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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Multilineage murine stem cells generate complex organoids to model distal lung development and disease

Authors:
Vazquez‐Armendariz AI, Heiner M, El Agha E, Salwig I, Hoek A, Hessler MC, Shalashova I, Shrestha A, Carraro G, Mengel JP, Günther A, Morty RE, Vadász I, Schwemmle M, Kummer W, Hain T, Goesmann A, Bellusci S, Seeger W, Braun T, Herold S
Citation:
EMBO J. 2020;e103476 [Epub] doi:10.15252/embj.2019103476
Epub:
Not Epub
Abstract:
Organoids derived from mouse and human stem cells have recently emerged as a powerful tool to study organ development and...
Link:
https://www.embopress.org/doi/full/10.15252/embj.2019103476
Delivery Method:
cell bathing
Organism or Cell Type:
cell culture: murine bronchioalveolar lung organoid (BALO)
Citation Extract:
Vazquez‐Armendariz AI, Heiner M, El Agha E, Salwig I, Hoek A, Hessler MC, Shalashova I, Shrestha A, Carraro G, Mengel JP, Günther A, Morty RE, Vadász I, Schwemmle M, Kummer W, Hain T, Goesmann A, Bellusci S, Seeger W, Braun T, Herold S. Multilineage murine stem cells generate complex organoids to model distal lung development and disease. EMBO J. 2020;e103476 [Epub] doi:10.15252/embj.2019103476.

Internal Oligoguanidinium Transporter: Mercury Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitisation of Taxol

Authors:
Kundu J, Banerjee P, Bose C, Das U, Ghosh U, Sinha S
Citation:
Bioconjug Chem. 2020:[Epub ahead of print] doi:10.1021/acs.bioconjchem.0c00444
Epub:
Yes
Abstract:
A non toxic delivery vehicle is essential for the therapeutic applications of antisense phosphorodiamidate morpholino...
Link:
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.0c00444
Delivery Method:
internal oligoguanidinium transporter (IGT)
Organism or Cell Type:
cell culture: MCF-7
Citation Extract:
Kundu J, Banerjee P, Bose C, Das U, Ghosh U, Sinha S. Internal Oligoguanidinium Transporter: Mercury Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitisation of Taxol. Bioconjug Chem. 2020:[Epub ahead of print] doi:10.1021/acs.bioconjchem.0c00444.

Slit2 is essential for correct retinal ganglion cell axon fasciculation and midline crossing in the zebrafish

Authors:
Davison C, Zolessi FR
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.09.25.314062
Epub:
Not Epub
Abstract:
The functional connection of the retina with the brain implies the extension of retinal ganglion cells axons through a long and...
Link:
https://www.biorxiv.org/content/10.1101/2020.09.25.314062v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Davison C, Zolessi FR. Slit2 is essential for correct retinal ganglion cell axon fasciculation and midline crossing in the zebrafish. bioRxiv. 2020;[preprint] doi:10.1101/2020.09.25.314062 .

Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics

Authors:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ
Citation:
PLoS ONE. 2020;15(9):e0239467. doi:10.1371/journal.pone.0239467
Epub:
Not Epub
Abstract:
Dystrophin plays a vital role in maintaining muscle health, yet low mRNA expression, lengthy transcription time and the...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239467
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ. Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics. PLoS ONE. 2020;15(9):e0239467. doi:10.1371/journal.pone.0239467.

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

Authors:
Weger M, Weger BD, Schink A, Takamiya M, Stegmaier J, Gobet C, Parisi A, Kobitski AY, Mertes J, Krone N, Strähle U, Nienhaus GU, Mikut R, Gachon F, Gut P, Dickmeis T
Citation:
eLife. 2020;9:e57088 doi:10.7554/eLife.57068
Epub:
Not Epub
Abstract:
The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in...
Link:
https://elifesciences.org/articles/57068
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Weger M, Weger BD, Schink A, Takamiya M, Stegmaier J, Gobet C, Parisi A, Kobitski AY, Mertes J, Krone N, Strähle U, Nienhaus GU, Mikut R, Gachon F, Gut P, Dickmeis T. MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. eLife. 2020;9:e57088 doi:10.7554/eLife.57068.

