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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes
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Citation:
J Med Genet. 2020 Jul 6:jmedgenet-2019-106805. doi:10.1136/jmedgenet-2019-106805. Online ahead of print Epub:
Yes Abstract:
Background: Cilia are dynamic cellular extensions that generate and sense signals to orchestrate proper development and tissue... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Marquez J, Mann N, Arana K, Deniz E, Ji W, Konstantino M, Mis EK, Deshpande C, Jeffries L, McGlynn J, Hugo H, Widmeier E, Konrad M, Tasic V, Morotti R, Baptista J, Ellard S, Lakhani SA, Hildebrandt F, Khokha MK. DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes. J Med Genet. 2020 Jul 6:jmedgenet-2019-106805. doi:10.1136/jmedgenet-2019-106805. Online ahead of print. |
TLR7 ligation augments haematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling and enhanced differentiation
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.07.06.175000 Epub:
Not Epub Abstract:
Myelodysplastic syndrome (MDS) is a haematological malignancy characterised by blood cytopenias and predisposition to acute... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Peña OC, Lubin A, Rowell J, Hockings CA, Jung Y, Hoade Y, Dace P, Valdivia LE, Tuschl K, Böiers C, Virgilio MC, Richardson S, Payne EM. TLR7 ligation augments haematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling and enhanced differentiation. bioRxiv. 2020;[preprint] doi:10.1101/2020.07.06.175000. |
A Conserved Notochord Enhancer Controls Pancreas Development in Vertebrates
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Citation:
Cell Rep. 2020;32(1):107862. doi:10.1016/j.celrep.2020.107862 Epub:
Not Epub Abstract:
The notochord is an evolutionary novelty in vertebrates that functions as an important signaling center during development.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Amorim JP, Gali-Macedo A, Marcelino H, Bordeira-Carriço R, Naranjo S, Rivero-Gil S, Teixeira J, Galhardo M, Marques J, Bessa J. A Conserved Notochord Enhancer Controls Pancreas Development in Vertebrates. Cell Rep. 2020;32(1):107862. doi:10.1016/j.celrep.2020.107862. |
Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry
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Citation:
Nat Comm. 2020;11(1):3393. doi:10.1038/s41467-020-17088-6 Epub:
Not Epub Abstract:
Meiotic divisions in oocytes are extremely asymmetric and require pre- and post-anaphase-onset phases of spindle migration. The... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Wei Z, Greaney J, Loh W-GN, Homer HA. Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry. Nat Comm. 2020;11(1):3393. doi:10.1038/s41467-020-17088-6. |
Studies in zebrafish demonstrate that CNNM2 and NT5C2 are most likely the causal genes at the blood pressure-associated locus on human chromosome 10q24.32
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Citation:
Front Cardiovasc Med. 2020 Sep 2;7:135. doi: 10.3389/fcvm.2020.00135 Epub:
Not Epub Abstract:
Background: Globally, high blood pressure (BP) is the most important risk factor for cardiovascular disease. Several genome-... Organism or Cell Type:
zebrafish Citation Extract: Vishnolia KK, Hoene C, Tarhbalouti K, Revenstorff J, Aherrahrou Z, Erdmann J. Studies in zebrafish demonstrate that CNNM2 and NT5C2 are most likely the causal genes at the blood pressure-associated locus on human chromosome 10q24.32. Front Cardiovasc Med. 2020 Sep 2;7:135. doi: 10.3389/fcvm.2020.00135. |
Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish
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Citation:
Dev Biol. 2020;[Epub ahead of print] doi:10.1016/j.ydbio.2020.06.007 Epub:
Yes Abstract:
ETS transcription factors play an important role in the specification and differentiation of endothelial cells during vascular... Organism or Cell Type:
zebrafish Citation Extract: Chetty SC, Sumanas S. Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish. Dev Biol. 2020;[Epub ahead of print] doi:10.1016/j.ydbio.2020.06.007. |
Premature termination codons in the DMD gene cause reduced local mRNA synthesis
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Citation:
Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.1910456117 Epub:
Yes Abstract:
Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene leading to the presence of premature termination... Delivery Method:
injection Organism or Cell Type:
mice mdx Citation Extract: García-Rodríguez R, Hiller M, Jiménez-Gracia L, van der Pal Z, Balog J, Adamzek K, Aartsma-Rus A, Spitali P
. Premature termination codons in the DMD gene cause reduced local mRNA synthesis. Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.1910456117. |
Microglia phagocytose myelin sheaths to modify developmental myelination
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Citation:
Nat Neurosci. 2020;[Epub ahead of print] doi:10.1038/s41593-020-0654-2 Epub:
Yes Abstract:
During development, oligodendrocytes contact and wrap neuronal axons with myelin. Similarly to neurons and synapses, excess... Organism or Cell Type:
zebrafish Citation Extract: Hughes AN, Appel B. Microglia phagocytose myelin sheaths to modify developmental myelination. Nat Neurosci. 2020;[Epub ahead of print] doi:10.1038/s41593-020-0654-2. |
Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish
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Citation:
Nat Commun. 2020 Jul 3;11(1):3317. doi:10.1038/s41467-020-17196-3 Epub:
Not Epub Abstract:
Oriented cell division is a fundamental mechanism to control asymmetric stem cell division, neural tube elongation and body... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Castanon I, Hannich JT, Abrami L, Huber F, Dubois M, Müller M, van der Goot FG, Gonzalez-Gaitan M. Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish. Nat Commun. 2020 Jul 3;11(1):3317. doi:10.1038/s41467-020-17196-3. |
Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2
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Citation:
Sci Adv. 2020;6(37):eaaz8534 [Epub] doi:10.1126/sciadv.aaz8534 Epub:
Not Epub Abstract:
The stringent expression of the hypoxia inducible factor-1α (HIF-1α) is critical to a variety of pathophysiological conditions... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Dey A, Prabhudesai S, Zhang Y, Rao G, Thirugnanam K, Hossen MdN, Dwivedi SKD, Ramchandran R, Mukherjee P, Bhattacharya R. Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2. Sci Adv. 2020;6(37):eaaz8534 [Epub] doi:10.1126/sciadv.aaz8534 . |