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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Correction of Bcl‐x splicing improves responses to imatinib in chronic myeloid leukaemia cells and mouse models

Authors:
Zhang J, Wang Y, Li S-Q, Fang L, Wang X-Z, Li J, Zhang H-B, Huang B, Xu Y-M, Yang W-M, Lin J, Min Q-H, ZLiao Z-H, Wu Y, Liu J
Citation:
Brit J Hematol. 2020;[Epub] doi:10.1111/bjh.16472
Epub:
Yes
Abstract:
Imatinib mesylate (IM) resistance has become a major clinical problem for chronic myeloid leukaemia (CML). It is known that Bcl...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1111/bjh.16472
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: chronic myeloid leukaemia (CML) cells
Citation Extract:
Zhang J, Wang Y, Li S-Q, Fang L, Wang X-Z, Li J, Zhang H-B, Huang B, Xu Y-M, Yang W-M, Lin J, Min Q-H, ZLiao Z-H, Wu Y, Liu J. Correction of Bcl‐x splicing improves responses to imatinib in chronic myeloid leukaemia cells and mouse models. Brit J Hematol. 2020;[Epub] doi:10.1111/bjh.16472.

tRIP‐seq reveals repression of premature polyadenylation by co‐transcriptional FUS‐U1 snRNP assembly

Authors:
Masuda A, Kawachi T, Takeda J-i, Ohkawara B, Ito M, Ohno K
Citation:
EMBO Rep. 2020;[Epub] doi:10.15252/embr.201949890
Epub:
Not Epub
Abstract:
RNA processing occurs co‐transcriptionally through the dynamic recruitment of RNA processing factors to RNA polymerase II (...
Link:
https://www.embopress.org/doi/abs/10.15252/embr.201949890
Citation Extract:
Masuda A, Kawachi T, Takeda J-i, Ohkawara B, Ito M, Ohno K. tRIP‐seq reveals repression of premature polyadenylation by co‐transcriptional FUS‐U1 snRNP assembly. EMBO Rep. 2020;[Epub] doi:10.15252/embr.201949890.

De Novo Frameshift Variants in the Neuronal Splicing Factor NOVA2 Result in a Common C-Terminal Extension and Cause a Severe Form of Neurodevelopmental Disorder

Authors:
Mattioli F, Hayot G, Drouot N, Isidor B, Courraud J, Hinckelmann M-V, Mau-Them FT, Sellier C, Goldman A, Telegrafi A, Boughton A, Gamble C, Moutton S, Quartier A, Jean N, Van Ness P, Grotto S, Nambot S, Douglas G, Si YC, Chelly J, Shad Z, Kaplan E, Dineen R, Golzio C, Charlet-Berguerand N, Mandel J-L, Piton A
Citation:
Am J Hum Genet. 2020;[Epub ahead of print] doi:10.1016/j.ajhg.2020.02.013
Epub:
Yes
Abstract:
The neuro-oncological ventral antigen 2 (NOVA2) protein is a major factor regulating neuron-specific alternative splicing (AS...
Link:
https://www.cell.com/ajhg/pdfExtended/S0002-9297(20)30055-0
Organism or Cell Type:
zebrafish
Citation Extract:
Mattioli F, Hayot G, Drouot N, Isidor B, Courraud J, Hinckelmann M-V, Mau-Them FT, Sellier C, Goldman A, Telegrafi A, Boughton A, Gamble C, Moutton S, Quartier A, Jean N, Van Ness P, Grotto S, Nambot S, Douglas G, Si YC, Chelly J, Shad Z, Kaplan E, Dineen R, Golzio C, Charlet-Berguerand N, Mandel J-L, Piton A. De Novo Frameshift Variants in the Neuronal Splicing Factor NOVA2 Result in a Common C-Terminal Extension and Cause a Severe Form of Neurodevelopmental Disorder. Am J Hum Genet. 2020;[Epub ahead of print] doi:10.1016/j.ajhg.2020.02.013.

Combined treatment with peptide-conjugated phosphorodiamidate morpholino oligomer-PPMO and AAV-U7 rescues the severe DMD phenotype in mice

Authors:
Forand A, Muchir A, Mougenot N, Sevoz-Couche C, Peccate C, Lemaitre M, Izabelle C, Wood MJA, Lorain SL, Piétri-Rouxel F
Citation:
Molec Ther Methods Clin Devel. 2020;17:695-708. doi:10.1016/j.omtm.2020.03.011
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease caused by an absence of the dystrophin protein, which...
Link:
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(20)30041-3
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Forand A, Muchir A, Mougenot N, Sevoz-Couche C, Peccate C, Lemaitre M, Izabelle C, Wood MJA, Lorain SL, Piétri-Rouxel F. Combined treatment with peptide-conjugated phosphorodiamidate morpholino oligomer-PPMO and AAV-U7 rescues the severe DMD phenotype in mice. Molec Ther Methods Clin Devel. 2020;17:695-708. doi:10.1016/j.omtm.2020.03.011.

