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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Molecular mechanism of CHRDL1-mediated X-linked megalocornea in humans and in Xenopus model

Authors:
Pfirrmann T, Emmerich D, Ruokonen P, Quandt D, Buchen R, Fischer-Zirnsak B, Hecht J, Krawitz P, Meyer P, Klopocki E, Stricker S, Lausch E, Seliger B, Hollemann T, Reinhard T, Auw-Haedrich C, Zabel B, Hoffmann K, Villavicencio-Lorini P
Citation:
Hum Mol Genet. 2015 Jun 1;24(11):3119-32. doi: 10.1093/hmg/ddv063. Epub 2015 Feb 23
Epub:
Not Epub
Abstract:
Chordin-Like 1 (CHRDL1) mutations cause non-syndromic X-linked megalocornea (XMC) characterized by enlarged anterior eye...
Link:
https://academic.oup.com/hmg/article/24/11/3119/720148
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Pfirrmann T, Emmerich D, Ruokonen P, Quandt D, Buchen R, Fischer-Zirnsak B, Hecht J, Krawitz P, Meyer P, Klopocki E, Stricker S, Lausch E, Seliger B, Hollemann T, Reinhard T, Auw-Haedrich C, Zabel B, Hoffmann K, Villavicencio-Lorini P. Molecular mechanism of CHRDL1-mediated X-linked megalocornea in humans and in Xenopus model. Hum Mol Genet. 2015 Jun 1;24(11):3119-32. doi: 10.1093/hmg/ddv063. Epub 2015 Feb 23.

Characterization of cGAS homologs in innate and adaptive mucosal immunities in zebrafish gives evolutionary insights into cGAS-STING pathway

Authors:
Liu ZF, Ji JF, Jiang XF, Shao T, Fan DD, Jiang XH, Lin AF, Xiang LX, Shao JZ
Citation:
FASEB J. 2020 Apr 14. doi: 10.1096/fj.201902833R. [Epub ahead of print]
Epub:
Yes
Abstract:
Cyclic GMP-AMP synthase (cGAS) is one of the most-characterized cytoplasmic DNA sensors in humans and other mammals. However,...
Link:
https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201902833R
Citation Extract:
Liu ZF, Ji JF, Jiang XF, Shao T, Fan DD, Jiang XH, Lin AF, Xiang LX, Shao JZ. Characterization of cGAS homologs in innate and adaptive mucosal immunities in zebrafish gives evolutionary insights into cGAS-STING pathway. FASEB J. 2020 Apr 14. doi: 10.1096/fj.201902833R. [Epub ahead of print].

Analysis of mucolipidosis II/III GNPTAB missense mutations identifies domains of UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase involved in catalytic function and lysosomal enzyme recognition

Authors:
Qian Y, van Meel E, Flanagan-Steet H, Yox A, Steet R, Kornfeld S
Citation:
J Biol Chem. 2015 Jan 30;290(5):3045-56. doi: 10.1074/jbc.M114.612507. Epub 2014 Dec 11
Epub:
Not Epub
Abstract:
UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase tags newly synthesized lysosomal enzymes with mannose 6-phosphate...
Link:
https://www.jbc.org/content/290/5/3045.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Qian Y, van Meel E, Flanagan-Steet H, Yox A, Steet R, Kornfeld S. Analysis of mucolipidosis II/III GNPTAB missense mutations identifies domains of UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase involved in catalytic function and lysosomal enzyme recognition. J Biol Chem. 2015 Jan 30;290(5):3045-56. doi: 10.1074/jbc.M114.612507. Epub 2014 Dec 11.

RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells

Authors:
Chen HY, Liu W, Wu SY, Chiou PP, Li YH, Chen YC, Lin GH, Lu MW, Wu JL
Citation:
Fish Shellfish Immunol. 2015 Apr;43(2):427-35. doi: 10.1016/j.fsi.2015.01.012. Epub 2015 Jan 26
Epub:
Not Epub
Abstract:
The type I interferon (IFN) response has been shown to be crucial for the survival of zebrafish larvae infected with nervous...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1050464815000133
Organism or Cell Type:
cell culture: zebrafish
Citation Extract:
Chen HY, Liu W, Wu SY, Chiou PP, Li YH, Chen YC, Lin GH, Lu MW, Wu JL. RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells. Fish Shellfish Immunol. 2015 Apr;43(2):427-35. doi: 10.1016/j.fsi.2015.01.012. Epub 2015 Jan 26.

