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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

The role of TASK-2 channels in CO2 sensing in zebrafish (Danio rerio)

Authors:
Koudrina N, Perry SF, Gilmour KM
Citation:
Am J Physiol Regul Integr Comp Physiol. 2020 Jul 22. doi: 10.1152/ajpregu.00132.2020. Online ahead of print
Epub:
Not Epub
Abstract:
Peripheral chemosensitivity in fishes is thought to be mediated by serotonin-enriched neuroepithelial cells (NECs) that are...
Link:
https://journals.physiology.org/doi/abs/10.1152/ajpregu.00132.2020
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Koudrina N, Perry SF, Gilmour KM. The role of TASK-2 channels in CO2 sensing in zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2020 Jul 22. doi: 10.1152/ajpregu.00132.2020. Online ahead of print.

INTS13 Mutations Causing a Developmental Ciliopathy Disrupt Integrator Complex Assembly

Authors:
Mascibroda LG, Shboul M, Elrod ND, Colleaux L, Hamamy H, Huang K-L, Peart NJ, Singh MK, Lee H, Merriman B, Jodoin JN, Lee LA, Al-Rawashdeh B, Ababneh O, El-Khateeb M, Fathalla R, Escande-Beillard N, Nelson SF, Wu Y, Tong L, Kenney LJ, Russell WK, Amiel J, Reversade B, Wagner EJ
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.07.20.209130
Epub:
Not Epub
Abstract:
Oral-facial-digital syndromes (OFD) are a heterogeneous group of congenital disorders characterized by malformations of the...
Link:
https://www.biorxiv.org/content/10.1101/2020.07.20.209130v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Mascibroda LG, Shboul M, Elrod ND, Colleaux L, Hamamy H, Huang K-L, Peart NJ, Singh MK, Lee H, Merriman B, Jodoin JN, Lee LA, Al-Rawashdeh B, Ababneh O, El-Khateeb M, Fathalla R, Escande-Beillard N, Nelson SF, Wu Y, Tong L, Kenney LJ, Russell WK, Amiel J, Reversade B, Wagner EJ. INTS13 Mutations Causing a Developmental Ciliopathy Disrupt Integrator Complex Assembly. bioRxiv. 2020;[preprint] doi:10.1101/2020.07.20.209130 .

Automated Fast-Flow Synthesis of Antisense Phosphorodiamidate Morpholino Oligomers

Authors:
Li C, Callahan AJ, Simon MD, Totaro KA, Mijalis AJ, Hartrampf N, Schissel CK, Zhou M, Zong H, Hanson GJ, Loas A, Pohl NLB, Pentelute BL
Citation:
ChemRxiv. 2020;[preprint] doi:10.26434/chemrxiv.12685886.v1
Epub:
Not Epub
Abstract:
The antisense phosphorodiamidate morpholino oligomer (PMO) drugs Eteplirsen and Golodirsen are improving the lives of some...
Link:
https://chemrxiv.org/articles/preprint/Automated_Fast-Flow_Synthesis_of_Antisense_Phosphorodiamidate_Morpholino_Oligomers/12685886
Citation Extract:
Li C, Callahan AJ, Simon MD, Totaro KA, Mijalis AJ, Hartrampf N, Schissel CK, Zhou M, Zong H, Hanson GJ, Loas A, Pohl NLB, Pentelute BL. Automated Fast-Flow Synthesis of Antisense Phosphorodiamidate Morpholino Oligomers. ChemRxiv. 2020;[preprint] doi:10.26434/chemrxiv.12685886.v1.

MARCKS mediates vascular contractility through regulating interactions between voltage-gated Ca2+ channels and PIP2

Authors:
Jahan KS, Shi J, Greenberg HZE, Khavandi S, Baudel MM-A, Barrese V, Greenwood IA, Albert AP
Citation:
Vasc Pharmacol. 2020;[Epub] doi:10.1016/j.vph.2020.106776
Epub:
Not Epub
Abstract:
Phosphatidylinositol 4,5-bisphosphate (PIP2) acts as substrate and unmodified ligand for Gq-protein-coupled receptor signalling...
Link:
http://www.sciencedirect.com/science/article/pii/S1537189120300987
Citation Extract:
Jahan KS, Shi J, Greenberg HZE, Khavandi S, Baudel MM-A, Barrese V, Greenwood IA, Albert AP. MARCKS mediates vascular contractility through regulating interactions between voltage-gated Ca2+ channels and PIP2. Vasc Pharmacol. 2020;[Epub] doi:10.1016/j.vph.2020.106776.

Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling

Authors:
Mirando AC, Lima e Silva R, Chu Z, Campochiaro PA, Pandey NB, Popel AS
Citation:
Int J Molec Sci. 2020;21(14):1422-0067 doi:10.3390/ijms21145142
Epub:
Not Epub
Abstract:
Persistent inflammation is a complication associated with many ocular diseases. Changes in ocular vessels can amplify disease...
Link:
https://www.mdpi.com/1422-0067/21/14/5142
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HUVEC
Citation Extract:
Mirando AC, Lima e Silva R, Chu Z, Campochiaro PA, Pandey NB, Popel AS. Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling. Int J Molec Sci. 2020;21(14):1422-0067 doi:10.3390/ijms21145142.

Interplay of TRIM2E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis

Authors:
Lokapally A, Neuhaus H, Herfurth J, Hollemann T
Citation:
Cells. 2020;9(7):2073-4409 doi:10.3390/cells9071734
Epub:
Not Epub
Abstract:
Tripartite motif 2 (TRIM2) drives neurite outgrowth and polarization, is involved in axon specification, and confers...
Link:
https://www.mdpi.com/2073-4409/9/7/1734
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Lokapally A, Neuhaus H, Herfurth J, Hollemann T. Interplay of TRIM2E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis. Cells. 2020;9(7):2073-4409 doi:10.3390/cells9071734.

Chitosan-Shelled Nanobubbles Irreversibly Encapsulate Morpholino Conjugate Antisense Oligonucleotides and Are Ineffective for Phosphorodiamidate Morpholino-Mediated Gene Silencing of DUX4

Authors:
Falzarano MS, Argenziano M, Marsollier AC, Mariot V, Rossi D, Selvatici R, Dumonceaux J, Cavalli R, Ferlini A
Citation:
Nucleic Acid Ther. 2020 Jul 13. doi: 10.1089/nat.2020.0862. Online ahead of print
Epub:
Yes
Abstract:
Orphan drugs, including antisense oligonucleotides (AONs), siRNAs/miRNAs, Cas9 nuclease, and recombinant genes, have recently...
Link:
https://www.liebertpub.com/doi/10.1089/nat.2020.0862
Delivery Method:
chitosan nanobubble
Organism or Cell Type:
cell culture
Citation Extract:
Falzarano MS, Argenziano M, Marsollier AC, Mariot V, Rossi D, Selvatici R, Dumonceaux J, Cavalli R, Ferlini A. Chitosan-Shelled Nanobubbles Irreversibly Encapsulate Morpholino Conjugate Antisense Oligonucleotides and Are Ineffective for Phosphorodiamidate Morpholino-Mediated Gene Silencing of DUX4. Nucleic Acid Ther. 2020 Jul 13. doi: 10.1089/nat.2020.0862. Online ahead of print.

CFTR Depletion Confers Hypersusceptibility to Mycobacterium fortuitum in a Zebrafish Model

Authors:
Johansen MD, Kremer L
Citation:
Front Cell Infect Microbiol. 2020;10:357. doi:10.3389/fcimb.2020.00357
Epub:
Not Epub
Abstract:
The Mycobacterium fortuitum complex comprises several closely related species, causing pulmonary and extra-pulmonary infections...
Link:
https://www.frontiersin.org/articles/10.3389/fcimb.2020.00357/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Johansen MD, Kremer L. CFTR Depletion Confers Hypersusceptibility to Mycobacterium fortuitum in a Zebrafish Model. Front Cell Infect Microbiol. 2020;10:357. doi:10.3389/fcimb.2020.00357.

Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptide

Authors:
Nikan M, Tanowitz M, Dwyer CA, Jackson M, Gaus H, Swayze E, Rigo F, Seth PP, Prakash TP
Citation:
J Med Chem. 2020 Jul 17. doi:10.1021/acs.jmedchem.0c00840. Online ahead of print
Epub:
Not Epub
Abstract:
Despite recent advances, targeted delivery of therapeutic oligonucleotide to extra-hepatic tissues continues to be a...
Link:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00840
Delivery Method:
peptide-linked, intracerebroventricular (i.c.v.) injection in mice
Organism or Cell Type:
cell culture: HEK293, mice
Citation Extract:
Nikan M, Tanowitz M, Dwyer CA, Jackson M, Gaus H, Swayze E, Rigo F, Seth PP, Prakash TP. Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptide. J Med Chem. 2020 Jul 17. doi:10.1021/acs.jmedchem.0c00840. Online ahead of print.

Kowalczyk I, Lee C, Schuster E, Hoeren J, Trivigno V, Riedel L, Goerne J, Wallingford JB, Hammes-Lewin A, Feistel K

Authors:
Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.07.15.205252
Epub:
Not Epub
Abstract:
Recent studies have revealed that pathogenic mutations in the endocytic receptor LRP2 in humans are associated with severe...
Link:
https://www.biorxiv.org/content/10.1101/2020.07.15.205252v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds. Kowalczyk I, Lee C, Schuster E, Hoeren J, Trivigno V, Riedel L, Goerne J, Wallingford JB, Hammes-Lewin A, Feistel K. bioRxiv. 2020;[preprint] doi:10.1101/2020.07.15.205252 .

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