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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

The micropeptide LEMP plays an evolutionarily conserved role in myogenesis

Authors:
Wang L, Fan J, Han L, Qi H, Wang Y, Wang H, Chen S, Du L, Li S, Zhang Y, Tang W, Ge G, Pan W, Hu P, Cheng H
Citation:
Cell Death Dis. 2020;11:357. doi:10.1038/s41419-020-2570-5
Epub:
Not Epub
Abstract:
In recent years, micropeptides have been increasingly identified as important regulators in various biological processes....
Link:
https://www.nature.com/articles/s41419-020-2570-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang L, Fan J, Han L, Qi H, Wang Y, Wang H, Chen S, Du L, Li S, Zhang Y, Tang W, Ge G, Pan W, Hu P, Cheng H. The micropeptide LEMP plays an evolutionarily conserved role in myogenesis. Cell Death Dis. 2020;11:357. doi:10.1038/s41419-020-2570-5.

Effective Pseudo-Exon Skipping of a COL6A1 Intronic Mutation in Cultured Muscle Interstitial Fibroblasts from a Novel Humanized Mouse Model

Authors:
Bolduc V, Guirguis F, Aguti S, Zhou H, Cheng J, Garrett L, Muntoni F, Bönnemann CG
Citation:
Molec Ther. 2020;28(4S1):401. abstract 925. doi:10.1016/j.ymthe.2020.04.019
Epub:
Not Epub
Abstract:
Collagen VI-related dystrophies (COL6-RDs) are a group of frequently severe, congenital-onset muscular dystrophies for which...
Link:
https://www.cell.com/action/showPdf?pii=S1525-0016%2820%2930200-8
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Bolduc V, Guirguis F, Aguti S, Zhou H, Cheng J, Garrett L, Muntoni F, Bönnemann CG. Effective Pseudo-Exon Skipping of a COL6A1 Intronic Mutation in Cultured Muscle Interstitial Fibroblasts from a Novel Humanized Mouse Model. Molec Ther. 2020;28(4S1):401. abstract 925. doi:10.1016/j.ymthe.2020.04.019.

A Reversible RNA On-Switch That Controls Expression of Aav-Delivered Transgenes In Vivo

Authors:
Zhong G, Wang H, Farzan M
Citation:
Molec Ther. 2020;28(4S1):224. abstract 510. doi:10.1016/j.ymthe.2020.04.019
Epub:
Not Epub
Abstract:
Widespread use of gene therapy technologies is limited in part by the lack of small genetic switches with wide dynamic ranges...
Link:
https://www.cell.com/action/showPdf?pii=S1525-0016%2820%2930200-8
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Zhong G, Wang H, Farzan M. A Reversible RNA On-Switch That Controls Expression of Aav-Delivered Transgenes In Vivo. Molec Ther. 2020;28(4S1):224. abstract 510. doi:10.1016/j.ymthe.2020.04.019.

Development of a Minimized Exons 45-55 Skipping Cocktail for the Treatment of Duchenne Muscular Dystrophy

Authors:
Lim KRQ, Huang Y, Maruyama R, Woo S, Dzierlega K, Moulton H, Yokota T
Citation:
Molec Ther. 2020;28(4S1):113 abstract 237. doi:10.1016/j.ymthe.2020.04.019
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive neuromuscular disorder characterized by...
Link:
https://www.cell.com/action/showPdf?pii=S1525-0016%2820%2930200-8
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Lim KRQ, Huang Y, Maruyama R, Woo S, Dzierlega K, Moulton H, Yokota T. Development of a Minimized Exons 45-55 Skipping Cocktail for the Treatment of Duchenne Muscular Dystrophy. Molec Ther. 2020;28(4S1):113 abstract 237. doi:10.1016/j.ymthe.2020.04.019.

