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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Loss-of-spen disturbs cardiac conduction in zebrafish mediated by impaired connexin43 function

Authors:
Rattka M, Westphal S, Pott A, Kessler M, Weinmann K, Just S, Rottbauer W
Citation:
Eur Heart J, 2019;40(Supplement_1):ehz746.0023. doi:10.1093/eurheartj/ehz746.0023
Epub:
Not Epub
Abstract:
Genome-wide association studies identified SPLIT ENDS (SPEN) gene as an interesting candidate in the pathogenesis of heart...
Link:
https://academic.oup.com/eurheartj/article-abstract/40/Supplement_1/ehz746.0023/5595331
Organism or Cell Type:
zebrafish
Citation Extract:
Rattka M, Westphal S, Pott A, Kessler M, Weinmann K, Just S, Rottbauer W. Loss-of-spen disturbs cardiac conduction in zebrafish mediated by impaired connexin43 function. Eur Heart J, 2019;40(Supplement_1):ehz746.0023. doi:10.1093/eurheartj/ehz746.0023.

Bioinformatics Screening of Genes Specific for Well-Regenerating Vertebrates Reveals c-answer, a Regulator of Brain Development and Regeneration

Authors:
Korotkova DD, Lyubetsky VA, Ivanova AS, Rubanov LI, Seliverstov AV, Zverkov OA, Martynova NY, Nesterenko AM, Tereshina MB, Peshkin L, Zaraisky AG
Citation:
Cell Rep. 2019 Oct 22;29(4):1027-1040.e6. doi: 10.1016/j.celrep.2019.09.038
Epub:
Not Epub
Abstract:
The molecular basis of higher regenerative capacity of cold-blooded animals comparing to warm-blooded ones is poorly understood...
Link:
https://www.sciencedirect.com/science/article/pii/S2211124719312264
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Korotkova DD, Lyubetsky VA, Ivanova AS, Rubanov LI, Seliverstov AV, Zverkov OA, Martynova NY, Nesterenko AM, Tereshina MB, Peshkin L, Zaraisky AG. Bioinformatics Screening of Genes Specific for Well-Regenerating Vertebrates Reveals c-answer, a Regulator of Brain Development and Regeneration. Cell Rep. 2019 Oct 22;29(4):1027-1040.e6. doi: 10.1016/j.celrep.2019.09.038.

Differential Expression of a Classic Cadherin Directs Tissue-Level Contractile Asymmetry during Neural Tube Closure

Authors:
Hashimoto H, Munro E
Citation:
Dev Cell. 2019 Oct 21;51(2):158-172.e4. doi: 10.1016/j.devcel.2019.10.001
Epub:
Not Epub
Abstract:
Embryos control force generation at tissue bound-aries, but how they do so remains poorly understood.Here we show how tissue-...
Link:
https://www.cell.com/developmental-cell/pdfExtended/S1534-5807(19)30810-X
Delivery Method:
microinjection
Organism or Cell Type:
Ciona robusta (AKA C. intestinalis; ascidian)
Citation Extract:
Hashimoto H, Munro E. Differential Expression of a Classic Cadherin Directs Tissue-Level Contractile Asymmetry during Neural Tube Closure. Dev Cell. 2019 Oct 21;51(2):158-172.e4. doi: 10.1016/j.devcel.2019.10.001.

Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia

Authors:
Wagner M, Osborn DPS, Gehweiler I, Nagel M, Ulmer U, Bakhtiari S, Amouri R, Boostani R, Hentati F, Hockley MM, Hölbling B, Schwarzmayr T, Karimiani EG, Kernstock C, Maroofian R, Müller-Felber W, Ozkan E, Padilla-Lopez S, Reich S, Reichbauer J, Darvish H, Shahmohammadibeni N, Tafakhori A, Vill K, Zuchner S, Kruer MC, Winkelmann J, Jamshidi Y, Schüle R
Citation:
Nat Commun. 2019 Oct 21;10(1):4790. doi: 10.1038/s41467-019-12620-9
Epub:
Not Epub
Abstract:
Alterations of Ca2+ homeostasis have been implicated in a wide range of neurodegenerative diseases. Ca2+ efflux from the...
Link:
https://www.nature.com/articles/s41467-019-12620-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wagner M, Osborn DPS, Gehweiler I, Nagel M, Ulmer U, Bakhtiari S, Amouri R, Boostani R, Hentati F, Hockley MM, Hölbling B, Schwarzmayr T, Karimiani EG, Kernstock C, Maroofian R, Müller-Felber W, Ozkan E, Padilla-Lopez S, Reich S, Reichbauer J, Darvish H, Shahmohammadibeni N, Tafakhori A, Vill K, Zuchner S, Kruer MC, Winkelmann J, Jamshidi Y, Schüle R. Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia. Nat Commun. 2019 Oct 21;10(1):4790. doi: 10.1038/s41467-019-12620-9.

The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis

Authors:
Cuenca A, Insinna C, Zhao H, John P, Weiss MA, Lu Q, Walia V, Specht S, Manivannan S, Stauffer J, Peden AA, Westlake CJ
Citation:
J Biol Chem. 2019 Oct 18;294(42):15418-15434. doi: 10.1074/jbc.RA119.008615. Epub 2019 Aug 29
Epub:
Not Epub
Abstract:
The primary cilium is a cellular sensor that detects light, chemicals, and movement and is important for morphogen and growth...
Link:
http://www.jbc.org/content/294/42/15418.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cuenca A, Insinna C, Zhao H, John P, Weiss MA, Lu Q, Walia V, Specht S, Manivannan S, Stauffer J, Peden AA, Westlake CJ. The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis. J Biol Chem. 2019 Oct 18;294(42):15418-15434. doi: 10.1074/jbc.RA119.008615. Epub 2019 Aug 29.

