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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12179 scientific papers returned from the database with the search filters currently being used below.

Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish

Authors:
Demy DL, Campanari M-L, Munoz-Ruiz R,Durham HD, Gentil B, Kabashi E
Citation:
Cells. 2020;9(5):1238 doi:10.3390/cells9051238
Epub:
Not Epub
Abstract:
Neurofilaments (NFs), a major cytoskeletal component of motor neurons, play a key role in the differentiation, establishment...
Link:
https://www.mdpi.com/2073-4409/9/5/1238
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Demy DL, Campanari M-L, Munoz-Ruiz R,Durham HD, Gentil B, Kabashi E. Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish. Cells. 2020;9(5):1238 doi:10.3390/cells9051238.

Dach1 regulates neural crest migration during embryonic development

Authors:
Kim Y-K, Lee H, Ismail T, Kim Y, Lee H-S
Citation:
Biochem Biophys Res Comm. 2020;[Epub ahead of print] doi:10.1016/j.bbrc.2020.05.009
Epub:
Yes
Abstract:
Dachshund 1(Dach1) is a key component of the retinal determination gene network that plays significant roles in cell fate...
Link:
http://www.sciencedirect.com/science/article/pii/S0006291X20309141
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Kim Y-K, Lee H, Ismail T, Kim Y, Lee H-S. Dach1 regulates neural crest migration during embryonic development. Biochem Biophys Res Comm. 2020;[Epub ahead of print] doi:10.1016/j.bbrc.2020.05.009.

Neuroprotective Brain-Derived Neurotrophic Factor signaling in the TAU-P301L tauopathy zebrafish model

Authors:
Barbereau C, Yehya A, Silhol M, Cubedo N, Verdier JM, Maurice T, Rossel M
Citation:
Pharmacol Res. 2020 May 14:104865. doi: 10.1016/j.phrs.2020.104865. [Epub ahead of print]
Epub:
Yes
Abstract:
Brain-derived neurotrophic factor (BDNF) dysregulations contribute to the neurotoxicity in neurodegenerative pathologies and...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1043661820311737
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Barbereau C, Yehya A, Silhol M, Cubedo N, Verdier JM, Maurice T, Rossel M. Neuroprotective Brain-Derived Neurotrophic Factor signaling in the TAU-P301L tauopathy zebrafish model. Pharmacol Res. 2020 May 14:104865. doi: 10.1016/j.phrs.2020.104865. [Epub ahead of print].

Enzyme-linked oligonucleotide hybridization assay for direct oligo measurement in blood

Authors:
Lorenson MY, Chen KE, Walker AM
Citation:
Biol Methods Protoc. 2019 Jan 7;4(1):bpy014. doi: 10.1093/biomethods/bpy014. eCollection 2019
Epub:
Not Epub
Abstract:
Small oligonucleotides (oligos) are increasingly being utilized as diagnostics or treatments for disease. An impediment to...
Link:
https://academic.oup.com/biomethods/article/4/1/bpy014/5280037
Delivery Method:
Vivo-Morpholino
Citation Extract:
Lorenson MY, Chen KE, Walker AM. Enzyme-linked oligonucleotide hybridization assay for direct oligo measurement in blood. Biol Methods Protoc. 2019 Jan 7;4(1):bpy014. doi: 10.1093/biomethods/bpy014. eCollection 2019.

Two Quantitative Assays for the Phosphorodiamidate Morpholino Oligomer (PMO) SRP-4045 in Mouse Plasma Using HPLC-MS/MS Coupled with Solid Phase Micro-Extraction

Authors:
Liu A, Zhang J, Zhao N, Burton S, Carver M, Liu S, Meng M, SReuschel S, Voelker T
Citation:
Presented at ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 5-9, 2016
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomers (PMO) are among the most advanced antisense therapeutics and a promising strategy for...
Link:
https://www.covance.com/content/dam/covance/assetLibrary/posters/Voelker-PMO-ASMS17.pdf
Organism or Cell Type:
mice
Citation Extract:
Liu A, Zhang J, Zhao N, Burton S, Carver M, Liu S, Meng M, SReuschel S, Voelker T. Two Quantitative Assays for the Phosphorodiamidate Morpholino Oligomer (PMO) SRP-4045 in Mouse Plasma Using HPLC-MS/MS Coupled with Solid Phase Micro-Extraction. Presented at ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 5-9, 2016.

