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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Functional analysis of new human Bardet-Biedl syndrome loci specific variants in the zebrafish model
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Citation:
Sci Rep. 2019;9(1):12936. doi:10.1038/s41598-019-49217-7 Epub:
Not Epub Abstract:
The multiple genetic approaches available for molecular diagnosis of human diseases have made possible to identify an... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Castro-Sánchez S, Suarez-Bregua P, Novas R, Álvarez-Satta M, Badano JL, Rotllant J, Valverde D. Functional analysis of new human Bardet-Biedl syndrome loci specific variants in the zebrafish model. Sci Rep. 2019;9(1):12936. doi:10.1038/s41598-019-49217-7. |
Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides
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Citation:
Sci Rep. 2019;9(1):12994. doi:10.1038/s41598-019-49385-6 Epub:
Not Epub Abstract:
With recent approvals of antisense oligonucleotides as therapeutics, there is an increasing interest in expanding the... Delivery Method:
in vitro lipofectamine (fibroblasts) electroporation (Jurkat) , in vivo peptide-linked Organism or Cell Type:
cell culture: primary dermal fibroblasts, Jurkat; autoimmune encephalomyelitis mouse model of multiple sclerosis Citation Extract: Aung-Htut MT, Comerford I, Johnsen R, Foyle K, Fletcher S, Wilton SD. Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides. Sci Rep. 2019;9(1):12994. doi:10.1038/s41598-019-49385-6. |
Identification of a Novel Deep Intronic Mutation in CAPN3 Presenting a Promising Target for Therapeutic Splice Modulation
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Citation:
J Neuromuscul Dis. 2019 Aug 31. doi: 10.3233/JND-190414. [Epub ahead of print] Epub:
Yes Abstract:
Calpainopathy, also known as limb girdle muscular dystrophy (LGMD) type 2A (LGMD2A) or LGMD R1 Calpain3-related, is one of the... Organism or Cell Type:
cell culture: primary cells Citation Extract: Hu Y, Mohassel P, Donkervoort S, Yun P, Bolduc V, Ezzo D, Dastgir J, Marshall JL, Lek M, MacArthur DG, Reghan Foley A, Bönnemann CG. Identification of a Novel Deep Intronic Mutation in CAPN3 Presenting a Promising Target for Therapeutic Splice Modulation. J Neuromuscul Dis. 2019 Aug 31. doi: 10.3233/JND-190414. [Epub ahead of print]. |
Nucleoporin 62-Like Protein is Required for the Development of Pharyngeal Arches through Regulation of Wnt/β-Catenin Signaling and Apoptotic Homeostasis in Zebrafish
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Citation:
Cells. 2019;8(9):1038. doi:10.3390/cells8091038 Epub:
Not Epub Abstract:
We have previously observed the predominant expression of nucleoporin 62-like (Nup62l) mRNA in the pharyngeal region of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yang X, Li X, Gu Q, Li Q, Cui Z. Nucleoporin 62-Like Protein is Required for the Development of Pharyngeal Arches through Regulation of Wnt/β-Catenin Signaling and Apoptotic Homeostasis in Zebrafish. Cells. 2019;8(9):1038. doi:10.3390/cells8091038. |
Mechanical Forces Regulate Cardiomyocyte Myofilament Maturation via the VCL-SSH1-CFL Axis
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Citation:
Dev Cell. 2019;[Epub ahead of print] doi:10.1016/j.devcel.2019.08.006 Epub:
Yes Abstract:
Mechanical forces regulate cell behavior and tissue morphogenesis. During cardiac development, mechanical stimuli from the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Fukuda R, Gunawan F,Ramadass R, Beisaw A, Konzer A, Mullapudi ST, Gentile A, Maischein H-M, Graumann J, Stainier DYR. Mechanical Forces Regulate Cardiomyocyte Myofilament Maturation via the VCL-SSH1-CFL Axis. Dev Cell. 2019;[Epub ahead of print] doi:10.1016/j.devcel.2019.08.006. |
