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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Gastrointestinal Neurons Expressing HCN4 Regulate Retrograde Peristalsis

Authors:
Fujii K, Nakajo K, Egashira Y, Yamamoto Y, Kitada K, Taniguchi K, Kawai M, Tomiyama H, Kawakami K, Uchiyama K, Ono F
Citation:
Cell Rep. 2020;30(9):2879-88. doi:10.1016/j.celrep.2020.02.024
Epub:
Not Epub
Abstract:
Peristalsis is indispensable for physiological function of the gut. The enteric nervous system (ENS) plays an important role in...
Link:
https://www.sciencedirect.com/science/article/pii/S2211124720301856
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fujii K, Nakajo K, Egashira Y, Yamamoto Y, Kitada K, Taniguchi K, Kawai M, Tomiyama H, Kawakami K, Uchiyama K, Ono F. Gastrointestinal Neurons Expressing HCN4 Regulate Retrograde Peristalsis. Cell Rep. 2020;30(9):2879-88. doi:10.1016/j.celrep.2020.02.024.

Amelioration of Large Bile Duct Damage by Histamine-2 Receptor Vivo-Morpholino Treatment

Authors:
Kennedy L, Meadows V, Kyritsi K, Pham L, Kundu D, Kulkarni R, Cerritos K, Demieville J, Hargrove L, Glaser S, Zhou T, Jaeger V, Alpini G, Francis H
Citation:
Am J Pathol. 2020;190( 5):1018–29 doi:10.1016/j.ajpath.2020.01.013
Epub:
Not Epub
Abstract:
Histamine binds to one of the four G-protein–coupled receptors expressed by large cholangiocytes. Histamine specifically...
Link:
https://ajp.amjpathol.org/article/S0002-9440(20)30093-6/fulltext
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Kennedy L, Meadows V, Kyritsi K, Pham L, Kundu D, Kulkarni R, Cerritos K, Demieville J, Hargrove L, Glaser S, Zhou T, Jaeger V, Alpini G, Francis H. Amelioration of Large Bile Duct Damage by Histamine-2 Receptor Vivo-Morpholino Treatment. Am J Pathol. 2020;190( 5):1018–29 doi:10.1016/j.ajpath.2020.01.013.

Genome-wide molecular effects of the neuropsychiatric 16p11 CNVs in an iPSC-to-iN neuronal model

Authors:
Ward TR, Zhang X, Louis C. Leung, Zhou B, Muench K, Roth JG, Khechaduri A, Plastini MJ, Charlton C, Pattni R, Ho S, Ho M, Huang Y, Hallmayer JF, Mourrain P, Palmer TD, Urban AE
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.02.09.940965
Epub:
Not Epub
Abstract:
Copy number variants (CNVs), either deletions or duplications, at the 16p11.2 locus in the human genome are known to increase...
Link:
https://www.biorxiv.org/content/10.1101/2020.02.09.940965v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ward TR, Zhang X, Louis C. Leung, Zhou B, Muench K, Roth JG, Khechaduri A, Plastini MJ, Charlton C, Pattni R, Ho S, Ho M, Huang Y, Hallmayer JF, Mourrain P, Palmer TD, Urban AE. Genome-wide molecular effects of the neuropsychiatric 16p11 CNVs in an iPSC-to-iN neuronal model. bioRxiv. 2020;[preprint] doi:10.1101/2020.02.09.940965 .

Transcriptome profiling of the branchial arches reveals cell type composition and a conserved signature of neural crest cell invasion

Authors:
Morrison JA, McLennan R, Teddy JM, Scott AR, Kasemeier-Kulesa K-K, Gogol MM, Kulesa PM
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.02.28.969915
Epub:
Not Epub
Abstract:
The vertebrate branchial arches that give rise to structures of the head, neck, and heart form with very dynamic tissue growth...
Link:
https://www.biorxiv.org/content/10.1101/2020.02.28.969915v1
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Morrison JA, McLennan R, Teddy JM, Scott AR, Kasemeier-Kulesa K-K, Gogol MM, Kulesa PM. Transcriptome profiling of the branchial arches reveals cell type composition and a conserved signature of neural crest cell invasion. bioRxiv. 2020;[preprint] doi:10.1101/2020.02.28.969915 .

