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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12146 scientific papers returned from the database with the search filters currently being used below.
There are 12146 scientific papers returned from the database with the search filters currently being used below.
Unravelling the disease mechanism for TSPYL1 deficiency
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Citation:
Hum Mol Genet. 2020;[Epub aheaed of print] doi:10.1093/hmg/ddaa233 Epub:
Yes Abstract:
We describe a lethal combined nervous and reproductive systems disease in three affected siblings of a consanguineous family.... Organism or Cell Type:
zebrafish Citation Extract: Buyse G, Di Michele M, Wijgaerts A, Louwette S, Wittevrongel C, Thys C, Downes K, Ceulemans B, Van Esch H, Van Geet C, Freson K. Unravelling the disease mechanism for TSPYL1 deficiency. Hum Mol Genet. 2020;[Epub aheaed of print] doi:10.1093/hmg/ddaa233. |
setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals
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Citation:
Cell Discov. 2020;6(1):72 doi:10.1038/s41421-020-00203-8 Epub:
Not Epub Abstract:
Setd2 is the only enzyme that catalyzes histone H3 lysine 36 trimethylation (H3K36me3) on virtually all actively transcribed... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Liu D-J, Zhang F, Chen Y, Jin Y, Zhang Y-L, Chen S-B, Xie Y-Y, Huang Q-H, Zhao W-L, Wang L, Xu P-F, Chen Z, Chen S-J, Li B, Zhang A, Sun X-J. setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals. Cell Discov. 2020;6(1):72 doi:10.1038/s41421-020-00203-8. |
Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development
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Citation:
Genetics. 2020 Dec;216(4):1153-1185. doi: 10.1534/genetics.120.303748. Epub 2020 Oct 19. PMID: 33077489; PMCID: PMC7768253 Epub:
Yes Abstract:
Transcription factors that contain a homeodomain DNA-binding domain have crucial functions in most aspects of cellular function... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: England SJ, Cerda GA, Kowalchuk A, Sorice T, Grieb G, Lewis KE. Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development. Genetics. 2020 Dec;216(4):1153-1185. doi: 10.1534/genetics.120.303748. Epub 2020 Oct 19. PMID: 33077489; PMCID: PMC7768253. |
The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG
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Citation:
Cell Rep. 2020;33(3):108295. doi:10.1016/j.celrep.2020.108295 Epub:
Not Epub Abstract:
TMEM18 is the strongest candidate for childhood obesity identified from GWASs, yet as for most GWAS-derived obesity-... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Landgraf K, Klöting N, Gericke M, Maixner N, Guiu-Jurado E, Scholz M, Witte AV, Beyer F, Schwartze JT, Lacher M, Villringer A, Kovacs P, Rudich A, Blüher M, Kiess W, Körner A. The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG. Cell Rep. 2020;33(3):108295. doi:10.1016/j.celrep.2020.108295. |
A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites
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Citation:
Elife. 2019 Mar 11;8:e42455. doi:10.7554/eLife.42455 Epub:
Not Epub Abstract:
Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Jiang N, Rasmussen JP, Clanton JA, Rosenberg MF, Luedke KP, Cronan MR, Parker ED, Kim HJ, Vaughan JC, Sagasti A, Parrish JZ. A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites. Elife. 2019 Mar 11;8:e42455. doi:10.7554/eLife.42455. |
Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis
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Citation:
Elife. 2018 Dec 6;7:e40556. doi:10.7554/eLife.40556 Epub:
Not Epub Abstract:
A crucial step in cell differentiation is the silencing of developmental programs underlying multipotency. While much is known... Delivery Method:
electroporation Organism or Cell Type:
Gallus gallus (chick) Citation Extract: Bhattacharya D, Rothstein M, Azambuja AP, Simoes-Costa M. Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis. Elife. 2018 Dec 6;7:e40556. doi:10.7554/eLife.40556. |
Morpholino-Mediated Knockdown of Ciliary Genes in Euplotes vannus, a Novel Marine Ciliated Model Organism
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Citation:
Front Microbiol. 2020;11:254 doi:10.3389/fmicb.2020.549781 Epub:
Not Epub Abstract:
Cilia are highly conserved organelles present in almost all types of eukaryotic cells, and defects in cilia structure and/or... Delivery Method:
microinjection Organism or Cell Type:
Euplotes vannus (ciliate) Citation Extract: Tang D, Wang X, Dong J, Li Y, Gao F, Xie H, Zhao C. Morpholino-Mediated Knockdown of Ciliary Genes in Euplotes vannus, a Novel Marine Ciliated Model Organism. Front Microbiol. 2020;11:254 doi:10.3389/fmicb.2020.549781 . |
Nonsequential Splicing Events Alter Antisense-Mediated Exon Skipping Outcome in COL7A1
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Citation:
Int J Molec Sci. 2020;21(20):1422-0067 doi:10.3390/ijms21207705 Epub:
Not Epub Abstract:
The COL7A1 gene encodes homotrimer fibrils essential for anchoring dermal and epidermal layers, and pathogenic mutations in... Delivery Method:
electroporation Organism or Cell Type:
cell culture: primary human dermal fibroblasts Citation Extract: Ham KA, Aung-Htut MT, Fletcher D, Wilton SD. Nonsequential Splicing Events Alter Antisense-Mediated Exon Skipping Outcome in COL7A1. Int J Molec Sci. 2020;21(20):1422-0067 doi:10.3390/ijms21207705. |
Collective cancer cell invasion requires RNA accumulation at the invasive front
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Citation:
Proc Natl Acad Sci U S A. 2020;[Epub ahead of print] doi:10.1073/pnas.2010872117 Epub:
Yes Abstract:
Localization of RNAs at protrusive regions of cells is important for single-cell migration on two-dimensional surfaces.... Delivery Method:
Endo-Porter or Vivo-Morpholino Organism or Cell Type:
cell culture: MDA-MB-231 Citation Extract: Chrisafis G, Wang T, Moissoglu K, Gasparski AN, Ng Y, Weigert R, Lockett SJ, Mili S. Collective cancer cell invasion requires RNA accumulation at the invasive front. Proc Natl Acad Sci U S A. 2020;[Epub ahead of print] doi:10.1073/pnas.2010872117 . |
Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation
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Citation:
JCI Insight. 2020;5(20):e133019. doi:10.1172/jci.insight.133019 Epub:
Not Epub Abstract:
Although congenital heart defects (CHDs) represent the most common birth defect, a comprehensive understanding of disease... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lu P-N, Moreland T, Christian CJ, Lund TC, Steet RA, Flanagan-Steet H. Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation. JCI Insight. 2020;5(20):e133019. doi:10.1172/jci.insight.133019. |