Downregulation of p16 decreases biliary damage and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis

Authors:
Kyritsi K, Francis H, Zhou T, Ceci L, Wu N, Yhang Z, Meng F, Chen L, Baiocchi L, Kundu D, Kennedy L, Liangpunsakul S, Wu C, Glaser S, Alpini G
Citation:
Gene Expr. 2020 May 11. doi: 10.3727/105221620X15889714507961. [Epub ahead of print]
Epub:
Yes
Abstract:
Biliary senescence and hepatic fibrosis are hallmarks of cholangiopathies including primary sclerosing cholangitis (PSC)....
Link:
https://www.ingentaconnect.com/content/cog/ge/pre-prints/content-ge-000610
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Kyritsi K, Francis H, Zhou T, Ceci L, Wu N, Yhang Z, Meng F, Chen L, Baiocchi L, Kundu D, Kennedy L, Liangpunsakul S, Wu C, Glaser S, Alpini G. Downregulation of p16 decreases biliary damage and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis. Gene Expr. 2020 May 11. doi: 10.3727/105221620X15889714507961. [Epub ahead of print].

The micropeptide LEMP plays an evolutionarily conserved role in myogenesis

Authors:
Wang L, Fan J, Han L, Qi H, Wang Y, Wang H, Chen S, Du L, Li S, Zhang Y, Tang W, Ge G, Pan W, Hu P, Cheng H
Citation:
Cell Death Dis. 2020;11:357. doi:10.1038/s41419-020-2570-5
Epub:
Not Epub
Abstract:
In recent years, micropeptides have been increasingly identified as important regulators in various biological processes....
Link:
https://www.nature.com/articles/s41419-020-2570-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang L, Fan J, Han L, Qi H, Wang Y, Wang H, Chen S, Du L, Li S, Zhang Y, Tang W, Ge G, Pan W, Hu P, Cheng H. The micropeptide LEMP plays an evolutionarily conserved role in myogenesis. Cell Death Dis. 2020;11:357. doi:10.1038/s41419-020-2570-5.

Effective Pseudo-Exon Skipping of a COL6A1 Intronic Mutation in Cultured Muscle Interstitial Fibroblasts from a Novel Humanized Mouse Model

Authors:
Bolduc V, Guirguis F, Aguti S, Zhou H, Cheng J, Garrett L, Muntoni F, Bönnemann CG
Citation:
Molec Ther. 2020;28(4S1):401. abstract 925. doi:10.1016/j.ymthe.2020.04.019
Epub:
Not Epub
Abstract:
Collagen VI-related dystrophies (COL6-RDs) are a group of frequently severe, congenital-onset muscular dystrophies for which...
Link:
https://www.cell.com/action/showPdf?pii=S1525-0016%2820%2930200-8
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Bolduc V, Guirguis F, Aguti S, Zhou H, Cheng J, Garrett L, Muntoni F, Bönnemann CG. Effective Pseudo-Exon Skipping of a COL6A1 Intronic Mutation in Cultured Muscle Interstitial Fibroblasts from a Novel Humanized Mouse Model. Molec Ther. 2020;28(4S1):401. abstract 925. doi:10.1016/j.ymthe.2020.04.019.

A Reversible RNA On-Switch That Controls Expression of Aav-Delivered Transgenes In Vivo

Authors:
Zhong G, Wang H, Farzan M
Citation:
Molec Ther. 2020;28(4S1):224. abstract 510. doi:10.1016/j.ymthe.2020.04.019
Epub:
Not Epub
Abstract:
Widespread use of gene therapy technologies is limited in part by the lack of small genetic switches with wide dynamic ranges...
Link:
https://www.cell.com/action/showPdf?pii=S1525-0016%2820%2930200-8
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Zhong G, Wang H, Farzan M. A Reversible RNA On-Switch That Controls Expression of Aav-Delivered Transgenes In Vivo. Molec Ther. 2020;28(4S1):224. abstract 510. doi:10.1016/j.ymthe.2020.04.019.

Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes

Authors:
Garland MA, Geier MC, Bugel SM, Shankar P, Dunham CL, Brown JM, Tilton SC, Tanguay RL
Citation:
Toxicol Sci. 2020 May 8. pii: kfaa063. doi: 10.1093/toxsci/kfaa063. [Epub ahead of print]
Epub:
Yes
Abstract:
The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic...
Link:
https://academic.oup.com/toxsci/advance-article-abstract/doi/10.1093/toxsci/kfaa063/5834730
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Garland MA, Geier MC, Bugel SM, Shankar P, Dunham CL, Brown JM, Tilton SC, Tanguay RL. Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes. Toxicol Sci. 2020 May 8. pii: kfaa063. doi: 10.1093/toxsci/kfaa063. [Epub ahead of print].

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