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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells

Authors:
Michaels WE, Bridges RJ, Hastings ML
Citation:
Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa490
Epub:
Not Epub
Abstract:
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CF transmembrane conductance regulator (CFTR...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa490/5855636
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human primary bronchial epithelial cells
Citation Extract:
Michaels WE, Bridges RJ, Hastings ML. Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells. Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa490.

Viltolarsen: First Approval

Authors:
Dhillon S
Citation:
Drugs. 2020 Jun 9. doi: 10.1007/s40265-020-01339-3. Online ahead of print
Epub:
Yes
Abstract:
Viltolarsen (Viltepso® in Japan) is a phosphorodiamidate morpholino antisense oligonucleotide being developed by Nippon...
Link:
https://link.springer.com/article/10.1007%2Fs40265-020-01339-3
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Dhillon S. Viltolarsen: First Approval. Drugs. 2020 Jun 9. doi: 10.1007/s40265-020-01339-3. Online ahead of print.

U1 snRNP Telescripting Roles in Transcription and Its Mechanism

Authors:
Di C, So BR, Cai Z, Arai C, Duan J, Dreyfuss G
Citation:
Cold Spring Harb Symp Quant Biol. 2020 Jun 9:040451. doi:10.1101/sqb.2019.84.040451. Online ahead of print
Epub:
Not Epub
Abstract:
Telescripting is a fundamental cotranscriptional gene regulation process that relies on U1 snRNP (U1) to suppress premature 3...
Link:
http://symposium.cshlp.org/content/early/2020/06/09/sqb.2019.84.040451
Organism or Cell Type:
cell culture
Citation Extract:
Di C, So BR, Cai Z, Arai C, Duan J, Dreyfuss G. U1 snRNP Telescripting Roles in Transcription and Its Mechanism. Cold Spring Harb Symp Quant Biol. 2020 Jun 9:040451. doi:10.1101/sqb.2019.84.040451. Online ahead of print.

Amyloid-β precursor protein mutant zebrafish exhibit seizure susceptibility that depends on prion protein

Authors:
Kanyo R, Leighton PLA, Neil GJ, Locskai LF, Allison WT
Citation:
Exp Neurol. 2020;328:113283 doi:10.1016/j.expneurol.2020.113283
Epub:
Not Epub
Abstract:
It has been proposed that Amyloid β Precursor Protein (APP) might act as a rheostat controlling neuronal excitability, but...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S001448862030114X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kanyo R, Leighton PLA, Neil GJ, Locskai LF, Allison WT. Amyloid-β precursor protein mutant zebrafish exhibit seizure susceptibility that depends on prion protein. Exp Neurol. 2020;328:113283 doi:10.1016/j.expneurol.2020.113283.

Lamprey VLRB participates in pathogen detection, VLRB/L-BLNK/L-NF-κB (B-like cells) signal transduction, and development

Authors:
Han Y, Li J, Pang Y, Xu L, Ma Q, Liu H, Song X, Su P, Sun F, Gou M, Lu J, Shan Y, Liu X, Li Q
Citation:
Fish Shellfish Immun. 2020;[Epub ahead of print] doi:10.1016/j.fsi.2020.05.030
Epub:
Yes
Abstract:
In jawed vertebrates, B cell receptors (BCR) are primary pathogen detectors that activate downstream signaling pathways to...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1050464820303569
Delivery Method:
microinjection
Organism or Cell Type:
Lampetra morii (lamprey)
Citation Extract:
Han Y, Li J, Pang Y, Xu L, Ma Q, Liu H, Song X, Su P, Sun F, Gou M, Lu J, Shan Y, Liu X, Li Q. Lamprey VLRB participates in pathogen detection, VLRB/L-BLNK/L-NF-κB (B-like cells) signal transduction, and development. Fish Shellfish Immun. 2020;[Epub ahead of print] doi:10.1016/j.fsi.2020.05.030.

Acute knockdown of extracellular matrix protein Tinagl1 disrupts heart laterality and pronephric cilia in zebrafish embryonic development

Authors:
Neiswender H, LeMosy EK
Citation:
bioRxiv. 2020;[preprint] doi: doi:10.1101/2020.06.05.136747
Epub:
Not Epub
Abstract:
A highly-conserved extracellular matrix protein, Tinagl1, modulates Wnt, integrin, TGF-β, and EGF-R signaling in vitro, but its...
Link:
https://www.biorxiv.org/content/10.1101/2020.06.05.136747v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Neiswender H, LeMosy EK. Acute knockdown of extracellular matrix protein Tinagl1 disrupts heart laterality and pronephric cilia in zebrafish embryonic development. bioRxiv. 2020;[preprint] doi: doi:10.1101/2020.06.05.136747.