Restoration of Full-Length Dystrophin Expression in the Dup2 Mouse Induced by Systemic Delivery of a Peptide-Conjugated Morpholino Oligomer

Authors:
Gushchina LV, Grounds KM, Huang N, Frair E, Schnell FJ, Hanson GJ, Simmons T, Wein N, Flanigan KM
Citation:
Molec Ther. 2020;28(4S1):20 abstract 39. doi:10.1016/j.ymthe.2020.04.019
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is an x-linked recessive genetic disorder caused by mutations that disrupt the...
Link:
https://www.cell.com/action/showPdf?pii=S1525-0016%2820%2930200-8
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Gushchina LV, Grounds KM, Huang N, Frair E, Schnell FJ, Hanson GJ, Simmons T, Wein N, Flanigan KM. Restoration of Full-Length Dystrophin Expression in the Dup2 Mouse Induced by Systemic Delivery of a Peptide-Conjugated Morpholino Oligomer. Molec Ther. 2020;28(4S1):20 abstract 39. doi:10.1016/j.ymthe.2020.04.019.

Pharyngeal pouches provide a niche microenvironment for arch artery progenitor specification

Authors:
Mao A, Li L, Liu J, Mingming Z, Ning G, Cao Y, Wang Q
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.07.083493
Epub:
Not Epub
Abstract:
The paired pharyngeal arch arteries (PAAs) are transient blood vessels connecting the heart with the dorsal aorta during...
Link:
https://www.biorxiv.org/content/10.1101/2020.05.07.083493v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mao A, Li L, Liu J, Mingming Z, Ning G, Cao Y, Wang Q. Pharyngeal pouches provide a niche microenvironment for arch artery progenitor specification. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.07.083493.

Furry is required for cell movements during gastrulation and functionally interacts with NDR1

Authors:
Cervino AS, Moretti B, Stuckenholz C, Grecco HE, Davidson LA, Cirio MC
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.08.083980
Epub:
Not Epub
Abstract:
Gastrulation is a key event in animal embryogenesis during which the germ layers precursors are rearranged and the embryonic...
Link:
https://www.biorxiv.org/content/10.1101/2020.05.08.083980v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Cervino AS, Moretti B, Stuckenholz C, Grecco HE, Davidson LA, Cirio MC. Furry is required for cell movements during gastrulation and functionally interacts with NDR1. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.08.083980.

Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes

Authors:
Garland MA, Geier MC, Bugel SM, Shankar P, Dunham CL, Brown JM, Tilton SC, Tanguay RL
Citation:
Toxicol Sci. 2020 May 8. pii: kfaa063. doi: 10.1093/toxsci/kfaa063. [Epub ahead of print]
Epub:
Yes
Abstract:
The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic...
Link:
https://academic.oup.com/toxsci/advance-article-abstract/doi/10.1093/toxsci/kfaa063/5834730
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Garland MA, Geier MC, Bugel SM, Shankar P, Dunham CL, Brown JM, Tilton SC, Tanguay RL. Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes. Toxicol Sci. 2020 May 8. pii: kfaa063. doi: 10.1093/toxsci/kfaa063. [Epub ahead of print].

Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching

Authors:
Marchalot A, Ashi MO, Lambert JM, Carrion C, Lecardeur S, Srour N, Delpy L, Le Pennec S
Citation:
Front Immunol. 2020;11:780. doi:10.3389/fimmu.2020.00780
Epub:
Not Epub
Abstract:
Class switch recombination (CSR) changes antibody isotype by replacing Cμ constant exons with different constant exons located...
Link:
https://www.frontiersin.org/articles/10.3389/fimmu.2020.00780/full
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: murine splenic B cells
Citation Extract:
Marchalot A, Ashi MO, Lambert JM, Carrion C, Lecardeur S, Srour N, Delpy L, Le Pennec S. Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching. Front Immunol. 2020;11:780. doi:10.3389/fimmu.2020.00780.

Composition-dependent thermodynamics of intracellular phase separation

Authors:
Riback JA, Zhu L, Ferrolino MC, Tolbert M, Mitrea DM, Sanders DW, Wei M-T, Kriwacki RW, Brangwynne CP
Citation:
Nature. 2020;[Epub]. doi:10.1038/s41586-020-2256-2
Epub:
Yes
Abstract:
Intracellular bodies such as nucleoli, Cajal bodies and various signalling assemblies represent membraneless organelles, or...
Link:
https://www.nature.com/articles/s41586-020-2256-2
Citation Extract:
Riback JA, Zhu L, Ferrolino MC, Tolbert M, Mitrea DM, Sanders DW, Wei M-T, Kriwacki RW, Brangwynne CP. Composition-dependent thermodynamics of intracellular phase separation. Nature. 2020;[Epub]. doi:10.1038/s41586-020-2256-2.

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