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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Connexin43 gap junctional intercellular communication inhibits evx1 expression and joint formation in regenerating fins

Authors:
Bhattacharya S, Hyland C, Falk MM, Iovine MK
Citation:
Development. 2020;[Epub ahead of print] doi:10.1242/dev.190512
Epub:
Yes
Abstract:
The gap junction protein Connexin43 (Cx43) contributes to cell fate decisions that determine the location of fin ray joints...
Organism or Cell Type:
zebrafish
Citation Extract:
Bhattacharya S, Hyland C, Falk MM, Iovine MK. Connexin43 gap junctional intercellular communication inhibits evx1 expression and joint formation in regenerating fins. Development. 2020;[Epub ahead of print] doi:10.1242/dev.190512.

Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa

Authors:
Yi Z, Ouyang J, Sun W, Li S, Xiao X, Zhang Q
Citation:
EBioMedicine. 2020;56:102792. doi:10.1016/j.ebiom.2020.102792
Epub:
Not Epub
Abstract:
Background: Retinitis pigmentosa (RP) is the most common form of inherited retinal degeneration, but genetic defects in nearly...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yi Z, Ouyang J, Sun W, Li S, Xiao X, Zhang Q. Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa. EBioMedicine. 2020;56:102792. doi:10.1016/j.ebiom.2020.102792.

Requirement of Irf6 and Esrp1/2 in frontonasal and palatal epithelium to regulate craniofacial and palate morphogenesis in mouse and zebrafish

Authors:
Carroll SH, Trevino CM, Li EB-H, Kawasaki K, Alhazmi N, Hallett S, Cotney J, Carstens RP, Liao EC
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.14.149773
Epub:
Not Epub
Abstract:
Orofacial clefts are among the most common congenital structural anomalies. From genome-wide association studies over a decade...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Carroll SH, Trevino CM, Li EB-H, Kawasaki K, Alhazmi N, Hallett S, Cotney J, Carstens RP, Liao EC. Requirement of Irf6 and Esrp1/2 in frontonasal and palatal epithelium to regulate craniofacial and palate morphogenesis in mouse and zebrafish. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.14.149773 .

A polo-like kinase modulates cytokinesis and flagella biogenesis in Giardia lamblia

Authors:
Park E-A, Kim J, Shin MY, Park S-J
Citation:
Research Square. 2020;[preprint]. doi:10.21203/rs.3.rs-34665/v1
Epub:
Not Epub
Abstract:
Background: Polo-like kinases (PLKs) are conserved serine/threonine kinase, regulating cell cycle. Giardia lamblia PLK (GlPLK)...
Delivery Method:
electroporation
Organism or Cell Type:
Giardia lamblia
Citation Extract:
Park E-A, Kim J, Shin MY, Park S-J. A polo-like kinase modulates cytokinesis and flagella biogenesis in Giardia lamblia. Research Square. 2020;[preprint]. doi:10.21203/rs.3.rs-34665/v1.

Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos

Authors:
Otten ABC, Kamps R, Lindsey P, Gerards M, Pendeville-Samain H, Muller M, van Tienen FHJ, Smeets HJM
Citation:
Front Cell Dev Biol. 2020;8:831. doi:10.3389/fcell.2020.00381
Epub:
Not Epub
Abstract:
High mitochondrial DNA (mtDNA) copy numbers are essential for oogenesis and embryogenesis and correlate with fertility of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Otten ABC, Kamps R, Lindsey P, Gerards M, Pendeville-Samain H, Muller M, van Tienen FHJ, Smeets HJM. Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos. Front Cell Dev Biol. 2020;8:831. doi:10.3389/fcell.2020.00381.

Use Of Non-Ablative Dose Of Radiation To Enhance Delivery Of Unmodified Morpholino Oligonucleotides In A Brain Tumor Model To Silence MGMT And Enhance The Efficacy Of Chemo-Radiation (4281)

Authors:
Ambady P, Wu J, Walker J, Kersch C, Morris DA, Bills J, Holland S, Pagel M, Muldoon L, Neuwelt E
Citation:
Neurology. 2020;94 (15 Supplement)
Epub:
Not Epub
Abstract:
Objective: Non-ablative Ionizing radiation ( XRT) is well known to alter neuro-vascular unit (NVU) permeability. We evaluate...
Delivery Method:
injection and ionizing radiation
Organism or Cell Type:
Intracranial tumor bearing athymic nude rats
Citation Extract:
Ambady P, Wu J, Walker J, Kersch C, Morris DA, Bills J, Holland S, Pagel M, Muldoon L, Neuwelt E. Use Of Non-Ablative Dose Of Radiation To Enhance Delivery Of Unmodified Morpholino Oligonucleotides In A Brain Tumor Model To Silence MGMT And Enhance The Efficacy Of Chemo-Radiation (4281). Neurology. 2020;94 (15 Supplement).

