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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Using an aquatic model, Xenopus laevis, to uncover the role of chromodomain 1 in craniofacial disorders

Authors:
Wyatt BH, Raymond TO, Lansdon LA, Darbro BW, Murray JC, Manak JR, Dickinson AJG
Citation:
Genesis. 2020 Sep 11:e23394. doi: 10.1002/dvg.23394. Online ahead of print
Epub:
Yes
Abstract:
The chromodomain family member chromodomain 1 (CHD1) has been shown to have numerous critical molecular functions including...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/dvg.23394
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Wyatt BH, Raymond TO, Lansdon LA, Darbro BW, Murray JC, Manak JR, Dickinson AJG. Using an aquatic model, Xenopus laevis, to uncover the role of chromodomain 1 in craniofacial disorders. Genesis. 2020 Sep 11:e23394. doi: 10.1002/dvg.23394. Online ahead of print.

Esco2 and Cohesin Regulate CRL4 Ubiquitin Ligase ddb1 Expression and Thalidomide Teratogenicity

Authors:
Sanchez AC, Thren ED, Iovine MK, Skibbens RV
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.09.02.280149
Epub:
Not Epub
Abstract:
Cornelia de Lange syndrome (CdLS) and Roberts syndrome (RBS) are severe developmental maladies that arise from mutation of...
Link:
https://www.biorxiv.org/content/10.1101/2020.09.02.280149v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sanchez AC, Thren ED, Iovine MK, Skibbens RV. Esco2 and Cohesin Regulate CRL4 Ubiquitin Ligase ddb1 Expression and Thalidomide Teratogenicity. bioRxiv. 2020;[preprint] doi:10.1101/2020.09.02.280149.

Twinfilin1 controls lamellipodial protrusive activity and actin turnover during vertebrate gastrulation

Authors:
Devitt CC, Lee C, Cox RM, Papoulas O, Alvarado J, Marcotte EM, Wallingford JB
Citation:
bioRxiv. 2020;[preprint] doi:/10.1101/2020.09.03.281659
Epub:
Not Epub
Abstract:
The dynamic control of the actin cytoskeleton is a key aspect of essentially all animal cell movements. Experiments in single...
Link:
https://www.biorxiv.org/content/10.1101/2020.09.03.281659v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Devitt CC, Lee C, Cox RM, Papoulas O, Alvarado J, Marcotte EM, Wallingford JB. Twinfilin1 controls lamellipodial protrusive activity and actin turnover during vertebrate gastrulation. bioRxiv. 2020;[preprint] doi:/10.1101/2020.09.03.281659.

A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs

Authors:
Inoue D, Ohe M, Kanemori Y, Nobui T, Sagata N
Citation:
Nature. 2007 Apr 26;446(7139):1100-4. doi: 10.1038/nature05688. Epub 2007 Apr 4
Epub:
Not Epub
Abstract:
In vertebrates, unfertilized eggs (or mature oocytes) are arrested at metaphase of meiosis II by a cytoplasmic activity called...
Link:
https://www.nature.com/articles/nature05688
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Inoue D, Ohe M, Kanemori Y, Nobui T, Sagata N. A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs. Nature. 2007 Apr 26;446(7139):1100-4. doi: 10.1038/nature05688. Epub 2007 Apr 4.

Critical Role for Cold Shock Protein YB-1 in Cytokinesis

Authors:
Mehta S, Algie M, Al-Jabry T, McKinney C, Kannan S, Verma CS, Ma W, Zhang J, Bartolec TK, Masamsetti VP, Parker K, Henderson L, Gould ML, Bhatia P, Harfoot R, Chircop M, Kleffmann T, Cohen SB, Woolley AG, Cesare AJ, Braithwaite A
Citation:
Cancers (Basel). 2020 Sep 1;12(9):E2473. doi: 10.3390/cancers12092473
Epub:
Not Epub
Abstract:
High levels of the cold shock protein Y-box-binding protein-1, YB-1, are tightly correlated with increased cell proliferation...
Link:
https://www.mdpi.com/2072-6694/12/9/2473
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mehta S, Algie M, Al-Jabry T, McKinney C, Kannan S, Verma CS, Ma W, Zhang J, Bartolec TK, Masamsetti VP, Parker K, Henderson L, Gould ML, Bhatia P, Harfoot R, Chircop M, Kleffmann T, Cohen SB, Woolley AG, Cesare AJ, Braithwaite A. Critical Role for Cold Shock Protein YB-1 in Cytokinesis. Cancers (Basel). 2020 Sep 1;12(9):E2473. doi: 10.3390/cancers12092473.

Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish

Authors:
Katikaneni A, Jelcic M, Gerlach GF, Ma Y, Overholtzer M, Niethammer P
Citation:
Nat Cell Biol. 2020 Sep;22(9):1049-1055. doi: 10.1038/s41556-020-0564-2. Epub 2020 Aug 31
Epub:
Not Epub
Abstract:
Rapid wound detection by distant leukocytes is essential for antimicrobial defence and post-infection survival1. The reactive...
Link:
https://www.nature.com/articles/s41556-020-0564-2
Organism or Cell Type:
zebrafish
Citation Extract:
Katikaneni A, Jelcic M, Gerlach GF, Ma Y, Overholtzer M, Niethammer P. Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish. Nat Cell Biol. 2020 Sep;22(9):1049-1055. doi: 10.1038/s41556-020-0564-2. Epub 2020 Aug 31.

Pinhead signaling regulates mesoderm heterogeneity via FGF receptor-dependent pathway

Authors:
Ossipova O, Itoh K, Radu A, Ezan J, Sokol SY
Citation:
Development. 2020 Aug 28:dev.188094. doi: 10.1242/dev.188094. Online ahead of print
Epub:
Yes
Abstract:
Among the three embryonic germ layers, the mesoderm plays a central role in the establishment of the vertebrate body plan. The...
Link:
https://dev.biologists.org/content/147/17/dev188094
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Ossipova O, Itoh K, Radu A, Ezan J, Sokol SY. Pinhead signaling regulates mesoderm heterogeneity via FGF receptor-dependent pathway. Development. 2020 Aug 28:dev.188094. doi: 10.1242/dev.188094. Online ahead of print.

Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease

Authors:
Izarzugaza JMG, Ellesøe SG, Doganli C, Ehlers NS, Dalgaard MD, Audain E, Dombrowsky G, Banasik K, Sifrim A, Wilsdon A, Thienpont B, Breckpot J, Gewillig M; Competence Network for Congenital Heart Defects, Germany, Brook JD, Hitz MP, Larsen LA, Brunak S
Citation:
Genome Med. 2020 Aug 28;12(1):76. doi: 10.1186/s13073-020-00772-z
Epub:
Not Epub
Abstract:
Background: Congenital heart disease (CHD) occurs in almost 1% of newborn children and is considered a multifactorial disorder...
Link:
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00772-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Izarzugaza JMG, Ellesøe SG, Doganli C, Ehlers NS, Dalgaard MD, Audain E, Dombrowsky G, Banasik K, Sifrim A, Wilsdon A, Thienpont B, Breckpot J, Gewillig M; Competence Network for Congenital Heart Defects, Germany, Brook JD, Hitz MP, Larsen LA, Brunak S. Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease. Genome Med. 2020 Aug 28;12(1):76. doi: 10.1186/s13073-020-00772-z.

NOX5 is Expressed Aberrantly but Not a Critical Pathogenetic Gene in Hirschsprung Disease

Authors:
Wang J, Xiao J, Meng X, Chu X, Zhuansun DD, Xiong B, Feng J
Citation:
Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-45296/v1
Epub:
Not Epub
Abstract:
Background: Hirschsprung disease (HSCR) is a congenital disorder characterized by the absence of intramural ganglion cells in...
Link:
https://www.researchsquare.com/article/rs-45296/v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang J, Xiao J, Meng X, Chu X, Zhuansun DD, Xiong B, Feng J. NOX5 is Expressed Aberrantly but Not a Critical Pathogenetic Gene in Hirschsprung Disease. Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-45296/v1.

Klotho Exerts an Emerging Role in Cytokinesis

Authors:
Sun CY, Chou CY, Hsieh YY, Lo KC, Liou YL, Chen YH
Citation:
Genes (Basel). 2020 Sep 4;11(9):E1048. doi: 10.3390/genes11091048
Epub:
Not Epub
Abstract:
The Klotho gene functions as an anti-aging gene. A previous klotho-knockout mice study indicated that neither male nor female...
Link:
https://www.mdpi.com/2073-4425/11/9/1048/htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sun CY, Chou CY, Hsieh YY, Lo KC, Liou YL, Chen YH. Klotho Exerts an Emerging Role in Cytokinesis. Genes (Basel). 2020 Sep 4;11(9):E1048. doi: 10.3390/genes11091048.

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