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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

A polo-like kinase modulates cytokinesis and flagella biogenesis in Giardia lamblia

Authors:
Park E-A, Kim J, Shin MY, Park S-J
Citation:
Research Square. 2020;[preprint]. doi:10.21203/rs.3.rs-34665/v1
Epub:
Not Epub
Abstract:
Background: Polo-like kinases (PLKs) are conserved serine/threonine kinase, regulating cell cycle. Giardia lamblia PLK (GlPLK)...
Link:
https://www.researchsquare.com/article/rs-34665/v1
Delivery Method:
electroporation
Organism or Cell Type:
Giardia lamblia
Citation Extract:
Park E-A, Kim J, Shin MY, Park S-J. A polo-like kinase modulates cytokinesis and flagella biogenesis in Giardia lamblia. Research Square. 2020;[preprint]. doi:10.21203/rs.3.rs-34665/v1.

Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos

Authors:
Otten ABC, Kamps R, Lindsey P, Gerards M, Pendeville-Samain H, Muller M, van Tienen FHJ, Smeets HJM
Citation:
Front Cell Dev Biol. 2020;8:831. doi:10.3389/fcell.2020.00381
Epub:
Not Epub
Abstract:
High mitochondrial DNA (mtDNA) copy numbers are essential for oogenesis and embryogenesis and correlate with fertility of...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2020.00381/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Otten ABC, Kamps R, Lindsey P, Gerards M, Pendeville-Samain H, Muller M, van Tienen FHJ, Smeets HJM. Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos. Front Cell Dev Biol. 2020;8:831. doi:10.3389/fcell.2020.00381.

Use Of Non-Ablative Dose Of Radiation To Enhance Delivery Of Unmodified Morpholino Oligonucleotides In A Brain Tumor Model To Silence MGMT And Enhance The Efficacy Of Chemo-Radiation (4281)

Authors:
Ambady P, Wu J, Walker J, Kersch C, Morris DA, Bills J, Holland S, Pagel M, Muldoon L, Neuwelt E
Citation:
Neurology. 2020;94 (15 Supplement)
Epub:
Not Epub
Abstract:
Objective: Non-ablative Ionizing radiation ( XRT) is well known to alter neuro-vascular unit (NVU) permeability. We evaluate...
Link:
https://n.neurology.org/content/94/15_Supplement/4281.abstract
Delivery Method:
injection and ionizing radiation
Organism or Cell Type:
Intracranial tumor bearing athymic nude rats
Citation Extract:
Ambady P, Wu J, Walker J, Kersch C, Morris DA, Bills J, Holland S, Pagel M, Muldoon L, Neuwelt E. Use Of Non-Ablative Dose Of Radiation To Enhance Delivery Of Unmodified Morpholino Oligonucleotides In A Brain Tumor Model To Silence MGMT And Enhance The Efficacy Of Chemo-Radiation (4281). Neurology. 2020;94 (15 Supplement).

Energy and nitrogenous waste from glutamate/glutamine catabolism facilitates acute osmotic adjustment in non-neuroectodermal branchial cells

Authors:
Huang P, Liu T, Hu MY, Casties I, Tseng Y-C
Citation:
Sci Rep. 2020;10:9460. doi:10.1038/s41598-020-65913-1
Epub:
Not Epub
Abstract:
Maintenance of homeostasis is one of the most important physiological responses for animals upon osmotic perturbations....
Link:
https://www.nature.com/articles/s41598-020-65913-1
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Huang P, Liu T, Hu MY, Casties I, Tseng Y-C. Energy and nitrogenous waste from glutamate/glutamine catabolism facilitates acute osmotic adjustment in non-neuroectodermal branchial cells. Sci Rep. 2020;10:9460. doi:10.1038/s41598-020-65913-1.

Vertebrate Models to Investigate CCM Pathogenesis: The Zebrafish and Mouse Model

Authors:
Abou-Fadel J, Zhang J
Citation:
Methods Mol Biol. 2020;2152:225-251. doi: 10.1007/978-1-0716-0640-7_17
Epub:
Not Epub
Abstract:
The use of vertebrate models allows researchers to investigate mechanisms of CCM pathogenesis in vivo, to investigate...
Link:
https://www.springer.com/gp/book/9781071606391
Organism or Cell Type:
zebrafish
Citation Extract:
Abou-Fadel J, Zhang J. Vertebrate Models to Investigate CCM Pathogenesis: The Zebrafish and Mouse Model. Methods Mol Biol. 2020;2152:225-251. doi: 10.1007/978-1-0716-0640-7_17.

