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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism

Authors:
Messina A, Pulli K, Santini S, Acierno J, Känsäkoski J, Cassatella D, Xu C, Casoni F, Malone SA, Ternier G, Conte D, Sidis Y, Tommiska J, Vaaralahti K, Dwyer A, Gothilf Y, Merlo GR, Santoni F, Niederländer NJ, Giacobini P, Raivio T, Pitteloud N
Citation:
Am J Hum Genet. 2020 Jan 2;106(1):58-70. doi: 10.1016/j.ajhg.2019.12.003. Epub 2019 Dec 26
Epub:
Not Epub
Abstract:
Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disorder characterized by infertility and the absence of...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0002929719304677
Organism or Cell Type:
zebrafish
Citation Extract:
Messina A, Pulli K, Santini S, Acierno J, Känsäkoski J, Cassatella D, Xu C, Casoni F, Malone SA, Ternier G, Conte D, Sidis Y, Tommiska J, Vaaralahti K, Dwyer A, Gothilf Y, Merlo GR, Santoni F, Niederländer NJ, Giacobini P, Raivio T, Pitteloud N. Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism. Am J Hum Genet. 2020 Jan 2;106(1):58-70. doi: 10.1016/j.ajhg.2019.12.003. Epub 2019 Dec 26.

H3K27me3 suppresses sister-lineage somatic gene expression in late embryonic germline cells of the ascidian, Halocynthia roretzi

Authors:
Zheng T, Nakamoto A, Kumano G
Citation:
Dev Biol. 2020 Jan 2. pii: S0012-1606(19)30499-3. doi: 10.1016/j.ydbio.2019.12.017. [Epub ahead of print]
Epub:
Yes
Abstract:
Protection of the germline from somatic differentiation programs is crucial for germ cell development. In many animals, whose...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160619304993
Delivery Method:
microinjection
Organism or Cell Type:
Halocynthia roretzi (ascidian)
Citation Extract:
Zheng T, Nakamoto A, Kumano G. H3K27me3 suppresses sister-lineage somatic gene expression in late embryonic germline cells of the ascidian, Halocynthia roretzi. Dev Biol. 2020 Jan 2. pii: S0012-1606(19)30499-3. doi: 10.1016/j.ydbio.2019.12.017. [Epub ahead of print].

Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos

Authors:
Zuccarini G, D'Atri I, Cottone E, Mackie K, Shainer I, Gothilf Y, Provero P, Bovolin P, Merlo GR
Citation:
Int J Mol Sci. 2019 Dec 25;21(1). pii: E168. doi: 10.3390/ijms21010168
Epub:
Not Epub
Abstract:
The G protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), and their endocannabinoid (eCBs) ligands, have...
Link:
https://www.mdpi.com/1422-0067/21/1/168/htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zuccarini G, D'Atri I, Cottone E, Mackie K, Shainer I, Gothilf Y, Provero P, Bovolin P, Merlo GR. Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos. Int J Mol Sci. 2019 Dec 25;21(1). pii: E168. doi: 10.3390/ijms21010168.

Claudin-7b and Claudin-h are required for controlling cilia morphogenesis in the zebrafish kidney

Authors:
Jin M, Wang D, Xu W, Wang H, Cao Y
Citation:
Mech Dev. 2019 Dec 27:103595. doi: 10.1016/j.mod.2019.103595. [Epub ahead of print]
Epub:
Yes
Abstract:
Claudins are a family of proteins which are the most important components of the tight junctions. The location of Claudins on...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0925477319301510
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jin M, Wang D, Xu W, Wang H, Cao Y. Claudin-7b and Claudin-h are required for controlling cilia morphogenesis in the zebrafish kidney. Mech Dev. 2019 Dec 27:103595. doi: 10.1016/j.mod.2019.103595. [Epub ahead of print].

CFAP43 modulates ciliary beating in mouse and Xenopus

Authors:
Rachev E, Schuster-Gossler K, Fuhl F, Ott T, Tveriakhina L, Beckers A, Hegermann J, Boldt K, Mai M, Kremmer E, Ueffing M, Blum M, Gossler A
Citation:
Dev Biol. 2019 Dec 27. pii: S0012-1606(19)30471-3. doi: 10.1016/j.ydbio.2019.12.010. [Epub ahead of print]
Epub:
Yes
Abstract:
Malfunctions of motile cilia cause a variety of developmental defects and diseases in humans and animal model organisms....
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160619304713
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Rachev E, Schuster-Gossler K, Fuhl F, Ott T, Tveriakhina L, Beckers A, Hegermann J, Boldt K, Mai M, Kremmer E, Ueffing M, Blum M, Gossler A. CFAP43 modulates ciliary beating in mouse and Xenopus. Dev Biol. 2019 Dec 27. pii: S0012-1606(19)30471-3. doi: 10.1016/j.ydbio.2019.12.010. [Epub ahead of print].

