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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

A dual role for Axin in establishing the anterior-posterior axis in the early sea urchin embryo

Authors:
Sun S, Peng CFJ, Wang L, Feng H, Wikramanayake AH
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.04.02.022640
Epub:
Not Epub
Abstract:
The activation of Wnt/β-catenin (cWnt) signaling at the future posterior end of early embryos is a highly conserved mechanism...
Delivery Method:
microinjection
Organism or Cell Type:
Lytechinus variegatus, Strongylocentrotus purpuratus (sea urchins)
Citation Extract:
Sun S, Peng CFJ, Wang L, Feng H, Wikramanayake AH. A dual role for Axin in establishing the anterior-posterior axis in the early sea urchin embryo. bioRxiv. 2020;[preprint] doi:10.1101/2020.04.02.022640 .

Trade-off between somatic and germline repair in a vertebrate supports the expensive germ line hypothesis

Authors:
Chen HY, Jolly C, Bublys K, Marcu D, Immler S
Citation:
Proc Natl Acad Sci U S A. 2020 Apr 3. pii: 201918205. doi: 10.1073/pnas.1918205117. [Epub ahead of print]
Epub:
Yes
Abstract:
The disposable soma theory is a central tenet of the biology of aging where germline immortality comes at the cost of an aging...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen HY, Jolly C, Bublys K, Marcu D, Immler S. Trade-off between somatic and germline repair in a vertebrate supports the expensive germ line hypothesis. Proc Natl Acad Sci U S A. 2020 Apr 3. pii: 201918205. doi: 10.1073/pnas.1918205117. [Epub ahead of print].

Distinct Vegfa isoforms control endothelial cell proliferation through PI3 kinase signalling mediated regulation of cdkn1a/p21

Authors:
Lange M, Leonard E, Ohnesorge N, Hoffmann D, Rocha S, Benedito R, Siekmann AF
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.04.01.018796
Epub:
Not Epub
Abstract:
The formation of appropriately patterned blood vessel networks requires endothelial cell migration and proliferation. Signaling...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lange M, Leonard E, Ohnesorge N, Hoffmann D, Rocha S, Benedito R, Siekmann AF. Distinct Vegfa isoforms control endothelial cell proliferation through PI3 kinase signalling mediated regulation of cdkn1a/p21. bioRxiv. 2020;[preprint] doi:10.1101/2020.04.01.018796.

Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/planar cell polarity pathway

Authors:
Lee Y-H, Kawakami K, HuangFu W-C, Liu I-H
Citation:
PLoS ONE. 2020;15(4):e0230943. doi:10.1371/journal.pone.0230943
Epub:
Not Epub
Abstract:
Pericellular and extracellular proteoglycans play an important role in modulating morphogen gradients and signal transductions...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lee Y-H, Kawakami K, HuangFu W-C, Liu I-H. Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/planar cell polarity pathway. PLoS ONE. 2020;15(4):e0230943. doi:10.1371/journal.pone.0230943.

Igf2bp1 is required for hepatic outgrowth during early liver development in zebrafish

Authors:
Wu J, Lu C, Ge S, Mei J, Li X, Guo W
Citation:
Gene. 2020 Mar 30:144632. doi: 10.1016/j.gene.2020.144632. [Epub ahead of print]
Epub:
Yes
Abstract:
IGF2BPs, a subclass of RNA-binding proteins, regulate cellular differentiation, proliferation and migration during multiple...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu J, Lu C, Ge S, Mei J, Li X, Guo W. Igf2bp1 is required for hepatic outgrowth during early liver development in zebrafish. Gene. 2020 Mar 30:144632. doi: 10.1016/j.gene.2020.144632. [Epub ahead of print].

Systematic Chromatin Architecture Analysis in Xenopus tropicalis Reveals Conserved Three-Dimensional Folding Principles of Vertebrate Genomes

Authors:
Niu L, Shen W, Shi Z, He N, Wan J, Sun J, Zhang Y, Huang Y, Wenjing Wang W, Fang C, Li J, Zheng P, Cheung E, Chen Y, Li L, Hou C
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.04.02.021378
Epub:
Not Epub
Abstract:
Metazoan genomes are folded into 3D structures in interphase nuclei. However, the molecular mechanism remains unknown. Here, we...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Niu L, Shen W, Shi Z, He N, Wan J, Sun J, Zhang Y, Huang Y, Wenjing Wang W, Fang C, Li J, Zheng P, Cheung E, Chen Y, Li L, Hou C. Systematic Chromatin Architecture Analysis in Xenopus tropicalis Reveals Conserved Three-Dimensional Folding Principles of Vertebrate Genomes. bioRxiv. 2020;[preprint] doi:10.1101/2020.04.02.021378.

NvPOU4/Brain3 functions as a terminal selector gene in the nervous system of the cnidarian Nematostella vectensis

Authors:
Tournière O, Dolan D, Richards GS, Sunagar K, Columbus-Shenkar YY, Moran Y, Rentzsch F
Citation:
Cell Rep. 2020;40(13):4473-89. doi:10.1016/j.celrep.2020.03.031
Epub:
Not Epub
Abstract:
Terminal selectors are transcription factors that control the morphological, physiological, and molecular features that...
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Tournière O, Dolan D, Richards GS, Sunagar K, Columbus-Shenkar YY, Moran Y, Rentzsch F. NvPOU4/Brain3 functions as a terminal selector gene in the nervous system of the cnidarian Nematostella vectensis. Cell Rep. 2020;40(13):4473-89. doi:10.1016/j.celrep.2020.03.031.

Golodirsen

Authors:
The LiverTox team
Citation:
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. 2020 Feb 27
Epub:
Not Epub
Abstract:
Golodirsen is synthetic antisense oligonucleotide designed to cause skipping of abnormal exons in the synthesis of the...
Citation Extract:
The LiverTox team. Golodirsen. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. 2020 Feb 27.

Eteplirsen

Authors:
The LiverTox team
Citation:
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. 2020 Feb 27
Epub:
Not Epub
Abstract:
Eteplirsen is synthetic antisense oligonucleotide designed to cause skipping of abnormal exons during synthesis of the...
Citation Extract:
The LiverTox team. Eteplirsen. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. 2020 Feb 27.

EphA7 is required for otic epithelial homeostasis by modulating Claudin6 in Xenopus

Authors:
Wang X, Sun J, Wang Z, Li C, Mao B
Citation:
Biochem Biophys Res Commun. 2020 Mar 25. pii: S0006-291X(20)30590-8. doi: 10.1016/j.bbrc.2020.03.099. [Epub ahead of print]
Epub:
Yes
Abstract:
Receptor tyrosine kinase EphA7 is specifically expressed in otic region in Xenopus early development. However, its role in...
Organism or Cell Type:
Xenopus
Citation Extract:
Wang X, Sun J, Wang Z, Li C, Mao B. EphA7 is required for otic epithelial homeostasis by modulating Claudin6 in Xenopus. Biochem Biophys Res Commun. 2020 Mar 25. pii: S0006-291X(20)30590-8. doi: 10.1016/j.bbrc.2020.03.099. [Epub ahead of print].

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