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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk

Authors:
Pined S, Nikolova-Krstevski V, Leimena C, Atkinson AJ, Altekoester A-K, Cox CD, Jacoby A, Huttner IG, Ju Y-K, Soka M, Ohanian M, Trived G, Johnson R, Molenaar P, Kuchar D, Allen DG, Hill AP, Bodmer R, Vogler G, Dobrzyn H, Ocorr K, Fatkin D
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.28.176495
Epub:
Not Epub
Abstract:
Background: KCNMA1 encodes the a-subunit of the large-conductance Ca2+-activated K+ channel, KCa1.1, and lies within a linkage...
Link:
https://www.biorxiv.org/content/10.1101/2020.06.28.176495v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pined S, Nikolova-Krstevski V, Leimena C, Atkinson AJ, Altekoester A-K, Cox CD, Jacoby A, Huttner IG, Ju Y-K, Soka M, Ohanian M, Trived G, Johnson R, Molenaar P, Kuchar D, Allen DG, Hill AP, Bodmer R, Vogler G, Dobrzyn H, Ocorr K, Fatkin D. Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.28.176495 .

Dopachrome tautomerase variants in patients with oculocutaneous albinism

Authors:
Pennamen P, Tingaud-Sequeira A, Gazova I, Keighren M, McKie L, Marlin S, Halem SG, Kaplan J, Delevoye C, Lacombe D, Plaisant C, Michaud V, Lasseaux E, Javerzat S, Jackson I, Arveiler B
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.26.171223
Epub:
Not Epub
Abstract:
Purpose: Albinism is a clinically and genetically heterogeneous condition. Despite analysis of the nineteen known genes, ~30%...
Link:
https://www.biorxiv.org/content/10.1101/2020.06.26.171223v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pennamen P, Tingaud-Sequeira A, Gazova I, Keighren M, McKie L, Marlin S, Halem SG, Kaplan J, Delevoye C, Lacombe D, Plaisant C, Michaud V, Lasseaux E, Javerzat S, Jackson I, Arveiler B. Dopachrome tautomerase variants in patients with oculocutaneous albinism. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.26.171223 .

Nrl is dispensable for specification of rod photoreceptors in adult zebrafish contrasting a deeply conserved requirement earlier in ontogeny

Authors:
Oel AP, Neil GJ, Dong EM, Balay SD, Collett K, Allison WT
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.26.173930
Epub:
Not Epub
Abstract:
The transcription factor NRL (Neural Retinal Leucine-zipper) has been canonized, appropriately enough, as the master regulator...
Link:
https://www.biorxiv.org/content/10.1101/2020.06.26.173930v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oel AP, Neil GJ, Dong EM, Balay SD, Collett K, Allison WT. Nrl is dispensable for specification of rod photoreceptors in adult zebrafish contrasting a deeply conserved requirement earlier in ontogeny. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.26.173930.

Schwann cells selectively myelinate primary motor axons via neuregulin‐ErbB signaling

Authors:
Lee D-W, Kim E, Inyoung Jeong I, Hwan‐Ki Kim H-K, Suhyun Kim S, Hae‐Chul Park H-C
Citation:
Glia. 2020;[Epub ahead of print] doi:10.1002/glia.23871
Epub:
Not Epub
Abstract:
Spinal motor neurons project their axons out of the spinal cord via the motor exit point (MEP) and regulate their target muscle...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/glia.23871
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lee D-W, Kim E, Inyoung Jeong I, Hwan‐Ki Kim H-K, Suhyun Kim S, Hae‐Chul Park H-C. Schwann cells selectively myelinate primary motor axons via neuregulin‐ErbB signaling. Glia. 2020;[Epub ahead of print] doi:10.1002/glia.23871.

Epb41l5 interacts with Iqcb1 and regulates ciliary function in zebrafish embryos

Authors:
Yu T, Matsuda M
Citation:
J Cell Sci. 2020;133(12):jcs240648 doi:10.1242/jcs.240648
Epub:
Not Epub
Abstract:
Erythrocyte protein band 4.1 like 5 (EPB41L5) is an adaptor protein beneath the plasma membrane that functions to control...
Link:
https://jcs.biologists.org/content/133/12/jcs240648
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yu T, Matsuda M. Epb41l5 interacts with Iqcb1 and regulates ciliary function in zebrafish embryos. J Cell Sci. 2020;133(12):jcs240648 doi:10.1242/jcs.240648.

