You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Genetic Compensation of γ CaMKII, an Evolutionarily Conserved Gene

Authors:
Rothschild SC, Ingram SR, Lu FI, Thisse B, Thisse C, Parkerson JA, Tombes RM
Citation:
Gene. 2020 Mar 9:144567. doi: 10.1016/j.gene.2020.144567. [Epub ahead of print]
Epub:
Yes
Abstract:
CaMKII is a Ca2+/CaM-dependent protein kinase encoded by a family of conserved genes found throughout all metazoan species and...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0378111920302365
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rothschild SC, Ingram SR, Lu FI, Thisse B, Thisse C, Parkerson JA, Tombes RM. Genetic Compensation of γ CaMKII, an Evolutionarily Conserved Gene. Gene. 2020 Mar 9:144567. doi: 10.1016/j.gene.2020.144567. [Epub ahead of print].

The zebrafish Znt1asa17 mutant reveals roles of zinc transporter-1a in embryonic development

Authors:
Muraina IA, Bury NR, Scott A, Graham A, Hogstrand C
Citation:
J Trace Elem Med Bio. 2020 Mar 12;60:126496. doi: 10.1016/j.jtemb.2020.126496. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Background: Zinc is one of the vital micronutrients required through various developmental stages in animals. Zinc transporter-...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0946672X20300614
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Muraina IA, Bury NR, Scott A, Graham A, Hogstrand C. The zebrafish Znt1asa17 mutant reveals roles of zinc transporter-1a in embryonic development. J Trace Elem Med Bio. 2020 Mar 12;60:126496. doi: 10.1016/j.jtemb.2020.126496. [Epub ahead of print].

miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation

Authors:
Adusumilli L, Facchinello N, Teh C, Busolin G, Le TM, Yang H, Beffagna G, Campanaro S, Tam LW, Argenton F, Lim B, Korzh V, Tiso N
Citation:
Cells. 2020;9(3):2073-4409 doi:10.3390/cells9030711
Epub:
Not Epub
Abstract:
During the development of the central nervous system, the proliferation of neural progenitors and differentiation of neurons...
Link:
https://www.mdpi.com/2073-4409/9/3/711/htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Adusumilli L, Facchinello N, Teh C, Busolin G, Le TM, Yang H, Beffagna G, Campanaro S, Tam LW, Argenton F, Lim B, Korzh V, Tiso N. miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation. Cells. 2020;9(3):2073-4409 doi:10.3390/cells9030711.

Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy

Authors:
Frank DE, Schnell FJ, Akana C, El-Husayni SH, Desjardins CA, Morgan J, Charleston JS, Sardone V, Domingos J, Dickson G, Straub V, Guglieri M, Mercuri E, Servais L, Muntoni F; SKIP-NMD Study Group
Citation:
Neurology. 2020 Mar 5. pii: 10.1212/WNL.0000000000009233. doi: 10.1212/WNL.0000000000009233. [Epub ahead of print]
Epub:
Yes
Abstract:
Objective: To report safety, pharmacokinetics, exon 53 skipping, and dystrophin expression in golodirsen-treated patients with...
Link:
https://n.neurology.org/content/early/2020/03/04/WNL.0000000000009233
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Frank DE, Schnell FJ, Akana C, El-Husayni SH, Desjardins CA, Morgan J, Charleston JS, Sardone V, Domingos J, Dickson G, Straub V, Guglieri M, Mercuri E, Servais L, Muntoni F; SKIP-NMD Study Group. Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy. Neurology. 2020 Mar 5. pii: 10.1212/WNL.0000000000009233. doi: 10.1212/WNL.0000000000009233. [Epub ahead of print].

The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation

Authors:
Yang C-R, Rajkovic G, Daldello EM, Luong XG, Chen J, Conti M
Citation:
Nat Comm. 2020;11:1399. doi:10.1038/s41467-020-15209-9
Epub:
Not Epub
Abstract:
Deleted in azoospermia-like (DAZL) is an RNA-binding protein critical for gamete development. In full-grown oocytes, the DAZL...
Link:
https://www.nature.com/articles/s41467-020-15209-9
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Yang C-R, Rajkovic G, Daldello EM, Luong XG, Chen J, Conti M. The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation. Nat Comm. 2020;11:1399. doi:10.1038/s41467-020-15209-9.

Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease

Authors:
Verschuren EHJ, Rigalli JP, Castenmiller C, Rohrbach MU, Bindels RJM, Peters DJM, Arjona FJ, Hoenderop JGJ
Citation:
FASEB J. 2020 Mar 11. doi: 10.1096/fj.201902901R. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Tubular ATP release is regulated by mechanosensation of fluid shear stress (FSS). Polycystin-1/polycystin-2 (PC1/PC2) functions...
Link:
https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201902901R
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Verschuren EHJ, Rigalli JP, Castenmiller C, Rohrbach MU, Bindels RJM, Peters DJM, Arjona FJ, Hoenderop JGJ. Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease. FASEB J. 2020 Mar 11. doi: 10.1096/fj.201902901R. [Epub ahead of print].

U1 snRNP regulates chromatin retention of noncoding RNAs

Authors:
Yin Y, Lu JY, Zhang X, Shao W, Xu Y, Li P, Hong Y, Cui L, Shan G, Tian B, Zhang QC, Shen X
Citation:
Nature. 2020;[Epub ahead of print] doi:10.1038/s41586-020-2105-3
Epub:
Yes
Abstract:
Long noncoding RNAs (lncRNAs) and promoter- or enhancer-associated unstable transcripts locate preferentially to chromatin,...
Link:
https://www.nature.com/articles/s41586-020-2105-3
Citation Extract:
Yin Y, Lu JY, Zhang X, Shao W, Xu Y, Li P, Hong Y, Cui L, Shan G, Tian B, Zhang QC, Shen X. U1 snRNP regulates chromatin retention of noncoding RNAs. Nature. 2020;[Epub ahead of print] doi:10.1038/s41586-020-2105-3.

Glycine enhances satellite cell proliferation, cell transplantation and oligonucleotide efficacy in dystrophic muscle

Authors:
Lin C, Han G, Ning H, Song J, Ran N, Yi X, Seow Y, Yin HF
Citation:
Molec Ther. 2020;28(5):1339-58. doi: 10.1016/j.ymthe.2020.03.003. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The need to distribute therapy evenly systemically throughout the large muscle volume within the body makes Duchenne muscular...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1525001620301374
Organism or Cell Type:
mice
Citation Extract:
Lin C, Han G, Ning H, Song J, Ran N, Yi X, Seow Y, Yin HF. Glycine enhances satellite cell proliferation, cell transplantation and oligonucleotide efficacy in dystrophic muscle. Molec Ther. 2020;28(5):1339-58. doi: 10.1016/j.ymthe.2020.03.003. [Epub ahead of print].

Structural and mechanistic insights into secretagogin-mediated exocytosis

Authors:
Qin J, Liu Q, Liu Z, Pan Y-Z, Sifuentes-Dominguez L, Stepien KP, Wang Y, Tu Y, Tan S, Wang Y, Sun Q, Mo X, Rizo J, Burstein E, Jia D
Citation:
Proc Nat Acad Sci USA. 2020;201919698;[Epub ahead of print] doi:10.1073/pnas.1919698117
Epub:
Yes
Abstract:
Secretagogin (SCGN) is a hexa–EF-hand protein that is highly expressed in the pancreas, brain, and gastrointestinal tract. SCGN...
Link:
https://www.pnas.org/content/early/2020/03/09/1919698117.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Qin J, Liu Q, Liu Z, Pan Y-Z, Sifuentes-Dominguez L, Stepien KP, Wang Y, Tu Y, Tan S, Wang Y, Sun Q, Mo X, Rizo J, Burstein E, Jia D. Structural and mechanistic insights into secretagogin-mediated exocytosis. Proc Nat Acad Sci USA. 2020;201919698;[Epub ahead of print] doi:10.1073/pnas.1919698117.

Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation

Authors:
Lu JY, Shao W, Chang L, Ramalho-Santos M, Sun Y, Shen X
Citation:
Cell Rep. 2020;30(10):3296-3311.e5 doi:10.1016/j.celrep.2020.02.048
Epub:
Not Epub
Abstract:
Repetitive elements are abundantly distributed in mammalian genomes. Here, we reveal a striking association between repeat...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30209-6
Organism or Cell Type:
cell culture: embryonic stem cells (ESCs)
Citation Extract:
Lu JY, Shao W, Chang L, Ramalho-Santos M, Sun Y, Shen X. Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation. Cell Rep. 2020;30(10):3296-3311.e5 doi:10.1016/j.celrep.2020.02.048.

Pages