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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer

Authors:
Li L, Hobson L, Perry L, Clark B, Heavey S, Haider A, Sridhar A, Shaw G, Kelly J, Freeman A, Wilson I, Whitaker H, Nurmemmedov E, Oltean S, Porazinski S, Ladomery M
Citation:
Br J Cancer. 2020;[Epub ahead of print]doi:10.1038/s41416-020-0951-2. Online ahead of print
Epub:
Yes
Abstract:
Background: The ERG oncogene, a member of the ETS family of transcription factor encoding genes, is a genetic driver of...
Link:
https://www.nature.com/articles/s41416-020-0951-2
Delivery Method:
Vivo-Morpholino Endo-Porter
Organism or Cell Type:
Cell culture MG63, VCaP; xenograft mice; primary human tumor explant
Citation Extract:
Li L, Hobson L, Perry L, Clark B, Heavey S, Haider A, Sridhar A, Shaw G, Kelly J, Freeman A, Wilson I, Whitaker H, Nurmemmedov E, Oltean S, Porazinski S, Ladomery M. Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer. Br J Cancer. 2020;[Epub ahead of print]doi:10.1038/s41416-020-0951-2. Online ahead of print.

Notch Regulates Vascular Collagen IV Basement Membrane Through Modulation of Lysyl Hydroxylase 3 Trafficking

Authors:
Gross SJ, Webb AM, Peterlin AD, Durrant JR, Judson RJ, Kushner EJ
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.22.165431
Epub:
Not Epub
Abstract:
During angiogenesis, endothelial cells secrete proteins that make up a planar protein network surrounding blood vessels termed...
Link:
https://www.biorxiv.org/content/10.1101/2020.06.22.165431v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gross SJ, Webb AM, Peterlin AD, Durrant JR, Judson RJ, Kushner EJ. Notch Regulates Vascular Collagen IV Basement Membrane Through Modulation of Lysyl Hydroxylase 3 Trafficking. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.22.165431 .

The mevalonate pathway is a crucial regulator of tendon cell specification

Authors:
Chen JW, Niu X, King MJ, Noedl M-T, Tabin CJ, Galloway JL
Citation:
Development. 2020 Jun 24;147(12):dev185389. doi:10.1242/dev.185389.
Epub:
Not Epub
Abstract:
Tendons and ligaments are crucial components of the musculoskeletal system, yet the pathways specifying these fates remain...
Link:
https://dev.biologists.org/content/147/12/dev185389
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen JW, Niu X, King MJ, Noedl M-T, Tabin CJ, Galloway JL. The mevalonate pathway is a crucial regulator of tendon cell specification. Development. 2020 Jun 24;147(12):dev185389. doi:10.1242/dev.185389. .

Hapln1b organizes the ECM to modulate kit signaling and control developmental hematopoiesis in zebrafish

Authors:
Mahony C, Pasche C, Braunersreuther V, Savvides S, Deagostini A, Bertrand J
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.23.161406
Epub:
Not Epub
Abstract:
During early vertebrate development, hematopoietic stem cells (HSCs) are produced from a hemogenic endothelium located in the...
Link:
https://www.biorxiv.org/content/10.1101/2020.06.23.161406v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mahony C, Pasche C, Braunersreuther V, Savvides S, Deagostini A, Bertrand J. Hapln1b organizes the ECM to modulate kit signaling and control developmental hematopoiesis in zebrafish. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.23.161406 .

Human-specific staphylococcal virulence factors enhance pathogenicity in a humanised zebrafish C5a receptor model

Authors:
Buchan KD, van Gent M, Prajsnar TK, Ogryzko NV, de Jong NWM, Kolata J, Foster SJ, van Strijp JAG, Renshaw SA
Citation:
bioRxiv. 2020; doi:10.1101/2020.02.18.955021
Epub:
Not Epub
Abstract:
Staphylococcus aureus infects approximately 30% of the human population and causes a spectrum of pathologies ranging from mild...
Link:
https://www.biorxiv.org/content/10.1101/2020.02.18.955021v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Buchan KD, van Gent M, Prajsnar TK, Ogryzko NV, de Jong NWM, Kolata J, Foster SJ, van Strijp JAG, Renshaw SA. Human-specific staphylococcal virulence factors enhance pathogenicity in a humanised zebrafish C5a receptor model. bioRxiv. 2020; doi:10.1101/2020.02.18.955021 .

