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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Microglial activation increases cocaine self-administration following adolescent nicotine exposure

Authors:
Linker KE, Elabd MG, Tawadrous P, Cano M, Green KN, Wood MA, Leslie FM
Citation:
Nat Commun. 2020 Jan 16;11(1):306. doi: 10.1038/s41467-019-14173-3
Epub:
Not Epub
Abstract:
With the rise of e-cigarette use, teen nicotine exposure is becoming more widespread. Findings from clinical and preclinical...
Delivery Method:
intracranial Vivo-Morpholino
Organism or Cell Type:
Sprague-Dawley rat
Citation Extract:
Linker KE, Elabd MG, Tawadrous P, Cano M, Green KN, Wood MA, Leslie FM. Microglial activation increases cocaine self-administration following adolescent nicotine exposure. Nat Commun. 2020 Jan 16;11(1):306. doi: 10.1038/s41467-019-14173-3.

The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation

Authors:
Wang Y, Liu X, Xie B, Yuan H, Zhang Y, Zhu J
Citation:
Redox Biol. 2020 Jan;28:101313. doi: 10.1016/j.redox.2019.101313. Epub 2019 Sep 2
Epub:
Not Epub
Abstract:
Hypoxia is widely considered as a limiting factor in vertebrate embryonic development, which requires adequate oxygen delivery...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang Y, Liu X, Xie B, Yuan H, Zhang Y, Zhu J. The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Redox Biol. 2020 Jan;28:101313. doi: 10.1016/j.redox.2019.101313. Epub 2019 Sep 2.

The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

Authors:
Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C
Citation:
Elife. 2020 Jan 14;9. pii: e51248. doi: 10.7554/eLife.51248. [Epub ahead of print]
Epub:
Not Epub
Abstract:
A hallmark of Spemann organizer function is its expression of Wnt antagonists that regulate axial embryonic patterning. Here we...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C. The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer. Elife. 2020 Jan 14;9. pii: e51248. doi: 10.7554/eLife.51248. [Epub ahead of print].

Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts

Authors:
Parra M, Zhang W, Vu J, DeWitt M, Conboy JG
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.13.902544
Epub:
Not Epub
Abstract:
Galanin (Gal) is a peptide with a role in neuroendocrine regulation of the liver. In this study we assessed the role of Gal and...
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: human erythroblasts
Citation Extract:
Parra M, Zhang W, Vu J, DeWitt M, Conboy JG. Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.13.902544.

Co-ordinated targeting of galanin receptors on cholangiocytes and hepatic stellate cells ameliorates liver fibrosis in Mdr2-knockout mice

Authors:
Petrescu AD, Grant S, Williams E, Frampton G, Parks N, Blaney H, Davies M, John R, Reinhart EH, McMillin M, DeMorrow S
Citation:
Am J Pathol. 2020 Jan 14. pii: S0002-9440(20)30003-1. doi: 10.1016/j.ajpath.2019.10.023. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Galanin (Gal) is a peptide with a role in neuroendocrine regulation of the liver. In this study we assessed the role of Gal and...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Petrescu AD, Grant S, Williams E, Frampton G, Parks N, Blaney H, Davies M, John R, Reinhart EH, McMillin M, DeMorrow S. Co-ordinated targeting of galanin receptors on cholangiocytes and hepatic stellate cells ameliorates liver fibrosis in Mdr2-knockout mice. Am J Pathol. 2020 Jan 14. pii: S0002-9440(20)30003-1. doi: 10.1016/j.ajpath.2019.10.023. [Epub ahead of print].

Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model

Authors:
Da'as SI, Yalcin HC, Nasrallah GK, Mohamed IA, Nomikos M, Yacoub MH, Fakhro KA
Citation:
J Cell Physiol. 2020 Jan 13. doi: 10.1002/jcp.29441. [Epub ahead of print]
Epub:
Yes
Abstract:
Myosin‐binding protein C 3 (MYBPC3) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Da'as SI, Yalcin HC, Nasrallah GK, Mohamed IA, Nomikos M, Yacoub MH, Fakhro KA. Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model. J Cell Physiol. 2020 Jan 13. doi: 10.1002/jcp.29441. [Epub ahead of print].

Leucine-rich repeat containing 8A contributes to the expansion of brain ventricles in zebrafish embryos

Authors:
Tseng YT, Ko CL, Chang CT, Lee YH, Huang Fu WC, Liu IH
Citation:
Biol Open. 2020 Jan 15. pii: bio.048264. doi: 10.1242/bio.048264. [Epub ahead of print]
Epub:
Yes
Abstract:
The sodium osmotic gradient is necessary for the initiation of brain ventricle inflation, but a previous study predicted that...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tseng YT, Ko CL, Chang CT, Lee YH, Huang Fu WC, Liu IH. Leucine-rich repeat containing 8A contributes to the expansion of brain ventricles in zebrafish embryos. Biol Open. 2020 Jan 15. pii: bio.048264. doi: 10.1242/bio.048264. [Epub ahead of print].

Novel eye genes systematically discovered through an integrated analysis of mouse transcriptomes and phenome

Authors:
Chiang CY, Ching YH, Chang TY, Hu LS, Yong YS, Keak PY, Mustika I, Lin MD, Liao BY
Citation:
Comput Struct Biotechnol J. 2019 Dec 27;18:73-82. doi: 10.1016/j.csbj.2019.12.009. eCollection 2020
Epub:
Not Epub
Abstract:
In the last few decades, reverse genetic and high throughput approaches have been frequently applied to the mouse (Mus musculus...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chiang CY, Ching YH, Chang TY, Hu LS, Yong YS, Keak PY, Mustika I, Lin MD, Liao BY. Novel eye genes systematically discovered through an integrated analysis of mouse transcriptomes and phenome. Comput Struct Biotechnol J. 2019 Dec 27;18:73-82. doi: 10.1016/j.csbj.2019.12.009. eCollection 2020.

Germ plasm localisation dynamics mark distinct phases of transcriptional and post-transcriptional regulation control in primordial germ cells

Authors:
D'Orazio FM, Balwierz P, Guo Y, Rodriguez B, Jasiulewicz A, Vaquerizas JM, Cairns B, Lenhard B, Mueller F
Citation:
https://www.biorxiv.org/content/10.1101/2020.01.12.903336v1
Epub:
Not Epub
Abstract:
In many animal models, primordial germ cell (PGC) development depends on maternally-deposited germ plasm to avoid somatic cell...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
D'Orazio FM, Balwierz P, Guo Y, Rodriguez B, Jasiulewicz A, Vaquerizas JM, Cairns B, Lenhard B, Mueller F. Germ plasm localisation dynamics mark distinct phases of transcriptional and post-transcriptional regulation control in primordial germ cells. https://www.biorxiv.org/content/10.1101/2020.01.12.903336v1.

Functional characterization of human myosin‐binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon‐specific cardiac phenotypes in zebrafish model

Authors:
Da'as SI, Yalcin HC, Nasrallah GK, Mohamed IA, Nomikos M, Yacoub M, Fakhro KA
Citation:
J Cellular Phys. 2020;[Epub ahead of print] doi:10.1002/jcp.29441
Epub:
Yes
Abstract:
Myosin‐binding protein C 3 (MYBPC3) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Da'as SI, Yalcin HC, Nasrallah GK, Mohamed IA, Nomikos M, Yacoub M, Fakhro KA. Functional characterization of human myosin‐binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon‐specific cardiac phenotypes in zebrafish model. J Cellular Phys. 2020;[Epub ahead of print] doi:10.1002/jcp.29441.

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