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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled

Authors:
Kratzer MC, Becker SFS, Grund A, Merks A, Harnoš J, Bryja V, Giehl K, Kashef J, Borchers A
Citation:
Development. 2020 May 4. pii: dev.186338. doi: 10.1242/dev.186338. [Epub ahead of print]
Epub:
Yes
Abstract:
Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to...
Link:
https://dev.biologists.org/content/early/2020/05/01/dev.186338.long
Organism or Cell Type:
Xenopus
Citation Extract:
Kratzer MC, Becker SFS, Grund A, Merks A, Harnoš J, Bryja V, Giehl K, Kashef J, Borchers A. The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled. Development. 2020 May 4. pii: dev.186338. doi: 10.1242/dev.186338. [Epub ahead of print].

Pcgf1 regulates early neural tube development through histone methylation in zebrafish

Authors:
Li X, Ji G, Zhou J, Du J, Li X, Hu Y, Zhou W, Hao A
Citation:
Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-25978/v1
Epub:
Not Epub
Abstract:
Objective: Early neural tube development in the embryo includes neural induction and self-renewal of neural stem cells (NSCs)....
Link:
https://www.researchsquare.com/article/rs-25978/v1
Organism or Cell Type:
zebrafish
Citation Extract:
Li X, Ji G, Zhou J, Du J, Li X, Hu Y, Zhou W, Hao A. Pcgf1 regulates early neural tube development through histone methylation in zebrafish. Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-25978/v1.

Rspo2 antagonizes FGF signaling during vertebrate mesoderm formation and patterning

Authors:
Reis AH, Sokol SY
Citation:
Development. 2020;[Epub ahead of print] dev.189324 doi: 10.1242/dev.189324
Epub:
Yes
Abstract:
R-spondins are a family of secreted proteins that play important roles in embryonic development and cancer. R-spondins have...
Link:
https://dev.biologists.org/content/early/2020/05/01/dev.189324
Organism or Cell Type:
Xenopus
Citation Extract:
Reis AH, Sokol SY. Rspo2 antagonizes FGF signaling during vertebrate mesoderm formation and patterning. Development. 2020;[Epub ahead of print] dev.189324 doi: 10.1242/dev.189324.

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

Authors:
Chen JL, Zhang P, Abe M, Aikawa H, Zhang L, Frank AJ, Zembryski T, Hubbs C, Park HJ, Withka J, Steppan C, Rogers L, Cabral S, Pettersson M, Wager TT, Fountain MA, Rumbaugh G, Childs-Disney JL, Disney MD
Citation:
J Am Chem Soc. 2020;[Epub ahead of print] doi:10.1021/jacs.0c00768
Epub:
Yes
Abstract:
Approximately 95% of human genes are alternatively spliced, and aberrant splicing events can cause disease. One pre-mRNA that...
Link:
https://pubs.acs.org/doi/10.1021/jacs.0c00768
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Chen JL, Zhang P, Abe M, Aikawa H, Zhang L, Frank AJ, Zembryski T, Hubbs C, Park HJ, Withka J, Steppan C, Rogers L, Cabral S, Pettersson M, Wager TT, Fountain MA, Rumbaugh G, Childs-Disney JL, Disney MD. Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. J Am Chem Soc. 2020;[Epub ahead of print] doi:10.1021/jacs.0c00768.

Myogenesis modelled by human pluripotent stem cells uncovers Duchenne muscular dystrophy phenotypes prior to skeletal muscle commitment

Authors:
Mournetas V, Massouridès E, Dupont J-B, Kornobis E, Polvèche H, Jarrige M, Gosselin MRF, Manousopoulou A, Garbis SD, Górecki DC, Pinset C
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/720920
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) causes severe disability of children and death of young men, with an incidence of...
Link:
https://www.biorxiv.org/content/10.1101/720920v3
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: M180
Citation Extract:
Mournetas V, Massouridès E, Dupont J-B, Kornobis E, Polvèche H, Jarrige M, Gosselin MRF, Manousopoulou A, Garbis SD, Górecki DC, Pinset C. Myogenesis modelled by human pluripotent stem cells uncovers Duchenne muscular dystrophy phenotypes prior to skeletal muscle commitment. bioRxiv. 2020;[preprint] doi:10.1101/720920 .