Energy and nitrogenous waste from glutamate/glutamine catabolism facilitates acute osmotic adjustment in non-neuroectodermal branchial cells

Authors:
Huang P, Liu T, Hu MY, Casties I, Tseng Y-C
Citation:
Sci Rep. 2020;10:9460. doi:10.1038/s41598-020-65913-1
Epub:
Not Epub
Abstract:
Maintenance of homeostasis is one of the most important physiological responses for animals upon osmotic perturbations....
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Huang P, Liu T, Hu MY, Casties I, Tseng Y-C. Energy and nitrogenous waste from glutamate/glutamine catabolism facilitates acute osmotic adjustment in non-neuroectodermal branchial cells. Sci Rep. 2020;10:9460. doi:10.1038/s41598-020-65913-1.

Vertebrate Models to Investigate CCM Pathogenesis: The Zebrafish and Mouse Model

Authors:
Abou-Fadel J, Zhang J
Citation:
Methods Mol Biol. 2020;2152:225-251. doi: 10.1007/978-1-0716-0640-7_17
Epub:
Not Epub
Abstract:
The use of vertebrate models allows researchers to investigate mechanisms of CCM pathogenesis in vivo, to investigate...
Organism or Cell Type:
zebrafish
Citation Extract:
Abou-Fadel J, Zhang J. Vertebrate Models to Investigate CCM Pathogenesis: The Zebrafish and Mouse Model. Methods Mol Biol. 2020;2152:225-251. doi: 10.1007/978-1-0716-0640-7_17.

Vascular Injury Changes Topology of Vessel Network to Adapt to Partition of Blood Flow for New Arteriovenous Specification

Authors:
Baek KI, Chang S-S, Chang C-C, Roustaei M, Ding Y, Wang Y, Chen J, Odonnelle R, Chen H, Ashby JW, Mack JJ, Xu X, Cavallero S, Hsiai TK
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.09.141408
Epub:
Not Epub
Abstract:
Within vascular networks, wall shear stress (WSS) modulates endothelial cell proliferation and arteriovenous specification....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Baek KI, Chang S-S, Chang C-C, Roustaei M, Ding Y, Wang Y, Chen J, Odonnelle R, Chen H, Ashby JW, Mack JJ, Xu X, Cavallero S, Hsiai TK. Vascular Injury Changes Topology of Vessel Network to Adapt to Partition of Blood Flow for New Arteriovenous Specification. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.09.141408.

Patient-specific functional genomics and disease modeling suggest a role for LRP2 in Hypoplastic Left Heart Syndrome

Authors:
Theis JL, Vogler G, Missinato MA, Li X, Martinez-Fernandez A, Nielsen T, Walls SM, Kervadec A, Zeng X-XI, Kezos JM, Birker K, Evans JM, O'Byrne MM, Fogarty ZC, Terzic A, Grossfeld P, Ocorr K, Colas AR, Nelson TJ, Olson TM, Bodmer R
Citation:
bioRxiv. 2020:835439;[preprint] doi:10.1101/835439
Epub:
Not Epub
Abstract:
Background: Congenital heart diseases, such as hypoplastic left heart syndrome (HLHS), are considered to have complex genetic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Theis JL, Vogler G, Missinato MA, Li X, Martinez-Fernandez A, Nielsen T, Walls SM, Kervadec A, Zeng X-XI, Kezos JM, Birker K, Evans JM, O'Byrne MM, Fogarty ZC, Terzic A, Grossfeld P, Ocorr K, Colas AR, Nelson TJ, Olson TM, Bodmer R. Patient-specific functional genomics and disease modeling suggest a role for LRP2 in Hypoplastic Left Heart Syndrome. bioRxiv. 2020:835439;[preprint] doi:10.1101/835439.

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