TRPP2-dependent Ca2+ signaling in dorso-lateral mesoderm is required for kidney field establishment in Xenopus

Authors:
Futel M, Leclerc C, Le Bouffant R, Buisson I, Néant I, Umbhauer M, Moreau M, Riou JF
Citation:
J Cell Sci. 2015 Mar 1;128(5):888-99. doi: 10.1242/jcs.155499. Epub 2015 Jan 14
Epub:
Not Epub
Abstract:
In Xenopus laevis embryos, kidney field specification is dependent on retinoic acid (RA) and coincides with a dramatic increase...
Link:
https://jcs.biologists.org/content/128/5/888.long
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Futel M, Leclerc C, Le Bouffant R, Buisson I, Néant I, Umbhauer M, Moreau M, Riou JF. TRPP2-dependent Ca2+ signaling in dorso-lateral mesoderm is required for kidney field establishment in Xenopus. J Cell Sci. 2015 Mar 1;128(5):888-99. doi: 10.1242/jcs.155499. Epub 2015 Jan 14.

Xhe2 is a member of the astacin family of metalloproteases that promotes Xenopus hatching

Authors:
Hong CS, Saint-Jeannet JP
Citation:
Genesis. 2014 Dec;52(12):946-51. doi: 10.1002/dvg.22841. Epub 2014 Nov 28
Epub:
Not Epub
Abstract:
Transcription factors Pax3 and Zic1 are among the earliest genes activated at the neural plate border. In Xenopus, they are...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/dvg.22841
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Hong CS, Saint-Jeannet JP. Xhe2 is a member of the astacin family of metalloproteases that promotes Xenopus hatching. Genesis. 2014 Dec;52(12):946-51. doi: 10.1002/dvg.22841. Epub 2014 Nov 28.

Neutralization of mitochondrial superoxide by superoxide dismutase 2 promotes bacterial clearance and regulates phagocyte numbers in zebrafish

Authors:
Peterman EM, Sullivan C, Goody MF, Rodriguez-Nunez I, Yoder JA, Kim CH
Citation:
Infect Immun. 2015 Jan;83(1):430-40. doi: 10.1128/IAI.02245-14. Epub 2014 Nov 10
Epub:
Not Epub
Abstract:
Mitochondria are known primarily as the location of the electron transport chain and energy production in cells. More recently...
Link:
https://iai.asm.org/content/83/1/430.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Peterman EM, Sullivan C, Goody MF, Rodriguez-Nunez I, Yoder JA, Kim CH. Neutralization of mitochondrial superoxide by superoxide dismutase 2 promotes bacterial clearance and regulates phagocyte numbers in zebrafish. Infect Immun. 2015 Jan;83(1):430-40. doi: 10.1128/IAI.02245-14. Epub 2014 Nov 10.

Blood Flow Limits Endothelial Cell Extrusion in the Zebrafish Dorsal Aorta

Authors:
Campinho P, Lamperti P, Boselli F, Vilfan A, Vermot J
Citation:
Cell Rep. 2020;31(2):107505. doi:j.celrep.2020.03.069
Epub:
Not Epub
Abstract:
Blood flow modulates endothelial cell (EC) response during angiogenesis. Shear stress is known to control gene expression...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30395-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Campinho P, Lamperti P, Boselli F, Vilfan A, Vermot J. Blood Flow Limits Endothelial Cell Extrusion in the Zebrafish Dorsal Aorta. Cell Rep. 2020;31(2):107505. doi:j.celrep.2020.03.069.

Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility

Authors:
Goudarzi M, Berg K, Pieper LM, Schier AF
Citation:
Elife. 2019 Jan 8;8. pii: e40815. doi: 10.7554/eLife.40815
Epub:
Not Epub
Abstract:
Hundreds of long non-coding RNAs (lncRNAs) have been identified as potential regulators of gene expression, but their functions...
Link:
https://elifesciences.org/articles/40815
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Goudarzi M, Berg K, Pieper LM, Schier AF. Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility. Elife. 2019 Jan 8;8. pii: e40815. doi: 10.7554/eLife.40815.

Genetic basis for divergence in developmental gene expression in two closely related sea urchins

Authors:
Wang L, Israel JW, Edgar A, Raff RA, Elizabeth C. Raff EC, Byrne M, Wray GA
Citation:
Nat Ecol Evol. 2020;[Epub] doi:10.1038/s41559-020-1165-y
Epub:
Yes
Abstract:
The genetic basis for divergence in developmental gene expression among species is poorly understood, despite growing evidence...
Link:
https://www.nature.com/articles/s41559-020-1165-y
Delivery Method:
microinjection
Organism or Cell Type:
Heliocidaris tuberculata, Heliocidaris erythrogramma (sea urchin)
Citation Extract:
Wang L, Israel JW, Edgar A, Raff RA, Elizabeth C. Raff EC, Byrne M, Wray GA. Genetic basis for divergence in developmental gene expression in two closely related sea urchins. Nat Ecol Evol. 2020;[Epub] doi:10.1038/s41559-020-1165-y.

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