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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Abnormal expression of GABAA receptor sub-units and hypomotility upon loss of gabra1 in zebrafish

Authors:
Reyes-Nava N, Yu H-C, Coughlin CR II, Shaikh TH, Quintana AM
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.31.929455
Epub:
Not Epub
Abstract:
We used whole exome sequencing (WES) to determine the genetic etiology of a patient with a multi-system disorder characterized...
Link:
https://www.biorxiv.org/content/10.1101/2020.01.31.929455v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Reyes-Nava N, Yu H-C, Coughlin CR II, Shaikh TH, Quintana AM. Abnormal expression of GABAA receptor sub-units and hypomotility upon loss of gabra1 in zebrafish. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.31.929455 .

Sox2 and canonical Wnt signaling interact to activate a developmental checkpoint coordinating morphogenesis with mesodermal fate acquisition

Authors:
Kinney BA, Row RH, Tseng Y-J, Weidmann MD, Knaut H, Martin BL
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.29.924050
Epub:
Not Epub
Abstract:
Animal embryogenesis requires a precise coordination between morphogenesis and cell fate specification. It is unclear if there...
Link:
https://www.biorxiv.org/content/10.1101/2020.01.29.924050v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kinney BA, Row RH, Tseng Y-J, Weidmann MD, Knaut H, Martin BL. Sox2 and canonical Wnt signaling interact to activate a developmental checkpoint coordinating morphogenesis with mesodermal fate acquisition. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.29.924050.

Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons

Authors:
Sitaraman S, Yadav G, Jabeen S, Agarwal V, Thirumalai V
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.31.928242
Epub:
Not Epub
Abstract:
Gap junctions between neurons serve as electrical synapses, in addition to conducting metabolites and signaling molecules....
Link:
https://www.biorxiv.org/content/10.1101/2020.01.31.928242v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sitaraman S, Yadav G, Jabeen S, Agarwal V, Thirumalai V. Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.31.928242.

Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development

Authors:
Rojas-Benítez D, Allende ML
Citation:
Int J Mol Sci. 2020;21(3):925. doi:10.3390/ijms21030925
Epub:
Not Epub
Abstract:
Transfer RNAs (tRNAs) are the most post-transcriptionally modified RNA species. Some of these modifications, especially the...
Link:
https://www.mdpi.com/1422-0067/21/3/925
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rojas-Benítez D, Allende ML. Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development. Int J Mol Sci. 2020;21(3):925. doi:10.3390/ijms21030925.

Lnc-ECAL-1 controls cerebrovascular homeostasis by targeting endothelium-specific tight junction protein Cldn5b

Authors:
Li F-F, Liang Y-L, Zhang J-J, Jing Q
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.30.926279
Epub:
Not Epub
Abstract:
Cerebrovascular disorder-induced brain blood flow interruption or intracranial hemorrhage pose a great threaten to health....
Link:
https://www.biorxiv.org/content/10.1101/2020.01.30.926279v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li F-F, Liang Y-L, Zhang J-J, Jing Q. Lnc-ECAL-1 controls cerebrovascular homeostasis by targeting endothelium-specific tight junction protein Cldn5b. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.30.926279 .

Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs

Authors:
Zhang F, Li X, He M, Ye D, Xiong F, Amin G, Zhu Z, Sun Y
Citation:
J Genet Genom. 2020;[Epub] doi:10.1016/j.jgg.2019.12.004
Epub:
Yes
Abstract:
The CRISPR/Cas9 technology has been widely utilized for knocking out genes involved in various biological processes in...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1673852720300102
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang F, Li X, He M, Ye D, Xiong F, Amin G, Zhu Z, Sun Y. Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs. J Genet Genom. 2020;[Epub] doi:10.1016/j.jgg.2019.12.004.

Bicc1 and dicer regulate left-right patterning through post-transcriptional control of the Nodal-inhibitor dand5.

Authors:
Maerker M, Getwan M, Dowdle ME, Pelliccia JL, McSheene JC, Yartseva V, Minegishi K, Vick P, Giraldez AJ, Hamada H, Burdine RD, Sheets MD, Schweickert A, Blum M.
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.29.924456
Epub:
Not Epub
Abstract:
Rotating cilia at the vertebrate left-right organizer (LRO) generate an asymmetric leftward flow, which is sensed by cells at...
Link:
https://www.biorxiv.org/content/10.1101/2020.01.29.924456v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish, Xenopus laevis
Citation Extract:
Maerker M, Getwan M, Dowdle ME, Pelliccia JL, McSheene JC, Yartseva V, Minegishi K, Vick P, Giraldez AJ, Hamada H, Burdine RD, Sheets MD, Schweickert A, Blum M.. Bicc1 and dicer regulate left-right patterning through post-transcriptional control of the Nodal-inhibitor dand5. . bioRxiv. 2020;[preprint] doi:10.1101/2020.01.29.924456.

Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish

Authors:
Sharma P, Gupta S, Chaudhary M, Mitra S, Chawla B, Khursheed MA, Saran NK, Ramachandran R
Citation:
iScience. 2020 Jan 7;23(2):100817. doi: 10.1016/j.isci.2019.100817. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Tgf-β signaling is a major antiproliferative pathway governing different biological functions, including cellular reprogramming...
Link:
https://www.sciencedirect.com/science/article/pii/S2589004219305632
Delivery Method:
injection then electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Sharma P, Gupta S, Chaudhary M, Mitra S, Chawla B, Khursheed MA, Saran NK, Ramachandran R. Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish. iScience. 2020 Jan 7;23(2):100817. doi: 10.1016/j.isci.2019.100817. [Epub ahead of print].

The regulatory proteins DSCR6 and Ezh2 oppositely regulate Stat3 transcriptional activity in mesoderm patterning during Xenopus development

Authors:
Loreti M, Shi DL, Carron C
Citation:
J Biol Chem. 2020;295, 2724-2735. doi: 10.1074/jbc.RA119.010719.
Epub:
Not Epub
Abstract:
Embryonic cell fate specification and axis patterning requires integration of several signaling pathways that orchestrate...
Link:
https://www.jbc.org/content/early/2020/01/29/jbc.RA119.010719.abstract
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Loreti M, Shi DL, Carron C. The regulatory proteins DSCR6 and Ezh2 oppositely regulate Stat3 transcriptional activity in mesoderm patterning during Xenopus development. J Biol Chem. 2020;295, 2724-2735. doi: 10.1074/jbc.RA119.010719. .

Greb1 is required for axial elongation and segmentation in vertebrate embryos

Authors:
Prajapati RS, Mitter R, Vezzaro A, Ish-Horowicz D
Citation:
Biol Open. 2020 Jan 27. pii: bio.047290. doi: 10.1242/bio.047290. [Epub ahead of print]
Epub:
Yes
Abstract:
During vertebrate embryonic development, the formation of axial structures is driven by a population of stem-like cells that...
Link:
https://bio.biologists.org/content/early/2020/01/17/bio.047290.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Prajapati RS, Mitter R, Vezzaro A, Ish-Horowicz D. Greb1 is required for axial elongation and segmentation in vertebrate embryos. Biol Open. 2020 Jan 27. pii: bio.047290. doi: 10.1242/bio.047290. [Epub ahead of print].

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