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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts
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Citation:
RNA. 2020 Apr 20. pii: rna.075028.120. doi: 10.1261/rna.075028.120. [Epub ahead of print] Epub:
Not Epub Abstract:
The decoy exon model has been proposed to regulate a subset of intron retention (IR) events involving predominantly larger... Delivery Method:
electroporation Organism or Cell Type:
cell culture: human erythroblasts Citation Extract: Parra MK, Zhang W, Vu J, DeWitt MA, Conboy JG. Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts. RNA. 2020 Apr 20. pii: rna.075028.120. doi: 10.1261/rna.075028.120. [Epub ahead of print]. |
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1
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Citation:
Cell Rep. 2020;31(3):107531. doi:10.1016/j.celrep.2020.107531 Epub:
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TRAP1 is the mitochondrial paralog of the heat shock protein 90 (HSP90) chaperone family. Its activity as an energy metabolism... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sanchez-Martin C, Moroni E, Ferraro M, Laquatra C, Cannino G, Masgras I, Negro A, Quadrelli P, Rasola A, Colombo G. Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1. Cell Rep. 2020;31(3):107531. doi:10.1016/j.celrep.2020.107531. |
The cationic amino acid exporter Slc7a7 is vital for and induced in tissue macrophages with sustained efferocytic activity
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.04.20.051664 Epub:
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Most tissues harbor a substantial population of resident macrophages. It is not quite known yet how their quite diverse... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Demy DL, Carrère M, Noche R, Tauzin M, Le Bris M, Baek C, Yousfi M, Leshchiner I, Goessling W, Herbomel P. The cationic amino acid exporter Slc7a7 is vital for and induced in tissue macrophages with sustained efferocytic activity. bioRxiv. 2020;[preprint] doi:10.1101/2020.04.20.051664. |
Splice modulating antisense oligonucleotides restore some acid-alpha-glucosidase activity in cells derived from patients with late-onset Pompe disease
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Citation:
Sci Rep. 2020;10;6702. doi:10.1038/s41598-020-63461-2 Epub:
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Pompe disease is caused by mutations in the GAA gene, resulting in deficient lysosomal acid-α-glucosidase activity in patients... Delivery Method:
electroporation Organism or Cell Type:
cell culture: Pompe patients-derived fibroblasts GM00443 and GM11661 Citation Extract: Aung-Htut MT, Ham KA, Tchan M, Johnsen R, Schnell FJ, Fletcher S, Wilton SD. Splice modulating antisense oligonucleotides restore some acid-alpha-glucosidase activity in cells derived from patients with late-onset Pompe disease. Sci Rep. 2020;10;6702. doi:10.1038/s41598-020-63461-2. |
Wnt-PLC-IP3-Connexin-Ca2+ axis maintains ependymal motile cilia in zebrafish spinal cord
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Citation:
Nat Comm. 2020;11(1):1860. doi:10.1038/s41467-020-15248-2 Epub:
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Ependymal cells (ECs) are multiciliated neuroepithelial cells that line the ventricles of the brain and the central canal of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang J, Chandrasekaran G, Li W, Kim D-Y, Jeong, Lee S-H, Liang T, Bae JY, Choi I, Kang H, Maeng Jin-Soo, Kim M-K, Lee T, Park SW, Kim MJ, Kim H-S, Ro H, Bae YC, Park H-C, Choi EY, Choi S-Y. Wnt-PLC-IP3-Connexin-Ca2+ axis maintains ependymal motile cilia in zebrafish spinal cord. Nat Comm. 2020;11(1):1860. doi:10.1038/s41467-020-15248-2. |
Blood vessels are primary targets for 2,3,7,8-tetrachlorodibenzo-p-dioxin in pre-cardiac edema formation in larval zebrafish
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Citation:
Chemosphere. 2020;[Epub ahead of pint] doi:10.1016/j.chemosphere.2020.126808 Epub:
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has adverse effects on the development and function of the heart in zebrafish... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Nijoukubo D, Adachi H, Kitazawa T, Teraoka H. Blood vessels are primary targets for 2,3,7,8-tetrachlorodibenzo-p-dioxin in pre-cardiac edema formation in larval zebrafish. Chemosphere. 2020;[Epub ahead of pint] doi:10.1016/j.chemosphere.2020.126808. |
Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish
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Citation:
Dis Model Mech. 2016 May 1;9(5):529-40. doi: 10.1242/dmm.023309. Epub 2016 Feb 18 Epub:
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Smooth muscle contraction is controlled by the regulated activity of the myosin heavy chain ATPase (Myh11). Myh11 mutations... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Abrams J, Einhorn Z, Seiler C, Zong AB, Sweeney HL, Pack M. Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish. Dis Model Mech. 2016 May 1;9(5):529-40. doi: 10.1242/dmm.023309. Epub 2016 Feb 18. |
A zebrafish hox gene acts before gastrulation to specify the hemangioblast
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Citation:
Genesis. 2020 Apr 17:e23363. doi: 10.1002/dvg.23363. [Epub ahead of print] Epub:
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Hox genes encode transcription factors that have been implicated in embryonic, adult and disease processes. The earliest... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang C, Featherstone M. A zebrafish hox gene acts before gastrulation to specify the hemangioblast. Genesis. 2020 Apr 17:e23363. doi: 10.1002/dvg.23363. [Epub ahead of print]. |
Developmental Control of Cell-Cycle Compensation Provides a Switch for Patterned Mitosis at the Onset of Chordate Neurulation
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Citation:
Dev Cell. 2016 Apr 18;37(2):148-61. doi: 10.1016/j.devcel.2016.03.013 Epub:
Not Epub Abstract:
During neurulation of chordate ascidians, the 11th mitotic division within the epidermal layer shows a posterior-to-anterior... Delivery Method:
microinjection Organism or Cell Type:
Ciona intentinalis (ascidian) Citation Extract: Ogura Y, Sasakura Y. Developmental Control of Cell-Cycle Compensation Provides a Switch for Patterned Mitosis at the Onset of Chordate Neurulation. Dev Cell. 2016 Apr 18;37(2):148-61. doi: 10.1016/j.devcel.2016.03.013. |
The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis
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Citation:
Cell Cycle. 2016;15(7):957-62. doi: 10.1080/15384101.2016.1151585 Epub:
Not Epub Abstract:
Stressed replication forks can be conservatively repaired and restarted using homologous recombination (HR), initiated by... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chun C, Wu Y, Lee SH, Williamson EA, Reinert BL, Jaiswal AS, Nickoloff JA, Hromas RA. The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis. Cell Cycle. 2016;15(7):957-62. doi: 10.1080/15384101.2016.1151585. |