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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish

Authors:
Demy DL, Campanari M-L, Munoz-Ruiz R,Durham HD, Gentil B, Kabashi E
Citation:
Cells. 2020;9(5):1238 doi:10.3390/cells9051238
Epub:
Not Epub
Abstract:
Neurofilaments (NFs), a major cytoskeletal component of motor neurons, play a key role in the differentiation, establishment...
Link:
https://www.mdpi.com/2073-4409/9/5/1238
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Demy DL, Campanari M-L, Munoz-Ruiz R,Durham HD, Gentil B, Kabashi E. Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish. Cells. 2020;9(5):1238 doi:10.3390/cells9051238.

Dach1 regulates neural crest migration during embryonic development

Authors:
Kim Y-K, Lee H, Ismail T, Kim Y, Lee H-S
Citation:
Biochem Biophys Res Comm. 2020;[Epub ahead of print] doi:10.1016/j.bbrc.2020.05.009
Epub:
Yes
Abstract:
Dachshund 1(Dach1) is a key component of the retinal determination gene network that plays significant roles in cell fate...
Link:
http://www.sciencedirect.com/science/article/pii/S0006291X20309141
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Kim Y-K, Lee H, Ismail T, Kim Y, Lee H-S. Dach1 regulates neural crest migration during embryonic development. Biochem Biophys Res Comm. 2020;[Epub ahead of print] doi:10.1016/j.bbrc.2020.05.009.

Neuroprotective Brain-Derived Neurotrophic Factor signaling in the TAU-P301L tauopathy zebrafish model

Authors:
Barbereau C, Yehya A, Silhol M, Cubedo N, Verdier JM, Maurice T, Rossel M
Citation:
Pharmacol Res. 2020 May 14:104865. doi: 10.1016/j.phrs.2020.104865. [Epub ahead of print]
Epub:
Yes
Abstract:
Brain-derived neurotrophic factor (BDNF) dysregulations contribute to the neurotoxicity in neurodegenerative pathologies and...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1043661820311737
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Barbereau C, Yehya A, Silhol M, Cubedo N, Verdier JM, Maurice T, Rossel M. Neuroprotective Brain-Derived Neurotrophic Factor signaling in the TAU-P301L tauopathy zebrafish model. Pharmacol Res. 2020 May 14:104865. doi: 10.1016/j.phrs.2020.104865. [Epub ahead of print].

Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence

Authors:
Traver D, Sahai P, Pouget C, Svoboda O
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.14.096305
Epub:
Not Epub
Abstract:
Development of the dorsal aorta is a key step in the establishment of the adult blood-forming system, since hematopoietic...
Link:
https://www.biorxiv.org/content/10.1101/2020.05.14.096305v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Traver D, Sahai P, Pouget C, Svoboda O. Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.14.096305.

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells

Authors:
Michaels WE, Bridges RJ, Hastings ML
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.12.089417
Epub:
Not Epub
Abstract:
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CF transmembrane conductance regulator (CFTR...
Link:
https://www.biorxiv.org/content/10.1101/2020.05.12.089417v1
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: lymphoblast cell lines, hBE cells
Citation Extract:
Michaels WE, Bridges RJ, Hastings ML. Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.12.089417 .

Enzyme-linked oligonucleotide hybridization assay for direct oligo measurement in blood

Authors:
Lorenson MY, Chen KE, Walker AM
Citation:
Biol Methods Protoc. 2019 Jan 7;4(1):bpy014. doi: 10.1093/biomethods/bpy014. eCollection 2019
Epub:
Not Epub
Abstract:
Small oligonucleotides (oligos) are increasingly being utilized as diagnostics or treatments for disease. An impediment to...
Link:
https://academic.oup.com/biomethods/article/4/1/bpy014/5280037
Delivery Method:
Vivo-Morpholino
Citation Extract:
Lorenson MY, Chen KE, Walker AM. Enzyme-linked oligonucleotide hybridization assay for direct oligo measurement in blood. Biol Methods Protoc. 2019 Jan 7;4(1):bpy014. doi: 10.1093/biomethods/bpy014. eCollection 2019.

