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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways

Authors:
Yin H, Peng R, Chen Z, Wang H, Zhang T, Zheng Y
Citation:
J Hum Genet. 2020;[Epub ahead of print] doi:10.1038/s10038-020-0793-z
Epub:
Yes
Abstract:
Neural tube defects (NTDs) are debilitating human congenital abnormalities due to failure of neural tube closure. Sonic...
Link:
https://www.nature.com/articles/s10038-020-0793-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yin H, Peng R, Chen Z, Wang H, Zhang T, Zheng Y. WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways. J Hum Genet. 2020;[Epub ahead of print] doi:10.1038/s10038-020-0793-z.

Novel EGFP reporter cell and mouse models for sensitive imaging and quantification of exon skipping

Authors:
Hara Y, Mizobe Y, Inoue YU, Hashimoto Y, Motohashi N, Masaki Y, Seio K, Takeda S, Nagata T, Wood MJA, Inoue T, Aoki Y
Citation:
Sci Rep. 2020;10(1):10110. doi: 10.1038/s41598-020-67077-4
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a fatal X-linked disorder caused by nonsense or frameshift mutations in the DMD gene....
Link:
https://www.nature.com/articles/s41598-020-67077-4
Delivery Method:
Endo-Porter, local injection
Organism or Cell Type:
cell culture, mice
Citation Extract:
Hara Y, Mizobe Y, Inoue YU, Hashimoto Y, Motohashi N, Masaki Y, Seio K, Takeda S, Nagata T, Wood MJA, Inoue T, Aoki Y. Novel EGFP reporter cell and mouse models for sensitive imaging and quantification of exon skipping. Sci Rep. 2020;10(1):10110. doi: 10.1038/s41598-020-67077-4.

Protein Regulator of Cytokinesis 1 (PRC1) Regulates Chromosome Dynamics and Cytoplasmic Division During Mouse Oocyte Meiotic Maturation and Early Embryonic Development

Authors:
Zhou CJ, Wang DH, Kong XW, Han Z, Hao X, Wang XY, Wen X, Liang CG
Citation:
FEBS J. 2020 Jun 19. doi: 10.1111/febs.15458. Online ahead of print
Epub:
Yes
Abstract:
In contrast to the homeokinesis of mitosis, asymmetric division of cytoplasm is the conspicuous feature of meiosis in mammalian...
Link:
https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15458
Delivery Method:
microinjection
Organism or Cell Type:
mouse zygote & 2-cell embryo
Citation Extract:
Zhou CJ, Wang DH, Kong XW, Han Z, Hao X, Wang XY, Wen X, Liang CG. Protein Regulator of Cytokinesis 1 (PRC1) Regulates Chromosome Dynamics and Cytoplasmic Division During Mouse Oocyte Meiotic Maturation and Early Embryonic Development. FEBS J. 2020 Jun 19. doi: 10.1111/febs.15458. Online ahead of print.

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

Authors:
Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan C-H, Singh RK, Apken LK, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP, Askan G, Grbovic-Huezo O, Ogrodowski P, Bermeo J, Saglimbeni J, Cruz CD, Ho Y-J, Lawrence SA, Melchor JP, Goda Ga, Bai K, Pastore A, Hogg SJ, Raghavan S, Bailey P, Chang DK, Biankin A, Shroyer KR, Wolpin BM, Aguirre AJ, Ventura A, Taylor B, Der CJ, Dominguez D, Kümmel D, Oeckinghaus A, Lowe SW, Bradley RK, Abdel-Wahab O, Leach SD
Citation:
Cancer Cell. 2020;[Epub ahead of print] doi:10.1016/j.ccell.2020.05.010
Epub:
Yes
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is driven by co-existing mutations in KRAS and TP53. However, how these mutations...
Link:
https://www.cell.com/cancer-cell/pdfExtended/S1535-6108(20)30260-9
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture
Citation Extract:
Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan C-H, Singh RK, Apken LK, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP, Askan G, Grbovic-Huezo O, Ogrodowski P, Bermeo J, Saglimbeni J, Cruz CD, Ho Y-J, Lawrence SA, Melchor JP, Goda Ga, Bai K, Pastore A, Hogg SJ, Raghavan S, Bailey P, Chang DK, Biankin A, Shroyer KR, Wolpin BM, Aguirre AJ, Ventura A, Taylor B, Der CJ, Dominguez D, Kümmel D, Oeckinghaus A, Lowe SW, Bradley RK, Abdel-Wahab O, Leach SD. Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer. Cancer Cell. 2020;[Epub ahead of print] doi:10.1016/j.ccell.2020.05.010.

Tracking periocular mesenchyme derived anterior segment development using single cell transcriptomic analysis

Authors:
Voecking O, Smith J, Famulski J
Citation:
Invest Ophthalmol Vis Sci. 2020;61:3175
Epub:
Not Epub
Abstract:
Purpose: The anterior segment (AS) of the eye, as well as further anterior structures, are formed by a subgroup of neural crest...
Link:
https://iovs.arvojournals.org/article.aspx?articleid=2767926
Organism or Cell Type:
zebrafish
Citation Extract:
Voecking O, Smith J, Famulski J. Tracking periocular mesenchyme derived anterior segment development using single cell transcriptomic analysis. Invest Ophthalmol Vis Sci. 2020;61:3175.