The buds of Oscarella lobularis (Porifera): a new convenient model for sponge cell and developmental biology

Authors:
Rocher C, Vernale A, Fierro-Constain L, Sejourne N, Chenesseau S, Marschal C, Le Golf E, Dutilleul M, Matthews C, Marschal F, Brouilly N, Massey-Harroche D, Ereskovsky A, Le Bivic A, Borchiellini C, Renard E
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.23.167296
Epub:
Not Epub
Abstract:
The comparative study of the four non-bilaterian phyla (Cnidaria, Placozoa, Ctenophora, Porifera) should provide insights into...
Link:
https://www.biorxiv.org/content/10.1101/2020.06.23.167296v1
Delivery Method:
bathing, Endo-Porter
Organism or Cell Type:
Oscarella lobularis (Porifera)
Citation Extract:
Rocher C, Vernale A, Fierro-Constain L, Sejourne N, Chenesseau S, Marschal C, Le Golf E, Dutilleul M, Matthews C, Marschal F, Brouilly N, Massey-Harroche D, Ereskovsky A, Le Bivic A, Borchiellini C, Renard E. The buds of Oscarella lobularis (Porifera): a new convenient model for sponge cell and developmental biology. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.23.167296 .

Histone H3.3 Hira chaperone complex contributes to zygote formation in mice and humans

Authors:
Smith R, Pickering S, Kopakaki A, Thong KJ, Anderson RA, Lin C-J
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.18.159954
Epub:
Not Epub
Abstract:
Elucidating the underlining mechanisms underpinning successful fertilisation is imperative in optimising IVF treatments, and...
Link:
https://www.biorxiv.org/content/10.1101/2020.06.18.159954v1
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Smith R, Pickering S, Kopakaki A, Thong KJ, Anderson RA, Lin C-J. Histone H3.3 Hira chaperone complex contributes to zygote formation in mice and humans. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.18.159954 .

The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos

Authors:
Willsey HR, Xu Y, Everitt A, Dea J, Exner CRT, Willsey AJ, State MW, Harland RM
Citation:
Development. 2020 Jun 22;147(21):dev189290. doi: 10.1242/dev.189290
Epub:
Not Epub
Abstract:
DYRK1A [dual specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 A] is a high-confidence autism risk gene that encodes...
Link:
https://dev.biologists.org/content/147/21/dev189290
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Willsey HR, Xu Y, Everitt A, Dea J, Exner CRT, Willsey AJ, State MW, Harland RM. The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos. Development. 2020 Jun 22;147(21):dev189290. doi: 10.1242/dev.189290.

Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity

Authors:
Babolmorad G, Latif A, Pollock NM, Domingo IK, Delyea C, Rieger AM, Allison WT, Bhavsar AP
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.19.162057
Epub:
Not Epub
Abstract:
Toll-like receptor 4 (TLR4) is famous for recognizing the bacterial endotoxin lipopolysaccharide (LPS) as its canonical ligand...
Link:
https://www.biorxiv.org/content/10.1101/2020.06.19.162057v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Babolmorad G, Latif A, Pollock NM, Domingo IK, Delyea C, Rieger AM, Allison WT, Bhavsar AP. Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.19.162057.

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

Authors:
Cao L, Yonis A, Vaghela M, Barriga EH, Chugh P, Smith MB, Maufront J, Lavoie G, Méant A, Ferber E, Bovellan M, Alberts A, Bertin A, Mayor R, Paluch EK, Roux PP, Jégou A, Romet-Lemonne G, Charras G
Citation:
Nat Cell Biol. 2020:[Epub ahead of print] doi:10.1038/s41556-020-0531-y
Epub:
Yes
Abstract:
Cell shape is controlled by the submembranous cortex, an actomyosin network mainly generated by two actin nucleators: the Arp2/...
Link:
https://www.nature.com/articles/s41556-020-0531-y
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Cao L, Yonis A, Vaghela M, Barriga EH, Chugh P, Smith MB, Maufront J, Lavoie G, Méant A, Ferber E, Bovellan M, Alberts A, Bertin A, Mayor R, Paluch EK, Roux PP, Jégou A, Romet-Lemonne G, Charras G. SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization. Nat Cell Biol. 2020:[Epub ahead of print] doi:10.1038/s41556-020-0531-y.

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