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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Safety, Tolerability, and Efficacy of Viltolarsen in Boys With Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping
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Citation:
JAMA Neurology. 2020;[Epub] doi:10.1001/jamaneurol.2020.1264 Epub:
Yes Abstract:
Importance: An unmet need remains for safe and efficacious treatments for Duchenne muscular dystrophy (DMD). To date, there... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, Smith EC, McDonald CM, Zaidman CM, Morgenroth LP, Osaki H, Satou Y, Yamashita T, Hoffman EP, for the CINRG DNHS Investigators. Safety, Tolerability, and Efficacy of Viltolarsen in Boys With Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping. JAMA Neurology. 2020;[Epub] doi:10.1001/jamaneurol.2020.1264. |
Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos
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Citation:
Mol Pharmacol. 2008 Dec;74(6):1544-53. doi:10.1124/mol.108.050435 Epub:
Not Epub Abstract:
Exposure to environmental contaminants can disrupt normal development of the early vertebrate skeleton. 2,3,7,8-... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Xiong KM, Peterson RE, Heideman W. Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos. Mol Pharmacol. 2008 Dec;74(6):1544-53. doi:10.1124/mol.108.050435. |
Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.21.106914 Epub:
Not Epub Abstract:
Sprouting angiogenesis is an essential vascularisation mechanism and consists of two phases: sprouting and remodelling. The... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhou Q, Perovic T, Fechner I, Edgar LT, Hoskins PR, Gerhardt H, Krüger T, Bernabeu MO. Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.21.106914 . |
Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function
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Citation:
Commun Biol. 3030;3:265 doi:10.1038/s42003-020-0987-0 Epub:
Not Epub Abstract:
Blood vessels are constantly exposed to shear stress, a biomechanical force generated by blood flow. Normal shear stress... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Stanicek L, Lozano-Vidal N, Bink DI, Hooglugt A, Yao W, Wittig I, van Rijssel J, van Buul JD, van Bergen A, Klems A, Ramms AS, Le Noble F, Hofmann P, Szulcek R, Wang S, Offermanns S, Ercanoglu MS, Kwon H-B, Stainier D, Huveneers S, Kurian L, Dimmeler S, Boon RA. Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function. Commun Biol. 3030;3:265 doi:10.1038/s42003-020-0987-0. |
FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection
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Citation:
Front Immunol. 2017;8:617. doi: 10.3389/fimmu.2017.00617 Epub:
Not Epub Abstract:
Tripartite motif (TRIM) proteins are involved in various cellular functions and constitute key factors of the antiviral innate... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Langevin C, Aleksejeva E, Houel A, Briolat V, Torhy C, Lunazzi A, Levraud J-P, Boudinot P. FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection. Front Immunol. 2017;8:617. doi: 10.3389/fimmu.2017.00617. |
Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
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Citation:
J Vis Exp. 2021 Oct 19;(176). doi: 10.3791/58837 Epub:
Not Epub Abstract:
Epilepsy represents one of the most common neurological disorders, affecting an estimated 50 million people worldwide. Recent... Link:
Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: de Calbiac H, Dabacan A, Muresan R, Kabashi E, Ciura S. Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy. J Vis Exp. 2021 Oct 19;(176). doi: 10.3791/58837. |
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation
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Citation:
Sci Adv. 2020;6(1):eaax3333 doi:10.1126/sciadv.aax3333 Epub:
Not Epub Abstract:
Inflammation is an essential part of immunity against pathogens and tumors but can promote disease if not tightly regulated.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Guerra J, Valadao A-L, D. Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, B. Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N. Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation. Sci Adv. 2020;6(1):eaax3333 doi:10.1126/sciadv.aax3333. |
Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation
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Citation:
Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.04.018 Epub:
Yes Abstract:
Embryonic genome activation (EGA) is orchestrated by an intrinsic developmental program initiated during oocyte maturation with... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Gambini A, Stein A, Savy V, Grow EJ, Papas BN, Zhang Y, Kenan AC, Padilla-Banks E, Cairns BR, Williams CJ. Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation. Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.04.018. |
Complement component C1q plays a critical role in VLRA/VLRC-mediated immune response
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Citation:
Dev Comp Immunol. 2020;[Epub ahead of print] doi:10.1016/j.dci.2020.103750 Epub:
Yes Abstract:
In jawless vertebrates, the lamprey complement component C1q (LC1q) acts as a lectin and activates lamprey complement component... Delivery Method:
microinjection Organism or Cell Type:
Lampetra morii (lamprey) Citation Extract: Li J, Ma Q, Liu H, Song X, Pang Y, Su P, Sun F, Gou M, Lu J, Shan Y, Liu X, Li Q, Han Y. Complement component C1q plays a critical role in VLRA/VLRC-mediated immune response. Dev Comp Immunol. 2020;[Epub ahead of print] doi:10.1016/j.dci.2020.103750. |
Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.18.101071 Epub:
Not Epub Abstract:
Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Geusz RJ, Wang A, Chiou J, Lancman JJ, Wetton N, Kefalopoulou S, Wang J, Qiu Y, Yan J, Aylward A, Ren B, Dong PDC, Gaulton KJ, Sander M. Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.18.101071 . |