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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

MARCKS mediates vascular contractility through regulating interactions between voltage-gated Ca2+ channels and PIP2

Authors:
Jahan KS, Shi J, Greenberg HZE, Khavandi S, Baudel MM-A, Barrese V, Greenwood IA, Albert AP
Citation:
Vasc Pharmacol. 2020;[Epub] doi:10.1016/j.vph.2020.106776
Epub:
Not Epub
Abstract:
Phosphatidylinositol 4,5-bisphosphate (PIP2) acts as substrate and unmodified ligand for Gq-protein-coupled receptor signalling...
Citation Extract:
Jahan KS, Shi J, Greenberg HZE, Khavandi S, Baudel MM-A, Barrese V, Greenwood IA, Albert AP. MARCKS mediates vascular contractility through regulating interactions between voltage-gated Ca2+ channels and PIP2. Vasc Pharmacol. 2020;[Epub] doi:10.1016/j.vph.2020.106776.

Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling

Authors:
Mirando AC, Lima e Silva R, Chu Z, Campochiaro PA, Pandey NB, Popel AS
Citation:
Int J Molec Sci. 2020;21(14):1422-0067 doi:10.3390/ijms21145142
Epub:
Not Epub
Abstract:
Persistent inflammation is a complication associated with many ocular diseases. Changes in ocular vessels can amplify disease...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HUVEC
Citation Extract:
Mirando AC, Lima e Silva R, Chu Z, Campochiaro PA, Pandey NB, Popel AS. Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling. Int J Molec Sci. 2020;21(14):1422-0067 doi:10.3390/ijms21145142.

Interplay of TRIM2E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis

Authors:
Lokapally A, Neuhaus H, Herfurth J, Hollemann T
Citation:
Cells. 2020;9(7):2073-4409 doi:10.3390/cells9071734
Epub:
Not Epub
Abstract:
Tripartite motif 2 (TRIM2) drives neurite outgrowth and polarization, is involved in axon specification, and confers...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Lokapally A, Neuhaus H, Herfurth J, Hollemann T. Interplay of TRIM2E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis. Cells. 2020;9(7):2073-4409 doi:10.3390/cells9071734.

Chitosan-Shelled Nanobubbles Irreversibly Encapsulate Morpholino Conjugate Antisense Oligonucleotides and Are Ineffective for Phosphorodiamidate Morpholino-Mediated Gene Silencing of DUX4

Authors:
Falzarano MS, Argenziano M, Marsollier AC, Mariot V, Rossi D, Selvatici R, Dumonceaux J, Cavalli R, Ferlini A
Citation:
Nucleic Acid Ther. 2020 Jul 13. doi: 10.1089/nat.2020.0862. Online ahead of print
Epub:
Yes
Abstract:
Orphan drugs, including antisense oligonucleotides (AONs), siRNAs/miRNAs, Cas9 nuclease, and recombinant genes, have recently...
Delivery Method:
chitosan nanobubble
Organism or Cell Type:
cell culture
Citation Extract:
Falzarano MS, Argenziano M, Marsollier AC, Mariot V, Rossi D, Selvatici R, Dumonceaux J, Cavalli R, Ferlini A. Chitosan-Shelled Nanobubbles Irreversibly Encapsulate Morpholino Conjugate Antisense Oligonucleotides and Are Ineffective for Phosphorodiamidate Morpholino-Mediated Gene Silencing of DUX4. Nucleic Acid Ther. 2020 Jul 13. doi: 10.1089/nat.2020.0862. Online ahead of print.

CFTR Depletion Confers Hypersusceptibility to Mycobacterium fortuitum in a Zebrafish Model

Authors:
Johansen MD, Kremer L
Citation:
Front Cell Infect Microbiol. 2020;10:357. doi:10.3389/fcimb.2020.00357
Epub:
Not Epub
Abstract:
The Mycobacterium fortuitum complex comprises several closely related species, causing pulmonary and extra-pulmonary infections...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Johansen MD, Kremer L. CFTR Depletion Confers Hypersusceptibility to Mycobacterium fortuitum in a Zebrafish Model. Front Cell Infect Microbiol. 2020;10:357. doi:10.3389/fcimb.2020.00357.

Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptide

Authors:
Nikan M, Tanowitz M, Dwyer CA, Jackson M, Gaus H, Swayze E, Rigo F, Seth PP, Prakash TP
Citation:
J Med Chem. 2020 Jul 17. doi:10.1021/acs.jmedchem.0c00840. Online ahead of print
Epub:
Not Epub
Abstract:
Despite recent advances, targeted delivery of therapeutic oligonucleotide to extra-hepatic tissues continues to be a...
Delivery Method:
peptide-linked, intracerebroventricular (i.c.v.) injection in mice
Organism or Cell Type:
cell culture: HEK293, mice
Citation Extract:
Nikan M, Tanowitz M, Dwyer CA, Jackson M, Gaus H, Swayze E, Rigo F, Seth PP, Prakash TP. Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptide. J Med Chem. 2020 Jul 17. doi:10.1021/acs.jmedchem.0c00840. Online ahead of print.

Kowalczyk I, Lee C, Schuster E, Hoeren J, Trivigno V, Riedel L, Goerne J, Wallingford JB, Hammes-Lewin A, Feistel K

Authors:
Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.07.15.205252
Epub:
Not Epub
Abstract:
Recent studies have revealed that pathogenic mutations in the endocytic receptor LRP2 in humans are associated with severe...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds. Kowalczyk I, Lee C, Schuster E, Hoeren J, Trivigno V, Riedel L, Goerne J, Wallingford JB, Hammes-Lewin A, Feistel K. bioRxiv. 2020;[preprint] doi:10.1101/2020.07.15.205252 .

VLRs expression were significantly affected by complement C3 knockdown morphants in Lampetra morii

Authors:
Li J, Liu H, Ma Q, Song X, Pang Y, Su P, Sun F, Gou M, Lu J, Shan Y, Guan H, Liu X, Li Q, Han Y
Citation:
Fish Shellfish Immun. 2020;[Epub ahead of print] doi:10.1016/j.fsi.2020.07.013
Epub:
Yes
Abstract:
The complement component 3 of the lamprey, a jawless vertebrate, functions as an opsonin during the phagocytosis of rabbit red...
Delivery Method:
microinjection
Organism or Cell Type:
Lampetra morii (lamprey)
Citation Extract:
Li J, Liu H, Ma Q, Song X, Pang Y, Su P, Sun F, Gou M, Lu J, Shan Y, Guan H, Liu X, Li Q, Han Y. VLRs expression were significantly affected by complement C3 knockdown morphants in Lampetra morii. Fish Shellfish Immun. 2020;[Epub ahead of print] doi:10.1016/j.fsi.2020.07.013.

Wang X, Dunlap K, Satterfield M, Frank J, Li X, Ying W, Burghardt R, Johnson GA, Wu G, Antoniazzi AQ, Nett TM, Hansen TR, Bazer FW

Authors:
Effects of In Vivo Knockdown of Translation of Arginine-Associated Gene Transcripts in Conceptus Trophectoderm on Growth, Development, and Gene Expression by Ovine Conceptuses
Citation:
Biol Reprod. 2012;87(suppl 1)394. doi:10.1093/biolreprod/87.s1.394
Epub:
Not Epub
Abstract:
Arginine (Arg), a nutritionally essential amino acid for conceptus development, can be metabolized to nitric oxide (NO) and...
Delivery Method:
bathing in uterine lumen
Organism or Cell Type:
Ovis aries (sheep) conceptus
Citation Extract:
Effects of In Vivo Knockdown of Translation of Arginine-Associated Gene Transcripts in Conceptus Trophectoderm on Growth, Development, and Gene Expression by Ovine Conceptuses . Wang X, Dunlap K, Satterfield M, Frank J, Li X, Ying W, Burghardt R, Johnson GA, Wu G, Antoniazzi AQ, Nett TM, Hansen TR, Bazer FW. Biol Reprod. 2012;87(suppl 1)394. doi:10.1093/biolreprod/87.s1.394.

Sensory Neuroblast Quiescence Dependson Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood Flow

Authors:
Taberner L, Banñó A, Alsina B
Citation:
Cell Rep. 2020;32:107903. doi:10.1016/j.celrep.2020.107903
Epub:
Not Epub
Abstract:
In many organs, stem cell function depends on communication with their niche partners. Cranial sensory neurons develop in...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Taberner L, Banñó A, Alsina B. Sensory Neuroblast Quiescence Dependson Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood Flow. Cell Rep. 2020;32:107903. doi:10.1016/j.celrep.2020.107903.

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