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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch
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Citation:
Glia. 2019 Nov 8. doi: 10.1002/glia.23732. [Epub ahead of print] Epub:
Yes Abstract:
In contrast to humans and other mammals, zebrafish can successfully regenerate and remyelinate central nervous system (CNS)... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Nagarajan B, Harder A, Japp A, Häberlein F, Mingardo E, Kleinert H, Yilmaz Ö, Zoons A, Rau B, Christ A, Kubitscheck U, Eiberger B, Sandhoff R, Eckhardt M, Hartmann D, Odermatt B. CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch. Glia. 2019 Nov 8. doi: 10.1002/glia.23732. [Epub ahead of print]. |
AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos
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Citation:
J Hazard Mater. 2019 Oct 25:121521. doi: 10.1016/j.jhazmat.2019.121521. [Epub ahead of print] Epub:
Yes Abstract:
Trichloroethylene (TCE), a widely used chlorinated solvent, is a common environmental pollutant. Current evidence shows that... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Jin H, Ji C, Ren F, Aniagu S, Tong J, Jiang Y, Chen T. AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. J Hazard Mater. 2019 Oct 25:121521. doi: 10.1016/j.jhazmat.2019.121521. [Epub ahead of print]. |
Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model
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Citation:
J Am Soc Nephrol. 2019 Nov 1. pii: ASN.2019020125. doi: 10.1681/ASN.2019020125. [Epub ahead of print] Epub:
Yes Abstract:
BACKGROUND: Lowe syndrome (LS) is an X-linked recessive disorder caused by mutations in OCRL, which encodes the enzyme OCRL.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gliozzi ML, Espiritu EB, Shipman KE, Rbaibi Y, Long KR, Roy N, Duncan AW, Lazzara MJ, Hukriede NA, Baty CJ, Weisz OA. Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model. J Am Soc Nephrol. 2019 Nov 1. pii: ASN.2019020125. doi: 10.1681/ASN.2019020125. [Epub ahead of print]. |
Genes and Variants Underlying Human Congenital Lactic Acidosis—From Genetics to Personalized Treatment
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Citation:
J Clin Med. 2019;8(11):1811. doi:10.3390/jcm8111811 Epub:
Not Epub Abstract:
Congenital lactic acidosis (CLA) is a rare condition in most instances due to a range of inborn errors of metabolism that... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: patient fibroblasts Citation Extract: Bravo-Alonso I, Navarrete R, Vega AI, Ruíz-Sala P, Silva MTG, Martín-Hernández E, Quijada-Fraile P, Belanger-Quintana A, Stanescu S, Bueno M, Vitoria I, Toledo L, Couce ML, García-Jiménez I, Ramos-Ruiz R, Martín MA, Desviat LR, Ugarte M, Pérez-Cerdá C, Merinero B, Pérez B, Rodríguez-Pombo P. Genes and Variants Underlying Human Congenital Lactic Acidosis—From Genetics to Personalized Treatment. J Clin Med. 2019;8(11):1811. doi:10.3390/jcm8111811. |
An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles
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Citation:
Nat Comm. 2019;10:5012. doi:10.1038/s41467-019-12906-y Epub:
Not Epub Abstract:
Peptides and biologics provide unique opportunities to modulate intracellular targets not druggable by conventional small... Delivery Method:
Vivo-Morpholino with anionic delivery polymer PPAA Organism or Cell Type:
cell culture: human microvascular endothelial cells HMVEC Citation Extract: Evans BC, Fletcher RB, Kilchrist KV, Dailing EA, Mukalel AJ, Colazo JM, Oliver M, Cheung-Flynn J, Brophy CM, Tierney JW, Isenberg JS, Hankenson KD, Ghimire K, Lander C, Gersbach CA, Duvall CL. An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. Nat Comm. 2019;10:5012. doi:10.1038/s41467-019-12906-y. |
A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing
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Citation:
PLoS Genet. 2019;15(10):e1008460. doi:10.1371/journal.pgen.1008460 Epub:
Not Epub Abstract:
Malfunction of pre-mRNA processing factors are linked to several human diseases including cancer and neurodegeneration. Here we... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chen T, Zhang B, Ziegenhals T, Prusty AB, Fröhler S, Grimm C, Hu Y, Schaefke B, Fang L, Zhang M, Kraemer N, Kaindl AM, Fischer U, Chen W. A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. PLoS Genet. 2019;15(10):e1008460. doi:10.1371/journal.pgen.1008460. |
Synchronous chromosome segregation in mouse oocytes is ensured by biphasic securin destruction and cyclin B1-Cdk1
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Citation:
bioRxiv. 2019;[preprint] doi:10.1101/824763 Epub:
Not Epub Abstract:
Successful cell division relies on the faithful segregation of chromosomes. If chromosomes segregate prematurely the cell is at... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Thomas C, Levasseur MD, Harris RJ, Davies OR, Madgwick S. Synchronous chromosome segregation in mouse oocytes is ensured by biphasic securin destruction and cyclin B1-Cdk1. bioRxiv. 2019;[preprint] doi:10.1101/824763 . |
Short-wavelength violet light (420nm) stimulates melanopsin-dependent acute alertness responses in zebrafish
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Citation:
bioRxiv. 2019;[preprint] doi:10.1101/825257 Epub:
Not Epub Abstract:
Sunlight throughout the day and seasons strongly influences our biological rhythms and activity. In recent years, it has become... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Contreras JE, Lisse TS, Bouzidi C, Cavanaugh AM, Matynia A, Rieger S. Short-wavelength violet light (420nm) stimulates melanopsin-dependent acute alertness responses in zebrafish. bioRxiv. 2019;[preprint] doi:10.1101/825257. |
ER transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, Cellular Adherence and Embryonic Gastrulation
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Citation:
bioRxiv. 2019;[preprint] doi:10.1101/822270 Epub:
Not Epub Abstract:
Protein glycosylation plays essential roles in protein structure, stability and activity such as cell adhesion. The cadherin... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Graham JB, Sunryd JC, Mathavan K, Weir E, Larsen ISB, Halim A, Clausen H, Cousin H, Alfandari D, Hebert DN. ER transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, Cellular Adherence and Embryonic Gastrulation. bioRxiv. 2019;[preprint] doi:10.1101/822270. |
Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing
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Citation:
Int J Mol Sci. 2019;20(21):5434. doi:10.3390/ijms20215434 Epub:
Not Epub Abstract:
Spinocerebellar ataxia type 3 (SCA3) is a devastating neurodegenerative disease for which there is currently no cure, nor... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: SCA3 patient-derived dermal fibroblasts Citation Extract: McIntosh CS, Aung-Htut MT, Fletcher S, Wilton SD. Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing. Int J Mol Sci. 2019;20(21):5434. doi:10.3390/ijms20215434. |