Prmt5 promotes vascular morphogenesis in zebrafish independently of its methyltransferase activity

Authors:
Quillien A, Boulet M, Ethuin S, Vandel L
Citation:
BioRxiv. 2020;[preprint] doi:10.1101/2020.02.27.967810
Epub:
Not Epub
Abstract:
In vertebrate, blood cell formation is tightly associated with the development of the vascular system. While the...
Link:
https://www.biorxiv.org/content/10.1101/2020.02.27.967810v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Quillien A, Boulet M, Ethuin S, Vandel L. Prmt5 promotes vascular morphogenesis in zebrafish independently of its methyltransferase activity. BioRxiv. 2020;[preprint] doi:10.1101/2020.02.27.967810.

Zebrafish miR-462-731 is required for digestive organs development

Authors:
Huang Y, Huang C-X, Wang W-F, Liu H, Wang H-L
Citation:
Comp Biochem Physiol Part D Genomics Proteomics. 2020 Feb 29;34:100679. doi: 10.1016/j.cbd.2020.100679. [Epub ahead of print]
Epub:
Not Epub
Abstract:
With-no-lysine (K)-1 (WNK1) is the founding member of family of four protein kinases with atypical placement of catalytic...
Link:
https://www.sciencedirect.com/science/article/pii/S1744117X20300265
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Huang Y, Huang C-X, Wang W-F, Liu H, Wang H-L. Zebrafish miR-462-731 is required for digestive organs development. Comp Biochem Physiol Part D Genomics Proteomics. 2020 Feb 29;34:100679. doi: 10.1016/j.cbd.2020.100679. [Epub ahead of print].

WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis

Authors:
Sie Z-L, Li R-Y, Sampurna PB, Hsu P-J, Liu S-C, Wang H-D, Huang C-L, Yuh C-H
Citation:
Cancers. 2020;12(3):[Epub] doi:0.3390/cancers12030575
Epub:
Not Epub
Abstract:
With-no-lysine (K)-1 (WNK1) is the founding member of family of four protein kinases with atypical placement of catalytic...
Link:
https://www.mdpi.com/2072-6694/12/3/575
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sie Z-L, Li R-Y, Sampurna PB, Hsu P-J, Liu S-C, Wang H-D, Huang C-L, Yuh C-H. WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis. Cancers. 2020;12(3):[Epub] doi:0.3390/cancers12030575.

Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy

Authors:
Misra C, Bangru S, Lin F, Lam K, Koenig SN, Lubbers ER, Hedhli J, Murphy NP, Parker DJ, Dobrucki LW, Cooper TA, Tajkhorshid E, Mohler PJ, Kalsotra A
Citation:
Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.01.037
Epub:
Yes
Abstract:
Myotonic dystrophy type 1 (DM1) is a multisystemic genetic disorder caused by the CTG repeat expansion in the 3′-untranslated...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580720300691
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HL-1
Citation Extract:
Misra C, Bangru S, Lin F, Lam K, Koenig SN, Lubbers ER, Hedhli J, Murphy NP, Parker DJ, Dobrucki LW, Cooper TA, Tajkhorshid E, Mohler PJ, Kalsotra A. Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy. Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.01.037.

Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo

Authors:
Floc'hlay S, Jimenez MDM, Hernandez C, Haillot E, Thomas-Chollier M, Lepage T, Thieffry D
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.02.26.966556
Epub:
Not Epub
Abstract:
During sea urchin development, secretion of Nodal and BMP2/4 ligands and their antagonists Lefty and Chordin from a ventral...
Link:
https://www.biorxiv.org/content/10.1101/2020.02.26.966556v1
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotus lividus (sea urchin)
Citation Extract:
Floc'hlay S, Jimenez MDM, Hernandez C, Haillot E, Thomas-Chollier M, Lepage T, Thieffry D. Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo. bioRxiv. 2020;[preprint] doi:10.1101/2020.02.26.966556.

Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling

Authors:
Park D-S, Yoon G-H, Kim E-Y, Lee T, Kim K, Lee PCW, Chang E-J, Choi S-C
Citation:
EMBO Rep. 2020;[Epub] doi:10.15252/embr.201948693
Epub:
Yes
Abstract:
The tumor suppressor Smad4, a key mediator of the TGF‐β/BMP pathways, is essential for development and tissue homeostasis....
Link:
https://www.embopress.org/doi/abs/10.15252/embr.201948693
Organism or Cell Type:
Xenopus
Citation Extract:
Park D-S, Yoon G-H, Kim E-Y, Lee T, Kim K, Lee PCW, Chang E-J, Choi S-C. Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling. EMBO Rep. 2020;[Epub] doi:10.15252/embr.201948693.

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