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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis

Authors:
Pijuan-Sala B, Wilson NK, Xia J, Hou X, Hannah RL, Kinston S, Calero-Nieto FJ, Olivier Poirion O, Preissl S, Liu F, Göttgens B
Citation:
Nat Cell Biol. 2020;[Epub ahead of print] doi:10.1038/s41556-020-0489-9
Epub:
Yes
Abstract:
During mouse embryonic development, pluripotent cells rapidly divide and diversify, yet the regulatory programs that define the...
Link:
https://www.nature.com/articles/s41556-020-0489-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pijuan-Sala B, Wilson NK, Xia J, Hou X, Hannah RL, Kinston S, Calero-Nieto FJ, Olivier Poirion O, Preissl S, Liu F, Göttgens B. Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis. Nat Cell Biol. 2020;[Epub ahead of print] doi:10.1038/s41556-020-0489-9.

RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

Authors:
Santoriello C, Sporrij A, Yang S, Flynn RA, Henriques T, Dorjsuren B, Greig EC, McCall W, Stanhope ME, Fazio M, Superdock M, Lichtig A, Adatto I, Brian J. Abraham BJ, Kalocsay M, Jurynec M, Zhou Y, Adelman K, Calo E, Zon LI
Citation:
Nat Cell Biol. 2020;[Epub ahead of print] doi:10.1038/s41556-020-0493-0
Epub:
Yes
Abstract:
The availability of nucleotides has a direct impact on transcription. The inhibition of dihydroorotate dehydrogenase (DHODH)...
Link:
https://www.nature.com/articles/s41556-020-0493-0
Organism or Cell Type:
zebrafish
Citation Extract:
Santoriello C, Sporrij A, Yang S, Flynn RA, Henriques T, Dorjsuren B, Greig EC, McCall W, Stanhope ME, Fazio M, Superdock M, Lichtig A, Adatto I, Brian J. Abraham BJ, Kalocsay M, Jurynec M, Zhou Y, Adelman K, Calo E, Zon LI. RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nat Cell Biol. 2020;[Epub ahead of print] doi:10.1038/s41556-020-0493-0.

Oocytes mount a noncanonical DNA damage response involving APC-Cdh1–mediated proteolysis

Authors:
Subramanian GN, Greaney J, Wei Z, Becherel O, Lavin M, Homer HA
Citation:
J Cell Biol. 2020;219(4):[Epub ahead of print] doi:10.1083/jcb.201907213
Epub:
Yes
Abstract:
In mitotic cells, DNA damage induces temporary G2 arrest via inhibitory Cdk1 phosphorylation. In contrast, fully grown G2-stage...
Link:
https://rupress.org/jcb/article-abstract/219/4/e201907213/151594/Oocytes-mount-a-noncanonical-DNA-damage-response
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Subramanian GN, Greaney J, Wei Z, Becherel O, Lavin M, Homer HA. Oocytes mount a noncanonical DNA damage response involving APC-Cdh1–mediated proteolysis. J Cell Biol. 2020;219(4):[Epub ahead of print] doi:10.1083/jcb.201907213.

DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies

Authors:
Reid AL, Wang Y, Samani A, Hightower RM, Lopez MA, Shawn R Gilbert, Ianov L, Crossman DK, Italia LJD, Millay DP, van Groen T, Halade GV, Alexander MS
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.03.27.010223
Epub:
Not Epub
Abstract:
DOCK3 is a member of the DOCK family of guanine nucleotide exchange factors that function to regulate cell migration, fusion,...
Link:
https://www.biorxiv.org/content/10.1101/2020.03.27.010223v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Reid AL, Wang Y, Samani A, Hightower RM, Lopez MA, Shawn R Gilbert, Ianov L, Crossman DK, Italia LJD, Millay DP, van Groen T, Halade GV, Alexander MS. DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies. bioRxiv. 2020;[preprint] doi:10.1101/2020.03.27.010223 .

Triploidization Disrupts Early Reproductive Development of Females and Alters Phenotypic Sex Ratios of Sablefish Anoplopoma fimbria

Authors:
Luckenbach JA, Hayman ES, Fairgrieve WT, Wong T-T, Zohar Y, Huynh TB
Citation:
Presentation at Aquaculture America 2020, Honolulu Hawaii
Epub:
Not Epub
Abstract:
Escapement is an ecological concern for marine finfishes reared in net-pen systems. To mitigate this risk, we have initiated...
Link:
https://www.was.org/Meeting/Program/PaperDetail/156393
Delivery Method:
Vivo-Morpholino bathing
Organism or Cell Type:
Anoplopoma fimbria (black cod)
Citation Extract:
Luckenbach JA, Hayman ES, Fairgrieve WT, Wong T-T, Zohar Y, Huynh TB. Triploidization Disrupts Early Reproductive Development of Females and Alters Phenotypic Sex Ratios of Sablefish Anoplopoma fimbria. Presentation at Aquaculture America 2020, Honolulu Hawaii.

