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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12176 scientific papers returned from the database with the search filters currently being used below.
There are 12176 scientific papers returned from the database with the search filters currently being used below.
p63 is a cereblon substrate involved in thalidomide teratogenicity
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Citation:
Nat Chem Biol. 2019;[Epub ahead of print] doi:10.1038/s41589-019-0366-7 Epub:
Yes Abstract:
Cereblon (CRBN) is a primary target of thalidomide and mediates its multiple pharmacological activities, including teratogenic... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Asatsuma-Okumura T, Ando H, De Simone M, Yamamoto J, Sato T, Shimizu N, Asakawa K, Yamaguchi Y, Ito T, Guerrini L, Handa H. p63 is a cereblon substrate involved in thalidomide teratogenicity. Nat Chem Biol. 2019;[Epub ahead of print] doi:10.1038/s41589-019-0366-7. |
Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes
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Citation:
Biochem Biophys Res Commun. 2019 Oct 1. pii: S0006-291X(19)31825-X. doi: 10.1016/j.bbrc.2019.09.095. [Epub ahead of print] Epub:
Yes Abstract:
Duchenne muscular dystrophy (DMD) is a devastating muscle disorder caused by frameshift mutations in the DMD gene. DMD involves... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: iPSC-derived cardiomyocytes Citation Extract: Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Takizawa H, Aoki Y, Takeda S, Nakamura A. Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Commun. 2019 Oct 1. pii: S0006-291X(19)31825-X. doi: 10.1016/j.bbrc.2019.09.095. [Epub ahead of print]. |
ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing
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Citation:
Sci Rep. 2019;9(1):14248. doi:10.1038/s41598-019-50566-6 Epub:
Not Epub Abstract:
Modulation of energy metabolism to a highly glycolytic phenotype, i.e. Warburg effect, is a common phenotype of cancer and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Imle R, Wang B-T, Stützenberger N, Birkenhagen J, Tandon A, Carl M, Himmelreich N, Thiel C, Gröne H-J, Poschet G, Völkers M, Gülow K, Schröder A, Carillo S, Mittermayr S, Bones J, Kamiński MM, Kölker S, Sauer SW. ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing. Sci Rep. 2019;9(1):14248. doi:10.1038/s41598-019-50566-6. |
Size control of the inner ear via hydraulic feedback
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Citation:
Elife. 2019 Oct 1;8. pii: e39596. doi: 10.7554/eLife.39596 Epub:
Not Epub Abstract:
Animals make organs of precise size, shape, and symmetry but how developing embryos do this is largely unknown. Here, we... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Mosaliganti KR, Swinburne IA, Chan CU, Obholzer ND, Green AA, Tanksale S, Mahadevan L, Megason SG. Size control of the inner ear via hydraulic feedback. Elife. 2019 Oct 1;8. pii: e39596. doi: 10.7554/eLife.39596. |
Otoferlin Depletion Results in Abnormal Synaptic Ribbons and Altered Intracellular Calcium Levels in Zebrafish
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Citation:
Sci Rep. 2019;9(1):14273. doi:10.1038/s41598-019-50710-2 Epub:
Not Epub Abstract:
The protein otoferlin plays an essential role at the sensory hair cell synapse. Mutations in otoferlin result in deafness and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Manchanda A, Chatterjee P, Bonventre JA, Haggard DE, Kindt KS, Tanguay RL, Johnson CP. Otoferlin Depletion Results in Abnormal Synaptic Ribbons and Altered Intracellular Calcium Levels in Zebrafish. Sci Rep. 2019;9(1):14273. doi:10.1038/s41598-019-50710-2. |
VDAC1 is essential for neurite maintenance and the inhibition of its oligomerization protects spinal cord from demyelination and facilitates locomotor function recovery after spinal cord injury
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Citation:
Sci Rep. 2019 Oct 1;9(1):14063. doi: 10.1038/s41598-019-50506-4 Epub:
Not Epub Abstract:
During the progression of the neurodegenerative process, mitochondria participates in several intercellular signaling pathways... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: rat primary spinal cord Citation Extract: Paschon V, Morena BC, Correia FF, Beltrame GR, Dos Santos GB, Cristante AF, Kihara AH. VDAC1 is essential for neurite maintenance and the inhibition of its oligomerization protects spinal cord from demyelination and facilitates locomotor function recovery after spinal cord injury. Sci Rep. 2019 Oct 1;9(1):14063. doi: 10.1038/s41598-019-50506-4. |
Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis
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Citation:
Development. 2019 Sep 30;146(19). pii: dev179127. doi: 10.1242/dev.179127 Epub:
Not Epub Abstract:
Histone post-translational modifications are key gene expression regulators, but their rapid dynamics during development remain... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sato Y, Hilbert L, Oda H, Wan Y, Heddleston JM, Chew TL, Zaburdaev V, Keller P, Lionnet T, Vastenhouw N, Kimura H. Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis. Development. 2019 Sep 30;146(19). pii: dev179127. doi: 10.1242/dev.179127. |
NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress
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Citation:
eLife. 2019;8:e49044. doi:10.7554/eLife.49044 Epub:
Not Epub Abstract:
Base excision repair (BER) functions not only in the maintenance of genomic integrity but also in active DNA demethylation and... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Han D, Schomacher L, Schüle KM, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A, Niehrs C. NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress. eLife. 2019;8:e49044. doi:10.7554/eLife.49044. |
Defective Excitatory/Inhibitory Synaptic Balance and Increased Neuron Apoptosis in a Zebrafish Model of Dravet Syndrome
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Citation:
Cells. 2019 Oct 4;8(10):1199. doi: 10.3390/cells8101199. PMID: 31590334; PMCID: PMC6829503 Epub:
Not Epub Abstract:
Dravet syndrome is a type of severe childhood epilepsy that responds poorly to current anti-epileptic drugs. In recent years,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Brenet A, Hassan-Abdi R, Somkhit J, Yanicostas C, Soussi-Yanicostas N. Defective Excitatory/Inhibitory Synaptic Balance and Increased Neuron Apoptosis in a Zebrafish Model of Dravet Syndrome. Cells. 2019 Oct 4;8(10):1199. doi: 10.3390/cells8101199. PMID: 31590334; PMCID: PMC6829503. |
Preservation of zebrafish genetic resources through testis cryopreservation and spermatogonia transplantation
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Citation:
Sci Rep. 2019;9(1):13681. doi:10.1038/s41598-019-50169-1 Epub:
Not Epub Abstract:
Zebrafish is one of the most commonly used model organisms in biomedical, developmental and genetic research. The production of... Citation Extract: Marinović Z, Li Q, Lujić J, Iwasaki Y, Csenki Z, Urbányi B, Yoshizaki G, Horváth Á. Preservation of zebrafish genetic resources through testis cryopreservation and spermatogonia transplantation. Sci Rep. 2019;9(1):13681. doi:10.1038/s41598-019-50169-1. |