Single Amino Acid Change Underlies Distinct Roles of H2A.Z Subtypes in Human Syndrome
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Citation:
Cell. 2019;178(6):1421-36. doi:10.1016/j.cell.2019.08.002 Epub:
Not Epub Abstract:
The developmental disorder Floating-Harbor syndrome (FHS) is caused by heterozygous truncating mutations in SRCAP, a gene... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Greenberg RS, Long HK, Swigut T, Wysocka J. Single Amino Acid Change Underlies Distinct Roles of H2A.Z Subtypes in Human Syndrome. Cell. 2019;178(6):1421-36. doi:10.1016/j.cell.2019.08.002. |
Inhibition of mmp13a during zebrafish fin regeneration disrupts fin growth, osteoblasts differentiation and Laminin organization
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Citation:
Dev Dyn. 2019 Sep 5. doi: 10.1002/dvdy.112. [Epub ahead of print] Epub:
Yes Abstract:
BACKGROUND: Matrix metalloproteinases 13 (MMP13) is a potent endopeptidase that regulate cell growth, migration, and... Delivery Method:
injection, electroporation Organism or Cell Type:
zebrafish Citation Extract: Li L, Zhang J, Akimenko MA. Inhibition of mmp13a during zebrafish fin regeneration disrupts fin growth, osteoblasts differentiation and Laminin organization. Dev Dyn. 2019 Sep 5. doi: 10.1002/dvdy.112. [Epub ahead of print]. |
Aspergillus fumigatus establishes infection in zebrafish by germination of phagocytized conidia, while Aspergillus niger relies on extracellular germination
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Citation:
Sci Rep. 2019;9(1):12791. doi:10.1038/s41598-019-49284-w Epub:
Not Epub Abstract:
Among opportunistically pathogenic filamentous fungi of the Aspergillus genus, Aspergillus fumigatus stands out as a... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Koch BEV, Hajdamowicz NH, Lagendijk E, Ram AFJ, Meijer AH. Aspergillus fumigatus establishes infection in zebrafish by germination of phagocytized conidia, while Aspergillus niger relies on extracellular germination. Sci Rep. 2019;9(1):12791. doi:10.1038/s41598-019-49284-w. |
TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity
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Citation:
J Immunol. 2016 Jan 15;196(2):738-49. doi: 10.4049/jimmunol.1501729. Epub 2015 Dec 16. Erratum in: J Immunol. 2016 Apr 15;196(8):3494 Epub:
Not Epub Abstract:
As an organism is exposed to pathogens during very early development, specific defense mechanisms must take effect. In this... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Galindo-Villegas J, Montalban-Arques A, Liarte S, de Oliveira S, Pardo-Pastor C, Rubio-Moscardo F, Meseguer J, Valverde MA, Mulero V. TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity. J Immunol. 2016 Jan 15;196(2):738-49. doi: 10.4049/jimmunol.1501729. Epub 2015 Dec 16. Erratum in: J Immunol. 2016 Apr 15;196(8):3494. |
Disruption of splicing-regulatory elements using CRISPR/Cas9 rescues spinal muscular atrophy in human iPSCs and mice
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Citation:
Nat Sci Rev. 2019;[Epub] doi:10.1093/nsr/nwz131 Epub:
Not Epub Abstract:
We here report a genome-editing strategy to correct spinal muscular atrophy (SMA). Rather than directly targeting the... Organism or Cell Type:
cell culture: SMA-2 iPSC Citation Extract: Li J-J, Lin X, Cheng Tang, Lu Y-Q, Hu X, Zuo E, Li H, Ying W, Sun Y, Lai L-L, Chen H-Z, Guo X-X, Zhang Q-J, Wu S, Zhou C, Shen X, Wang Q, Lin M-T, Ma L-X, Wang N, Krainer AR, Shi L, Yang H, Chen W-J. Disruption of splicing-regulatory elements using CRISPR/Cas9 rescues spinal muscular atrophy in human iPSCs and mice. Nat Sci Rev. 2019;[Epub] doi:10.1093/nsr/nwz131. |