The cationic amino acid exporter Slc7a7 is induced and vital in tissue macrophages with sustained efferocytic activity

Authors:
Demy DL, Carrère M, Noche R, Tauzin M, Le Bris M, Baek C, Leshchiner I, Goessling W, Herbomel P
Citation:
J Cell Sci. 2020;[Epub ahead of print] doi: 10.1242/jcs.249037
Epub:
Not Epub
Abstract:
Most tissues harbor a substantial population of resident macrophages. Here we elucidate a functional link between the Slc7a7...
Link:
https://jcs.biologists.org/content/early/2020/09/21/jcs.249037
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Demy DL, Carrère M, Noche R, Tauzin M, Le Bris M, Baek C, Leshchiner I, Goessling W, Herbomel P. The cationic amino acid exporter Slc7a7 is induced and vital in tissue macrophages with sustained efferocytic activity. J Cell Sci. 2020;[Epub ahead of print] doi: 10.1242/jcs.249037.

Functional evidence that Activin/Nodal signaling is required for establishing the dorsal-ventral axis in the annelid Capitella teleta

Authors:
Lanza AR, Seaver EC
Citation:
Development. 2020 Sep 23;147(18):dev189373. doi: 10.1242/dev.189373
Epub:
Not Epub
Abstract:
The TGF-β superfamily comprises two distinct branches: the Activin/Nodal and BMP pathways. During development, signaling by...
Link:
https://dev.biologists.org/content/147/18/dev189373
Delivery Method:
microinjection
Organism or Cell Type:
Capitella teleta (annelid)
Citation Extract:
Lanza AR, Seaver EC. Functional evidence that Activin/Nodal signaling is required for establishing the dorsal-ventral axis in the annelid Capitella teleta. Development. 2020 Sep 23;147(18):dev189373. doi: 10.1242/dev.189373.

Imaging the Dynamic Branching and Synaptic Differentiation of Xenopus Optic Axons In Vivo

Authors:
Santos RA, Rio RD Jr, Cohen-Cory S
Citation:
Cold Spring Harb Protoc. 2020 Sep 22. doi: 10.1101/pdb.prot106823. Online ahead of print
Epub:
Yes
Abstract:
In the developing Xenopus tadpole visual system, the targeting and branching of optic axons in the brain is a dynamic process...
Link:
http://cshprotocols.cshlp.org/content/early/2020/09/22/pdb.prot106823.abstract
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Santos RA, Rio RD Jr, Cohen-Cory S. Imaging the Dynamic Branching and Synaptic Differentiation of Xenopus Optic Axons In Vivo. Cold Spring Harb Protoc. 2020 Sep 22. doi: 10.1101/pdb.prot106823. Online ahead of print.

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation

Authors:
Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J, Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, Kathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Göttgens B, Speck NA, Zon LI
Citation:
Proc Natl Acad Sci U S A. 2020 Sep 3:202003228. doi: 10.1073/pnas.2003228117. Online ahead of print
Epub:
Yes
Abstract:
Hematopoietic stem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs...
Link:
https://www.pnas.org/content/117/38/23626
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J, Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, Kathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Göttgens B, Speck NA, Zon LI. CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proc Natl Acad Sci U S A. 2020 Sep 3:202003228. doi: 10.1073/pnas.2003228117. Online ahead of print.

Notch3 and DeltaB maintain Müller glia quiescence and act as negative regulators of regeneration in the light‐damaged zebrafish retina

Authors:
Campbell LJ, Hobgood JS, Jia M, Boyd P, Hipp RI, Hyde DR
Citation:
Glia. 2020;[Epub ahead of pint] doi:10.1002/glia.23912
Epub:
Yes
Abstract:
Damage to the zebrafish retina stimulates resident Müller glia to reprogram, reenter the cell cycle, divide asymmetrically, and...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.23912
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Campbell LJ, Hobgood JS, Jia M, Boyd P, Hipp RI, Hyde DR. Notch3 and DeltaB maintain Müller glia quiescence and act as negative regulators of regeneration in the light‐damaged zebrafish retina. Glia. 2020;[Epub ahead of pint] doi:10.1002/glia.23912.

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