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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Twist3 is required for dedifferentiation during extraocular muscle regeneration in adult zebrafish

Authors:
Zhao Y, Louie KW, Tingle CF, Sha C, Heisel CJ, Unsworth SP, Kish PE, Kahana A
Citation:
PLoS ONE. 2020;15(4):e0231963. doi:10.1371/journal.pone.0231963
Epub:
Not Epub
Abstract:
Severely damaged adult zebrafish extraocular muscles (EOMs) regenerate through dedifferentiation of residual myocytes involving...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231963
Delivery Method:
injection then electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Zhao Y, Louie KW, Tingle CF, Sha C, Heisel CJ, Unsworth SP, Kish PE, Kahana A. Twist3 is required for dedifferentiation during extraocular muscle regeneration in adult zebrafish. PLoS ONE. 2020;15(4):e0231963. doi:10.1371/journal.pone.0231963.

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins

Authors:
Lee C, Cox R, Papoulas O, Horani A, Drew K, Devitt C, Brody SL, Marcotte E, Wallingford JB
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.04.21.052837
Epub:
Not Epub
Abstract:
Ciliary motility is driven by axonemal dyneins that are assembled in the cytoplasm before deployment to cilia. Motile...
Link:
https://www.biorxiv.org/content/10.1101/2020.04.21.052837v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Lee C, Cox R, Papoulas O, Horani A, Drew K, Devitt C, Brody SL, Marcotte E, Wallingford JB. Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins. bioRxiv. 2020;[preprint] doi:10.1101/2020.04.21.052837.

Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1

Authors:
Herkenne S, Ek O, Zamberlan M, Pellattiero A, Chergova M, Chivite I, Novotná E, Rigoni G, Fonseca TB, Samardzic D, Agnellini A, Bean C, Di Benedetto G, Tiso N, Argenton F, Viola A, Soriano ME, Giacomello M, Ziviani E, Sales G, Claret M, Graupera M, Scorrano L
Citation:
Cell Metab. 2020 Apr 17. pii: S1550-4131(20)30189-3. doi: 10.1016/j.cmet.2020.04.007. [Epub ahead of print]
Epub:
Yes
Abstract:
While endothelial cell (EC) function is influenced by mitochondrial metabolism, the role of mitochondrial dynamics in...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1550413120301893
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Herkenne S, Ek O, Zamberlan M, Pellattiero A, Chergova M, Chivite I, Novotná E, Rigoni G, Fonseca TB, Samardzic D, Agnellini A, Bean C, Di Benedetto G, Tiso N, Argenton F, Viola A, Soriano ME, Giacomello M, Ziviani E, Sales G, Claret M, Graupera M, Scorrano L. Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1. Cell Metab. 2020 Apr 17. pii: S1550-4131(20)30189-3. doi: 10.1016/j.cmet.2020.04.007. [Epub ahead of print].

Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts

Authors:
Parra MK, Zhang W, Vu J, DeWitt MA, Conboy JG
Citation:
RNA. 2020 Apr 20. pii: rna.075028.120. doi: 10.1261/rna.075028.120. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The decoy exon model has been proposed to regulate a subset of intron retention (IR) events involving predominantly larger...
Link:
https://rnajournal.cshlp.org/content/early/2020/04/20/rna.075028.120.abstract
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: human erythroblasts
Citation Extract:
Parra MK, Zhang W, Vu J, DeWitt MA, Conboy JG. Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts. RNA. 2020 Apr 20. pii: rna.075028.120. doi: 10.1261/rna.075028.120. [Epub ahead of print].

Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1

Authors:
Sanchez-Martin C, Moroni E, Ferraro M, Laquatra C, Cannino G, Masgras I, Negro A, Quadrelli P, Rasola A, Colombo G
Citation:
Cell Rep. 2020;31(3):107531. doi:10.1016/j.celrep.2020.107531
Epub:
Not Epub
Abstract:
TRAP1 is the mitochondrial paralog of the heat shock protein 90 (HSP90) chaperone family. Its activity as an energy metabolism...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30431-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sanchez-Martin C, Moroni E, Ferraro M, Laquatra C, Cannino G, Masgras I, Negro A, Quadrelli P, Rasola A, Colombo G. Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1. Cell Rep. 2020;31(3):107531. doi:10.1016/j.celrep.2020.107531.