Live imaging defines the dynamics and molecular basis of in vivo mitophagy

Authors:
Wrighton PJ, Shwartz A, Heo J-M, Quenzer ED, LaBella KA, Harper JW, Wolfram Goessling W
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.03.26.010405
Epub:
Not Epub
Abstract:
Mitophagy defects are linked to aging, sarcopenia, and neurodegenerative diseases. To target this process for clinical...
Link:
https://www.biorxiv.org/content/10.1101/2020.03.26.010405v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wrighton PJ, Shwartz A, Heo J-M, Quenzer ED, LaBella KA, Harper JW, Wolfram Goessling W. Live imaging defines the dynamics and molecular basis of in vivo mitophagy. bioRxiv. 2020;[preprint] doi:10.1101/2020.03.26.010405 .

GABA-Induced GnRH Release Triggers Chordate Metamorphosis

Authors:
Hozumi A, Matsunobu S, Mita K, Treen N, Sugihara T, Horie T, Sakuma T, Yamamoto T, Shiraishi A, Hamada M, Satoh N, Sakurai K, Satake H, Sasakura Y
Citation:
Curr Biol. 2020;[Epub ahead of print] doi:10.1016/j.cub.2020.02.003
Epub:
Yes
Abstract:
Metamorphosis, a widespread life history strategy in metazoans, allows dispersal and use of different ecological niches through...
Link:
https://www.cell.com/current-biology/fulltext/S0960-9822(20)30176-7
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intentinalis (ascidian)
Citation Extract:
Hozumi A, Matsunobu S, Mita K, Treen N, Sugihara T, Horie T, Sakuma T, Yamamoto T, Shiraishi A, Hamada M, Satoh N, Sakurai K, Satake H, Sasakura Y. GABA-Induced GnRH Release Triggers Chordate Metamorphosis. Curr Biol. 2020;[Epub ahead of print] doi:10.1016/j.cub.2020.02.003.

Loss of ap4s1 in zebrafish leads to neurodevelopmental defects resembling spastic paraplegia 52

Authors:
D’Amore A, Tessa A, Naef V, Bassi MT, Citterio A, Romaniello R, Fichi G, Galatolo D, Mero S, Battini R, Bertocci G, Baldacci J, Sicca F, Gemignani F, Ricca I, Rubegni A, Hirst J, Marchese M, Sahin M, Ebrahimi‐Fakhari D, Filippo M. Santorelli FM
Citation:
Ann Clin Transl Neurol. 2020;[Epub] doi:10.1002/acn3.51018
Epub:
Yes
Abstract:
Autosomal recessive spastic paraplegia 52 is caused by biallelic mutations in AP4S1 which encodes a subunit of the adaptor...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.51018
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
D’Amore A, Tessa A, Naef V, Bassi MT, Citterio A, Romaniello R, Fichi G, Galatolo D, Mero S, Battini R, Bertocci G, Baldacci J, Sicca F, Gemignani F, Ricca I, Rubegni A, Hirst J, Marchese M, Sahin M, Ebrahimi‐Fakhari D, Filippo M. Santorelli FM. Loss of ap4s1 in zebrafish leads to neurodevelopmental defects resembling spastic paraplegia 52. Ann Clin Transl Neurol. 2020;[Epub] doi:10.1002/acn3.51018.

Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium

Authors:
Guo Y, Cheng BYL, Wang D, Ma ACH, He B-L, Man TK, Cheung MPL, Shi X, Ng NKL, Leung AYH
Citation:
Stem Cell Rep. 2020;[Epub ahead of print] doi:10.1016/j.stemcr.2020.02.012
Epub:
Yes
Abstract:
ADP-ribosylation factor-like 4aa (Arl4aa) is a member of the ADP-ribosylation factor family. It is expressed in hematopoietic...
Link:
https://www.sciencedirect.com/science/article/pii/S2213671120300680
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Guo Y, Cheng BYL, Wang D, Ma ACH, He B-L, Man TK, Cheung MPL, Shi X, Ng NKL, Leung AYH. Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium. Stem Cell Rep. 2020;[Epub ahead of print] doi:10.1016/j.stemcr.2020.02.012.

De Novo Phosphoinositide Synthesis in Zebrafish Is Required for Triad Formation but Not Essential for Myogenesis

Authors:
Dowling JJ, Smith L, Fabian L, Al-Maawali A, Noche RR
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.03.24.005306
Epub:
Not Epub
Abstract:
Phosphoinositides (PIPs) and their regulatory enzymes are key players in many cellular processes and are required for aspects...
Link:
https://www.biorxiv.org/content/10.1101/2020.03.24.005306v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dowling JJ, Smith L, Fabian L, Al-Maawali A, Noche RR. De Novo Phosphoinositide Synthesis in Zebrafish Is Required for Triad Formation but Not Essential for Myogenesis. bioRxiv. 2020;[preprint] doi:10.1101/2020.03.24.005306.

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