Wnt-inducible Lrp6-APEX2 Interacting Proteins identify ESCRT Machinery and Trk-Fused Gene as Components of the Wnt Signaling Pathway

Authors:
Colozza G, Jami-Alahmadi Y, Dsouza A, Tejeda-Munoz N, Albrecht LV, Sosa E, Wohlschlegel JA, De Robertis EM
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.03.072579
Epub:
Not Epub
Abstract:
The canonical Wnt signaling pathway serves as a hub connecting diverse cellular physiological processes, such as β-catenin...
Link:
https://www.biorxiv.org/content/10.1101/2020.05.03.072579v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Colozza G, Jami-Alahmadi Y, Dsouza A, Tejeda-Munoz N, Albrecht LV, Sosa E, Wohlschlegel JA, De Robertis EM. Wnt-inducible Lrp6-APEX2 Interacting Proteins identify ESCRT Machinery and Trk-Fused Gene as Components of the Wnt Signaling Pathway. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.03.072579 .

Peptide Conjugated Morpholinos for Management of The Huanglongbing Pathosystem

Authors:
Sandoval-Mojica AF, Altman S, Hunter WB, Pelz-Stelinski KS
Citation:
Pest Manag Sci. 2020 May 1. doi: 10.1002/ps.5877. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: 'Candidatus Liberibacter asiaticus' (CLas) is the causal agent of the devastating citrus disease...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/ps.5877
Delivery Method:
peptide-linked
Organism or Cell Type:
Candidatus Liberibacter asiaticus, Wolbachia
Citation Extract:
Sandoval-Mojica AF, Altman S, Hunter WB, Pelz-Stelinski KS. Peptide Conjugated Morpholinos for Management of The Huanglongbing Pathosystem. Pest Manag Sci. 2020 May 1. doi: 10.1002/ps.5877. [Epub ahead of print].

PolyA-modulating antisense oligonucleotides reveal opposing functions for long non-coding RNA NEAT1 isoforms in neuroblastoma

Authors:
Naveed A, Cooper JA, Li R, Hubbard A, Liu T, Wilton S, Fletcher S, Fox A
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.01.071696
Epub:
Not Epub
Abstract:
Many long non-coding RNAs (lncRNA) are highly dysregulated in cancer and are emerging as therapeutic targets. One example is...
Link:
https://www.biorxiv.org/content/10.1101/2020.05.01.071696v1
Delivery Method:
DNA leash and Lipofectamine
Organism or Cell Type:
cell culture: neuroblastoma lines: KELLY, BE2C & SK-N-AS
Citation Extract:
Naveed A, Cooper JA, Li R, Hubbard A, Liu T, Wilton S, Fletcher S, Fox A. PolyA-modulating antisense oligonucleotides reveal opposing functions for long non-coding RNA NEAT1 isoforms in neuroblastoma. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.01.071696.

HSP60 regulates monosodium urate crystal-induced inflammation by activating the TLR4-NF- κ B-MyD88 signaling pathway and disrupting mitochondrial function

Authors:
Gao W, Huang Q, Qin T, Mu H, Long F, Ren L, Tang H, Liu J, Zeng M
Citation:
Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-25061/v1
Epub:
Not Epub
Abstract:
Background: Acute gout is an inflammatory response induced by monosodium urate (MSU) crystals. HSP60 is a highly conserved...
Link:
https://www.researchsquare.com/article/rs-25061/v1
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Gao W, Huang Q, Qin T, Mu H, Long F, Ren L, Tang H, Liu J, Zeng M. HSP60 regulates monosodium urate crystal-induced inflammation by activating the TLR4-NF- κ B-MyD88 signaling pathway and disrupting mitochondrial function. Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-25061/v1.

The vertebrate-specific VENTX/NANOG gene empowers neural crest with ectomesenchyme potential

Authors:
Scerbo P, Monsoro-Burq AH
Citation:
Sci Adv. 2020;6(18):eaaz1469. doi:10.1126/sciadv.aaz1469
Epub:
Not Epub
Abstract:
During Cambrian, unipotent progenitors located at the neural (plate) border (NB) of an Olfactoria chordate embryo acquired the...
Link:
https://advances.sciencemag.org/content/6/18/eaaz1469
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Scerbo P, Monsoro-Burq AH. The vertebrate-specific VENTX/NANOG gene empowers neural crest with ectomesenchyme potential. Sci Adv. 2020;6(18):eaaz1469. doi:10.1126/sciadv.aaz1469 .

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