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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12156 scientific papers returned from the database with the search filters currently being used below.

Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects

Authors:
O'Donnell EF 3rd, Jang HS, Liefwalker DF, Kerkvliet NI, Kolluri SK
Citation:
Apoptosis. 2021 Jun;26(5-6):307-322. doi: 10.1007/s10495-021-01666-0. Epub 2021 Apr 24. PMID: 33893898
Epub:
Not Epub
Abstract:
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and a member of the bHLH/PAS (basic Helix-Loop-...
Link:
https://link.springer.com/article/10.1007/s10495-021-01666-0
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Hepa 1
Citation Extract:
O'Donnell EF 3rd, Jang HS, Liefwalker DF, Kerkvliet NI, Kolluri SK. Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects. Apoptosis. 2021 Jun;26(5-6):307-322. doi: 10.1007/s10495-021-01666-0. Epub 2021 Apr 24. PMID: 33893898.

Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis

Authors:
Shi Y, Liu Z, Zhang Q, Vallee I, Mo Z, Kishi S, Yang X-L
Citation:
PLoS Biol. 2020;18(12):e3000991. doi:10.1371/journal.pbio.3000991
Epub:
Not Epub
Abstract:
Hypoxia-induced angiogenesis maintains tissue oxygen supply and protects against ischemia but also enhances tumor progression...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000991
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shi Y, Liu Z, Zhang Q, Vallee I, Mo Z, Kishi S, Yang X-L. Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis. PLoS Biol. 2020;18(12):e3000991. doi:10.1371/journal.pbio.3000991.

Nrl is dispensable for specification of rod photoreceptors in adult zebrafish contrasting a deeply conserved requirement earlier in ontogeny

Authors:
Oel AP, Neil GJ, Dong EM, Balay SD, Collett K, Allison WT
Citation:
iScience. 2020;23(12):101805 doi:10.1016/j.isci.2020.101805
Epub:
Not Epub
Abstract:
The transcription factor NRL (neural retina leucine zipper) has been canonized as the master regulator of photoreceptor cell...
Link:
https://www.cell.com/iscience/fulltext/S2589-0042(20)31002-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oel AP, Neil GJ, Dong EM, Balay SD, Collett K, Allison WT. Nrl is dispensable for specification of rod photoreceptors in adult zebrafish contrasting a deeply conserved requirement earlier in ontogeny. iScience. 2020;23(12):101805 doi:10.1016/j.isci.2020.101805.

Post-transcriptional tuning of FGF signaling mediates neural crest induction

Authors:
Copeland J, Simoes-Costa M
Citation:
Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.2009997117
Epub:
Not Epub
Abstract:
Ectodermal patterning is required for the establishment of multiple components of the vertebrate body plan. Previous studies...
Link:
https://www.pnas.org/content/early/2020/12/18/2009997117
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Copeland J, Simoes-Costa M. Post-transcriptional tuning of FGF signaling mediates neural crest induction. Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.2009997117.

The Genome-Wide Impact of Nipblb Loss-of-Function on Zebrafish Gene Expression

Authors:
Spreafico M, Mangano E, Mazzola M, Consolandi C, Bordoni R, Battaglia C, Bicciato S, Marozzi A, Pistocchi A
Citation:
Int J Mol Sci. 2020 Dec 19;21(24):E9719. doi: 10.3390/ijms21249719
Epub:
Not Epub
Abstract:
Transcriptional changes normally occur during development but also underlie differences between healthy and pathological...
Link:
https://www.mdpi.com/1422-0067/21/24/9719
Organism or Cell Type:
zebrafish
Citation Extract:
Spreafico M, Mangano E, Mazzola M, Consolandi C, Bordoni R, Battaglia C, Bicciato S, Marozzi A, Pistocchi A. The Genome-Wide Impact of Nipblb Loss-of-Function on Zebrafish Gene Expression. Int J Mol Sci. 2020 Dec 19;21(24):E9719. doi: 10.3390/ijms21249719.

MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice

Authors:
Ran N, Lin C, Leng L, Han G, Geng M, Wu Y, Bittner S, Moulton H, Yin H
Citation:
EMBO Mol Med. 2020;13:e12993 doi:10.15252/emmm.202012993
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (AO)‐mediated exon‐skipping therapies show promise in Duchenne muscular dystrophy (DMD), a...
Link:
https://www.embopress.org/doi/full/10.15252/emmm.202012993
Delivery Method:
unlinked MOTS‐c peptide
Organism or Cell Type:
mouse mdx
Citation Extract:
Ran N, Lin C, Leng L, Han G, Geng M, Wu Y, Bittner S, Moulton H, Yin H. MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice. EMBO Mol Med. 2020;13:e12993 doi:10.15252/emmm.202012993.

Dpysl2 (CRMP2) is required for the migration of facial branchiomotor neurons in the developing zebrafish embryo

Authors:
Fiallos-Oliveros C, Ohshima T
Citation:
Int J Dev Biol. 2020;64(10-11-12):479-484. doi: 10.1387/ijdb.190375to
Epub:
Not Epub
Abstract:
Dihydropyrimidinase-like family proteins (Dpysls) are relevant in several processes during nervous system development; among...
Link:
http://www.ijdb.ehu.es/web/paper.php?doi=190375to
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fiallos-Oliveros C, Ohshima T. Dpysl2 (CRMP2) is required for the migration of facial branchiomotor neurons in the developing zebrafish embryo. Int J Dev Biol. 2020;64(10-11-12):479-484. doi: 10.1387/ijdb.190375to.

Kcnb1 plays a role in development of the inner ear

Authors:
Jedrychowska J, Gasanov EV, Korzha V
Citation:
Dev Biol. 2021;471:65-75. doi:10.1016/j.ydbio.2020.12.007
Epub:
Not Epub
Abstract:
The function of the inner ear depends on the maintenance of high concentrations of K+ ions. The slow-inactivating delayed...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160620303146
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jedrychowska J, Gasanov EV, Korzha V. Kcnb1 plays a role in development of the inner ear. Dev Biol. 2021;471:65-75. doi:10.1016/j.ydbio.2020.12.007.

Pharyngeal pouches provide a niche microenvironment for arch artery progenitor specification

Authors:
Mao A, Zhang M, Li L, Liu J, Ning G, Cao Y, Wang Q
Citation:
Development. 2020;148: dev192658 [Epub ahead of print] doi:10.1242/dev.192658
Epub:
Yes
Abstract:
The paired pharyngeal arch arteries (PAAs) are transient blood vessels connecting the heart with the dorsal aorta during...
Link:
https://dev.biologists.org/content/early/2020/12/16/dev.192658
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mao A, Zhang M, Li L, Liu J, Ning G, Cao Y, Wang Q. Pharyngeal pouches provide a niche microenvironment for arch artery progenitor specification. Development. 2020;148: dev192658 [Epub ahead of print] doi:10.1242/dev.192658.

Histone Demethylase PHF8 Is Required for the Development of the Zebrafish Inner Ear and Posterior Lateral Line

Authors:
He J, Zheng Z, Luo X, Hong Y, Su W, Cai C
Citation:
Front Cell Dev Biol. 2020 Nov 23;8:566504. doi: 10.3389/fcell.2020.566504. eCollection 2020
Epub:
Not Epub
Abstract:
Histone demethylase PHF8 is crucial for multiple developmental processes, and hence, the awareness of its function in...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2020.566504/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
He J, Zheng Z, Luo X, Hong Y, Su W, Cai C. Histone Demethylase PHF8 Is Required for the Development of the Zebrafish Inner Ear and Posterior Lateral Line. Front Cell Dev Biol. 2020 Nov 23;8:566504. doi: 10.3389/fcell.2020.566504. eCollection 2020.

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