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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression
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Citation:
Nat Commun. 2020;11(1):3501. doi:10.1038/s41467-020-17093-9 Epub:
Not Epub Abstract:
While most monogenic diseases are caused by loss or reduction of protein function, the need for technologies that can... Organism or Cell Type:
cell culture Citation Extract: Lim KH, Han Z, Jeon HY, Kach J, Jing E, Weyn-Vanhentenryck S, Downs M, Corrionero A, Oh R, Scharner J, Venkatesh A, Ji S, Liau G, Ticho B, Nash H, Aznarez I. Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression. Nat Commun. 2020;11(1):3501. doi:10.1038/s41467-020-17093-9. |
Fgf/Ets signalling in Xenopus ectoderm initiates neural induction and patterning in an autonomous and paracrine manners
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.07.07.191288 Epub:
Not Epub Abstract:
Fibroblast growth factor (Fgf) and anti-bone morphogenetic protein (Bmp) signals are derived from the organiser of mesoderm... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Hongo I, Okamoto H. Fgf/Ets signalling in Xenopus ectoderm initiates neural induction and patterning in an autonomous and paracrine manners. bioRxiv. 2020;[preprint] doi:10.1101/2020.07.07.191288. |
Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia
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Citation:
J Clin Invest. 2020 Jul 7:135479. doi:10.1172/JCI135479. Online ahead of print Epub:
Yes Abstract:
The congenital sideroblastic anemias (CSAs) can be caused by primary defects in mitochondrial iron-sulfur cluster (Fe-S)... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Crispin A, Guo C, Chen C, Campagna DR, Schmidt PJ, Lichtenstein DA, Cao C, Sendamarai AK, Hildick-Smith GJ, Huston NC, Boudreaux J, Bottomley SS, Heeney MM, Paw BH, Fleming MD, Ducamp S. Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia. J Clin Invest. 2020 Jul 7:135479. doi:10.1172/JCI135479. Online ahead of print. |
DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes
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Citation:
J Med Genet. 2020 Jul 6:jmedgenet-2019-106805. doi:10.1136/jmedgenet-2019-106805. Online ahead of print Epub:
Yes Abstract:
Background: Cilia are dynamic cellular extensions that generate and sense signals to orchestrate proper development and tissue... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Marquez J, Mann N, Arana K, Deniz E, Ji W, Konstantino M, Mis EK, Deshpande C, Jeffries L, McGlynn J, Hugo H, Widmeier E, Konrad M, Tasic V, Morotti R, Baptista J, Ellard S, Lakhani SA, Hildebrandt F, Khokha MK. DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes. J Med Genet. 2020 Jul 6:jmedgenet-2019-106805. doi:10.1136/jmedgenet-2019-106805. Online ahead of print. |
TLR7 ligation augments haematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling and enhanced differentiation
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.07.06.175000 Epub:
Not Epub Abstract:
Myelodysplastic syndrome (MDS) is a haematological malignancy characterised by blood cytopenias and predisposition to acute... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Peña OC, Lubin A, Rowell J, Hockings CA, Jung Y, Hoade Y, Dace P, Valdivia LE, Tuschl K, Böiers C, Virgilio MC, Richardson S, Payne EM. TLR7 ligation augments haematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling and enhanced differentiation. bioRxiv. 2020;[preprint] doi:10.1101/2020.07.06.175000. |
A Conserved Notochord Enhancer Controls Pancreas Development in Vertebrates
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Citation:
Cell Rep. 2020;32(1):107862. doi:10.1016/j.celrep.2020.107862 Epub:
Not Epub Abstract:
The notochord is an evolutionary novelty in vertebrates that functions as an important signaling center during development.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Amorim JP, Gali-Macedo A, Marcelino H, Bordeira-Carriço R, Naranjo S, Rivero-Gil S, Teixeira J, Galhardo M, Marques J, Bessa J. A Conserved Notochord Enhancer Controls Pancreas Development in Vertebrates. Cell Rep. 2020;32(1):107862. doi:10.1016/j.celrep.2020.107862. |
Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry
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Citation:
Nat Comm. 2020;11(1):3393. doi:10.1038/s41467-020-17088-6 Epub:
Not Epub Abstract:
Meiotic divisions in oocytes are extremely asymmetric and require pre- and post-anaphase-onset phases of spindle migration. The... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Wei Z, Greaney J, Loh W-GN, Homer HA. Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry. Nat Comm. 2020;11(1):3393. doi:10.1038/s41467-020-17088-6. |
Studies in zebrafish demonstrate that CNNM2 and NT5C2 are most likely the causal genes at the blood pressure-associated locus on human chromosome 10q24.32
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Citation:
Front Cardiovasc Med. 2020 Sep 2;7:135. doi: 10.3389/fcvm.2020.00135 Epub:
Not Epub Abstract:
Background: Globally, high blood pressure (BP) is the most important risk factor for cardiovascular disease. Several genome-... Organism or Cell Type:
zebrafish Citation Extract: Vishnolia KK, Hoene C, Tarhbalouti K, Revenstorff J, Aherrahrou Z, Erdmann J. Studies in zebrafish demonstrate that CNNM2 and NT5C2 are most likely the causal genes at the blood pressure-associated locus on human chromosome 10q24.32. Front Cardiovasc Med. 2020 Sep 2;7:135. doi: 10.3389/fcvm.2020.00135. |
Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish
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Citation:
Dev Biol. 2020;[Epub ahead of print] doi:10.1016/j.ydbio.2020.06.007 Epub:
Yes Abstract:
ETS transcription factors play an important role in the specification and differentiation of endothelial cells during vascular... Organism or Cell Type:
zebrafish Citation Extract: Chetty SC, Sumanas S. Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish. Dev Biol. 2020;[Epub ahead of print] doi:10.1016/j.ydbio.2020.06.007. |
Premature termination codons in the DMD gene cause reduced local mRNA synthesis
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Citation:
Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.1910456117 Epub:
Yes Abstract:
Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene leading to the presence of premature termination... Delivery Method:
injection Organism or Cell Type:
mice mdx Citation Extract: García-Rodríguez R, Hiller M, Jiménez-Gracia L, van der Pal Z, Balog J, Adamzek K, Aartsma-Rus A, Spitali P
. Premature termination codons in the DMD gene cause reduced local mRNA synthesis. Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.1910456117. |