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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2‐deficient leukoencephalopathy

Authors:
Hamilton N, Rutherford HA, Petts JJ, Isles HM, Weber T, Henneke M, Gärtner J, Dunning M, Renshaw SA
Citation:
Glia. 2020;[Epub ahead of print] doi:10.1002/glia.23829
Epub:
Yes
Abstract:
The contribution of microglia in neurological disorders is emerging as a leading disease driver rather than a consequence of...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/glia.23829
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hamilton N, Rutherford HA, Petts JJ, Isles HM, Weber T, Henneke M, Gärtner J, Dunning M, Renshaw SA. The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2‐deficient leukoencephalopathy. Glia. 2020;[Epub ahead of print] doi:10.1002/glia.23829.

BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin

Authors:
Mateus R, Holtzer L, Seum C, Hadjivasiliou Z, Dubois M, Jülicher F, Gonzalez-Gaitan M
Citation:
Cell Rep. 2020;30(12):4292-302.e7 doi:10.1016/j.celrep.2020.03.024
Epub:
Not Epub
Abstract:
Secreted growth factors can act as morphogens that form spatial concentration gradients in developing organs, thereby...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30338-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mateus R, Holtzer L, Seum C, Hadjivasiliou Z, Dubois M, Jülicher F, Gonzalez-Gaitan M. BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin. Cell Rep. 2020;30(12):4292-302.e7 doi:10.1016/j.celrep.2020.03.024.

Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease

Authors:
Buglo E, Sarmiento E, Martuscelli NB, Sant DW, Danzi MC, Abrams AJ, Dallman JE, Züchner S
Citation:
PLoS ONE. 2020;15(3):e0230566. doi:10.1371/journal.pone.0230566
Epub:
Not Epub
Abstract:
A phenomenon of genetic compensation is commonly observed when an organism with a disease-bearing mutation shows incomplete...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230566
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Buglo E, Sarmiento E, Martuscelli NB, Sant DW, Danzi MC, Abrams AJ, Dallman JE, Züchner S. Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease. PLoS ONE. 2020;15(3):e0230566. doi:10.1371/journal.pone.0230566.

Abnormal expression of GABAA receptor sub-units and hypomotility upon loss of gabra1 in zebrafish

Authors:
Reyes-Nava N, Yu HC, Coughlin CR 2nd, Shaikh TH, Quintana AM
Citation:
Biol Open. 2020 Mar 23. pii: bio.051367. doi: 10.1242/bio.051367. [Epub ahead of print]
Epub:
Yes
Abstract:
We used whole exome sequencing (WES) to determine the genetic etiology of a patient with a multi-system disorder characterized...
Link:
https://bio.biologists.org/content/early/2020/03/20/bio.051367.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Reyes-Nava N, Yu HC, Coughlin CR 2nd, Shaikh TH, Quintana AM. Abnormal expression of GABAA receptor sub-units and hypomotility upon loss of gabra1 in zebrafish. Biol Open. 2020 Mar 23. pii: bio.051367. doi: 10.1242/bio.051367. [Epub ahead of print].

Site-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs

Authors:
Chan ZC-K, Kwan H-LR, Wong YS, Jiang Z, Zhou Z, Tam KW, Chan Y-S, Chan CB, Lee CW
Citation:
eLife. 2020;9:e54379 doi:10.7554/eLife.54379
Epub:
Not Epub
Abstract:
At vertebrate neuromuscular junctions (NMJs), the synaptic basal lamina contains different extracellular matrix (ECM) proteins...
Link:
https://elifesciences.org/articles/54379
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Chan ZC-K, Kwan H-LR, Wong YS, Jiang Z, Zhou Z, Tam KW, Chan Y-S, Chan CB, Lee CW. Site-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs. eLife. 2020;9:e54379 doi:10.7554/eLife.54379.

Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3

Authors:
Jászai J, Thamm K, Karbanová J, Janich P, Fargeas CA, Huttner WB, Corbeil D
Citation:
J Biol Chem. 2020;295:6007-22. doi: 10.1074/jbc.RA119.011253. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Prominins (proms) are transmembrane glycoproteins conserved throughout the animal kingdom. They are associated with plasma...
Link:
https://www.jbc.org/content/early/2020/03/22/jbc.RA119.011253.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jászai J, Thamm K, Karbanová J, Janich P, Fargeas CA, Huttner WB, Corbeil D. Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3. J Biol Chem. 2020;295:6007-22. doi: 10.1074/jbc.RA119.011253. [Epub ahead of print].

Zebrafish (Danio rerio) as an animal model for bath infection by Flavobacterium psychrophilum

Authors:
Avendaño‐Herrera R, Benavides I, Espina JA, Soto‐Comte D, Poblete‐Morales M, Valdés JA, Feijóo CG, Reyes AE
Citation:
J Fish Dis. 2020;[Epub] doi:10.1111/jfd.13156
Epub:
Not Epub
Abstract:
Flavobacterium psychrophilum is the causative agent of bacterial cold‐water disease and rainbow trout syndrome in freshwater...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1111/jfd.13156
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Avendaño‐Herrera R, Benavides I, Espina JA, Soto‐Comte D, Poblete‐Morales M, Valdés JA, Feijóo CG, Reyes AE. Zebrafish (Danio rerio) as an animal model for bath infection by Flavobacterium psychrophilum. J Fish Dis. 2020;[Epub] doi:10.1111/jfd.13156.

IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro

Authors:
Ma Y-y, Li J-r, Peng Z-g, Zhang J-p
Citation:
Dell Death Dis. 2020;11:200. doi:10.1038/s41419-020-2400-9
Epub:
Not Epub
Abstract:
Interferon lambda-2 (IL28A) has a wide antiviral effect with fewer side-effects. Autophagy is a host mechanism to maintain...
Link:
https://www.nature.com/articles/s41419-020-2400-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ma Y-y, Li J-r, Peng Z-g, Zhang J-p. IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro. Dell Death Dis. 2020;11:200. doi:10.1038/s41419-020-2400-9.

Evolution of Epileptiform Activity in Zebrafish by Statistical-Based Integration of Electrophysiology and 2-Photon Ca2+ Imaging

Authors:
Cozzolino O, Sicca F, Paoli E, Trovato F, Santorelli MF, Ratto MG, Marchese M
Citation:
Cells. 2020;9(3):769. doi:10.3390/cells9030769
Epub:
Not Epub
Abstract:
The study of sources and spatiotemporal evolution of ictal bursts is critical for the mechanistic understanding of epilepsy and...
Link:
https://www.mdpi.com/2073-4409/9/3/769
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cozzolino O, Sicca F, Paoli E, Trovato F, Santorelli MF, Ratto MG, Marchese M. Evolution of Epileptiform Activity in Zebrafish by Statistical-Based Integration of Electrophysiology and 2-Photon Ca2+ Imaging. Cells. 2020;9(3):769. doi:10.3390/cells9030769.

ube3d, a New Gene Associated with Age-Related Macular Degeneration, Induces Functional Changes in Both In Vivo and In Vitro Studies

Authors:
Xia H, Zhang Q, Shen Y, Bai Y, Ma X, Zhang B, Qi Y, Zhang J, Hu Q, Du W, Zhu L, Zhou P, Wang B, Xu H, Huang L, Li X
Citation:
Mol Ther Nucleic Acids. 2020 Feb 28;20:217-230. doi: 10.1016/j.omtn.2020.02.010. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Neovascular age-related macular degeneration (AMD) is characterized by the formation of choroidal neovascularization, which is...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(20)30087-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xia H, Zhang Q, Shen Y, Bai Y, Ma X, Zhang B, Qi Y, Zhang J, Hu Q, Du W, Zhu L, Zhou P, Wang B, Xu H, Huang L, Li X. ube3d, a New Gene Associated with Age-Related Macular Degeneration, Induces Functional Changes in Both In Vivo and In Vitro Studies. Mol Ther Nucleic Acids. 2020 Feb 28;20:217-230. doi: 10.1016/j.omtn.2020.02.010. [Epub ahead of print].

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