Brain aromatase modulates cardiac functions in embryonic zebrafish

Authors:
Ulhaq ZS
Citation:
Int J Vet Sci Med. 2019;7(1):31-4. doi:10.1080/23144599.2019.1675287
Epub:
Not Epub
Abstract:
Oestradiol (E2) is known as a female reproductive hormone with pleiotropic effects on the cardiovascular system. Local E2...
Link:
https://www.tandfonline.com/doi/full/10.1080/23144599.2019.1675287
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ulhaq ZS. Brain aromatase modulates cardiac functions in embryonic zebrafish. Int J Vet Sci Med. 2019;7(1):31-4. doi:10.1080/23144599.2019.1675287.

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

Authors:
Higashikuse Y, Mittal N, Arimura T, Yoon SH, Oda M, Enomoto H, Kaneda R, Fumiyuki Hattori F, Suzuki T, Kawakami A, Gasch A, Furukawa T, Labeit S, Fukuda K, Kimura A, Makino S
Citation:
Dis Model Mech. 2019;[Epub] doi:10.1242/dmm.041103
Epub:
Yes
Abstract:
Hypertrophic cardiomyopathy (HCM) is a hereditary disease characterized by cardiac hypertrophy with diastolic dysfunction. Gene...
Link:
https://dmm.biologists.org/content/early/2019/10/17/dmm.041103
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Higashikuse Y, Mittal N, Arimura T, Yoon SH, Oda M, Enomoto H, Kaneda R, Fumiyuki Hattori F, Suzuki T, Kawakami A, Gasch A, Furukawa T, Labeit S, Fukuda K, Kimura A, Makino S. Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients. Dis Model Mech. 2019;[Epub] doi:10.1242/dmm.041103.

MicroRNAs Establish the Right-Handed Dominance of the Heart Laterality Pathway in Vertebrates

Authors:
Rago L, Castroviejo N, Fazilaty H, Garcia-Asencio F, Ocaña OH, Galcerán J, Nieto MA
Citation:
Dev Cell. 2019 Oct 17. pii: S1534-5807(19)30768-3. doi: 10.1016/j.devcel.2019.09.012. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Despite their external bilateral symmetry, vertebrates have internal left/right (L/R) asymmetries required for optimal organ...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580719307683
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rago L, Castroviejo N, Fazilaty H, Garcia-Asencio F, Ocaña OH, Galcerán J, Nieto MA. MicroRNAs Establish the Right-Handed Dominance of the Heart Laterality Pathway in Vertebrates. Dev Cell. 2019 Oct 17. pii: S1534-5807(19)30768-3. doi: 10.1016/j.devcel.2019.09.012. [Epub ahead of print].

YWHA (14-3-3) protein isoforms and their interactions with CDC25B phosphatase in mouse oogenesis and oocyte maturation

Authors:
Eisa AA, De S, Detwiler A, Gilker E, Ignatious AC, Vijayaraghavan S, Kline D
Citation:
BMC Dev Biol. 2019 Oct 22;19(1):20. doi: 10.1186/s12861-019-0200-1
Epub:
Not Epub
Abstract:
BACKGROUND: Immature mammalian oocytes are held arrested at prophase I of meiosis by an inhibitory phosphorylation of cyclin-...
Link:
https://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861-019-0200-1
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Eisa AA, De S, Detwiler A, Gilker E, Ignatious AC, Vijayaraghavan S, Kline D. YWHA (14-3-3) protein isoforms and their interactions with CDC25B phosphatase in mouse oogenesis and oocyte maturation. BMC Dev Biol. 2019 Oct 22;19(1):20. doi: 10.1186/s12861-019-0200-1.

Antisense targeting of CD47 enhances human cytotoxic T-cell activity and increases survival of mice bearing B16 melanoma when combined with anti-CTLA4 and tumor irradiation

Authors:
Schwartz AL, Nath PR, Allgauer M, Lessey-Morillon EC, Sipes JM, Ridnour LA, Morillon Ii YM, Yu Z, Restifo NP, Roberts DD
Citation:
Cancer Immunol Immunother. 2019 Oct 18. doi: 10.1007/s00262-019-02397-7. [Epub ahead of print]
Epub:
Yes
Abstract:
Antibodies targeting the T-cell immune checkpoint cytotoxic T-lymphocyte antigen-4 (CTLA4) enhance the effectiveness of...
Link:
https://link.springer.com/article/10.1007%2Fs00262-019-02397-7
Delivery Method:
oligo bathing; injection
Organism or Cell Type:
cell culture: human T cells; C57BL/6 mice with B16F10 melanomas
Citation Extract:
Schwartz AL, Nath PR, Allgauer M, Lessey-Morillon EC, Sipes JM, Ridnour LA, Morillon Ii YM, Yu Z, Restifo NP, Roberts DD. Antisense targeting of CD47 enhances human cytotoxic T-cell activity and increases survival of mice bearing B16 melanoma when combined with anti-CTLA4 and tumor irradiation. Cancer Immunol Immunother. 2019 Oct 18. doi: 10.1007/s00262-019-02397-7. [Epub ahead of print].

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