Optimizing oligotherapeutics for visual loss in Usher syndrome mice

Authors:
Lentz JJ, Hathaway M, Robillard KN, Ponnath A, Fisher M, Rigo F, Alapure BV
Citation:
Invest Ophthalmol Vis Sci. 2020;Vol.61:2445
Epub:
Not Epub
Abstract:
Purpose : Usher syndrome (Usher) is a syndromic form of inherited retinal dystrophy (IRD) characterized by hearing impairment...
Link:
https://iovs.arvojournals.org/article.aspx?articleid=2767542
Delivery Method:
intravitreal injection
Organism or Cell Type:
mice
Citation Extract:
Lentz JJ, Hathaway M, Robillard KN, Ponnath A, Fisher M, Rigo F, Alapure BV. Optimizing oligotherapeutics for visual loss in Usher syndrome mice. Invest Ophthalmol Vis Sci. 2020;Vol.61:2445.

Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract

Authors:
Sidhwani P, Leerberg DM, Boezio GLM, Capasso TL, Yang H, Chi NC, Roman BL, Stainier DYR, Yelon D
Citation:
Development. 2020;147:dev185900 doi:10.1242/dev.185900
Epub:
Not Epub
Abstract:
Physical forces are important participants in the cellular dynamics that shape developing organs. During heart formation, for...
Link:
https://dev.biologists.org/content/147/12/dev185900
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sidhwani P, Leerberg DM, Boezio GLM, Capasso TL, Yang H, Chi NC, Roman BL, Stainier DYR, Yelon D. Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract. Development. 2020;147:dev185900 doi:10.1242/dev.185900 .

Duped by a duplication: Heterozygous duplication in PRPF31 causes Retinitis pigmentosa in elusive gene family

Authors:
Scott H, Larson A, Chao KR, DiTroia SP, Butcher R, Place E, Pierce EA, Bujakowska K
Citation:
Invest Ophthalmol Vis Sci. 2020;61(7):4468
Epub:
Not Epub
Abstract:
Inherited retinal degenerations (IRD) are an important cause of blindness affecting 1/4000 people worldwide. Presently, over...
Link:
https://iovs.arvojournals.org/article.aspx?articleid=2768578
Organism or Cell Type:
zebrafish
Citation Extract:
Scott H, Larson A, Chao KR, DiTroia SP, Butcher R, Place E, Pierce EA, Bujakowska K. Duped by a duplication: Heterozygous duplication in PRPF31 causes Retinitis pigmentosa in elusive gene family. Invest Ophthalmol Vis Sci. 2020;61(7):4468.

Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves

Authors:
Takamiya M, Stegmaier J, Kobitski AY, Schott B, Weger BD, Margariti D, Delgado ARC, Gourain V, Scherr T, Yang L, Sorge S, Otte JC, Hartmann V, van Wezel J, Stotzka R, Reinhard T, Schlunck G, Dickmeis T, Rastegar S, Mikut R, Nienhaus GU, Strähle U
Citation:
PLoS Genet. 2020;16(6):e1008774. doi:10.1371/journal.pgen.1008774
Epub:
Not Epub
Abstract:
Cranial neural crest (NC) contributes to the developing vertebrate eye. By multidimensional, quantitative imaging, we traced...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008774
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Takamiya M, Stegmaier J, Kobitski AY, Schott B, Weger BD, Margariti D, Delgado ARC, Gourain V, Scherr T, Yang L, Sorge S, Otte JC, Hartmann V, van Wezel J, Stotzka R, Reinhard T, Schlunck G, Dickmeis T, Rastegar S, Mikut R, Nienhaus GU, Strähle U. Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves. PLoS Genet. 2020;16(6):e1008774. doi:10.1371/journal.pgen.1008774.

Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency

Authors:
Kozyra EJ, Pastor VB, Lefkopoulos S. Sahoo SS, Busch H, Voss RK, Erlacher M, Lebrecht D, Szvetnik EA, Hirabayashi S, Pasaulienė R, Pedace L, Tartaglia M, Klemann C, Metzger P, Boerries M, Catala A, Hasle H, de Haas V, Kállay K, Masetti R, De Moerloose B, Dworzak M, Schmugge M, Smith O, Starý J, Mejstrikova E, Ussowicz M, Morris E, Singh P, Collin M, Derecka M, Gudrun Göhring G, Flotho C, Strahm B, Locatelli F, Niemeyer CM, Trompouki E, Wlodarski MW, European Working Group of MDS in Childhood (EWOG-MDS)
Citation:
Leukemia. 2020;[Epub]. https://doi.org/10.1038/s41375-020-0899-5
Epub:
Yes
Abstract:
Deficiency of the transcription factor GATA2 is a highly penetrant genetic disorder predisposing to myelodysplastic syndromes (...
Link:
https://www.nature.com/articles/s41375-020-0899-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kozyra EJ, Pastor VB, Lefkopoulos S. Sahoo SS, Busch H, Voss RK, Erlacher M, Lebrecht D, Szvetnik EA, Hirabayashi S, Pasaulienė R, Pedace L, Tartaglia M, Klemann C, Metzger P, Boerries M, Catala A, Hasle H, de Haas V, Kállay K, Masetti R, De Moerloose B, Dworzak M, Schmugge M, Smith O, Starý J, Mejstrikova E, Ussowicz M, Morris E, Singh P, Collin M, Derecka M, Gudrun Göhring G, Flotho C, Strahm B, Locatelli F, Niemeyer CM, Trompouki E, Wlodarski MW, European Working Group of MDS in Childhood (EWOG-MDS). Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency. Leukemia. 2020;[Epub]. https://doi.org/10.1038/s41375-020-0899-5.

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