A nonsense variant in NME5 causes human primary ciliary dyskinesia with radial spoke defects

Authors:
Cho EH, Huh HJ, Jeong I, Lee NY, Koh WJ, Park HC, Ki CS
Citation:
Clin Genet. 2020 Mar 17. doi: 10.1111/cge.13742. [Epub ahead of print]
Epub:
Yes
Abstract:
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by defects in the function or structure...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.13742
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cho EH, Huh HJ, Jeong I, Lee NY, Koh WJ, Park HC, Ki CS. A nonsense variant in NME5 causes human primary ciliary dyskinesia with radial spoke defects. Clin Genet. 2020 Mar 17. doi: 10.1111/cge.13742. [Epub ahead of print].

The vitamin B12 processing enzyme, mmachc, is essential for zebrafish survival, growth and retinal morphology

Authors:
Sloan JL, Achilly NP, Arnold ML, Catlett JL, Blake T, Bishop K, Jones M, Harper U, English MA, Anderson S, Trivedi NS, Elkahloun A, Hoffmann V, Brooks BP, Sood R, Venditti CP
Citation:
Hum Molec Genet. 2020;[Epub anead of print] doi:10.1093/hmg/ddaa044
Epub:
Yes
Abstract:
Cobalamin C deficiency (cblC), the most common inborn error of intracellular cobalamin metabolism, is caused by mutations in...
Link:
https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddaa044/5809507
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sloan JL, Achilly NP, Arnold ML, Catlett JL, Blake T, Bishop K, Jones M, Harper U, English MA, Anderson S, Trivedi NS, Elkahloun A, Hoffmann V, Brooks BP, Sood R, Venditti CP. The vitamin B12 processing enzyme, mmachc, is essential for zebrafish survival, growth and retinal morphology. Hum Molec Genet. 2020;[Epub anead of print] doi:10.1093/hmg/ddaa044.

Gsx2 is involved in specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neuronal progenitors in zebrafish

Authors:
Itoh T, Miki T, Sakagami M, Asakawa K, Kawakami K, Shimizu T, Hibi M
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.03.16.993402
Epub:
Not Epub
Abstract:
Neurons in the inferior olivary nuclei (IO neurons) send climbing fibers to Purkinje cells to elicit functions of the...
Link:
https://www.biorxiv.org/content/10.1101/2020.03.16.993402v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Itoh T, Miki T, Sakagami M, Asakawa K, Kawakami K, Shimizu T, Hibi M. Gsx2 is involved in specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neuronal progenitors in zebrafish. bioRxiv. 2020;[preprint] doi:10.1101/2020.03.16.993402 .

Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome

Authors:
Wu Y, Xia Y, Li P, Qu H-Q, Liu Y, Yang Y, Lin J, Zheng M, Tian L, Wu Z, Huang S, Qin X, Zhou X, Chen S, Liu Y, Wang Y, Li X, Zeng H, Hakonarson H, Zhuang J
Citation:
Research Square. 2020;[preprint] doi:10.21203/rs.2.19377/v2
Epub:
Not Epub
Abstract:
Background ： Rubinstein–Taybi syndrome (RSTS) is a rare, congenital, plurimalformative, and neurodevelopmental disorder....
Link:
https://www.researchsquare.com/article/rs-9990/v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu Y, Xia Y, Li P, Qu H-Q, Liu Y, Yang Y, Lin J, Zheng M, Tian L, Wu Z, Huang S, Qin X, Zhou X, Chen S, Liu Y, Wang Y, Li X, Zeng H, Hakonarson H, Zhuang J. Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome. Research Square. 2020;[preprint] doi:10.21203/rs.2.19377/v2.

The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils

Authors:
Prajsnar TK, Serba JJ, Dekker BM, Gibson JF, Masud S, Fleming A, Johnston SA, Renshaw SA, Meijer AH
Citation:
Autophagy. 2020;[Epub] doi:10.1080/15548627.2020.1739443
Epub:
Yes
Abstract:
Staphylococcus aureus is a major human pathogen causing multiple pathologies, from cutaneous lesions to life-threatening sepsis...
Link:
https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1739443
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Prajsnar TK, Serba JJ, Dekker BM, Gibson JF, Masud S, Fleming A, Johnston SA, Renshaw SA, Meijer AH. The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils. Autophagy. 2020;[Epub] doi:10.1080/15548627.2020.1739443.

FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells

Authors:
Smith JA, Curry EG, Blue RE, Roden C, Dundon SER, Rodríguez-Vargas A, Jordan DC, Chen X, Lyons SM, Crutchley J, Anderson P, Horb ME, Gladfelter AS , Giudice J
Citation:
J Cell Biol. 2020;219(4):e201911129. doi:10.1083/jcb.201911129
Epub:
Yes
Abstract:
Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-binding protein. FXR1 depletion is...
Link:
https://rupress.org/jcb/article-abstract/219/4/e201911129/133869/FXR1-splicing-is-important-for-muscle-development
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Smith JA, Curry EG, Blue RE, Roden C, Dundon SER, Rodríguez-Vargas A, Jordan DC, Chen X, Lyons SM, Crutchley J, Anderson P, Horb ME, Gladfelter AS , Giudice J. FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. J Cell Biol. 2020;219(4):e201911129. doi:10.1083/jcb.201911129.

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