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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
Deletion of morpholino binding sites (DeMOBS) to assess specificity of morphant phenotypes
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Citation:
Sci Rep. 2020 Sep 21;10(1):15366. doi: 10.1038/s41598-020-71708-1 Epub:
Not Epub Abstract:
Two complimentary approaches are widely used to study gene function in zebrafish: induction of genetic mutations, usually using... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Cunningham CM, Bellipanni G, Habas R, Balciunas D. Deletion of morpholino binding sites (DeMOBS) to assess specificity of morphant phenotypes. Sci Rep. 2020 Sep 21;10(1):15366. doi: 10.1038/s41598-020-71708-1. |
Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides
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Citation:
J Vis Exp. 2020 May 7;(159). doi: 10.3791/60672 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a degenerative muscle disease that causes progressive loss of muscle mass, leading to... Link:
Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Nordin JZ, Mizobe Y, Nakamura H, Komaki H, Takeda S, Aoki Y. Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides. J Vis Exp. 2020 May 7;(159). doi: 10.3791/60672. |
Mouse fertilization triggers a conserved transcription program in one-cell embryos
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.09.15.298018 Epub:
Not Epub Abstract:
Following fertilization, the new embryo reprograms parental genomes to begin transcription (embryonic genome activation, EGA).... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Asami M, Lam BYH, Hoffmann M, Suzuki T, Lu X, VerMilyea MD, Yoshida N, Ma MK, Rainbow K, Braun S, Patwary N, Yeo GSH, Klein CA, Perry ACF. Mouse fertilization triggers a conserved transcription program in one-cell embryos. bioRxiv. 2020;[preprint] doi:10.1101/2020.09.15.298018 . |
Autophagy induction promotes renal cyst growth in polycystic kidney disease
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Citation:
EBioMedicine. 2020 Sep 16;60:102986. doi: 10.1016/j.ebiom.2020.102986. Online ahead of print Epub:
Yes Abstract:
Background: Polycystic kidney disease (PKD) involves renal cysts arising from proliferating tubular cells. Autophagy has been... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lee EJ, Ko JY, Oh S, Jun J, Mun H, Lim CJ, Seo S, Ko HW, Kim H, Oh YK, Ahn C, Kang M, Kim MJ, Yoo KH, Oh GT, Park JH. Autophagy induction promotes renal cyst growth in polycystic kidney disease. EBioMedicine. 2020 Sep 16;60:102986. doi: 10.1016/j.ebiom.2020.102986. Online ahead of print. |
Posttranscriptional regulation of maternal Pou5f1/Oct4 during mouse oogenesis and early embryogenesis
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Citation:
Histochem Cell Biol. 2020 Sep 15. doi: 10.1007/s00418-020-01915-4. Online ahead of print. PMID: 32930837 Epub:
Yes Abstract:
Protein syntheses at appropriate timings are important for promoting diverse biological processes and are controlled at the... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Takada Y, Iyyappan R, Susor A, Kotani T. Posttranscriptional regulation of maternal Pou5f1/Oct4 during mouse oogenesis and early embryogenesis. Histochem Cell Biol. 2020 Sep 15. doi: 10.1007/s00418-020-01915-4. Online ahead of print. PMID: 32930837 . |
Wasp controls oriented migration of endothelial cells to achieve functional vascular patterning
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.09.15.296574 Epub:
Not Epub Abstract:
Endothelial cell migration and proliferation are essential for the establishment of a hierarchical organization of blood... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Rosa A, Giese W, Meier K, Alt S, Klaus-Bergmann A, Edgar L, Bartels E, Collins R, Szymborska-Mell A, Coxam B, Bernabeu MO, Gerhardt H. Wasp controls oriented migration of endothelial cells to achieve functional vascular patterning. bioRxiv. 2020;[preprint] doi:10.1101/2020.09.15.296574. |
Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans
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Citation:
Redox Biol. 2020;101723. doi:10.1016/j.redox.2020.101723 Epub:
Not Epub Abstract:
Increased methylglyoxal (MG) formation is associated with diabetes and its complications. In zebrafish, knockout of the main MG... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lou B, Boger M, Bennewitz K, Sticht C, Kopf S, Morgenstern J, Fleming T, Hell R, Yuan Z, Nawroth PP, Kroll J. Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biol. 2020;101723. doi:10.1016/j.redox.2020.101723. |
Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells.
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.09.18.302984 Epub:
Not Epub Abstract:
The need to identify new therapeutic approaches to the treatment of cancers of the B lymphoid lineage is crucial. Unlike CRISPR... Delivery Method:
Vivo-Morpholino versus "transfection" of standard Morpholinos Organism or Cell Type:
cell culture: SUDHL4 and OCILY10 (DLBCL) lines, primary Human Peripheral Blood Mononuclear B Cells (PBMC) Citation Extract: Marchalot A, Lambert J-M, Boyer F, Pollet J, Moreau J, Feuillard J, Faumont N, Delpy L. Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells.. bioRxiv. 2020;[preprint] doi:10.1101/2020.09.18.302984 . |
Molluscan dorsal-ventral patterning relying on BMP2/4 and Chordin provides insights into spiralian development and bilaterian body plan evolution
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.11.245670 Epub:
Not Epub Abstract:
The molecular mechanisms of dorsal-ventral (DV) patterning in Spiralia are poorly understood. The few available studies... Delivery Method:
microinjection Organism or Cell Type:
Lottia goshimai (limpet) Citation Extract: Tan S, Huan P, Liu B. Molluscan dorsal-ventral patterning relying on BMP2/4 and Chordin provides insights into spiralian development and bilaterian body plan evolution. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.11.245670 . |
Role of matrix metalloproteinase-9 in neurodevelopmental disorders and experience-dependent plasticity in Xenopus tadpoles
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.29.123661 Epub:
Not Epub Abstract:
Matrix metalloproteinase-9 (MMP-9) is a secreted endopeptidase targeting extracellular matrix proteins, creating permissive... Delivery Method:
whole-brain electroporation Organism or Cell Type:
Xenopus laevis Citation Extract: Gore S, James EJ, Huang L-C, Park JJ, Berghella A, Thompson A, Cline HT, Aizenman CD. Role of matrix metalloproteinase-9 in neurodevelopmental disorders and experience-dependent plasticity in Xenopus tadpoles. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.29.123661. |