Vascular Injury Changes Topology of Vessel Network to Adapt to Partition of Blood Flow for New Arteriovenous Specification

Authors:
Baek KI, Chang S-S, Chang C-C, Roustaei M, Ding Y, Wang Y, Chen J, Odonnelle R, Chen H, Ashby JW, Mack JJ, Xu X, Cavallero S, Hsiai TK
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.06.09.141408
Epub:
Not Epub
Abstract:
Within vascular networks, wall shear stress (WSS) modulates endothelial cell proliferation and arteriovenous specification....
Link:
https://www.biorxiv.org/content/10.1101/2020.06.09.141408v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Baek KI, Chang S-S, Chang C-C, Roustaei M, Ding Y, Wang Y, Chen J, Odonnelle R, Chen H, Ashby JW, Mack JJ, Xu X, Cavallero S, Hsiai TK. Vascular Injury Changes Topology of Vessel Network to Adapt to Partition of Blood Flow for New Arteriovenous Specification. bioRxiv. 2020;[preprint] doi:10.1101/2020.06.09.141408.

Patient-specific functional genomics and disease modeling suggest a role for LRP2 in Hypoplastic Left Heart Syndrome

Authors:
Theis JL, Vogler G, Missinato MA, Li X, Martinez-Fernandez A, Nielsen T, Walls SM, Kervadec A, Zeng X-XI, Kezos JM, Birker K, Evans JM, O'Byrne MM, Fogarty ZC, Terzic A, Grossfeld P, Ocorr K, Colas AR, Nelson TJ, Olson TM, Bodmer R
Citation:
bioRxiv. 2020:835439;[preprint] doi:10.1101/835439
Epub:
Not Epub
Abstract:
Background: Congenital heart diseases, such as hypoplastic left heart syndrome (HLHS), are considered to have complex genetic...
Link:
https://www.biorxiv.org/content/10.1101/835439v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Theis JL, Vogler G, Missinato MA, Li X, Martinez-Fernandez A, Nielsen T, Walls SM, Kervadec A, Zeng X-XI, Kezos JM, Birker K, Evans JM, O'Byrne MM, Fogarty ZC, Terzic A, Grossfeld P, Ocorr K, Colas AR, Nelson TJ, Olson TM, Bodmer R. Patient-specific functional genomics and disease modeling suggest a role for LRP2 in Hypoplastic Left Heart Syndrome. bioRxiv. 2020:835439;[preprint] doi:10.1101/835439.

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells

Authors:
Michaels WE, Bridges RJ, Hastings ML
Citation:
Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa490
Epub:
Not Epub
Abstract:
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CF transmembrane conductance regulator (CFTR...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa490/5855636
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human primary bronchial epithelial cells
Citation Extract:
Michaels WE, Bridges RJ, Hastings ML. Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells. Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa490.

Viltolarsen: First Approval

Authors:
Dhillon S
Citation:
Drugs. 2020 Jun 9. doi: 10.1007/s40265-020-01339-3. Online ahead of print
Epub:
Yes
Abstract:
Viltolarsen (Viltepso® in Japan) is a phosphorodiamidate morpholino antisense oligonucleotide being developed by Nippon...
Link:
https://link.springer.com/article/10.1007%2Fs40265-020-01339-3
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Dhillon S. Viltolarsen: First Approval. Drugs. 2020 Jun 9. doi: 10.1007/s40265-020-01339-3. Online ahead of print.

U1 snRNP Telescripting Roles in Transcription and Its Mechanism

Authors:
Di C, So BR, Cai Z, Arai C, Duan J, Dreyfuss G
Citation:
Cold Spring Harb Symp Quant Biol. 2020 Jun 9:040451. doi:10.1101/sqb.2019.84.040451. Online ahead of print
Epub:
Not Epub
Abstract:
Telescripting is a fundamental cotranscriptional gene regulation process that relies on U1 snRNP (U1) to suppress premature 3...
Link:
http://symposium.cshlp.org/content/early/2020/06/09/sqb.2019.84.040451
Organism or Cell Type:
cell culture
Citation Extract:
Di C, So BR, Cai Z, Arai C, Duan J, Dreyfuss G. U1 snRNP Telescripting Roles in Transcription and Its Mechanism. Cold Spring Harb Symp Quant Biol. 2020 Jun 9:040451. doi:10.1101/sqb.2019.84.040451. Online ahead of print.

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