Two Quantitative Assays for the Phosphorodiamidate Morpholino Oligomer (PMO) SRP-4045 in Mouse Plasma Using HPLC-MS/MS Coupled with Solid Phase Micro-Extraction

Authors:
Liu A, Zhang J, Zhao N, Burton S, Carver M, Liu S, Meng M, SReuschel S, Voelker T
Citation:
Presented at ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 5-9, 2016
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomers (PMO) are among the most advanced antisense therapeutics and a promising strategy for...
Link:
https://www.covance.com/content/dam/covance/assetLibrary/posters/Voelker-PMO-ASMS17.pdf
Organism or Cell Type:
mice
Citation Extract:
Liu A, Zhang J, Zhao N, Burton S, Carver M, Liu S, Meng M, SReuschel S, Voelker T. Two Quantitative Assays for the Phosphorodiamidate Morpholino Oligomer (PMO) SRP-4045 in Mouse Plasma Using HPLC-MS/MS Coupled with Solid Phase Micro-Extraction. Presented at ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 5-9, 2016.

Downregulation of p16 decreases biliary damage and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis

Authors:
Kyritsi K, Francis H, Zhou T, Ceci L, Wu N, Yhang Z, Meng F, Chen L, Baiocchi L, Kundu D, Kennedy L, Liangpunsakul S, Wu C, Glaser S, Alpini G
Citation:
Gene Expr. 2020 May 11. doi: 10.3727/105221620X15889714507961. [Epub ahead of print]
Epub:
Yes
Abstract:
Biliary senescence and hepatic fibrosis are hallmarks of cholangiopathies including primary sclerosing cholangitis (PSC)....
Link:
https://www.ingentaconnect.com/content/cog/ge/pre-prints/content-ge-000610
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Kyritsi K, Francis H, Zhou T, Ceci L, Wu N, Yhang Z, Meng F, Chen L, Baiocchi L, Kundu D, Kennedy L, Liangpunsakul S, Wu C, Glaser S, Alpini G. Downregulation of p16 decreases biliary damage and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis. Gene Expr. 2020 May 11. doi: 10.3727/105221620X15889714507961. [Epub ahead of print].

The micropeptide LEMP plays an evolutionarily conserved role in myogenesis

Authors:
Wang L, Fan J, Han L, Qi H, Wang Y, Wang H, Chen S, Du L, Li S, Zhang Y, Tang W, Ge G, Pan W, Hu P, Cheng H
Citation:
Cell Death Dis. 2020;11:357. doi:10.1038/s41419-020-2570-5
Epub:
Not Epub
Abstract:
In recent years, micropeptides have been increasingly identified as important regulators in various biological processes....
Link:
https://www.nature.com/articles/s41419-020-2570-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang L, Fan J, Han L, Qi H, Wang Y, Wang H, Chen S, Du L, Li S, Zhang Y, Tang W, Ge G, Pan W, Hu P, Cheng H. The micropeptide LEMP plays an evolutionarily conserved role in myogenesis. Cell Death Dis. 2020;11:357. doi:10.1038/s41419-020-2570-5.

Effective Pseudo-Exon Skipping of a COL6A1 Intronic Mutation in Cultured Muscle Interstitial Fibroblasts from a Novel Humanized Mouse Model

Authors:
Bolduc V, Guirguis F, Aguti S, Zhou H, Cheng J, Garrett L, Muntoni F, Bönnemann CG
Citation:
Molec Ther. 2020;28(4S1):401. abstract 925. doi:10.1016/j.ymthe.2020.04.019
Epub:
Not Epub
Abstract:
Collagen VI-related dystrophies (COL6-RDs) are a group of frequently severe, congenital-onset muscular dystrophies for which...
Link:
https://www.cell.com/action/showPdf?pii=S1525-0016%2820%2930200-8
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Bolduc V, Guirguis F, Aguti S, Zhou H, Cheng J, Garrett L, Muntoni F, Bönnemann CG. Effective Pseudo-Exon Skipping of a COL6A1 Intronic Mutation in Cultured Muscle Interstitial Fibroblasts from a Novel Humanized Mouse Model. Molec Ther. 2020;28(4S1):401. abstract 925. doi:10.1016/j.ymthe.2020.04.019.

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