, Slevin E, Koyama S, Huang CK, Shetty AK, Li X, Harrison K, Li T, Zhou B, Lorenzo SR, Zhang Y, Salinas JM, Xu W, Klaunig JE, Wu C, Tsukamoto H, Meng F
Citation:
Hepatol Commun. 2023 Apr 4;7(4):e0089. doi: 10.1097/HC9.0000000000000089. eCollection 2023 Apr
Epub:
Not Epub
Abstract:
Background: Alcohol-associated liver disease (ALD) is a syndrome of progressive inflammatory liver injury and vascular...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Wan Y, Slevin E, Koyama S, Huang CK, Shetty AK, Li X, Harrison K, Li T, Zhou B, Lorenzo SR, Zhang Y, Salinas JM, Xu W, Klaunig JE, Wu C, Tsukamoto H, Meng F. miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury. Hepatol Commun. 2023 Apr 4;7(4):e0089. doi: 10.1097/HC9.0000000000000089. eCollection 2023 Apr.

Correction of Clcn1 alternative splicing reverses muscle fiber type transition in mice with myotonic dystrophy

Authors:
Hu N, Kim E, Antoury L, Wheeler TM
Citation:
Nat Commun. 2023 Apr 7;14(1):1956. doi: 10.1038/s41467-023-37619-1
Epub:
Not Epub
Abstract:
In myotonic dystrophy type 1 (DM1), deregulated alternative splicing of the muscle chloride channel Clcn1 causes myotonia, a...
Delivery Method:
intramuscular injection (i.m.) then electroporation
Organism or Cell Type:
mice
Citation Extract:
Hu N, Kim E, Antoury L, Wheeler TM. Correction of Clcn1 alternative splicing reverses muscle fiber type transition in mice with myotonic dystrophy. Nat Commun. 2023 Apr 7;14(1):1956. doi: 10.1038/s41467-023-37619-1.

Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease

Authors:
Mishra-Gorur K, Barak T, Kaulen LD, Henegariu O, Jin SC, Aguilera SM, Yalbir E, Goles G, Nishimura S, Miyagishima D, Djenoune L, Altinok S, Rai DK, Viviano S, Prendergast A, Zerillo C, Ozcan K, Baran B, Sencar L, Goc N, Yarman Y, Ercan-Sencicek AG, Bilguvar K, Lifton RP, Moliterno J, Louvi A, Yuan S, Deniz E, Brueckner M, Gunel M
Citation:
Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2214997120. doi: 10.1073/pnas.2214997120. Epub 2023 Apr 12
Epub:
Not Epub
Abstract:
While somatic variants of TRAF7 (Tumor necrosis factor receptor-associated factor 7) underlie anterior skull-base meningiomas,...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis and zebrafish
Citation Extract:
Mishra-Gorur K, Barak T, Kaulen LD, Henegariu O, Jin SC, Aguilera SM, Yalbir E, Goles G, Nishimura S, Miyagishima D, Djenoune L, Altinok S, Rai DK, Viviano S, Prendergast A, Zerillo C, Ozcan K, Baran B, Sencar L, Goc N, Yarman Y, Ercan-Sencicek AG, Bilguvar K, Lifton RP, Moliterno J, Louvi A, Yuan S, Deniz E, Brueckner M, Gunel M. Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2214997120. doi: 10.1073/pnas.2214997120. Epub 2023 Apr 12.

The RhoGEF protein Plekhg5 regulates medioapical and junctional actomyosin dynamics of apical constriction during Xenopus gastrulation

Authors:
Baldwin A, Popov IK, Keller R, Wallingford J, Chang C
Citation:
Mol Biol Cell. 2023 Apr 12:mbcE22090411. doi: 10.1091/mbc.E22-09-0411. Online ahead of print
Epub:
Not Epub
Abstract:
Apical constriction results in apical surface reduction in epithelial cells and is a widely used mechanism for epithelial...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Baldwin A, Popov IK, Keller R, Wallingford J, Chang C. The RhoGEF protein Plekhg5 regulates medioapical and junctional actomyosin dynamics of apical constriction during Xenopus gastrulation. Mol Biol Cell. 2023 Apr 12:mbcE22090411. doi: 10.1091/mbc.E22-09-0411. Online ahead of print.

Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System

Authors:
Badenetti L, Manzoli R, Rubin M, Cozza G, Moro E
Citation:
Int J Mol Sci. 2023 Apr 6;24(7):6804. doi: 10.3390/ijms24076804
Epub:
Not Epub
Abstract:
Among multiple cytoprotective mechanisms, eukaryotic cells exhibit a complex transcriptional program relying on the Nrf2...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Badenetti L, Manzoli R, Rubin M, Cozza G, Moro E. Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System. Int J Mol Sci. 2023 Apr 6;24(7):6804. doi: 10.3390/ijms24076804.

Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B

Authors:
Azad P, Zhou D, Tu HC, Villafuerte FC, Traver D, Rana TM, Haddad GG
Citation:
J Clin Invest. 2023 Apr 6:e165831. doi: 10.1172/JCI165831. Online ahead of print
Epub:
Not Epub
Abstract:
Excessive Erythrocytosis (EE) is a major hallmark of patients suffering from chronic mountain sickness (CMS, Monge's...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Azad P, Zhou D, Tu HC, Villafuerte FC, Traver D, Rana TM, Haddad GG. Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B. J Clin Invest. 2023 Apr 6:e165831. doi: 10.1172/JCI165831. Online ahead of print.

Nodal coordinates the anterior-posterior patterning of germ layers and induces head formation in zebrafish explants

Authors:
Cheng T, Xing YY, Liu C, Li YF, Huang Y, Liu X, Zhang YJ, Zhao GQ, Dong Y, Fu XX, Tian YM, Shu LP, Megason SG, Xu PF
Citation:
Cell Rep. 2023 Apr 4;42(4):112351. doi: 10.1016/j.celrep.2023.112351. Online ahead of print
Epub:
Not Epub
Abstract:
Much progress has been made toward generating analogs of early embryos, such as gastruloids and embryoids, in vitro. However,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cheng T, Xing YY, Liu C, Li YF, Huang Y, Liu X, Zhang YJ, Zhao GQ, Dong Y, Fu XX, Tian YM, Shu LP, Megason SG, Xu PF. Nodal coordinates the anterior-posterior patterning of germ layers and induces head formation in zebrafish explants. Cell Rep. 2023 Apr 4;42(4):112351. doi: 10.1016/j.celrep.2023.112351. Online ahead of print.

Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity

Authors:
Xia J, Liu M, Zhu C, Liu S, Ai L, Ma D, Zhu P, Wang L, Liu F
Citation:
Cell Res. 2023 Apr 4. doi: 10.1038/s41422-023-00797-0. Online ahead of print
Epub:
Yes
Abstract:
Hematopoietic stem and progenitor cells (HSPCs) are considered as a heterogeneous population, but precisely when, where and how...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xia J, Liu M, Zhu C, Liu S, Ai L, Ma D, Zhu P, Wang L, Liu F. Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity. Cell Res. 2023 Apr 4. doi: 10.1038/s41422-023-00797-0. Online ahead of print.

Characterization of regeneration initiating cells during Xenopus laevis tail regeneration

Authors:
Radek S, Pavel A, Daniel Z, Ravindra N, Daniel K, Jiri N, Karel Jr. S, Lacina L, Beduya EB, Jiri N, Martin P, Mikael K
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.03.30.534908
Epub:
Not Epub
Abstract:
Embryos are regeneration and wound healing masters. They not only rapidly close their wounds, remodel injured tissue without a...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Radek S, Pavel A, Daniel Z, Ravindra N, Daniel K, Jiri N, Karel Jr. S, Lacina L, Beduya EB, Jiri N, Martin P, Mikael K. Characterization of regeneration initiating cells during Xenopus laevis tail regeneration. bioRxiv. 2023;[preprint] doi:10.1101/2023.03.30.534908 .

Colec12 and Trail signaling confine cranial neural crest cell trajectories and promote collective cell migration

Authors:
McLennan R, Giniunaite R, Hildebrand K, Teddy JM, Kasemeier-Kulesa JC, Bolanos L, Baker RE, Maini PK, Kulesa PM
Citation:
Dev Dyn. 2023 Jan 24. doi:10.1002/dvdy.569. Online ahead of print
Epub:
Yes
Abstract:
Background: Collective and discrete neural crest cell (NCC) migratory streams are crucial to vertebrate head patterning....
Delivery Method:
microinjection then electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
McLennan R, Giniunaite R, Hildebrand K, Teddy JM, Kasemeier-Kulesa JC, Bolanos L, Baker RE, Maini PK, Kulesa PM. Colec12 and Trail signaling confine cranial neural crest cell trajectories and promote collective cell migration. Dev Dyn. 2023 Jan 24. doi:10.1002/dvdy.569. Online ahead of print.

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