The cationic amino acid exporter Slc7a7 is vital for and induced in tissue macrophages with sustained efferocytic activity

Authors:
Demy DL, Carrère M, Noche R, Tauzin M, Le Bris M, Baek C, Yousfi M, Leshchiner I, Goessling W, Herbomel P
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.04.20.051664
Epub:
Not Epub
Abstract:
Most tissues harbor a substantial population of resident macrophages. It is not quite known yet how their quite diverse...
Link:
https://www.biorxiv.org/content/10.1101/2020.04.20.051664v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Demy DL, Carrère M, Noche R, Tauzin M, Le Bris M, Baek C, Yousfi M, Leshchiner I, Goessling W, Herbomel P. The cationic amino acid exporter Slc7a7 is vital for and induced in tissue macrophages with sustained efferocytic activity. bioRxiv. 2020;[preprint] doi:10.1101/2020.04.20.051664.

Splice modulating antisense oligonucleotides restore some acid-alpha-glucosidase activity in cells derived from patients with late-onset Pompe disease

Authors:
Aung-Htut MT, Ham KA, Tchan M, Johnsen R, Schnell FJ, Fletcher S, Wilton SD
Citation:
Sci Rep. 2020;10;6702. doi:10.1038/s41598-020-63461-2
Epub:
Not Epub
Abstract:
Pompe disease is caused by mutations in the GAA gene, resulting in deficient lysosomal acid-α-glucosidase activity in patients...
Link:
https://www.nature.com/articles/s41598-020-63461-2
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: Pompe patients-derived fibroblasts GM00443 and GM11661
Citation Extract:
Aung-Htut MT, Ham KA, Tchan M, Johnsen R, Schnell FJ, Fletcher S, Wilton SD. Splice modulating antisense oligonucleotides restore some acid-alpha-glucosidase activity in cells derived from patients with late-onset Pompe disease. Sci Rep. 2020;10;6702. doi:10.1038/s41598-020-63461-2.

Wnt-PLC-IP3-Connexin-Ca2+ axis maintains ependymal motile cilia in zebrafish spinal cord

Authors:
Zhang J, Chandrasekaran G, Li W, Kim D-Y, Jeong, Lee S-H, Liang T, Bae JY, Choi I, Kang H, Maeng Jin-Soo, Kim M-K, Lee T, Park SW, Kim MJ, Kim H-S, Ro H, Bae YC, Park H-C, Choi EY, Choi S-Y
Citation:
Nat Comm. 2020;11(1):1860. doi:10.1038/s41467-020-15248-2
Epub:
Not Epub
Abstract:
Ependymal cells (ECs) are multiciliated neuroepithelial cells that line the ventricles of the brain and the central canal of...
Link:
https://www.nature.com/articles/s41467-020-15248-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang J, Chandrasekaran G, Li W, Kim D-Y, Jeong, Lee S-H, Liang T, Bae JY, Choi I, Kang H, Maeng Jin-Soo, Kim M-K, Lee T, Park SW, Kim MJ, Kim H-S, Ro H, Bae YC, Park H-C, Choi EY, Choi S-Y. Wnt-PLC-IP3-Connexin-Ca2+ axis maintains ependymal motile cilia in zebrafish spinal cord. Nat Comm. 2020;11(1):1860. doi:10.1038/s41467-020-15248-2.

Blood vessels are primary targets for 2,3,7,8-tetrachlorodibenzo-p-dioxin in pre-cardiac edema formation in larval zebrafish

Authors:
Nijoukubo D, Adachi H, Kitazawa T, Teraoka H
Citation:
Chemosphere. 2020;[Epub ahead of pint] doi:10.1016/j.chemosphere.2020.126808
Epub:
Not Epub
Abstract:
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has adverse effects on the development and function of the heart in zebrafish...
Link:
https://www.sciencedirect.com/science/article/pii/S0045653520310018
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nijoukubo D, Adachi H, Kitazawa T, Teraoka H. Blood vessels are primary targets for 2,3,7,8-tetrachlorodibenzo-p-dioxin in pre-cardiac edema formation in larval zebrafish. Chemosphere. 2020;[Epub ahead of pint] doi:10.1016/j.chemosphere.2020.126808.

Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish

Authors:
Abrams J, Einhorn Z, Seiler C, Zong AB, Sweeney HL, Pack M
Citation:
Dis Model Mech. 2016 May 1;9(5):529-40. doi: 10.1242/dmm.023309. Epub 2016 Feb 18
Epub:
Not Epub
Abstract:
Smooth muscle contraction is controlled by the regulated activity of the myosin heavy chain ATPase (Myh11). Myh11 mutations...
Link:
https://dmm.biologists.org/content/9/5/529.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Abrams J, Einhorn Z, Seiler C, Zong AB, Sweeney HL, Pack M. Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish. Dis Model Mech. 2016 May 1;9(5):529-40. doi: 10.1242/dmm.023309. Epub 2016 Feb 18.

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