Differential Induction of SOCS Isoforms by Leishmania donovani Impairs Macrophage-T Cell Cross-Talk and Host Defense

Authors:
Chandrakar P, Parmar N, Descoteaux A, Kar S
Citation:
J Immunol. 2019 Dec 27. pii: ji1900412. doi: 10.4049/jimmunol.1900412. [Epub ahead of print]
Epub:
Yes
Abstract:
Immune evasion strategies adopted by Leishmania donovani involve the exploitation of suppressor of cytokine signaling (SOCS)...
Link:
https://www.jimmunol.org/content/early/2019/12/26/jimmunol.1900412.long
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
BALB/c mice
Citation Extract:
Chandrakar P, Parmar N, Descoteaux A, Kar S. Differential Induction of SOCS Isoforms by Leishmania donovani Impairs Macrophage-T Cell Cross-Talk and Host Defense. J Immunol. 2019 Dec 27. pii: ji1900412. doi: 10.4049/jimmunol.1900412. [Epub ahead of print].

Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene

Authors:
Gawel K, Turski WA, van der Ent W, Mathai BJ, Kirstein-Smardzewska KJ, Simonsen A, Esguerra CV
Citation:
Mol Neurobiol. 2019 Dec 26. doi: 10.1007/s12035-019-01860-x. [Epub ahead of print]
Epub:
Yes
Abstract:
The CACNA1A gene encodes the pore-forming α1 subunit of voltage-gated P/Q type Ca2+ channels (Cav2.1). Mutations in this gene,...
Link:
https://link.springer.com/article/10.1007%2Fs12035-019-01860-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gawel K, Turski WA, van der Ent W, Mathai BJ, Kirstein-Smardzewska KJ, Simonsen A, Esguerra CV. Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene. Mol Neurobiol. 2019 Dec 26. doi: 10.1007/s12035-019-01860-x. [Epub ahead of print].

A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo

Authors:
Zhong G, Wang H, He W, Li Y, Mou H, Tickner ZJ, Tran MH, Ou T, Yin Y, Diao H, Farzan M
Citation:
Nat Biotechnol. 2019;[Epub ahead print] doi:10.1038/s41587-019-0357-y
Epub:
Not Epub
Abstract:
Widespread use of gene therapy technologies is limited in part by the lack of small genetic switches with wide dynamic ranges...
Link:
https://www.nature.com/articles/s41587-019-0357-y
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell cultures, mice
Citation Extract:
Zhong G, Wang H, He W, Li Y, Mou H, Tickner ZJ, Tran MH, Ou T, Yin Y, Diao H, Farzan M. A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo. Nat Biotechnol. 2019;[Epub ahead print] doi:10.1038/s41587-019-0357-y.

Hypomorphic zebrafish models mimic the musculoskeletal phenotype of β4GalT7-deficient Ehlers-Danlos syndrome

Authors:
Delbaere S, Van Damme T, Syx D, Symoens S, Coucke P, Willaert A, Malfait F
Citation:
Matrix Biol. 2019 Dec 17. pii: S0945-053X(19)30400-7. doi: 10.1016/j.matbio.2019.12.002. [Epub ahead of print]
Epub:
Yes
Abstract:
β4GalT7 is a transmembrane Golgi enzyme, encoded by B4GALT7, that plays a pivotal role in the proteoglycan linker region...
Link:
https://www.sciencedirect.com/science/article/pii/S0945053X19304007
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Delbaere S, Van Damme T, Syx D, Symoens S, Coucke P, Willaert A, Malfait F. Hypomorphic zebrafish models mimic the musculoskeletal phenotype of β4GalT7-deficient Ehlers-Danlos syndrome. Matrix Biol. 2019 Dec 17. pii: S0945-053X(19)30400-7. doi: 10.1016/j.matbio.2019.12.002. [Epub ahead of print].

Enhanced canonical Wnt signaling during early zebrafish development perturbs the interaction of cardiac mesoderm and pharyngeal endoderm and causes thyroid specification defects

Authors:
Vandernoot I, Haerlingen B, Trubiroha A, Gillotay P, Janssens V, Opitz R, Costagliola S
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/2019.12.19.880815
Epub:
Not Epub
Abstract:
Background: Congenital hypothyroidism (CH) due to thyroid dysgenesis is a frequent congenital endocrine disorder for which the...
Link:
https://www.biorxiv.org/content/10.1101/2019.12.19.880815v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vandernoot I, Haerlingen B, Trubiroha A, Gillotay P, Janssens V, Opitz R, Costagliola S. Enhanced canonical Wnt signaling during early zebrafish development perturbs the interaction of cardiac mesoderm and pharyngeal endoderm and causes thyroid specification defects. bioRxiv. 2019;[preprint] doi:10.1101/2019.12.19.880815.

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