Beclin 1 controls pigmentation by changing the nuclear localization of melanogenic factor MITF

Authors:
Rai A, Chatterjee B, Bhowmick S, Sagar S, Roy SS
Citation:
Biochem Biophys Res Comm. 2020;[Epub ahead of print] doi:10.1016/j.bbrc.2020.05.118
Epub:
Yes
Abstract:
The primary contributor for the determination of skin color is melanin, a pigment that is produced in specialized cells called...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0006291X20310408
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rai A, Chatterjee B, Bhowmick S, Sagar S, Roy SS. Beclin 1 controls pigmentation by changing the nuclear localization of melanogenic factor MITF. Biochem Biophys Res Comm. 2020;[Epub ahead of print] doi:10.1016/j.bbrc.2020.05.118.

Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a

Authors:
Muraina IA, Maret W, Bury NR, Hogstrand C
Citation:
Biochem Biophys Res Comm. 2020;[Epub ahead of print] doi:10.1016/j.bbrc.2020.05.131
Epub:
Yes
Abstract:
Zinc transporters of the ZIP (Slc39, importers) and ZnT (Slc30, exporters) protein families have evolutionary conserved roles...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0006291X20310603
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Muraina IA, Maret W, Bury NR, Hogstrand C. Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a. Biochem Biophys Res Comm. 2020;[Epub ahead of print] doi:10.1016/j.bbrc.2020.05.131.

Exon skipping of TGFβRI affects signalling and ECM expression in hypertrophic scar-derived fibroblasts

Authors:
Raktoe RS, Rietveld MH, Out-Luiting JJ, Kruithof-de Julio M, van Zuijlen PPM, van Doorn R, El Ghalbzouri A
Citation:
Scars Burn. Heal. 2020;6;[Epub] doi:10.1177/2059513120908857
Epub:
Not Epub
Abstract:
Background: In burn patients, wound healing is often accompanied by hypertrophic scar (HS) development, resulting in both...
Link:
https://journals.sagepub.com/doi/full/10.1177/2059513120908857
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: primary human fibroblasts
Citation Extract:
Raktoe RS, Rietveld MH, Out-Luiting JJ, Kruithof-de Julio M, van Zuijlen PPM, van Doorn R, El Ghalbzouri A. Exon skipping of TGFβRI affects signalling and ECM expression in hypertrophic scar-derived fibroblasts. Scars Burn. Heal. 2020;6;[Epub] doi:10.1177/2059513120908857.

Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress

Authors:
Kröll‐Hermi A, Ebstein F, Stoetzel C, Geoffroy V, Schaefer E, Scheidecker S, Bär S, Takamiya M, Kawakami K, Zieba BA, Studer F, Pelletier V, Eyermann C, Speeg‐Schatz C, Laugel V, Lipsker D, Sandron F, McGinn S, Boland A, Deleuze J-F, Kuhn L, Chicher J, Hammann P, Friant S, Etard C, Krüger E, Muller J, Strähle U, Dollfus H
Citation:
EMBO Mol Med. 2020;e11861 [Epub] doi:10.15252/emmm.201911861
Epub:
Yes
Abstract:
The ubiquitin–proteasome system degrades ubiquitin‐modified proteins to maintain protein homeostasis and to control signalling...
Link:
https://www.embopress.org/doi/10.15252/emmm.201911861
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kröll‐Hermi A, Ebstein F, Stoetzel C, Geoffroy V, Schaefer E, Scheidecker S, Bär S, Takamiya M, Kawakami K, Zieba BA, Studer F, Pelletier V, Eyermann C, Speeg‐Schatz C, Laugel V, Lipsker D, Sandron F, McGinn S, Boland A, Deleuze J-F, Kuhn L, Chicher J, Hammann P, Friant S, Etard C, Krüger E, Muller J, Strähle U, Dollfus H . Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress. EMBO Mol Med. 2020;e11861 [Epub] doi:10.15252/emmm.201911861.

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