Neuronal MT1-MMP mediates ECM clearance and Lrp4 cleavage for agrin deposition and signaling in presynaptic development

Authors:
Oentaryo MJ, Tse AC-K, Lee CW
Citation:
J Cell Sci. 2020;[Epub ahead of print] doi:10.1242/jcs.246710
Epub:
Yes
Abstract:
Agrin is a crucial factor that induces postsynaptic differentiation at neuromuscular junctions (NMJs), but how secreted agrin...
Link:
https://jcs.biologists.org/content/early/2020/06/25/jcs.246710
Organism or Cell Type:
Xenopus
Citation Extract:
Oentaryo MJ, Tse AC-K, Lee CW. Neuronal MT1-MMP mediates ECM clearance and Lrp4 cleavage for agrin deposition and signaling in presynaptic development. J Cell Sci. 2020;[Epub ahead of print] doi:10.1242/jcs.246710.

Characterization of Hspb8 in Zebrafish

Authors:
Dubińska-Magiera M, Niedbalska-Tarnowska J, Migocka-Patrzałek M, Posyniak E, Daczewska M
Citation:
Cells 2020;9(6);1562. doi:10.3390/cells9061562
Epub:
Not Epub
Abstract:
Hspb8 is a member of the small heat shock protein (sHSP) family. Its expression is known to be upregulated under heat shock....
Link:
https://www.mdpi.com/2073-4409/9/6/1562
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dubińska-Magiera M, Niedbalska-Tarnowska J, Migocka-Patrzałek M, Posyniak E, Daczewska M . Characterization of Hspb8 in Zebrafish. Cells 2020;9(6);1562. doi:10.3390/cells9061562.

Single Exon Skipping Can Address a Multi-Exon Duplication in the Dystrophin Gene

Authors:
Greer K, Johnsen R, Nevo Y, Fellig Y, Fletcher S, Wilton SD
Citation:
Int J Molec Sci. 2020;[Epub] doi:10.3390/ijms21124511
Epub:
Yes
Abstract:
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease typically caused by protein-truncating mutations that...
Link:
https://www.mdpi.com/1422-0067/21/12/4511
Delivery Method:
cell bathing, peptide-linked
Organism or Cell Type:
cell culture: primary human myoblasts
Citation Extract:
Greer K, Johnsen R, Nevo Y, Fellig Y, Fletcher S, Wilton SD. Single Exon Skipping Can Address a Multi-Exon Duplication in the Dystrophin Gene. Int J Molec Sci. 2020;[Epub] doi:10.3390/ijms21124511.

Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer

Authors:
Li L, Hobson L, Perry L, Clark B, Heavey S, Haider A, Sridhar A, Shaw G, Kelly J, Freeman A, Wilson I, Whitaker H, Nurmemmedov E, Oltean S, Porazinski S, Ladomery M
Citation:
Br J Cancer. 2020;[Epub ahead of print]doi:10.1038/s41416-020-0951-2. Online ahead of print
Epub:
Yes
Abstract:
Background: The ERG oncogene, a member of the ETS family of transcription factor encoding genes, is a genetic driver of...
Link:
https://www.nature.com/articles/s41416-020-0951-2
Delivery Method:
Vivo-Morpholino Endo-Porter
Organism or Cell Type:
Cell culture MG63, VCaP; xenograft mice; primary human tumor explant
Citation Extract:
Li L, Hobson L, Perry L, Clark B, Heavey S, Haider A, Sridhar A, Shaw G, Kelly J, Freeman A, Wilson I, Whitaker H, Nurmemmedov E, Oltean S, Porazinski S, Ladomery M. Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer. Br J Cancer. 2020;[Epub ahead of print]doi:10.1038/s41416-020-0951-2. Online ahead of print.

Notch Regulates Vascular Collagen IV Basement Membrane Through Modulation of Lysyl Hydroxylase 3 Trafficking

Authors:
Gross SJ, Webb AM, Peterlin AD, Durrant JR, Judson RJ, Kushner EJ
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.22.165431
Epub:
Not Epub
Abstract:
During angiogenesis, endothelial cells secrete proteins that make up a planar protein network surrounding blood vessels termed...
Link:
https://www.biorxiv.org/content/10.1101/2020.06.22.165431v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gross SJ, Webb AM, Peterlin AD, Durrant JR, Judson RJ, Kushner EJ. Notch Regulates Vascular Collagen IV Basement Membrane Through Modulation of Lysyl Hydroxylase 3 Trafficking. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.22.165431 .

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