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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12156 scientific papers returned from the database with the search filters currently being used below.
There are 12156 scientific papers returned from the database with the search filters currently being used below.
Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages
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Citation:
Cell Death Dis. 2020;11:277 doi:10.1038/s41419-020-2477-1 Epub:
Not Epub Abstract:
DNA damage regulated autophagy modulator 1 (DRAM1) is a stress-inducible regulator of autophagy and cell death. DRAM1 has been... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang R, Varela M, Forn-Cuní G, Torraca V, Michiel van der Vaart M, Meijer AH. Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages. Cell Death Dis. 2020;11:277 doi:10.1038/s41419-020-2477-1. |
miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis
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Citation:
Prog Neurobiol. 2020 Apr 23:101803. doi: 10.1016/j.pneurobio.2020.101803. [Epub ahead of print] Epub:
Yes Abstract:
Amyotrophic lateral sclerosis (ALS) is a relentless and fatal neurological disease characterized by the selective degeneration... Delivery Method:
intracerebroventricular (i.c.v.) injection Organism or Cell Type:
mice Citation Extract: Loffreda A, Nizzardo M, Arosio A, Ruepp MD, Calogero RA, Volinia S, Galasso M, Bendotti C, Ferrarese C, Lunetta C, Rizzuti M, Ronchi A, Mühlemann O, Tremolizzo L, Corti S, Barabino SML. miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis. Prog Neurobiol. 2020 Apr 23:101803. doi: 10.1016/j.pneurobio.2020.101803. [Epub ahead of print]. |
Rare mutations in the autophagy-regulating gene AMBRA1 contribute to human neural tube defects
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Citation:
Hum Mutat. 2020 Apr 25. doi: 10.1002/humu.24028. [Epub ahead of print] Epub:
Yes Abstract:
Neural tube defects (NTDs) are severe congenital malformations caused by failed neural tube closure. Recently, autophagy is... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ye J, Tong Y, Lv J, Peng R, Chen S, Kuang L, Su K, Zheng Y, Zhang T, Zhang F, Jin L, Yang X, Wang H. Rare mutations in the autophagy-regulating gene AMBRA1 contribute to human neural tube defects. Hum Mutat. 2020 Apr 25. doi: 10.1002/humu.24028. [Epub ahead of print]. |
A zebrafish model for HAX1-associated congenital neutropenia
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Citation:
Haematologica. 2020 Apr 23. pii: haematol.2019.240200. doi: 10.3324/haematol.2019.240200. [Epub ahead of print] Epub:
Not Epub Abstract:
Severe congenital neutropenia (CN) is a rare heterogeneous group of diseases, characterized by a granulocytic maturation arrest... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Doll L, Aghaallaei N, Dick AM, Welte K, Skokowa J, Bajoghli B. A zebrafish model for HAX1-associated congenital neutropenia. Haematologica. 2020 Apr 23. pii: haematol.2019.240200. doi: 10.3324/haematol.2019.240200. [Epub ahead of print]. |
Dysregulation of NIPBL leads to impaired RUNX1 expression and haematopoietic defects
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Citation:
J Cell Mol Med. 2020 Apr 23. doi: 10.1111/jcmm.15269. [Epub ahead of print] Epub:
Yes Abstract:
The transcription factor RUNX1, a pivotal regulator of HSCs and haematopoiesis, is a frequent target of chromosomal... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Mazzola M, Pezzotta A, Fazio G, Rigamonti A, Bresciani E, Gaudenzi G, Pelleri MC, Saitta C, Ferrari L, Parma M, Fumagalli M, Biondi A, Cazzaniga G, Marozzi A, Pistocchi A. Dysregulation of NIPBL leads to impaired RUNX1 expression and haematopoietic defects. J Cell Mol Med. 2020 Apr 23. doi: 10.1111/jcmm.15269. [Epub ahead of print]. |
Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus during Zebrafish Embryogenesis
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Citation:
J Immunol. 2020;204(9):2447-54. doi:10.4049/jimmunol.1901494 Epub:
Not Epub Abstract:
The caudal hematopoietic tissue in zebrafish, the equivalent to the fetal liver in mammals, is an intermediate hematopoietic... Organism or Cell Type:
zebrafish Citation Extract: Lu X, Zhang Y, Liu F, Wang L. Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus during Zebrafish Embryogenesis. J Immunol. 2020;204(9):2447-54. doi:10.4049/jimmunol.1901494. |
Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome
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Citation:
Orphanet J Rare Dis. 2020;15(1):101. doi:10.1186/s13023-020-01378-9 Epub:
Not Epub Abstract:
Background: Rubinstein–Taybi syndrome (RTS) is a rare, congenital, plurimalformative, and neurodevelopmental disorder. Previous... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Wu Y, Xia Y, Li P, Qu H-Q, Liu Y, Yang Y, Lin J, Zheng M, Tian L, Wu Z, Huang S, Qin X, Zhou X, Chen S, Liu Y, Wang Y, Li X, Zeng H, Hakonarson H, Zhuang J. Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome. Orphanet J Rare Dis. 2020;15(1):101. doi:10.1186/s13023-020-01378-9. |
Zebrafish ambra1a and ambra1b Silencing Affect Heart Development
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Citation:
Zebrafish. 2020 Apr 22. doi: 10.1089/zeb.2020.1860. [Epub ahead of print] Epub:
Yes Abstract:
In zebrafish, two paralogous genes, activating molecule in beclin-1 (BECN1)-regulated autophagy ambra1a and ambra1b, both... Citation Extract: Meneghetti G, Skobo T, Chrisam M, Fontana CM, Facchinello N, Nazio F, Cecconi F, Bonaldo P, Dalla Valle L. Zebrafish ambra1a and ambra1b Silencing Affect Heart Development. Zebrafish. 2020 Apr 22. doi: 10.1089/zeb.2020.1860. [Epub ahead of print]. |
Twist3 is required for dedifferentiation during extraocular muscle regeneration in adult zebrafish
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Citation:
PLoS ONE. 2020;15(4):e0231963. doi:10.1371/journal.pone.0231963 Epub:
Not Epub Abstract:
Severely damaged adult zebrafish extraocular muscles (EOMs) regenerate through dedifferentiation of residual myocytes involving... Delivery Method:
injection then electroporation Organism or Cell Type:
zebrafish Citation Extract: Zhao Y, Louie KW, Tingle CF, Sha C, Heisel CJ, Unsworth SP, Kish PE, Kahana A. Twist3 is required for dedifferentiation during extraocular muscle regeneration in adult zebrafish. PLoS ONE. 2020;15(4):e0231963. doi:10.1371/journal.pone.0231963. |
Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins
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Citation:
Elife. 2020 Dec 2;9:e58662. doi: 10.7554/eLife.58662. PMID: 33263282; PMCID: PMC7785291 Epub:
Not Epub Abstract:
Ciliary motility is driven by axonemal dyneins that are assembled in the cytoplasm before deployment to cilia. Motile... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Lee C, Cox RM, Papoulas O, Horani A, Drew K, Devitt CC, Brody SL, Marcotte EM, Wallingford JB. Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins. Elife. 2020 Dec 2;9:e58662. doi: 10.7554/eLife.58662. PMID: 33263282; PMCID: PMC7785291. |