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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain

Authors:
Bhattarai P, Cosacak MI, Mashkaryan V, Yilmaz S, Popova S, Govindarajan N, Brandt K, Zhang Y, Kizil C
Citation:
bioRxiv. 2019:[preprint] doi:10.1101/748970
Epub:
Not Epub
Abstract:
It was recently suggested that supplying the brain with new neurons could counteract Alzheimer's disease. This provocative...
Link:
https://www.biorxiv.org/content/10.1101/748970v1
Delivery Method:
i.c.v. intracerebroventricular injection
Organism or Cell Type:
zebrafish
Citation Extract:
Bhattarai P, Cosacak MI, Mashkaryan V, Yilmaz S, Popova S, Govindarajan N, Brandt K, Zhang Y, Kizil C. Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. bioRxiv. 2019:[preprint] doi:10.1101/748970 .

Gene silencing through RNAi and antisense Vivo-Morpholino increases the efficacy of pyrethroids on larvae of Anopheles stephensi

Authors:
Negri A, Ferrari M, Nodari R, Coppa E, Mastrantonio V, Zanzani S, Porretta D, Bandi C, Urbanelli S, Epis S
Citation:
Malar J. 2019;18:294. doi:10.1186/s12936-019-2925-5
Epub:
Not Epub
Abstract:
Background: Insecticides are still at the core of insect pest and vector control programmes. Several lines of evidence indicate...
Link:
https://malariajournal.biomedcentral.com/articles/10.1186/s12936-019-2925-5
Delivery Method:
Vivo-Morpholino bathing
Organism or Cell Type:
Anopheles stephensi (mosquito)
Citation Extract:
Negri A, Ferrari M, Nodari R, Coppa E, Mastrantonio V, Zanzani S, Porretta D, Bandi C, Urbanelli S, Epis S. Gene silencing through RNAi and antisense Vivo-Morpholino increases the efficacy of pyrethroids on larvae of Anopheles stephensi. Malar J. 2019;18:294. doi:10.1186/s12936-019-2925-5.

A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish

Authors:
Lee G-H, Chang C-L, Chiu W-T, Hsiao T-S, Chen P-Y, Wang K-C, Kuo C-H, Chen B-H, Shi G-Y, Wu H-L, Fu T-F
Citation:
J Biomed Sci. 2019;26(1):60. doi:10.1186/s12929-019-0549-2
Epub:
Not Epub
Abstract:
Background: Thrombomodulin (TM), an integral membrane protein, has long been known for its anticoagulant activity. Recent...
Link:
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-019-0549-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lee G-H, Chang C-L, Chiu W-T, Hsiao T-S, Chen P-Y, Wang K-C, Kuo C-H, Chen B-H, Shi G-Y, Wu H-L, Fu T-F. A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish. J Biomed Sci. 2019;26(1):60. doi:10.1186/s12929-019-0549-2.

Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis

Authors:
Wade SM, Ohnesorge N, McLoughlin H, Biniecka M, Carter SP, Trenkman M, Cunningham CC, McGarry T, Canavan M, Kennedy BN, Veale DJ, Fearon U
Citation:
EBioMedicine. 2019;[Epub ahead of print] doi:10.1016/j.ebiom.2019.08.043
Epub:
Yes
Abstract:
Background: Although neoangiogenesis is a hallmark of chronic inflammatory diseases such as inflammatory arthritis and many...
Link:
https://www.ebiomedicine.com/article/S2352-3964(19)30566-3/abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wade SM, Ohnesorge N, McLoughlin H, Biniecka M, Carter SP, Trenkman M, Cunningham CC, McGarry T, Canavan M, Kennedy BN, Veale DJ, Fearon U. Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis. EBioMedicine. 2019;[Epub ahead of print] doi:10.1016/j.ebiom.2019.08.043.

Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal

Authors:
Di Bella DJ, Carcagno AL, Bartolomeu ML, Pardi MB, Löhr H, Siegel N, Hammerschmidt M, Marín-Burgin A, Lanuza GM
Citation:
Cell Rep. 2019;28(9):2264-74. doi:10.1016/j.celrep.2019.07.087
Epub:
Not Epub
Abstract:
Generation of neuronal types at the right time, location, and number is essential for building a functional nervous system....
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31003-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Di Bella DJ, Carcagno AL, Bartolomeu ML, Pardi MB, Löhr H, Siegel N, Hammerschmidt M, Marín-Burgin A, Lanuza GM. Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal. Cell Rep. 2019;28(9):2264-74. doi:10.1016/j.celrep.2019.07.087.

Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy

Authors:
Fadzen CM, Holden R, Wolfe JM, Choo Z-N, Schissel CK, Yao M, Hanson GJ, Pentelute BL
Citation:
Biochemistry. 2019;[Epub ahead of print] doi:10.1021/acs.biochem.9b00413
Epub:
Yes
Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a promising class of therapeutics for genetic disease. PMOs designed...
Link:
https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.9b00413
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa-654
Citation Extract:
Fadzen CM, Holden R, Wolfe JM, Choo Z-N, Schissel CK, Yao M, Hanson GJ, Pentelute BL. Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy. Biochemistry. 2019;[Epub ahead of print] doi:10.1021/acs.biochem.9b00413.

Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation

Authors:
Ban H, Yokota D, Otosaka S, Kikuchi M, Kinoshita H, Fujino Y, Yabe T, Ovara H, Izuka A, Akama K, Yamasu K, Takada S, Kawamura A.
Citation:
Development. 2019 Aug 23. pii: dev.177063. doi: 10.1242/dev.177063. [Epub ahead of print]
Epub:
Yes
Abstract:
The presumptive somite boundary in the presomitic mesoderm (PSM) is defined by the anterior border of the expression domain of...
Link:
https://dev.biologists.org/content/early/2019/08/22/dev.177063
Organism or Cell Type:
zebrafish
Citation Extract:
Ban H, Yokota D, Otosaka S, Kikuchi M, Kinoshita H, Fujino Y, Yabe T, Ovara H, Izuka A, Akama K, Yamasu K, Takada S, Kawamura A.. Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation. Development. 2019 Aug 23. pii: dev.177063. doi: 10.1242/dev.177063. [Epub ahead of print].

A conserved regulatory program initiates lateral plate mesoderm emergence across chordates

Authors:
Prummel KD, Hess C, Nieuwenhuize S, Parker HJ, Rogers KW, Kozmikova I, Racioppi C, Brombacher EC, Anna Czarkwiani, Knapp D, Burger S, Chiavacci E, Shah G, Burger A, Huisken J, Yun MH, Christiaen L, Kozmik Z, Müller P, Bronner M, Krumlauf R, Mosimann C
Citation:
Nat Comm. 2019;10(1):3857. doi:10.1038/s41467-019-11561-7
Epub:
Not Epub
Abstract:
Cardiovascular lineages develop together with kidney, smooth muscle, and limb connective tissue progenitors from the lateral...
Link:
https://www.nature.com/articles/s41467-019-11561-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Prummel KD, Hess C, Nieuwenhuize S, Parker HJ, Rogers KW, Kozmikova I, Racioppi C, Brombacher EC, Anna Czarkwiani, Knapp D, Burger S, Chiavacci E, Shah G, Burger A, Huisken J, Yun MH, Christiaen L, Kozmik Z, Müller P, Bronner M, Krumlauf R, Mosimann C. A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nat Comm. 2019;10(1):3857. doi:10.1038/s41467-019-11561-7.

Microsyntenic Clusters Reveal Conservation of lncRNAs in Chordates Despite Absence of Sequence Conservation

Authors:
Herrera-Úbeda C, Marín-Barba M, Navas-Pérez E, Gravemeyer J, Albuixech-Crespo BA, Wheeler GN, Garcia-Fernàndez J
Citation:
Biology. 2019;8(3):61. doi:10.3390/biology8030061
Epub:
Not Epub
Abstract:
Homologous long non-coding RNAs (lncRNAs) are elusive to identify by sequence similarity due to their fast-evolutionary rate....
Link:
https://www.mdpi.com/2079-7737/8/3/61/htm
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Herrera-Úbeda C, Marín-Barba M, Navas-Pérez E, Gravemeyer J, Albuixech-Crespo BA, Wheeler GN, Garcia-Fernàndez J. Microsyntenic Clusters Reveal Conservation of lncRNAs in Chordates Despite Absence of Sequence Conservation. Biology. 2019;8(3):61. doi:10.3390/biology8030061.

Functional role of pax6 during eye and nervous system development in the annelid Capitella teleta

Authors:
Klann M, Seaver EC
Citation:
Dev Biol. 2019 Aug 21. pii: S0012-1606(18)30055-1. doi: 10.1016/j.ydbio.2019.08.011. [Epub ahead of print]
Epub:
Yes
Abstract:
The transcription factor Pax6 is an important regulator of early animal development. Loss of function mutations of pax6 in a...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160618300551
Delivery Method:
microinjection
Organism or Cell Type:
Capitella teleta (annelid)
Citation Extract:
Klann M, Seaver EC. Functional role of pax6 during eye and nervous system development in the annelid Capitella teleta. Dev Biol. 2019 Aug 21. pii: S0012-1606(18)30055-1. doi: 10.1016/j.ydbio.2019.08.011. [Epub ahead of print].

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