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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12353 scientific papers returned from the database with the search filters currently being used below.
There are 12353 scientific papers returned from the database with the search filters currently being used below.
Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm
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Citation:
Elife. 2016 Nov 2;5. pii: e19941. doi: 10.7554/eLife.19941 Epub:
Not Epub Abstract:
Proper organogenesis depends upon defining the precise dimensions of organ progenitor territories. Kidney progenitors originate... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Perens EA, Garavito-Aguilar ZV, Guio-Vega GP, Peña KT, Schindler YL, Yelon D. Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm. Elife. 2016 Nov 2;5. pii: e19941. doi: 10.7554/eLife.19941. |
Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation
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Citation:
Dev Cell. 2019 Nov 20. pii: S1534-5807(19)30911-6. doi: 10.1016/j.devcel.2019.11.003. [Epub ahead of print] Epub:
Yes Abstract:
The trachea and esophagus arise from the separation of a common foregut tube during early fetal development. Mutations in key... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Nasr T, Mancini P, Rankin SA, Edwards NA, Agricola ZN, Kenny AP, Kinney JL, Daniels K, Vardanyan J, Han L, Trisno SL, Cha SW, Wells JM, Kofron MJ, Zorn AM. Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation. Dev Cell. 2019 Nov 20. pii: S1534-5807(19)30911-6. doi: 10.1016/j.devcel.2019.11.003. [Epub ahead of print]. |
Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation
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Citation:
Dev Cell. 2019 Nov 20. pii: S1534-5807(19)30910-4. doi: 10.1016/j.devcel.2019.11.002. [Epub ahead of print] Epub:
Yes Abstract:
The esophagus and trachea arise from the dorsal and ventral aspects of the anterior foregut, respectively. Abnormal trachea-... Organism or Cell Type:
Xenopus laevis Citation Extract: Kim E, Jiang M, Huang H, Zhang Y, Tjota N, Gao X, Robert J, Gilmore N, Gan L, Que J. Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation. Dev Cell. 2019 Nov 20. pii: S1534-5807(19)30910-4. doi: 10.1016/j.devcel.2019.11.002. [Epub ahead of print]. |
The histone methyltransferase KMT2D, mutated in Kabuki syndrome patients, is required for neural crest cell formation and migration
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Citation:
Hum Mol Genet. 2019 Dec 9. pii: ddz284. doi: 10.1093/hmg/ddz284. [Epub ahead of print] Epub:
Yes Abstract:
Kabuki syndrome is an autosomal dominant developmental disorder with high similarities to CHARGE syndrome. It is characterized... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Schwenty-Lara J, Nehl D, Borchers A. The histone methyltransferase KMT2D, mutated in Kabuki syndrome patients, is required for neural crest cell formation and migration. Hum Mol Genet. 2019 Dec 9. pii: ddz284. doi: 10.1093/hmg/ddz284. [Epub ahead of print]. |
High-throughput custom capture sequencing identifies novel mutations in coloboma-associated genes: Mutation in DNA-binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma
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Citation:
Hum Mutat. 2019 Dec 9. doi: 10.1002/humu.23954. [Epub ahead of print] Epub:
Yes Abstract:
Uveal coloboma is a potentially blinding congenital ocular malformation caused by the failure of optic fissure closure during... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kalaskar VK, Alur RP, Li LK, Thomas JW, Sergeev YV, Blain D, Hufnagel RB, Cogliati T, Brooks BP. High-throughput custom capture sequencing identifies novel mutations in coloboma-associated genes: Mutation in DNA-binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma. Hum Mutat. 2019 Dec 9. doi: 10.1002/humu.23954. [Epub ahead of print]. |
The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development
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Citation:
Hum Mol Genet. 2019 Dec 9. pii: ddz278. doi: 10.1093/hmg/ddz278. [Epub ahead of print] Epub:
Yes Abstract:
Mutations in the key transcription factor, SOX2, alone account for 20% of anophthalmia (no eye) and microphthalmia (small eye)... Organism or Cell Type:
zebrafish Citation Extract: Dash S, Brastrom LK, Patel SD, Scott CA, Slusarski DC, Lachke SA. The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development. Hum Mol Genet. 2019 Dec 9. pii: ddz278. doi: 10.1093/hmg/ddz278. [Epub ahead of print]. |
EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway
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Citation:
Hum Genomics. 2019 Dec 5;13(1):63. doi: 10.1186/s40246-019-0238-y Epub:
Not Epub Abstract:
BACKGROUND: Mandibulofacial dysostosis with microcephaly (MFDM) is characteristic of multiple skeletal anomalies comprising... Organism or Cell Type:
zebrafish Citation Extract: Wu J, Yang Y, He Y, Li Q, Wang X, Sun C, Wang L, An Y, Luo F. EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway. Hum Genomics. 2019 Dec 5;13(1):63. doi: 10.1186/s40246-019-0238-y. |
Glis3 as a critical regulator of thyroid primordium specification
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Citation:
Thyroid. 2019 Dec 4. doi: 10.1089/thy.2019.0196. [Epub ahead of print] Epub:
Yes Abstract:
BACKGROUND: GLIS3 (GLI-Similar protein 3) is a transcription factor involved in several cellular processes. Homozygous... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Rurale G, Marelli F, Duminuco P, Persani L. Glis3 as a critical regulator of thyroid primordium specification. Thyroid. 2019 Dec 4. doi: 10.1089/thy.2019.0196. [Epub ahead of print]. |
IRSp53 shapes the plasma membrane and controls polarized transport at the nascent lumen during epithelial morphogenesis
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Citation:
bioRxiv. 2019;[preprint] doi: https://doi.org/10.1101/856369 Epub:
Not Epub Abstract:
Establishment of apical–basal cell polarity is necessary for generation of luminal and tubular structures during epithelial... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bisi S, Rizvi SA, Marchesi S, Carra D, Beznoussenko GV, Ferrara I, Deflorian G, Mironov A, Bertalot G, Pisati F, Oldani A, Cattaneo A, Pece S, Viale G, Bachi A, Tripodo C, Scita G, Disanza A. IRSp53 shapes the plasma membrane and controls polarized transport at the nascent lumen during epithelial morphogenesis. bioRxiv. 2019;[preprint] doi: https://doi.org/10.1101/856369 . |
Massive centriole production can occur in the absence of deuterosomes in multiciliated cells
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Citation:
Nat Cell Biol. 2019;21:1544–1552. doi: 10.1038/s41556-019-0427-x. Epub:
Not Epub Abstract:
Multiciliated cells (MCCs) amplify large numbers of centrioles that convert into basal bodies, which are required for producing... Organism or Cell Type:
cell culture: Xenopus epithelial cells Citation Extract: Mercey O, Levine MS, LoMastro GM, Rostaing P, Brotslaw E, Gomez V, Kumar A, Spassky N, Mitchell BJ, Meunier A, Holland AJ. Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Nat Cell Biol. 2019;21:1544–1552. doi: 10.1038/s41556-019-0427-x.. |