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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

The H3.3 chaperone Hira complex orchestrates oocyte developmental competence

Authors:
Smith R, Jiang Z, Susor A, Ming H, Tait J, Conti M, Lin C-J
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.25.114124
Epub:
Not Epub
Abstract:
Reproductive success relies on a healthy oocyte competent for fertilisation and capable of sustaining early embryo development...
Link:
https://www.biorxiv.org/content/10.1101/2020.05.25.114124v1
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Smith R, Jiang Z, Susor A, Ming H, Tait J, Conti M, Lin C-J. The H3.3 chaperone Hira complex orchestrates oocyte developmental competence. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.25.114124 .

Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain

Authors:
Liu D, Yang F, Liu Z, Wang J, Huang W, Meng W, Billadeau DD, Sun Q, Mo X, Jia D
Citation:
PLoS Biol. 2020;18(5):e3000746. doi:10.1371/journal.pbio.3000746
Epub:
Not Epub
Abstract:
Members of the Tre2-Bub2-Cdc16 (TBC) family often function to regulate membrane trafficking and to control signaling...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000746
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu D, Yang F, Liu Z, Wang J, Huang W, Meng W, Billadeau DD, Sun Q, Mo X, Jia D. Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain. PLoS Biol. 2020;18(5):e3000746. doi:10.1371/journal.pbio.3000746.

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development

Authors:
Wolf EJ, Miles A, Lee ES, Nabeel-Shah S, Greenblatt JF, Palazzo AF, Tropepe V, Emili A
Citation:
Cell Rep. 2020;31(8):107693. doi:10.1016/j.celrep.2020.107693
Epub:
Not Epub
Abstract:
The mammalian mRNA nuclear export process is thought to terminate at the cytoplasmic face of the nuclear pore complex through...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30646-X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wolf EJ, Miles A, Lee ES, Nabeel-Shah S, Greenblatt JF, Palazzo AF, Tropepe V, Emili A. MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development. Cell Rep. 2020;31(8):107693. doi:10.1016/j.celrep.2020.107693.

Safety, Tolerability, and Efficacy of Viltolarsen in Boys With Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping

Authors:
Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, Smith EC, McDonald CM, Zaidman CM, Morgenroth LP, Osaki H, Satou Y, Yamashita T, Hoffman EP, for the CINRG DNHS Investigators
Citation:
JAMA Neurology. 2020;[Epub] doi:10.1001/jamaneurol.2020.1264
Epub:
Yes
Abstract:
Importance: An unmet need remains for safe and efficacious treatments for Duchenne muscular dystrophy (DMD). To date, there...
Link:
https://jamanetwork.com/journals/jamaneurology/fullarticle/2766519
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, Smith EC, McDonald CM, Zaidman CM, Morgenroth LP, Osaki H, Satou Y, Yamashita T, Hoffman EP, for the CINRG DNHS Investigators. Safety, Tolerability, and Efficacy of Viltolarsen in Boys With Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping. JAMA Neurology. 2020;[Epub] doi:10.1001/jamaneurol.2020.1264.

Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos

Authors:
Xiong KM, Peterson RE, Heideman W
Citation:
Mol Pharmacol. 2008 Dec;74(6):1544-53. doi:10.1124/mol.108.050435
Epub:
Not Epub
Abstract:
Exposure to environmental contaminants can disrupt normal development of the early vertebrate skeleton. 2,3,7,8-...
Link:
http://molpharm.aspetjournals.org/content/74/6/1544.short
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xiong KM, Peterson RE, Heideman W. Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos. Mol Pharmacol. 2008 Dec;74(6):1544-53. doi:10.1124/mol.108.050435.

Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks

Authors:
Zhou Q, Perovic T, Fechner I, Edgar LT, Hoskins PR, Gerhardt H, Krüger T, Bernabeu MO
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.21.106914
Epub:
Not Epub
Abstract:
Sprouting angiogenesis is an essential vascularisation mechanism and consists of two phases: sprouting and remodelling. The...
Link:
https://www.biorxiv.org/content/10.1101/2020.05.21.106914v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou Q, Perovic T, Fechner I, Edgar LT, Hoskins PR, Gerhardt H, Krüger T, Bernabeu MO. Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.21.106914 .

Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function

Authors:
Stanicek L, Lozano-Vidal N, Bink DI, Hooglugt A, Yao W, Wittig I, van Rijssel J, van Buul JD, van Bergen A, Klems A, Ramms AS, Le Noble F, Hofmann P, Szulcek R, Wang S, Offermanns S, Ercanoglu MS, Kwon H-B, Stainier D, Huveneers S, Kurian L, Dimmeler S, Boon RA
Citation:
Commun Biol. 3030;3:265 doi:10.1038/s42003-020-0987-0
Epub:
Not Epub
Abstract:
Blood vessels are constantly exposed to shear stress, a biomechanical force generated by blood flow. Normal shear stress...
Link:
https://www.nature.com/articles/s42003-020-0987-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Stanicek L, Lozano-Vidal N, Bink DI, Hooglugt A, Yao W, Wittig I, van Rijssel J, van Buul JD, van Bergen A, Klems A, Ramms AS, Le Noble F, Hofmann P, Szulcek R, Wang S, Offermanns S, Ercanoglu MS, Kwon H-B, Stainier D, Huveneers S, Kurian L, Dimmeler S, Boon RA. Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function. Commun Biol. 3030;3:265 doi:10.1038/s42003-020-0987-0.

FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection

Authors:
Langevin C, Aleksejeva E, Houel A, Briolat V, Torhy C, Lunazzi A, Levraud J-P, Boudinot P
Citation:
Front Immunol. 2017;8:617. doi: 10.3389/fimmu.2017.00617
Epub:
Not Epub
Abstract:
Tripartite motif (TRIM) proteins are involved in various cellular functions and constitute key factors of the antiviral innate...
Link:
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00617/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Langevin C, Aleksejeva E, Houel A, Briolat V, Torhy C, Lunazzi A, Levraud J-P, Boudinot P. FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection. Front Immunol. 2017;8:617. doi: 10.3389/fimmu.2017.00617.

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Authors:
de Calbiac H, Dabacan A, Muresan R, Kabashi E, Ciura S
Citation:
J Vis Exp. 2021 Oct 19;(176). doi: 10.3791/58837
Epub:
Not Epub
Abstract:
Epilepsy represents one of the most common neurological disorders, affecting an estimated 50 million people worldwide. Recent...
Link:
hhttps://www.jove.com/v/58837/behavioral-and-physiological-analysis-in-a-zebrafish-model-of-epilepsy
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
de Calbiac H, Dabacan A, Muresan R, Kabashi E, Ciura S. Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy. J Vis Exp. 2021 Oct 19;(176). doi: 10.3791/58837.

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

Authors:
Guerra J, Valadao A-L, D. Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, B. Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N
Citation:
Sci Adv. 2020;6(1):eaax3333 doi:10.1126/sciadv.aax3333
Epub:
Not Epub
Abstract:
Inflammation is an essential part of immunity against pathogens and tumors but can promote disease if not tightly regulated....
Link:
https://advances.sciencemag.org/content/6/21/eaax3333.
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Guerra J, Valadao A-L, D. Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, B. Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N. Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation. Sci Adv. 2020;6(1):eaax3333 doi:10.1126/sciadv.aax3333.

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